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New immune regulators of sciatic nerve regeneration?lessons from the neighborhood

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Neural Regeneration Research 2024年第4期19卷 705-706页

作者： Andrél.Bombeiro rodrigo G.Q.Fernandes Julie C.Ribot Instituto de Medicina Molecular João lobo Antunes Faculdade de MedicinaUniversidade de LisboaLisbonPortugal

For decades,the immune system has been associated with host protection against infectious pathogens or tumors,while also contributing to ***,this paradigm is now changing,with recent studies highlighting novel roles for immune mediators in the maintenance of steady-state tissue *** this perspective,we review some of the latest findings featuring immune modulators of the nervous system pathophysiology,with a special focus on interleukin(Il)-17.

关键词： homeostasis neighborhood finding

Impacts of brood parasitism by shiny cowbird Molothrus bonariensis on the breeding success of a small host, the black-backed water tyrant Fluvicola albiventer

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Current Zoology 2024年第4期70卷 539-547页

作者： lorena Vanesa Sovrano Evelina Jesica leon rodrigo Ezequiel lorenzón Pamela Fernanda Olguin Adolfo Héctor Beltzer Alejandro Raúl Giraudo laboratorio de Biodiversidad y Conservacion de Tetrapodos Instituto Nacional de Limnologia(INALICONICET-UNL)Paraje El Pozo s/nSanta Fe(3000)Argentina Departamento de Biologia Universidad Autonoma de Entre RiosKm 10.5 RP 11Oro Verde(3100)Entre RiosArgentina Departamento de Biologia Universidad Nacional del LitoralFacultad de Humanidades y CienciasParaje Ei Pozo s/nSanta Fe(3000)Argentina

The shiny cowbird Molothrus bonariensis parasitizes many species with different life-history traits and has a detrimental effect on the survival of the progeny of the *** response,hosts have developed numerous antiparasitic ***,we examined the effects of brood parasitism by shiny cowbird on the clutch and brood sizes(83 nests)in a small host,the black-backed water tyrant Fluvicola *** also studied whether the death of parasite nestlings was related to the care of the foster parents and whether the host had any antiparasitic defense against the shiny *** results indicate that brood parasitism significantly decreased the host hatching and fledging *** majority of nest failures(57%)were caused by brood *** cowbird parasitism occurred in 52%of nests and the intensity of parasitism was 1.23±0.53 eggs per parasitized *** the total host eggs,54%were *** the incubation stage,20 nests(47%)were abandoned because of egg punctures by shiny cowbirds *** two parasitic fledglings were recorded,while the remaining nestlings either died from starvation(n=12)or predation(n=3).Foster parents abandoned parasitic nestlings between 5 and 10 days *** findings demonstrate that the shiny cowbird has very low rates of fledging success when parasitizing black-backed water ***,parasitism had a high reproductive cost in the black-backed water tyrant because a very low proportion(7%)of the parasitized nests(n=43)were successful.

关键词： brood parasitism host defenses nest desertion shiny cowbird small host.

Improving the radiological diagnosis of hepatic artery thrombosis after liver transplantation: Current approaches and future challenges

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World Journal of Transplantation 2024年第1期14卷 1-8页

作者： Cristian lindner Raúl Riquelme rodrigo San Martín Frank Quezada Jorge Valenzuela Juan P Maureira Martín Einersen Department of Radiology Faculty of MedicineUniversity of ConcepciónConcepción 4030000Chile Department of Radiology Hospital Clínico Regional Guillermo Grant BenaventeConcepción 4030000Chile Department of Statistics Catholic University of MauleTalca 3460000Chile Neurovascular Unit Department of RadiologyHospital Clínico Regional Guillermo Grant BenaventeConcepción 4030000Chile

Hepatic artery thrombosis(HAT)is a devastating vascular complication following liver transplantation,requiring prompt diagnosis and rapid revascularization treatment to prevent graft *** present,imaging modalities such as ultrasound,computed tomography,and magnetic resonance play crucial roles in diagnosing *** imaging techniques have improved sensitivity and specificity for HAT diagnosis,they have limitations that hinder the timely diagnosis of this *** this sense,the emergence of artificial intelligence(AI)presents a transformative opportunity to address these diagnostic *** development of machine learning algorithms and deep neural networks has demonstrated the potential to enhance the precision diagnosis of liver transplant complications,enabling quicker and more accurate detection of *** article examines the current landscape of imaging diagnostic techniques for HAT and explores the emerging role of AI in addressing future challenges in the diagnosis of HAT after liver transplant.

关键词： liver transplantation Postoperative complications Hepatic artery Thrombosis Radiology Artificial intelligence

Optical magnetic field enhancement using ultrafast azimuthally polarized laser beams and tailored metallic nanoantennas

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Photonics Research 2024年第5期12卷 1078-1092页

作者： rodrigo MARTIN-HERNANDEZ lORENZ GRUNEWAlD lUIS SANCHEZ-TEJERINA lUIS PlAJA ENRIQUECONEJERO JARQUE CARlOS HERNANDEZ-GARCIA SEBASTIAN MAI Grupo de Investigacion en Aplicaciones del laser y Fotonica Departamento de Fisica AplicadaUniversidad de SalamancaE-37008 SalamancaSpain Unidad de Excelencia en luz y Materia Estructuradas(lUMES) Universidad de SalamancaE-37008 SalamancaSpain Institute of Theoretical Chemistry Faculty of ChemistryUniversity of Vienna1090 ViennaAustria Vienna Doctoral School in Chemistry(DoSChem) Faculty of ChemistryUniversity of Vienna1090 ViennaAustria Departamento de Electricidad y Electrónica Universidad de Valladolid47011 ValladolidSpain

*** *** thank Valentina Shumakova,Elizaveta Gangrskaia,Alessandra Bellissimo,Audrius Pugzlys,and Andrius Baltu?ka for fruitful discussions and computational support by the Vienna Scientific Cluster(VSC 4).The authors thankfully acknowledge the computer resources at MareNostrum and SCAYlE,and the technical support provided by Barcelona Supercomputing Center(RES-FI-2022-3-0041).R.M.-H.,l.S.-T.,l.P.,E.C.J.,and C.H.-*** funding from the European Research Council(ERC)under the European Union’s Horizon 2020 research and innovation program(Grant Agreement No.851201)and support from Ministerio de Ciencia e Innovación(PID2022-142340NB-I00,PID2019-106910GB-I00).This research was funded in whole or in part by the Austrian Science Fund(FWF)(10.55776/ZK91).For open access purposes,the author has applied a CC BY public copyright license to any author accepted manuscript version arising from this submission.

关键词： metallic polarized discussions

Hummingbird-plant interactions in Chile:An ecological review of the available evidence

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Avian Research 2022年第3期13卷 332-340页

作者： rodrigo Medel Manuel lópez-Aliste Francisco E.Fontúrbel Departamento de Ciencias Ecol ogicas Facultad de CienciasUniversidad de ChileSantiagoChile Instituto de Biología Facultad de CienciasPontificia Universidad Cat olica de ValparaísoValparaísoChile Millennium Nucleus of Patagonian limit of life(lili) ValdiviaChile

Hummingbird species have closely evolved with the plants they feed on,which is confirmed by their often tight ecological relationships in natural ***-plant interactions are of interest for research areas such as ecology,evolution,and even agriculture,as they usually inform on the conservation status of interacting species assemblages,and its disappearance may precede the population extinction of the species involved in the *** Chile,there are nine hummingbird species,which interact with a large and diverse number of angiosperm species in forest,desert,and mountain range *** motivation to perform this review is to systematize the available information regarding the flowering plants visited by hummingbird species in Chile,to present some basic plant-hummingbird pollination network metrics,and on this basis to identify the components of the plant-hummingbird relationships in need of further research.A plant-hummingbird metanetwork revealed a low connectance value,low niche overlap,and strong modularity among ***,the fact that most species present a strong allopatric distribution across Chile,suggests that network structure results mostly from the history of colonization rather than from ecological ***,the main threats to Chilean hummingbirds are anthropogenic disturbance and climate change,which disrupt hummingbird-plant interactions,leading to unpredictable ecological consequences at the community *** periods of drought may reduce the resource base for hummingbirds,with dramatic consequences for the maintenance of bird and plant populations.

关键词： Conservation Endemic species Habitat disturbance Pollination Trochilidae

Experimental hybridization and reproductive isolation between two sympatric species of tephritid fruit flies in the Anastrepha fraterculus species group

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Insect Science 2018年第6期25卷 1045-1055页

作者： Juan Rull Eduardo Tadeo rodrigo lasa Christian l.Rodriguez Alma Altuzar-Molina Martin Aluja PROIMI Biotecnologia-OONICET LIEMEN-Division Control Biologico de PlagasTucumanArgentina Red de Manejo Biorracional de Plagas y Vectores Instituto de EcologiaA.C.XalapaVeracruzMexico

Among tephritid fruit flies,hybridization has been found to produce local adaptation and speciation,and in the case of pest species,induce behavioral and ecological alterations that can adversely impact efficient pest *** species group within Anastrepha (Diptera:Tephritidae),is a rapidly radiating aggregate,which includes cryptic species complexes,numerous sister species,and several pest species. Molecular studies have highlighted the possibility of introgression between *** and *** isolation has been studied among morphotypes of the A. fraterculus species complex as a tool for species *** we examined the exis- tence and strength of prezygotic and postzygotic isolation between sympatric populations of two closely related species within the highly derivedfraterculus group (*** and ***),coexisting in *** adults of both species showed a strong tendency for assortative mating,a small proportion of hybrid pairings in both directions were *** also observed asymmetric postzygotic isolation,with one hybrid cross displaying a strong reduction in fecundity and F1 egg *** was greater for the progeny of homotypic and hybrid crosses in the maternal *** was a marked female biased sex ratio distortion for both F1 hybrid *** between *** and *** in nature may be difficult but possible;these two species display stronger reproductive isolation than all pairs of species previously examined in the *** species *** postzygotie isolation is suggestive of Wolbachia mediated cytoplasmic incompatibilities that may be exploited in area-wide pest management.

关键词： Anastrephafraterculus Anastrepha obliqua Haldane's rule introgression prezygotic isolation postzygotic isolation

Dietary(poly)phenol intake is associated with cardiometabolic health parameters in adolescents

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Food Science and Human Wellness 2024年

作者： Emily P.laveriano-Santos Sara Castro-Barquero Camila Arancibia-Riveros Ana María Ruiz-león Rosa Casas Ramón Estruch Patricia Bodega Mercedes de Miguel Amaya de Cos-Gandoy Jesús Martínez-Gómez Gloria Santos-Beneit Juan M.Fernández-Alvira rodrigo Fernández-Jiménez Rosa M.lamuela-Raventós Anna Tresserra-Rimbau The Zena and Michael A.Wiener Cardiovascular Institute， Icahn School of Medicine at Mount Sinai Department de Nutrició， Ciències de l'Alimentació I Gastronomia， XIA， Facultat de Farmàcia i Ciències de l'alimentació， Institut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB)， Universitat de Barcelona Department of Internal Medicine， Hospital Clínic， Institutd'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS)， University of Barcelona Consorcio CIBER， M.P.Fisiopatología de la Obesidad y Nutrición (CIBERObn)， Instituto de Salud Carlos III (ISCIII) Mediterranean Diet Foundation 5. Foundation for Science， Health and Education (SHE) 6. Centro Nacional de Investigaciones Cardiovasculares (CNIC) CIBER de Enfermedades Cardiovasculares (CIBERCV) 9. Hospital Universitario Clínico San Carlos

Background: The protective role of (poly)phenols against metabolic disorders has been extensively studied in adults but not in ***: To assess associations of dietary (poly)phenols and their subclasses with cardiometabolic health parameters in adolescents. Methods: A cross-sectional study was conducted in 944 individuals aged 11 to 14 years enrolled in the SI! Program for Secondary Schools trial (NCT03504059). (Poly)phenol intake was assessed using semi-quantitative food frequency questionnaires and the Phenol-Explorer database. The measured cardiometabolic parameters were waist circumference (WC) age-sex z-score， blood pressure (BP) age-sex z-score， blood glucose (BG)， triglycerides (TG)， and high-density lipoprotein cholesterol (HDl-c). Multilevel mixed-effect linear regression models were applied to examine the association between (poly)phenol quintiles and cardiometabolic health ***: Compared to the lowest quintile， adolescents in the highest quintile of total (poly)phenol intake had lower WC z-scores (β=-0.09， 95%CI=-0.09;-0.08， P-for trend=0.002)， mean arterial pressure z-scores (β =-0.11， 95%CI=-0.12;-0.09， P-for trend=0.206)， and HDl-c (β=-1.52， 95%CI=-2.90;-0.14， P-for trend=0.108)， after multivariable adjustment. The WC z-scores (β=-0.11， 95%CI=-0.19;-0.03， P-for trend=0.013) and HDl-c (β=-2.16， 95%CI=-3.78;-0.53， P-for trend=0.046) were lower in the highest quintile of flavonoid intake compared to the lowest quintile. The highest quintile of phenolic acid intake was associated with a lower WC z-score (β=-0.14， 95%CI=-0.26;-0.02， P-for trend=0.011) and TG levels (β=-8.83， 95%CI=-12.37;-5.30， P-for trend le of stilbene intake with lower BG (β=-1.83， 95%CI= -3.103;-0.64， P-for trend l-c (β=2.328， 95%CI= 1.40;3.17， P-for trend=0.466) compared to the lowest quintile. Conclusion: A higher intake of (poly)phenols， espe

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Update on the management and treatment of viral hepatitis

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World Journal of Gastroenterology 2021年第23期27卷 3249-3261页

作者： Patricia Holanda Almeida Celso E l Matielo lilian A Curvelo rodrigo A Rocco Guilherme Felga Bianca Della Guardia Yuri l Boteon liver Unit Hospital Israelita Albert EinsteinSão Paulo 05652-900Brazil Instituto Israelita de Ensino e Pesquisa Albert Einstein Faculdade Israelita de Ciências da Saúde Albert EinsteinSão Paulo 05652-900Brazil

This review aims to summarize the current evidence on the treatment of viral hepatitis,focusing on its clinical ***,future treatment options and areas of potential research interest are *** and Scopus databases were searched for primary studies published within the last ten *** included hepatitis A virus,hepatitis B virus(HBV),hepatitis C virus,hepatitis D virus(HDV),hepatitis E virus,and *** reported in the studies were summarized,tabulated,and *** advances in viral hepatitis treatment were accomplished,such as the advent of curative therapies for hepatitis C and the development and improvement of hepatitis A,hepatitis B,and hepatitis E *** that cure hepatitis B,going beyond viral suppression,are so far unavailable;however,targeted antiviral drugs against HBV(immunomodulatory therapies and gene silencing technologies)are promising approaches to eradicating the ***,high vaccination coverage and large-scale test-and-treat programmes with high screening rates may eliminate viral hepatitis and mitigate their burden on health *** development of curative hepatitis C treatment renewed the enthusiasm for curing hepatitis B,albeit further investigation is *** therapeutic options targeting HDV life cycle are currently under clinical investigation.

关键词： Viral hepatitis Hepatitis A virus Hepatitis B virus Hepatitis C virus Hepatitis D virus Hepatitis E virus

G protein-coupled receptor 37(GPR37) emerges as an important modulator of adenosinergic transmission in the striatum

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Neural Regeneration Research 2019年第11期14卷 1912-1914页

作者： Xavier Morato rodrigo A. Cunha Francisco Ciruela Unitat de Farmacologia Departament Patologia i Terapeutica ExperimentalFacultat de MedicinaInstituto de Investigacion Biomedica de Bellvitge (IDIBELL)Universitat de BarcelonaL’Hospitalet de LlobregatBarcelonaSpainInstitut de NeurocienciesUniversitat de BarcelonaBarcelonaSpain (Morato X Ciruela F) Center for Neuroscience and Cell Biology (CNC)-Center for Neurosciences and Cell BiologyUniversity of CoimbraCoimbraPortugalFaculty of MedicineUniversity of CoimbraCoimbraPortugal

G protein-coupled receptor 37 (GPR37), also known as parkin associated endothelin-like (Pael) receptor, is an orphan G protein- coupled receptor, which suffers a defective parking ubiquitination in autosomal recessive Parkinson’s disease promoting its endoplasmic reticulum aggregation and stress, neurotoxicity and neuronal death (Takahashi and Imai, 2003). Interestingly, we have demonstrated previously that GPR37 heteromerizes with adenosine A2A receptor (A2AR) in the striatum (Morato et al., 2017;Sokolina et al., 2017).

关键词： G protein-coupled receptor 37(GPR37) important modulator adenosinergic transmission