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Pramipexole, a dopamine D3/D2 receptor-preferring agonist, attenuates reserpine-induced fibromyalgia-like model in mice

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Neural Regeneration Research 2022年第2期17卷 450-458页

作者： Carlos Pereira Martins Rodrigo Sebben Paes Gabriela Mantovani Baldasso Eduarda Gomes Ferrarini Rahisa Scussel Rubya Pereira Zaccaron Ricardo Andrez Machado-de-Avila Paulo Cesar Lock Silveira Rafael Cypriano Dutra Laboratory of Autoimmunity and Immunopharmacology Department of Health SciencesCampus AraranguaUniversidade Federal de Santa CatarinaAraranguáSCBrazil Post-Graduate Program of Neuroscience Center of Biological SciencesUniversidade Federal de Santa CatarinaFlorianópolisSCBrazil Laboratory of Experimental Physiopathology Program of Postgraduate in Science of HealthUniversidade do Extremo Sul CatarinenseCriciumaSCBrazil

Fibromyalgia(FM) is a complex pathology described as persistent hyperalgesia including somatic and mood dysfunctions, depression and anxiety. Although the etiology of FM is still unknown, a significant decrease in biogenic amines is a common characteristic in its pathogenesis. Here, our main objective was to investigate the role of dopamine D3/D2 receptor during the reserpine-induced pain in mice. Our results showed that pramipexole(PPX) – a dopaminergic D3/D2 receptor agonist – inhibited mechanical allodynia and thermal sensitivity induced by reserpine. Relevantly, PPX treatment decreased immobility time and increased the number of grooming in the forced swimming test and splash test, respectively. Animals that received PPX remained longer in the open arms than the reserpine group using elevated plusmaze apparatus. The repeated PPX administration, given daily for 4 days, significantly blocked the mechanical and thermal allodynia during FM model, similarly to pregabalin, although it failed to affect the reserpine-induced thermal nociception. Reserpine administration induced significant downregulation of dopamine concentration in the central nervous system, and repeated treatment with PPX restored dopamine levels in the frontal cortex and spinal cord tissues. Moreover, PPX treatment inhibited oxidants production such as DCFH(2′,7′-dichlorodihydrofluorescein) and nitrite, also decreased oxidative damage(carbonyl), and upregulated the activity of superoxide dismutase in the spinal cord. Together, our findings demonstrated the ability of dopamine D3/D2 receptor-preferring agonist in reducing pain and mood dysfunction allied to FM in mice. All experimental protocols were approved by the Universidade Federal de Santa Catarina(UFSC) Ethics Committee(approval No. 2572210218) on May 10, 2018.

关键词： dopamine dopaminergic system fibromyalgia hyperalgesia pain pramipexole reserpine

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Droughts in the Amazon: Identification, Characterization and Dynamical Mechanisms Associated

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American Journal of Climate Change 2017年第2期6卷 425-442页

作者： Sérgio rodrigo Quadros dos Santos Célia Campos Braga Clovis Angeli Sansigolo T. T. de Araujo Tiburtino Neves Ana Paula paes dos Santos National Institute for Space Research (INPE) S&atilde o José dos Campos SP Brazil Federal University of Campina Grande (UFCG) Campina Grande PB Brazil Federal University of Pará Western Brazil (UFOPA) Santarém Pa Brazil

In this study, we used the Standard Precipitation Index (SPI) to identify and to characterize the dry extreme events in the Amazon region. The results showed that the drought of 1998 was the most intense (SPI average equal to -1.69) in the period from 1979 to 2014. However, some papers have characterized the years 2005 and 2010 as the two largest droughts of the century. Thus, it was also carried out a comparative study of these droughts. The results showed that the drought 1998 was more intensive and extreme than the droughts of 2005 and 2010, although droughts of 2005 and 2010 lasted longer than 1998 due to oceanic and atmospheric conditions with influencing to cause greater social and economic impacts. Furthermore, it is suggested that the impact of the 2005 and 2010 droughts is a response from the dry occurred in 1993-1994 and 1997-1998.

关键词： Precipitation Extremes Dry Rainy SPI Amazonia

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Climatic Projections of Lightning in Southeastern Brazil Using CMIP5 Models in RCP’s Scenarios 4.5 and 8.5

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American Journal of Climate Change 2017年第3期6卷 539-553页

作者： Ana Paula paes dos Santos Osmar Pinto Júnior Sérgio rodrigo Quadros dos Santos Francisco José Lopes de Lima Everaldo Barreiros de Souza André Arruda Rodrigues de Morais Eldo E. ávila Analía Pedernera National Institute for Space Research (INPE) S&atilde o José dos Campos Brazil Vale Institute of Technology (ITV) Belém Brazil National University of Cordoba (UNC) Córdoba Argentina

Given the high and increasing lightning incidence over the Southeast of Brazil and the various impacts that this phenomenon generates to society, there is a growing need in predicting its occurrence, in order to minimize its consequences. In this context, this work presents the development of a methodology for the projection of lightning in the State of S?o Paulo (Southeastern Brazil), using the HadGEM2-ES and CSIRO-Mk3.6 models in two IPCC climate change scenarios: RCP4.5 and RCP8.5. Since lightning is not an output variable of climate models, tests were carried out to evaluate the relationship between the observed data of oceanic and atmospheric fields, which are known as outputs of the models, and the lightning from the RINDAT and BrasilDAT detection networks. As result, a correlation of 0.84 was obtained. In the projections, it was verified that, while during a large portion of the current climate we observed events of lightning below the average, the future climate reveals the preponderance of anomalously above average events, both in the scenario of intermediate-low emissions (RCP4.5) and in the scenario of high emissions (RCP8.5), suggesting a change in the pattern of the lightning incidence in the State of S?o Paulo.

关键词： Lightning Climatic Projections Southeastern Brazil

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