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Postpartum depression:A systematic review of the genetics involved

World Journal of Psychiatry 2015年第1期5卷 103-111页

作者： Tiago Castro e Couto Mayra Yara Martins Brancaglion António Alvim-Soares Lafaiete Moreira Frederico Duarte Garcia rodrigo nicolato Humberto Corrêa Regina Amélia Lopes P Aguiar Henrique Vitor Leite Postgraduate Program in Molecular Medicine School of MedicineUniversidade Federal de Minas Gerais Department of Mental Health School of MedicineUniversidade Federal de Minas Gerais Department of Obstetrics and Gynecology School of MedicineUniversidade Federal de Minas Gerais

Postpartum depression is one of the most prevalent psychopathologies. Its prevalence is estimated to be between 10% and 15%. Despite its multifactorial etiology, it is known that genetics play an important role in the genesis of this disorder. This paper reviews epidemiological evidence supporting the role of genetics in postpartum depression(PPD). The main objectives of this review are to determine which genes and polymorphisms are associated with PPD and discuss how this association may occur. In addition, this paper explores whether these genes are somehow related to or even the same as those linked to Major Depression(MD). To identify gaps in the current knowledge that require investigation, a systematic review was conducted in the electronic databases Pub Med, LILACS and Sci ELO using the index terms "postpartum depression" and "genetics". Literature searches for articles in peerreviewed journals were made until April 2014. PPD was indexed 56 times with genetics. The inclusion criteria were articles in Portuguese, Spanish or English that were available by institutional means or sent by authors upon request; this search resulted in 20 papers. Genes and polymorphisms traditionally related to MD, which are those involved in the serotonin, catecholamine, brain-derived neurotrophic factor and tryptophan metabolism, have been the most studied, and some have been related to PPD. The results are conflicting and some depend on epigenetics, which makes the data incipient. Further studies are required to determine the genes that are involved in PPD and establish the nature of the relationship between these genes and PPD.

关键词： Genetics Single nucleotide polymorphisms Molecular Postpartum depression Genes

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