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Role of peripheral amyloid-β aggregates in Alzheimer’s disease: mechanistic, diagnostic, and therapeutic implications

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Neural Regeneration Research 2025年第4期20卷 1087-1089页

作者： Nazaret Gamez rodrigo Morales Department of Neurology The University of Texas Health Science Center at HoustonHoustonTXUSA Centro Integrativo de Biologia y Quimica Aplicada(CIBQA) Universidad Bernardo O’HigginsSantiagoChile

Compelling evidence demonstrates that the levels of peripheral amyloid-β(Aβ)fluctuate in Alzheimer’s disease(AD)***,Aβdeposits have been identified in peripheral ***,the relevance of peripheral Aβ(misfolded or not)in pathological situations,and the temporal appearance of these pathological fluctuations,are not well *** presence of misfolded Aβin peripheral compartments raises concerns on potential inter-individual transmissions considering the well-reported prion-like properties of this disease-associated *** latter is supported by multiple reports demonstrating that Aβmisfolding can be transmitted between humans and experimental animals through multiple routes of *** this mini-review,we discuss the potential implications of peripheral,disease-associated Aβin disease mechanisms,as well as in diagnostic and therapeutic approaches.

关键词： therapeutic amyloid latter

Misfolded amyloid-beta conformational variants(strains)as drivers of Alzheimer's disease neuropathology

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Neural Regeneration Research 2025年第11期20卷 3219-3220页

作者： Salvatore Saieva rodrigo Morales Department of Neurology The University of Texas Health Science Center at HoustonHoustonTXUSA Centro Integrativo de Biologia y Quimica Aplicada(CIBQA) Universidad Bernardo O’HigginsSantiagoChile

pathological and clinical variability in Alzheimer's disease(AD):AD is clinically cha racterized by progressive memory loss and cognitive *** a pathological point of view,the main features of AD are the deposition of amyloid plaques(composed of amyloid-beta,Aβ)and neurofibrillary tangles containing hyperphosphorylated Tau in the brain,accompanied by neu ronal and synaptic loss,neuroinflammation and brain atrophy(Jellinger,2022).Regardless of these common traits,growing evidence shows increased heterogen eity in the brain of AD patients considering both clinical manifestations and pathological features.

关键词： amyloid Alzheimer clinical

Are assemblages of the fireworm Hermodice carunculata enhanced in sediments beneath offshore fish cages?

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Acta Oceanologica Sinica 2014年第4期33卷 108-111页

作者： rodrigo Riera Oscar pérez Myriam Rodríguez Eva Ramos óscar Monterroso Centro de Investigaciones Medioambientales del Atlántico (CIMA SL) Department of Biodiversity Qatar Environment and Energy Research Institute (QEERI)

Abundances of the fireworm Hermodice carunculata were counted through a monitoring assessment study of fish cages in Barranco Hondo（NE Tenerife）. Seven campaigns were conducted from November 2007 to June 2010 and temporal variations were found, as well as differences among sampling stations. The polychaete H. carunculata obtained its highest abundance in sediments beneath fish cages throughout the study period. Thus, the assemblages of this omnivorous species were favoured by the presence of fish cages.

关键词： aquaculture organic enrichment environmental impact polychaeta Hermodice carunculata Tenerife Canary Islands Atlantic Ocean

Feasibility of the 2-point method to determine the load-velocity relationship variables during the countermovement jump exercise

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Journal of Sport and Health Science 2023年第4期12卷 544-552,F0003页

作者： Alejandro pérez-Castilla rodrigo Ramirez-Campillo John F.T.Fernandes Amador García-Ramos Department of physical Education and Sport Faculty of Sport SciencesUniversity of GranadaGranada 18011Spain Human performance Laboratory Department of Physical Activity SciencesUniversidad de Los LagosSantiago 5170000Chile Centro de Investigacion en Fisiologıa del Ejercicio Facultad de CienciasUniversidad MayorSantiago 8580745Chile Higher Education Sport Hartpury UniversityHartpury GL193BEUK Department of Sports Sciences and physical Conditioning Faculty of EducationUniversidad Catolica de la Santısima ConcepcionConcepcion 4090541Chile

purpose:This study aimed to examine the reliability and validity of load-velocity(L-V)relationship variables obtained through the 2-point method using different load combinations and velocity ***:Twenty men performed 2 identical sessions consisting of 2 countermovement jumps against 4 external loads(20 kg,40 kg,60 kg,and80 kg)and a heavy squat against a load linked to a mean velocity(MV)of 0.55 m/s(load_(0.55)).The L-V relationship variables(load-axis intercept(L_(0)),velocity-axis intercept(v_(0)),and area under the L-V relationship line(A_(line)))were obtained using 3 velocity variables(MV,mean propulsive velocity(MpV),and peak velocity)by the multiple-point method including(20-40-60-80-load_(0.55))and excluding(20-40-60-80)the heavy squat,as well as from their respective 2-point methods(20-load_(0.55)and 20-80).Results:The L-V relationship variables were obtained with an acceptable reliability(coefncient of variation(CV)≤7.30%;intra-class correlation coefficient>0.63).The reliability of L_(0)and v_(0)was comparable for both methods(CV_(ratio)(calculated as higher value/lower value):1.11-1.12),but the multiple-point method provided Al_(ine)with a greater reliability(CV_(ratio)=1.26).The use of a heavy squat provided the L-V relationship variables with a comparable or higher reliability than the use of a heavy countermovement jump load(CV_(ratio):1.06-1.19).The peak velocity provided the load-velocity relationship variables with the greatest reliability(CV_(ratio):1.15-1.86)followed by the MV(CV_(ratio):1.07-1.18),and finally the *** 2-point methods only revealed an acceptable validity for the MV and MpV(effect size≤0.19;pearson s product-moment correlation coefficient≥0.96;Lin's concordance correlation coefficient≥0.94).Conclusion:The 2-point method obtained from a heavy squat load and MV or MpV is a quick,safe,and reliable procedure to evaluate the lower-body maximal neuromuscular capacities through the L-V relationship.

关键词： Force-velocity relationship Mean velocity Multiple-point method peak velocity Velocity-based training

Queens remate despite traumatic mating in stingless bees

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Current Zoology 2022年第1期68卷 81-92页

作者： Jamille Costa VEIGA Gustavo rodrigo Sanches RUIZ Gislene almeida CARVALHO-ZILSE Cristiano MENEZES Felipe Andres Leon CONTRERA Bee Biology and Ecology Lab Instituto de Ciencias BiologicasUniversidade Federal do ParaBelem66075-110 ParaBrazil Biodiversity and Ecosystem Services Research Group Instituto Tecnologico Vale-Desenvolvimento SustentavelBelem66055-090 ParaBrazil Ecology and Zoology of Invertebrates Lab Instituto de Ciencias BiologicasUniversidade Federal do ParaBelem66075-110 ParaBrazil Bee Research Group Instituto Nacional de Pesquisas da AmazoniaManaus69067-375 AmazonasBrazil Research and Development Embrapa Meio AmbienteJaguariuna13820-000 Sao PauloBrazil

Males can control female reproduction using genital plugs to impede access by *** social bees,ants,and wasps,plugging may involve traumatic mating,with females being *** stingless bees,chances are that plugs may promote ovarian activan,and are thought to ensure single mating—a general tendency among the social ***,understanding on relationships between mating plugs,traumatic mating,and mating systems in stingless bees remains *** address this,we(1)compared mated queens of 7 Neotropical species to understand the patterns of copulatory marks in females and(2)compared pre-and post-mating genitalia of males and females in Melipona fasciculata to depict plug functional *** revealed an unprecedented consequence of mating in stingless bees:the characteristic marks left by mating plugs on female abdomens and the inferences that can be made from *** our surprise,in 1 species *** we found that queens retain the plug long after mating,and may carry it for the rest of their *** the other 6 species retained the plug for only a short *** queens were only found in ***,whose multiple copulatory marks match previous findings of polyandry in this *** study shows that queens can remate,and suggests that male genital morphology may determine in part the time persistence of *** conclude that traumatic mating plugs do not fully prevent remating in stingless bees and that mating systems are not uniform in this ***,exceptional cases of facultative polyandry in social insects—for example,when mating plugs fail—may confirm a general tendency for single mating in close link with efficient mating plugs.

关键词： copulatory marks facultative polyandry genital morphology male harm sexual conflict

Land cover change and carbon stores in a tropical montane cloud forest in the Sierra Madre Oriental,Mexico

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Journal of Mountain Science 2018年第10期15卷 2136-2147页

作者： Edgar G.LEIJA-LOREDO Numa p.pAVóN Arturo SáNCHEZ-GONZáLEZ rodrigo RODRIGUEZ-LAGUNA GregorioáNGELES-péREZ Center for Biological Research Autonomous University of Hidalgo.42184 HidalgoMexico Institute oJ:Ag ricultural Sciences Academic Area of Forestry EngineeringAutonomous University of Hidalgo.43600 HidalgoMexico postgraduate School Campus MontecilloPostgraduate in Forest Sciences.56230 Estado de MexicoMexico

Tropical montane cloud forest is one of the ecosystems with the highest biomass worldwide, representing an important carbon store. Globally its deforestation index is –1.1%, but in Mexico it is higher than –3%. Carbon estimates are scarce globally, particularly in Mexico. The objective of this study was to simulate future land-cover scenarios for the Sierra Madre Oriental in Mexico, by analyzing past forest cover changes. Another objective was to estimate stored carbon in the two study areas. These objectives involve the generation of information that could be useful inputs to anti-deforestation public policy such as the REDD+ strategy. Remote sensing was used to measure land cover change and estimate carbon stocks. Satellite images from 2015, 2000 and 1986 were used, and Dinamica EGO freeware generatedmodels of future projections. Between 1986 and 2015, 5171 ha of forest were converted to pasture. The annual deforestation rates were –1.5% for Tlanchinol and –1.3% for the San Bartolo Tutotepec sites. Distance to roads and marginalization were highly correlated with deforestation. By 2030, an estimated 3608 ha of forest in these sites will have been converted to pasture. Stored carbon was estimated at 16.35 Mg C ha-1 for the Tlanchinol site and 12.7 Mg C ha-1 for the San Bartolo site. In the Sierra Madre Oriental deforestation due to land cover change(–1.4%) is higher than levels reported worldwide. Besides having high values of stored carbon(14.5 Mg C ha-1), these forests have high biodiversity. The models' outputs show that the deforestation process will continue if action is not taken to avoid the expansion of livestock pasturing. This can be done by paying incentives for forest conservation to the owners of the land. The results suggest that REDD+ is currently the most viable strategy for reducing deforestation rates in tropical montane cloud forests in Sierra Madre Oriental.

关键词： Cloud forest Carbon stores C mitigation Climate change Dinamica EGO Forest management Remote sensing.

Sexual differences in weaponry and defensive behavior in a neotropical harvestman

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Current Zoology 2019年第5期65卷 553-558页

作者： Julio M.G.SEGOVIA Gabriel p.MURAYAMA rodrigo H.WILLEMART Laboratorio de Ecologia Sensorial e Comportamento de Artropodes Escolade ArtesCiencias e Humanidades da Universidade de Sao PauloSao PauloBrazil programa de pos-Graduaqao em Zoologia Instituto de BiocienciasUniversidade de Sao PauloSao PauloBrazil programa de pos-Graduaqao em Ecologia e Evoluqao Universidade Federal de Sao PauloSao PauloBrazil

Sexual differences in morphology can evolve by sexual selection and/or natural *** some species,only males have morphological structures that are used as *** some weapons may also be used for defensive purposes,males and females may behave differently towards *** some species of harvestmen(Arachnida and Opiliones),males have sharp apophyses("spines")on their 4th pair of legs whereas females lack *** apophyses are used in malemale fights and in antipredatory *** harvestmen antipredatory repertory also encompasses passive defenses such as thanatosis(death feigning),retaliation(attack on predators),and chemical *** to the sexual differences on weaponry,we hypothesized that males and females of Mischonyx cuspidatus(Gonyleptidae)rely on different defensive *** experimentally induced males and females to perform 3 defensive behaviors:thanatosis,pinching with legs,and chemical *** predicted that females would engage more in passive and chemical defenses than males,whereas males would rely more on retaliation than *** expected,females performed thanatosis more often than ***,males performed retaliation more often than *** did not find differences in the rate of chemical defense use between the *** study provides evidence that due to sexual dimorphism,alternative antipredatory behaviors may have been selected in the different sexes in ***.

关键词： Arachnida death feigning nipping thanatosis weapon Opiliones

Microstructural, mechanical and corrosion characterization of an as-cast Mg-3Zn-0.4Ca alloy for biomedical applications

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Journal of Magnesium and Alloys 2020年第2期8卷 510-522页

作者： N.pulido-Gonzalez B.Torres p.rodrigo N.Hort J.Rams Department of Applied Mathematics Materials Science and Engineering and Electronics Technology.ESCETRey Juan Carlos UniversityC/Tulipan s/n28933 MdstolesMadridSpain Magnesium Innovation Centre Helmholtz-Zentrum Geesthacht21502 GeesthachtGermany

The as-cast Mg-3Zn-0.4Ca alloy shows a great potential to be used in biomedical applications due to its composition,mechanical properties and *** and Ca appear naturally in the organism accomplishing vital *** alloy consists of an a-Mg matrix and a eutectic composed of *** eutectic product enhances the mechanical properties of the studied alloy,causing strengthening and providing superior hardness *** this alloy,cracks initiate at the intermetallic compounds and progress through the matrix because of the open network formed by the *** to the corrosion results,the eutectic product presents a noble potential compared to the a-Mg *** this reason,the corrosion progresses preferentially through the matrix,avoiding the(α-Mg+Ca2Mg6Zri3)eutectic product,when the alloy is in direct contact to Hank's solution.

关键词： Mg-Zn-Ca alloys Biomaterials Biodegradable implants Nanoindentation Three-point bending test Corrosion behaviour

Materials as activator of future global science and technology challenges

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progress in Natural Science:Materials International 2021年第6期31卷 785-791页

作者： rodrigo Martins Full professor at FCT-NOVA president of the International Union of Materials Research Societies President of the European Academy of Sciences

The aim of this statement is to give a contribution towards the future, where for all, materials are the driven force for the transformations we aim to reach and for which a global common house is imperative to be established, as the International Union of Materials Research Societies, IUMRS aims to be the central vehicle for such, aiming to boost innovation to its maxima, without compromising vital global principles of opening science to the *** is consolidated by 4 main principles: Circular Economy; Trans disciplinarity; Horizontal cross cutting synergy(the introduced Metro Station concept); look always to the Big picture and not to silos. This means that the traditional vertical thematic topics that were essential to define so far, the so-called road maps for something should be revisited and reconverted towards much larger horizontal scenarios.

关键词： Materials science and engineering Green technologies and products Materials activator Materials accelerator of progress changes