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强化降压治疗对心房颤动风险的影响

中华高血压杂志 2020年第5期28卷 449-449页

作者：赵狄(译) 刘莉(校) Soliman EZ Rahman A Zhang Z rodriguez cj Chang TI Bates JT Ghazi L Blackshear JL Chonchol M Fine LJ Ambrosius WT Lewis CE 不详

强化降压治疗是否降低高血压患者心房颤动风险仍不明确。研究人员获取来自收缩压干预试验(systolic blood pressure intervention trial,SPRINT)中心血管病风险增加的高血压患者资料进行分析,评估与标准降压治疗(收缩压靶目标<140 mm Hg... 详细信息

强化降压治疗是否降低高血压患者心房颤动风险仍不明确。研究人员获取来自收缩压干预试验(systolic blood pressure intervention trial,SPRINT)中心血管病风险增加的高血压患者资料进行分析,评估与标准降压治疗(收缩压靶目标<140 mm Hg,1mm Hg=0.133kPa)比较,强化降压治疗(收缩压靶目标<120mm Hg)是否降低心房颤动风险。本研究纳入入组时无心房颤动,且有可用基线及随访心电图资料的患者8022例.

关键词：强化降压治疗心房颤动靶目标心血管病风险收缩压高血压患者

当前吸烟增加高血压发病风险:西班牙裔社区健康研究-拉美裔研究

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中华高血压杂志 2021年第12期29卷 1306-1306页

作者： Kaplan RC Baldoni PL Strizich GM Perez-Stable EJ Sacco-ne NL Peralta CA Perreira KM Gellman MD Williams-Nguyen JS rodriguez cj Lee DJ Daviglus M Talavera GA Lash JP Cai J Franceschini N 袁源(翻译) 郑武洪(审校) 不详

高血压是与吸烟相关的心血管病危险因素,但高血压和吸烟的剂量效应关系尚不清楚。本研究针对西班牙裔人群,他们吸烟暴露通常相对较低。方法:研究采用美国西班牙裔18~76岁成年人6年随访研究的数据,明确吸烟与高血压的剂量效应。高血压定... 详细信息

高血压是与吸烟相关的心血管病危险因素,但高血压和吸烟的剂量效应关系尚不清楚。本研究针对西班牙裔人群,他们吸烟暴露通常相对较低。方法:研究采用美国西班牙裔18~76岁成年人6年随访研究的数据,明确吸烟与高血压的剂量效应。高血压定义为血压≥140/90mm Hg(1 mm Hg=0.133kPa)或服用降压药。校正潜在的混杂因素及中介因素,包括尿白蛋白与肌酐比值(在吸烟者中随时间推移而恶化)。

关键词：随访研究混杂因素社区健康心血管病危险因素剂量效应关系中介因素降压药吸烟

收缩压干预试验中不同种族和民族间临床结局:一项随机临床试验

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中华高血压杂志 2018年第10期26卷 998-998页

作者： Still CH rodriguez cj Wright JT Jr Craven TE Bress AP Chertow GM Whelton PK Whittle JC Freedman BI Johnson KC Foy CG He J Kostis JB Lash JP Pedley CF Pisoni R Powell JR Wall BM 陈云叶鹏

收缩压干预试验（systolic blood pressure intervention trial，SPRINT）结果显示，与降压目标≤140mmHg（标准治疗组）相比，以目标收缩压≤120mmHg的强化治疗更能减少心血管事件的发生；然而，目前尚不清楚是否在所有种族／族群间都... 详细信息

收缩压干预试验（systolic blood pressure intervention trial，SPRINT）结果显示，与降压目标≤140mmHg（标准治疗组）相比，以目标收缩压≤120mmHg的强化治疗更能减少心血管事件的发生；然而，目前尚不清楚是否在所有种族／族群间都有相似的效应。

关键词：干预试验随机临床试验收缩压临床结局种族民族心血管事件降压目标

Characteristics of major minerals in volcanic ash in ice core from Collins ice cap, King George Island, Antarctic

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Chinese Science Bulletin 1997年第10期42卷 845-850页

作者： Zhang, WH Liu, JQ Wang, cj Lithosphere Tectonic Evolution Laboratory Institute of Geology Chinese Academy of Sciences Beijing 100029 China

COLLINS ice cap is located in King George Island south of Shetland Islands,*** icecap is exposed over an area of about 1 300 km^2,amounting to 90% of the *** na-tional scientific expeditions to the Antarctic studied and investigated Collins ice cap systemati-cally from May to October 1992 when they drilled six ice cores in Low ice *** ex-trusion in ice core from Collins ice cap suggested by Dia et *** favourable for

关键词： mineral volcanic ash ice core Collins ice cap Antarctic.

Increasing doses of diminazene aceturate:adverse reproductive effects in female Wistar rats

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Asian Pacific Journal of Tropical Medicine 2010年第11期3卷 887-889页

作者： Oguejiofor CF Ochiogu IS Umeoduagu cj Department of Veterinary Obstetrics and Reproductive Diseases Faculty of Veterinary MedicineUniversity of Nigeria NsukkaNigeria

Objective:To investigate the effects of comparatively high doses of diminazene aceturate on the reproductive performance of female rats in the early stage of ***:After oestrus synchronisation and successful mating,20 pregnant female rats were randomly divided into four groups(A-D).Group A rats served as the control and were given single intraperitoneal injection of 0.5 mL sterile water(vehicle only) while groups B.C and D rats were given single intraperitoneal doses of 7,14 and 21 mg/kg body weight diminazene aceturate respectively,on day 7 of *** gestation length,litter size and weight at birth,and areas of foetal resorption in the uterus were determined post *** post-implantation survival index(%) and the gestation index(group%) were also evaluated for rats in all the ***:There was a graded increase in the number of observed resorbed foetuses as the dose of diminazene aceturate was increased,although only groups C(14 mg/kg) and D(21 mg/kg) revealed a significant decrease(P<0.01,ANOVA) in the post implantation survival index of rat *** was also a significant decrease(P<0.05) in the litter weights of rats in groups C and ***: Although the pregnant rats showed no overt signs of systemic toxicity even at the highest dose of 21 mg/kg body weight diminazene aceturate in this study,it was concluded that the use of high doses of diminazene aceturate in an effort to combat resistant trypanosomes could have adverse reproductive effects on female animals in the early period of pregnancy.

关键词： Diminazene aceturate Fetal résorption Reproduction Gestation Litter Rat

Chemistry　and　Pharmacological　Activity　of　Peptidoglycan　from　Lycium　Barbaruml

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Chinese Chemical Letters 1996年第11期7卷 1009-1010页

作者： Zhao, cj He, YQ Li, RZ Cui, GH BEIJING MED UNIV DEPT TRADIT CHINESE MEDBEIJING 100083PEOPLES R CHINA

Two homogeneous new peptidoglycans were obtained from Lycium barbarum L. Theywere found to be effective ingredients capable of resining lipid peroxidation. The componentsand linkages of the two homogeneous polysaccharides were studied by means of complete acidhydrolysis, periodate oxidation. Smith degradation enzyme hydrolysis, IR, GC and aminoacid analysis. Homogeneous polysaccharide LBPC2 was found to be a β(1→4)(1→6) peptidoglycanwith MW of 1.2×104, composed of Xyl, Rha. Man in a molar ratio of8.8:2.3;1, LBPC4 was foundto be a a(1→4)(1→6) peptidoglycan with MW of 1.0×104, composed of glucans.

关键词： Activity Pharmacological Peptidoglycan Lycium Barbaruml

Need for improving quality of operating structures and processes for better ARV adherence for patients with HIV/AIDS in Tanzania and other African countries:an experience from Tanzania

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Asian Pacific Journal of Tropical Medicine 2009年第4期2卷 67-74页

作者： Irunde H Nsimba SED Comoro cj Tanzania Food and Drug Authority(TFDA) P.O.Box 77150Dares SalaamTanzania Muhimbili University of Health & Allied Sciences(MUHAS) Department of Clinical PharmacologyP.O.Box 65010Dares-SalaamTanzania Department of Sociology & Social Sciences University of Dares-SalaamP.O Box 35091Dares-Salaam Tanzania

Objective:The study was carried out in order to determine the following objectives:(1) To determine the proportion of patients who state achieving or not achieving optimal adherence to antiretroviral therapy(ART) in selected Care and Treatment Sites in Arusha and Dares Salaam regions in Tanzania.(2) To identify factors such as structural,cultural or disease related contributing to sub-optimal adherence to antiretroviral(ARVs). (3) To assess quality of operating structures and processes for provision of antiretroviral(ARVs) in the selected healthcare facilities.(4) To document suggestions and proposals for improving ART adherence among ARV ***:Data from 7 studied facilities(3 public and 4 private/or faith based) includes 207 interviews from ARV users,28 staff interview staff,26 observations during consultations,8 focus group discussions,10 key informant interviews,and stock checks in 6 *** study design was a cross-sectional using both qualitative and quantitative data collection *** data were collected by using an adherence tool check list,while qualitative data were obtained using a consultation observation checklist,semi-structured interviews,focus group discussions(FGDs) and key informant ***:There were slight variations in the quality of operating structures and processes in the two studied *** results indicate that ARV adherence in Arusha region was comparatively similar to that of Dares *** composite adherence for one month in seven facilities was 90%and only 21%of ARV users achieved optimal adherence. Conclusion:The overall mean composite adherence rate of 90%in the two areas surveyed is encouraging. More efforts to improve the quality and processes of operating structures in our study facilities and others in Tanzania are heeded to ensure optimal adherence among the larger group(79%) of ARV users who are currently taking less than the critical 95%of their medications.

关键词： Antiretrovirals(ARVs) HIV/AIDS Antiretroviral therapy(ART) Adherence Tanzania

Insight into endoplasmic reticulum-mitochondria contacts in human amyotrophic lateral sclerosis

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Neural Regeneration Research 2024年第7期19卷 1407-1408页

作者： Naomi Hartopp Andrea Markovinovic Christopher cj Miller Patricia Gomez-Suaga Sheffield Institute for Translational Neuroscience University of SheffieldSheffieldUK Department of Basic and Clinical Neuroscience Institute of PsychiatryPsychology and NeuroscienceLondonUK Universidad de Extremadura.Departamento de Bioquímica y Biología Molecular y Genética Facultad de Enfermería y Terapia OcupacionalCáceresSpain Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas-Instituto de Salud Carlos Ⅲ(CIBER-CIBERNED-ISCⅢ) MadridSpain Instituto Universitario de Investigación Biosanitaria de Extremadura(INUBE) CáceresSpain

Amyotrophic lateral sclerosis(ALS) is a fastprogressing fatal neurodegenerative disease and the most common form of motor neuron *** is currently no cure and approximately 90% of cases are *** shares genetic causes,clinical and neuropathological features with frontotemporal dementia,the second most common form of presenile *** and frontotemporal dementia are therefore considered a disease spectrum(Abramzon et al.,2020).

关键词： senile sclerosis

Complement activation by phospholipids: the interplay of factor H and C1q

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Protein & Cell 2010年第11期1卷 1033-1049页

作者： Lee Aun Tan Bingbin Yu Francis cj Sim Uday Kishore Robert B Sim MRC Immunochemistry Unit Department of BiochemistryUniversity of OxfordSouth Parks RdOxford OX13QUUK Department of Pharmacology University of OxfordMansfield RoadOxford OX13QTUK Centre for Infection Immunity and Disease MechanismsBiosciencesSchool of Health Sciences and Social CareBrunel UniversityUxbridge UB83PH West LondonUK Present address Department of Immunology Faculty of MedicineImperial College LondonHammersmith HospitalDu Cane RoadLondon W120NNUK Present address School of Life Sciences and Engineering Biology BuildingTsinghua UniversityBeijing 100084China

Complement proteins in blood recognize charged *** anionic phospholipid(aPL)cardiolipin binds both complement proteins C1q and factor H.C1q is an activator of the complement classical pathway,while factor H is an inhibitor of the alternative *** examine opposing effects of C1q and factor H on complement activation by aPL,we surveyed C1q and factor H binding,and complement activation by aPL,either coated on microtitre plates or in *** C1q and factor H bound to all aPL tested,and competed directly with each other for *** the aPL activated the complement classical pathway,but negligibly the alternative pathway,consistent with accepted roles of C1q and factor ***,in this system,factor H,by competing directly with C1q for binding to aPL,acts as a direct regulator of the complement classical *** regulatory mechanism is distinct from its action on the alternative *** of classical pathway activation by factor H was confirmed by measuring C4 activation by aPL in human sera in which the C1q:factor H molar ratio was adjusted over a wide *** factor H,which is regarded as a down-regulator only of the alternative pathway,has a distinct role in downregulating activation of the classical complement pathway by aPL.A factor H homologue,β2-glycoprotein-1,also strongly inhibits C1q binding to *** globular domains of C1q A,B and C chains bound aPL similarly to native C1q,confirming that C1q binds aPL via its globular heads.

关键词： complement regulation classical pathway C1q factor H anionic phospholipid