检索结果-南通市图书馆

Fish Nutrition Additives in SHK-1 Cells: Protective Effects of Silymarin

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Bioscience and Biotechnology 2016年第2期7卷 55-62页

作者： rodrigo sanchez Pamela Olivares Erico Carmona Allisson Astuya Hector Herrera Jorge Parodi Laboratorio Fisiología de la Reproducción Escuela de Medicina Veterinaria Núcleo de Investigación en Producción Alimentaria Facultad de Recursos Naturales Universidad Católica de Temuco Temuco Chile Empresa Vitapro Chile Castro Región de Los Lagos Chile Grupo de Genotoxicología Escuela de Medicina Veterinaria Núcleo de Estudios Ambientales Facultad de Recursos Naturales Universidad Católica de Temuco Temuco Chile Laboratory of Cell Culture and Marine Genomics Marine Biotechnology Unit Faculty of Natural and Oceanographic Sciences University of Concepcion and Sur-Austral COPAS Program University of Concepcion Concepción Chile

In nutrition for productive species, additives play an important role in boosting physiological processes. Only in recent years studies include models of the effects on fish cells of these additives. We observed effects of silymarin, a compound highly utilized in aquaculture. The cell line SHK-1 was used derived from the upper liver of the Atlantic salmon as a biological model. Samples were exposed to silymarin in incrementing time and concentrations, to evaluate by MTT and number of cells, the effects on cell viability. Also, oxidative stress models were used to find the protector effects of silymarin against these agents. Our data indicate that a dose of 100 ppm of silymarin is sufficient to stimulate cellular proliferation. Cultures were exposed to high glucose (15 mM) or H2O2 (0.1 mM) in presence of or absence of silymarin at 100 ppm. We observed that the toxic effects of both compounds were blocked by the presence of silymarin. Our results indicate that it is important to evaluate additive effects at a cellular level. Also, silymarin does have proliferative effects, and protect against cellular injury in our models. Our study helps to generate more rational applications of additives in the industry and presents new challenges in order to better manipulate the model in the laboratory, allowing us to obtain new evidence regarding the microalgae’s biology through in vitro studies.

关键词： Fish Nutrition Silymarin Cell Cultures

Malignant transformation of hepatocellular adenoma in a young female patient after ovulation induction fertility treatment:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2019年第4期11卷 229-236页

作者： Juan Glinka rodrigo sanchez Clariá Eugenia Fratanoni Juan Spina Eduardo Mullen Victoria Ardiles Oscar Mazza Juan Pekolj Martín de Santiba?es Eduardo de Santiba?es Department of General Surgery Hepatobilio-pancreatic Unit Hospital Italiano de Buenos Aires Department of Radiology Hospital Italiano de Buenos Aires Department of Surgical Pathology Hospital Italiano de Buenos Aires

BACKGROUND Hepatocellular adenoma(HCA) is a rare benign liver tumor usually affecting young women with a history of prolonged use of hormonal *** the majority is asymptomatic, a low proportion may have significant complications such as bleeding or malignancy. Despite responding to the hormonal stimulus, the desire for pregnancy in patients with small HCA is not contraindicated. However, through this work we demonstrate that intensive hormonal therapies such as those used in the treatment of infertility can trigger serious complications CASE SUMMARY A 33-year-old female with a 10-year history of oral contraceptive use was diagnosed with a hepatic tumor as an incidental finding in an abdominal ultrasound. The patient showed no symptoms and physical examination was unremarkable. Laboratory functional tests were within normal limits and tests for serum tumor markers were negative. An abdominal magnetic resonance imaging(MRI) was performed, showing a 30 mm × 29 mm focal lesion in segment VI of the liver compatible with HCA or Focal Nodular Hyperplasia with atypical behavior. After a total of six years of follow-up, the patient underwent ovulation induction treatment for infertility. On a following MRI, a suspected malignancy was warned and hence, surgery was decided. The surgical specimen revealed malignant transformation of HCA towards trabecular hepatocarcinoma with dedifferentiated areas. There was non-evidence of tumor recurrence after three years of clinical and imaging follow-up.,CONCLUSION HCAs can be malignant regardless its size and low-risk appearance on MRI when an ovultation induction therapy is indicated.

关键词： Hepatocellular adenoma Malignant transformation Focal liver lesion Adenoma Ovulation induction Case report

Preoperative portal vein embolization followed by right hepatectomy to treat a complex common bile duct injury in a 5-year-old child

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Pediatric Surgery 2019年第2期2卷 29-32页

作者： Juan Glinka Rocio Bruballa Martin de Santibañes rodrigo sanchez Clariá Victoria Ardiles Oscar María Mazza Juan Pekolj Eduardo de Santibañes Department of General Surgery Hepato-bilio-pancreatic and Liver Transplantation UnitHospital Italiano de Buenos AiresBuenos AiresArgentina

background Common bile duct injuries(CBDIs)remains a rare but serious complication in children undergoing laparoscopic cholecystectomy(LC),with an incidence of 0.44%.In severe lesions,a major liver resection may be necessary as a definitive *** current principles for safe hepatectomy are mainly focused on the liver parenchyma that remains after ***,one of the main factors related to posthepatectomy hepatic insufficiency is the quantity and quality of the future liver remnant(FLR).To achieve an optimal FLR,techniques such as portal vein embolization(PVE)are *** presentation We present the case of a 5-year-old child with a severe CBDI after LC,treated with preoperative PVE followed by a right hepatectomy as definitive *** reports of liver resections and PVE are described in the literature concerning the pediatric population.

关键词： hepatectomy bile injuries

Misfolded amyloid-beta conformational variants(strains)as drivers of Alzheimer's disease neuropathology

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3219-3220页

作者： Salvatore Saieva rodrigo Morales Department of Neurology The University of Texas Health Science Center at HoustonHoustonTXUSA Centro Integrativo de Biologia y Quimica Aplicada(CIBQA) Universidad Bernardo O’HigginsSantiagoChile

Pathological and clinical variability in Alzheimer's disease(AD):AD is clinically cha racterized by progressive memory loss and cognitive *** a pathological point of view,the main features of AD are the deposition of amyloid plaques(composed of amyloid-beta,Aβ)and neurofibrillary tangles containing hyperphosphorylated Tau in the brain,accompanied by neu ronal and synaptic loss,neuroinflammation and brain atrophy(Jellinger,2022).Regardless of these common traits,growing evidence shows increased heterogen eity in the brain of AD patients considering both clinical manifestations and pathological features.

关键词： amyloid Alzheimer clinical

Role of peripheral amyloid-β aggregates in Alzheimer’s disease: mechanistic, diagnostic, and therapeutic implications

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 1087-1089页

作者： Nazaret Gamez rodrigo Morales Department of Neurology The University of Texas Health Science Center at HoustonHoustonTXUSA Centro Integrativo de Biologia y Quimica Aplicada(CIBQA) Universidad Bernardo O’HigginsSantiagoChile

Compelling evidence demonstrates that the levels of peripheral amyloid-β(Aβ)fluctuate in Alzheimer’s disease(AD)***,Aβdeposits have been identified in peripheral ***,the relevance of peripheral Aβ(misfolded or not)in pathological situations,and the temporal appearance of these pathological fluctuations,are not well *** presence of misfolded Aβin peripheral compartments raises concerns on potential inter-individual transmissions considering the well-reported prion-like properties of this disease-associated *** latter is supported by multiple reports demonstrating that Aβmisfolding can be transmitted between humans and experimental animals through multiple routes of *** this mini-review,we discuss the potential implications of peripheral,disease-associated Aβin disease mechanisms,as well as in diagnostic and therapeutic approaches.

关键词： therapeutic amyloid latter

Materials as activator of future global science and technology challenges

在线全文

学校读者我要写书评

暂无评论

Progress in Natural Science:Materials International 2021年第6期31卷 785-791页

作者： rodrigo Martins Full Professor at FCT-NOVA President of the International Union of Materials Research Societies President of the European Academy of Sciences

The aim of this statement is to give a contribution towards the future, where for all, materials are the driven force for the transformations we aim to reach and for which a global common house is imperative to be established, as the International Union of Materials Research Societies, IUMRS aims to be the central vehicle for such, aiming to boost innovation to its maxima, without compromising vital global principles of opening science to the *** is consolidated by 4 main principles: Circular Economy; Trans disciplinarity; Horizontal cross cutting synergy(the introduced Metro Station concept); look always to the Big Picture and not to silos. This means that the traditional vertical thematic topics that were essential to define so far, the so-called road maps for something should be revisited and reconverted towards much larger horizontal scenarios.

关键词： Materials science and engineering Green technologies and products Materials activator Materials accelerator of progress changes

Cross-talk between T-cells and gut-microbiota in neurodegenerative disorders

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2019年第12期14卷 2091-2092页

作者： rodrigo Pacheco Departamento de Ciencias Biológicas Facultad de Ciencias de la Vida Universidad Andres Bello Laboratorio de Neuroinmunología Fundación Ciencia & Vida

The emerging role of gut microbiota as a key player in the development of neurodegenerative disorders: Mammals have evolved together with commensal microbiota to establish a symbiotic relationship in which they regulate reciprocally by synthesizing and responding to several common chemical substances. In this regard, gut microbiota constitutes a consortium of bacteria that not only participates in the degradation of nutrients, but also produces metabolites, fatty acids and neurotransmitters that can act on the enzymes and receptors expressed in eukaryotic cells, which considerably affects the physiology of the host and contribute to maintaining homeostasis (Lyte, 2013).

关键词： Cross-talk T-cells neurodegenerative disorders

Geostatistical seismic inversion and 3D modelling of metric flow units,porosity and permeability in Brazilian presalt reservoir

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2024年第3期21卷 1699-1718页

作者： rodrigo Penna Wagner Moreira Lupinacci Exploratory Interpretation and Reservoir Characterization Group(GIECAR) Department of Geology and GeophysicsUniversidade Federal FluminenseNiteroiRJ24210-346Brazil Petrobras Rio de JaneiroRJ20031-912Brazil

Flow units(FU)rock typing is a common technique for characterizing reservoir flow behavior,producing reliable porosity and permeability estimation even in complex geological ***,the lateral extrapolation of FU away from the well into the whole reservoir grid is commonly a difficult task and using the seismic data as constraints is rarely a subject of *** paper proposes a workflow to generate numerous possible 3D volumes of flow units,porosity and permeability below the seismic resolution limit,respecting the available seismic data at larger *** methodology is used in the Mero Field,a Brazilian presalt carbonate reservoir located in the Santos Basin,who presents a complex and heterogenic geological setting with different sedimentological processes and diagenetic *** generated metric flow units using the conventional core analysis and transposed to the well log ***,given a Markov chain Monte Carlo algorithm,the seismic data and the well log statistics,we simulated acoustic impedance,decametric flow units(DFU),metric flow units(MFU),porosity and permeability volumes in the metric *** aim is to estimate a minimum amount of MFU able to calculate realistic scenarios porosity and permeability scenarios,without losing the seismic lateral *** other words,every porosity and permeability volume simulated produces a synthetic seismic that match the real seismic of the area,even in the metric *** achieved 3D results represent a high-resolution fluid flow reservoir modelling considering the lateral control of the seismic during the process and can be directly incorporated in the dynamic characterization workflow.

关键词： Flowunits Geostatistical inversion Presalt reservoir 3D reservoir modelling Petrophysical modelling

The status of research and utilisation on the subtidal kelp along the Chilean coast:A literature review

在线全文

学校读者我要写书评

暂无评论

Acta Oceanologica Sinica 2022年第12期41卷 7-17页

作者： Simona Laukaityte rodrigo Riera School of Natural Sciences Macquarie UniversitySydney 2109Australia Groningen Institute for Evolutionary Life-Sciences University of GroningenGroningen 9747 AGthe Netherlands Biodiversity and Conservation Group(BIOCON) Instituto Universitario de Investigación en Acuicultura Sostenible y Ecosistemas Marinos(IU-ECOAQUA)Universidad de Las Palmas de Gran CanariaGran Canaria 35001Spain Departamento de Ecología Facultad de CienciasUniversidad Católica de la Santísima ConcepciónConcepción 2850Chile

The most important marine coastal ecosystem in the Chilean coast are kelp *** review is based on ecological studies regarding different aspects of subtidal kelp ecosystems along the Chilean *** highlights the most interesting findings in(1)biology of subtidal kelp in Chile,with particular reference to(2)habitats formed by kelp,and considered the successful examples and promising results in the(3)kelp as an industrial resource(Biotechnological approach of kelps and aquaculture).The impact caused by(4)El Niño-Southern Oscillation is discussed as an important climatic event that could help to forecast the future of the kelp *** addition,this literature review outlines the knowledge gaps on subtidal kelp along the Southeast Pacific Coast of Chile,so that research can be strengthened in the future.

关键词： kelp macroalgae harvesting commercial kelp subtidal SE Pacific Ocean