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Duodenal biopsy may be avoided when high transglutaminase antibody titers are present

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World Journal of Gastroenterology 2009年第38期15卷 4775-4780页

作者： santiago Vivas Jose G Ruiz de Morales Sabino Riestra Laura Arias Dolores Fuentes Noemi Alvarez Sara Calleja Mercedes Hernando Blanca Herrero Javier Casqueiro Luis rodrigo Department of Gastroenterology Hospital de León Institute of Biomedicine University of León Immunology Section Hospital de León Department of Gastroenterology Hospital Universitario Central de Asturias Department of Pathology Hospital de León Department of Pediatrics Hospital de León Faculty of Biology and Environmental Sciences University of León

AIM:To evaluate the predictive value of tissue transglutaminase (tTG) antibodies for villous atrophy in adult and pediatric populations to determine if duodenal biopsy can be ***: A total of 324 patients with celiac disease (CD; 97 children and 227 adults) were recruited prospectively at two tertiary centers. Human IgA class anti-tTG antibody measurement and upper gastrointestinal endoscopy were performed at diagnosis. A second biopsy was performed in 40 asymptomatic adults on a gluten-free diet (GFD) and with normal tTG ***: Adults showed less severe histopathology (26% vs 63%, P<0.0001) and lower tTG antibody titers than children. Levels of tTG antibody correlated with Marsh type in both populations (r=0.661, P<0.0001). Multiple logistic regression revealed that only tTG antibody was an independent predictor for Marsh type 3 lesions, but clinical presentation type and age were not. A cut-off point of 30 U tTG antibody yielded the highest area under the receiver operating characteristic curve (0.854). Based on the predictive value of this cut-off point, up to 95% of children and 53% of adults would be correctly diagnosed without biopsy. Despite GFDs and decreased tTG antibody levels, 25% of the adults did not recover from villous atrophy during the second year after ***: Strongly positive tTG antibody titers might be sufficient for CD diagnosis in children. However, duodenal biopsy cannot be avoided in adults because disease presentation and monitoring are different.

关键词： Biopsy Celiac disease Diagnosis Duodenum Transglutaminases

Meningeal T-cells in the cross-talk between memory consolidation and sleep

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Neural Regeneration Research 2023年第12期18卷 2687-2688页

作者： rodrigo Pacheco Valentina Ugalde Laboratorio de Neuroinmunología Centro Científico y Tecnológico de Excelencia Ciencia&VidaFundación Ciencia&VidaSantiagoChile Facultad de Medicina y Ciencia Universidad San SebastiánSantiagoChile

Some years ago,the infiltration of T-cells into the central nervous system(CNS) was considered a pathological condition ***,during the last two decades,a growing body of studies has shown that T-cells are essential pl... 详细信息

关键词： behavior. sleep consolidation

Small-scale edaphic heterogeneity as a floristic-structural complexity driver in Seasonally Dry Tropical Forests tree communities

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Journal of Forestry Research 2020年第6期31卷 2347-2357页

作者： Cle´ber rodrigo de Souza Jean Daniel Morel Alisson Borges Miranda Santos Wilder Bento da Silva Vinı´cius Andrade Maia Polyanne Aparecida coelho Vanessa Leite Rezende Rubens Manoel dos Santos Forest Sciences Departament Federal University of LavrasCx.P.3037Lavras 37200-000Brazil Biology Department Federal University of LavrasCx.P.3037Lavras 37200-000Brazil

Our work aimed to test the hypothesis that soil microscale heterogeneity act as a community ecological driver,increasing diversity and promoting structural shifts on the Seasonally Dry Tropical Forest(SDTF)tree *** evaluated the relationship between microscale edaphic variations and floristic–structural patterns of tree communities in a SDTF fragment located in the southern end of the Brazilian Caatinga *** and soil data were obtained through 27 sample units of 400 m2(20 m 920 m),within each one we measured and identified at species level all arboreal individuals with Circumference at the Breast Height greater or equal to 10 cm,and also collected the soil *** the data we evaluated soil variation influence on the tree community structural and floristic patterns trough generalized linear *** explained the small-scale structural and floristic variations,contributing significantly to biomass,sprouting and to floristic relationships between sample *** was also observed a possible relation of the result with the Caatinga domain biogeographic history,due the presence of Sedimentary Caatinga species,which are not expected for the study *** plays an important role in driving small-scale complexity and diversity of SDTF,but we also suggest that Caatinga biogeographic events have influence on the high heterogeneity patterns.

关键词： Caatinga domain Edaphic variables Sprouting Sedimentary Caatinga

Late Thrombolysis in Massive Pulmonary Thromboembolism

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Open Journal of Anesthesiology 2012年第5期2卷 234-236页

作者： rodrigo Molina Mendoza Daniel Arnal santiago García-del-Valle Unidad Anestesia y Reanimación Hospital Universitario Fundación Alcorcón Alcorcon Spain.

Pulmonary thromboembolism (PTE) remains a diagnostic and therapeutic challenge for physicians. Anticoagulation with heparin remains as the cornerstone in its management, reserving thrombolysis for cases with hemodynamic impairment. The later has been associated with haemorrhagic complications and has proved beneficial when initiated within the first 48 hours of PTE;but there is little evidence supporting its use passed this time. We present a case of an 84 year old female admitted in our unit and treated successfully with thrombolysis for massive PTE at the fifth day of diagnosis. The patient improved towards complete recovery and was discharged from the hospital 22 days after admission without complications.

关键词： Pulmonary Thromboembolism Thrombolysis Pulmonary Hypertension

Oligo-carrageenan kappa increases C, N and S assimilation, auxin and gibberellin contents, and growth in Pinus radiata trees

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Journal of Forestry Research 2015年第3期26卷 635-640页

作者： Silvia Saucedo rodrigo A. Contreras Alejandra Moenne University of santiago of Chile Santiago Chile Facultad de Ciencias Agrarias Universidad Te'cnica Estatal de Quevedo 63 Quevedo Ecuador

Oligo-carrageenans （OCs） obtained from pure carrageenans extracted from marine red algae stimulate growth by enhancing photosynthesis and basal metabolism in tobacco plants and Eucalyptus trees. In addition, OCs stimulate secondary metabolism, increasing the level of metabolites involved in defense against pathogens. In this work, we analyzed the effect of OC kappa on the increase in height, in activities of basal metabolism enzymes in- volved in carbon, nitrogen and sulphur assimilation, ribu- lose 1,5 biphosphate carboxylase/oxygenase （rubisco）, glutamate dehydrogenase （GDH） and O-acetylserine thiol- lyase （OASTL）, and in the level of growth-promoting hormones, the auxin indole acetic acid （IAA） and the gibberellin GA3, in pine （Pinus radiata） trees treated with OC kappa at concentrations of 1 and 5 mg mL-1 and cultivated for 9 months without additional treatment. Pines treated with OC kappa at 1 mg mL-1 showed a similar increase in height but displayed a higher increased in total chlorophyll, activities of rubisco, GDH and OASTL and level of IAA and GA3 than those treated with OC kappa at 5 mg mL-1. Thus, OC kappa stimulates growth and basal metabolism and increases the level of growth-promoting hormones in pine trees, mainly at 1 mg mL-1.

关键词： Auxin Basal metabolism C, N and Sassimilation Gibberellin Oligo-carrageenan kappaPinus radiata

Misfolded amyloid-βstrains and their potential roles in the clinical and pathological variability of Alzheimer’s disease

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Neural Regeneration Research 2023年第1期18卷 119-120页

作者： Sara Kelley Nelson Perez-Urrutia rodrigo Morales Department of Neurology University of Texas Health Science Center at HoustonHoustonTXUSA Centro Integrativo de Biologia y Quimica Aplicada(CIBQA) Universidad Bernardo O’HigginsSantiagoChile

Potential causes for the clinical and pathological variability observed in Alzheimer’s disease(AD):AD is an age-related neurodegenerative disorder characterized by the impairment of cognitive functions such as memory,learning,and *** commonly described clinical symptoms are due to particular pathological changes in the brain,including inflammation,synaptic loss,and neuronal *** changes are a consequence of the accumulation of abnormally folded amyloid-β(Aβ)and tau proteins in specific areas of the central nervous *** the progressive aging of the world’s population,the number of people affected by AD is expected to substantially and consistently increase in the coming *** positions AD as one of the main public health challenges in the near future.

关键词： clinical Alzheimer amyloid

Emerging Players in the Nitrate Signaling Pathway

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Molecular Plant 2017年第8期10卷 1019-1022页

作者： Grace Armijo rodrigo A. Gutierrez Departamento de Genetica Molecular y Microbiologia Facultad de Ciencias Biologicas FONDAP Center for Genome Regulation Pontificia Universidad Cat61ica de Chile Santiago 8331150 Chile Departamento de Genetica Molecular y Microbiologia Facultad de Ciencias Biologicas Millennium Nucleus Center for Plant Functional Genomics Pontificia Universidad Catolica de Chile Santiago 8331150 Chile

Nitrogen （N）-based fertilizers are routinely used to increase agricultural productivity for both food and non-food uses of crops. Unfortunately, excess N fertilizers escape to the environment, leading to detrimental effects on the ecosystem and human health. Understanding how plants sense and respond to different N nutrients or metabolites to regulate metabolism, physiology, growth, and development is essential for sustained yields while reducing agriculture＇s environmental and economic costs.

关键词： ARABIDOPSIS NETWORKS RESPONSES PLANTS CHL1

Targeting resolvins in cholestatic liver injury

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Hepatobiliary Surgery and Nutrition 2021年第5期10卷 689-691页

作者： Luis AVidela rodrigo Valenzuela Molecular and Clinical Pharmacology Program Institute of Biomedical ScienceSantiagoChile Department of Nutrition Faculty of MedicineUniversity of ChileSantiagoChile

In general terms,the acute inflammatory reaction in conditions of infection or tissue damage is a response of the immune system to cope with survival and return to ***,the reaction is initiated by edema followed by the progressive accumulation of polymorphonuclear leukocytes(PMN)and monocytes that differentiate into macrophages,with production of pro-inflammatory mediators such as leukotrienes(e.g.,LTB4)and prostaglandins(e.g.,PGE2,PGI2,PGF2),which in excess may progress to chronic inflammation(1).Considering that the acute inflammatory response is a protective and self-limited phenomenon,its resolution is an active programmed reaction that is set in by specific pro-resolving mediators(SPMs),which are derived from n-3 polyunsaturated fatty acids(n-3 PUFAs).

关键词： protective acute homeostasis

Synthetic Time Series Generation Model for Analysis of Power System Operation and Expansion with High Renewable Energy Penetration

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Journal of Modern Power Systems and Clean Energy 2021年第4期9卷 849-858页

作者： rodrigo Palma-Behnke Jorge Vega-Herrera Felipe Valencia Oscar Nunez-Mata Energy Center Department of Electrical EngineeringFaculty of Mathematical and Physical SciencesUniversity of ChileSantiagoChile Department of Electrical Engineering University of AntofagastaAntofagastaChile School of Electrical Engineering University of Costa RicaSan PedroCosta Rica

The increasing integration of renewable energy sources into current power systems has posed the challenge of adequately representing the statistical properties associated with their variable power generation. In this paper, a novel procedure is proposed to select a proper synthetic time series generation model for renewable energy sources to analyze power system problems. The procedure takes advantage of the objective of the specific analysis to be performed and the statistical characteristics of the available time series. The aim is to determine the suitable model to be used for generating synthetic time series of renewable energy sources. A set of indicators is proposed to verify that the statistical properties of synthetic time series fit the statistical properties of the original data. The proposal can be integrated into systematic tools available for data analysis without compromising the representation of the statistical properties of the original time series. The procedure is tested using real data from the New Zealand power system in a mid-term analysis on integrating wind power plants into the power system. The results show that the proposed procedure reduces the error obtained in analyzing power systems compared with reference models.

关键词： Time series analysis renewable energy source solar energy stochastic process statistical analysis wind energy