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Dietary(poly)phenol intake is associated with cardiometabolic health parameters in adolescents

Food Science and Human Wellness 2024年

作者： Emily P.Laveriano-Santos Sara Castro-Barquero Camila Arancibia-Riveros Ana María Ruiz-León Rosa Casas Ramón Estruch Patricia Bodega Mercedes de Miguel Amaya de Cos-Gandoy Jesús Martínez-Gómez Gloria Santos-Beneit Juan M.fernández-Alvira rodrigo fernández-jim.nez Rosa M.Lamuela-Raventós Anna Tresserra-Rimbau The Zena and Michael A.Wiener Cardiovascular Institute， Icahn School of Medicine at Mount Sinai Department de Nutrició， Ciències de l'Alimentació I Gastronomia， XIA， Facultat de Farmàcia i Ciències de l'alimentació， Institut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB)， Universitat de Barcelona Department of Internal Medicine， Hospital Clínic， Institutd'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS)， University of Barcelona Consorcio CIBER， M.P.Fisiopatología de la Obesidad y Nutrición (CIBERObn)， Instituto de Salud Carlos III (ISCIII) Mediterranean Diet Foundation 5. Foundation for Science， Health and Education (SHE) 6. Centro Nacional de Investigaciones Cardiovasculares (CNIC) CIBER de Enfermedades Cardiovasculares (CIBERCV) 9. Hospital Universitario Clínico San Carlos

Background: The protective role of (poly)phenols against metabolic disorders has been extensively studied in adults but not in ***: To assess associations of dietary (poly)phenols and their subclasses with cardiometabolic health parameters in adolescents. Methods: A cross-sectional study was conducted in 944 individuals aged 11 to 14 years enrolled in the SI! Program for Secondary Schools trial (NCT03504059). (Poly)phenol intake was assessed using semi-quantitative food frequency questionnaires and the Phenol-Explorer database. The measured cardiometabolic parameters were waist circumference (WC) age-sex z-score， blood pressure (BP) age-sex z-score， blood glucose (BG)， triglycerides (TG)， and high-density lipoprotein cholesterol (HDL-c). Multilevel mixed-effect linear regression models were applied to examine the association between (poly)phenol quintiles and cardiometabolic health ***: Compared to the lowest quintile， adolescents in the highest quintile of total (poly)phenol intake had lower WC z-scores (β=-0.09， 95%CI=-0.09;-0.08， P-for trend=0.002)， mean arterial pressure z-scores (β =-0.11， 95%CI=-0.12;-0.09， P-for trend=0.206)， and HDL-c (β=-1.52， 95%CI=-2.90;-0.14， P-for trend=0.108)， after multivariable adjustment. The WC z-scores (β=-0.11， 95%CI=-0.19;-0.03， P-for trend=0.013) and HDL-c (β=-2.16， 95%CI=-3.78;-0.53， P-for trend=0.046) were lower in the highest quintile of flavonoid intake compared to the lowest quintile. The highest quintile of phenolic acid intake was associated with a lower WC z-score (β=-0.14， 95%CI=-0.26;-0.02， P-for trend=0.011) and TG levels (β=-8.83， 95%CI=-12.37;-5.30， P-for trend <0.001)， and the highest quintile of stilbene intake with lower BG (β=-1.83， 95%CI= -3.103;-0.64， P-for trend <0.001) and TG (β=-3.22， 95%CI= -4.95;-1.49， P-for trend=0.034)， and with higher HDL-c (β=2.328， 95%CI= 1.40;3.17， P-for trend=0.466) compared to the lowest quintile. Conclusion: A higher intake of (poly)phenols， espe

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Gastroenterology case report of mesalazine-induced cardiopulmonary hypersensitivity

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World Journal of Gastroenterology 2015年第13期21卷 4069-4077页

作者： José Ferrusquía Isabel Pérez-Martínez Ricardo Gómez de la Torre María Luisa fernández-Almira Ruth de Francisco Luis rodrigo Sabino Riestra Department of Gastroenterology Central University Hospital of Asturias33011 OviedoAsturiasSpain Department of Internal Medicine Central University Hospital of Asturias33011 OviedoAsturiasSpain

Mesalazine is a 5-aminosalicylic acid derivative that has been widely used to treat patients with inflammatory bowel disease. Accumulating evidence indicates that mesalazine has a very low rate of adverse drug reactions and is well tolerated by patients. However, a few cases of pulmonary and cardiac disease related to mesalazine have been reported in the past, though infrequently, preventing clinicians from diagnosing the conditions early. We describe the case of a 32-yearold man with ulcerative colitis who was admitted with a two-month history of persistent fever following mesalazine treatment initiated 14 mo earlier. At the time of admission, mesalazine dose was increased from 1.5 to 3.0 g/d, and antibiotic therapy was started with no improvement. Three weeks after admission, the patient developed dyspnea, non-productive cough, and chest pain. Severe eosinophilia was detected in laboratory tests, and a computed tomography scan revealed interstitial infiltrates in both lungs, as well as a large pericardial effusion. The bronchoalveolar lavage reported a CD4/CD8 ratio of 0.5, and an increased eosinophil count. Transbronchial biopsy examination showed a severe eosinophilic infiltrate of the lung tissue. Mesalazine-induced cardiopulmonary hypersensitivity was suspected after excluding other possible etiologies. Consequently, mesalazine treatment was suspended, and corticosteroid therapy was initiated, resulting in resolution of symptoms and radiologic abnormalities. We conclude that mesalazine-induced pulmonary and cardiac hypersensitivity should always be considered in the differential diagnosis of unexplained cardiopulmonary symptoms and radiographic abnormalities in patients with inflammatory bowel disease.

关键词： Eosinophilia Mesalazine Pericardial effusion Lung

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Open versus laparoscopic cholecystectomies in patients with or without type 2 diabetes mellitus in Spain from 2003 to 2013

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Hepatobiliary & Pancreatic Diseases International 2016年第5期15卷 525-532页

作者： JoséM de Miguel-Yanes Manuel Méndez-Bailón rodrigo jim.nez-García Valentín Hernández-Barrera Napoleón Pérez-Farinós fernando Turégano Nuria Munoz-Rivas Ana López-de-Andrés Internal Medicine Department Hospital General Universitario“Gregorio Maranón”46Doctor Esquerdo28007MadridSpain Internal Medicine Department Hospital Clínico San CarlosCalle Profesor Martín Lagos28040MadridSpain Preventive Medicine and Public Health Department Health Sciences FacultyRey Juan Carlos UniversityAvenida de AtenasAlcorcón28292MadridSpain Spanish Agency of Alimentary Safety and Nutrition Ministry of HealthSocial Policy and Equality56Alcalá28071MadridSpain Internal Medicine Department Hospital Infanta Leonor80Avenida Gran Vía del Este28031MadridSpain Surgery Department Hospital General Universitario“Gregorio Maranón”46Doctor Esquerdo28007MadridSpain

BACKGROUND: This study aimed to compare the rates of open and laparoscopic cholecystectomies and outcomes in patients with or without type 2 diabetes mellitus (T2DM) in Spain from 2003 to 2013. METHODS: We collected all cases of open and laparoscopic cholecystectomies using national hospital discharge data and evaluated the annual cholecystectomy rates stratiifed by T2DM status. We analyzed tendency for in-hospital mortality (IHM). We also analyzed the impact of T2DM on IHM in patients who underwent cholecystectomies. RESULTS: We identiifed 611 533 cholecystectomies (71.3%laparoscopic) in the patients, in whom 78 227 (12.8%) patients had T2DM. The rates of open cholecystectomies were 3-fold higher (130.0/105 vs 41.1/105) in patients with T2DM than in those without T2DM, and the rate of laparoscopic cholecys-tectomies was almost 2-fold higher (195.2/105 vs 111.8/105) in patients with T2DM. The annual rate of laparoscopic pro-cedures showed an 11-year relative increase of 88.3% (from 117.0/105 to 220.3/105) in T2DM and 49.2% (from 79.2/105 to 118.2/105) in patients without T2DM (P CONCLUSION: The rate of cholecystectomy was higher in patients with T2DM, and laparoscopic cholecystectomy was p

关键词： diabetes mellitus cholecystectomy mortality in-hospital mortality

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What is the prognosis of emphysematous pyelonephritis associated with extended-spectrum beta-lactamases producing microorganisms?

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Asian Journal of Urology 2022年第2期9卷 146-151页

作者： JoséIván Robles-Torres Marco Alberto Ocaña-Munguía JoséGustavo Arrambide-Herrera Adrián Mauricio Martínez-fernández rodrigo Romero-Mata Lauro Salvador Gómez-Guerra Urology Department Hospital Universitario"Dr.Jose´Eleuterio Gonza´lez"Universidad Auto´noma de Nuevo LeonMonterreyNuevo LeonMexico

Objective:To describe the microbiological characteristics in emphysematous pyelonephritis(EPN),demonstrate the frequency of extended-spectrum beta-lactamase(ESBL)microorganisms,and determine if these microorganisms are associated with the prognosis of patients with ***:We conducted a retrospective study in patients with a diagnosis of EPN in a tertiary care hospital of the northeast region of Mexico during the period from January 2011 to January *** variables were analyzed to determine association with the presence of ESBL-producing *** significance was set with p<***:A total of 63 patients were included;55(87.3%)of them were females,with a median age of 55(interquartile range:45-65)*** management was indicated in 38.1%;42.9%were treated with ureteral stent;12.7%with open or percutaneous drainage;15.8%with early nephrectomy;and 9.5%with delayed *** mortality was 13(20.6%)cases;23(36.5%)cases required admission to the intensive care *** most frequent microorganism isolated was Escherichia coli(n=34,53.9%).ESBL microorganisms were found in 31.7%of the *** significant association of ESBL was found with admission to the intensive care unit,or with increased ***:To our knowledge,this is the first study that evaluates ESBL microorganisms as a prognostic factor in *** factors associated with a poor prognosis in patients with EPN have been *** microbiological factors,specifically ESBL-producing bacteria,do not seem to influence in the prognosis of these patients.

关键词： Emphysematous pyelonephritis Extended spectrum betalactamase Mortality Intensive care unit admission

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Water and nutrient and energy systems in urbanizing watersheds

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Frontiers of Environmental Science & Engineering 2012年第5期6卷 596-611页

作者： rodrigo VILLARROEL WALKER Michael Bruce BECKl, jim W. HALL Warnell School of Forestry & Natural Resources University of Georgia Athens GA 30602-2152 USA Environmental Change Institute University of Oxford Oxford University Centre for the Environment South Parks Road Oxford OXI 3QY UK

Driven by considerations of sustainability, it has become increasingly difficult over the past 15-20 years -- at least intellectually -- to separate out the water infrastructure and water metabolism of cities from their intimately inter-related nutrient and energy metabolisms. Much of the focus of this difficulty settles on the wastewater component of the city＇s water infrastructure and its associated fluxes of nutrients （N, P, C, and so on）. Indeed, notwithstanding the massive volumes of these materials flowing into and out of the city, the notion of an urban nutrient infrastructure is conspicuous by its absence. Likewise, we do not tend to discuss, or conduct research into, ＂soilshed＂ agencies, or soilshed management, or Integrated Nutrient Resources Management （as opposed to its most familiar companion, Integrated Water Resources Management, or IWRM）. The paper summarizes some of the benefits （and challenges） deriving from adopting this broader, multi-sectoral ＂systems＂ perspective on addres- sing water-nutrient-energy systems in city-watershed settings. Such a perspective resonates with the growing interest in broader policy circles in what is called the ＂water-food-energy security nexus＂. The benefits and challenges of our Multi-sectoral Systems Analysis （MSA） are illustrated through computational results from two primary case studies： Atlanta, Georgia, USA; and London, UK. Since our work is part of the International Network on Cities as Forces for Good in the Environment （CFG; see ***）, in which other case studies are currently being initiated -- for example, on Kath- mandu, Nepal we close by reflecting upon these issues of water-nutrient-energy systems in three urban settings with quite different styles and speeds of development.

关键词： cities climate change energy sector nutrientsector systems analysis resource recovery water-food-energy security

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Multiplexed Biosensing Diagnostic Platforms Detecting Autoantibodies to Tumor-Associated Antigens from Exosomes Released by CRC Cells and Tissue Samples Showed High Diagnostic Ability for Colorectal Cancer

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Engineering 2021年第10期7卷 1393-1412页

作者： Ana Montero-Calle Itziar Aranguren-Abeigon María Garranzo-Asensio Carmen Poves María Jesús fernández-Aceñero Javier Martínez-Useros rodrigo Sanz Jana Dziaková Javier Rodriguez-Cobos Guillermo Solís-fernández Eloy Povedano Maria Gamella Rebeca Magnolia Torrente-Rodríguez Miren Alonso-Navarro Vivian de los Ríos J.Ignacio Casal Gemma Domínguez Ana Guzman-Aranguez Alberto Peláez-García JoséManuel Pingarrón Susana Campuzano rodrigo Barderas Chronic Disease Program(UFIEC) Carlos III Health InstituteMadrid E-28220Spain Department of Biochemistry and Molecular Biology Faculty of Optics and OptometryComplutense University of MadridMadrid E-28040Spain Gastroenterology Unit San Carlos Clinical HospitalMadrid E-28040Spain Surgical Pathology Department San Carlos Clinical HospitalMadrid E-28040Spain Translational Oncology Division OncoHealth InstituteJimenez Diaz Foundation University HospitalMadrid E-28040Spain Department of Biochemistry Faculty of MedicineAlberto Sols Institute of Biomedical ResearchCSIC-UAMMadrid E-28029Spain Department of Analytical Chemistry Faculty of Chemical SciencesComplutense University of MadridMadrid E-28040Spain Center for Biological Research Spanish National Research Council(CSIC)MadridE-28040Spain Molecular Pathology and Therapeutic Targets Group La Paz University Hospital(IdiPAZ)Madrid E-28046Spain

Colorectal cancer(CRC)is the second leading cause of cancer-related death *** five-year survival rate of CRC patients depends on the stage at diagnosis,being higher than 80%when CRC is diagnosed in the early stages but lower than 10%when CRC is diagnosed in advanced *** against specific CRC autoantigens(tumor-associated antigens(TAAs))in the sera of patients have been widely demonstrated to aid in early ***,we herein aim to identify autoantigens target of autoantibodies specific to CRC that possess a significant ability to discriminate between CRC patients and healthy individuals by means of liquid *** that end,we examined the protein content of the exosomes released by five CRC cell lines and tissue samples from CRC patients by means of immunoprecipitation coupled with mass spectrometry analysis.A total of 103 proteins were identified as potential autoantigens specific to *** bioinformatics and meta-analysis,we selected 15 proteins that are more likely to be actual CRC autoantigens in order to evaluate their role in CRC prognosis by Western blot(WB)and immunohistochemistry(IHC).We found dysregulation at the protein level for 11 of these proteins in both tissue and plasma exosome samples from patients,along with an association of nine of these proteins with CRC *** validation,all but one showed a statistically significant high diagnostic ability to distinguish CRC patients and individuals with premalignant lesions from healthy individuals,either by luminescence Halotag-based beads,or by a multiplexed biosensing platform involving the use of magnetic microcarriers as solid support modified with covalently immobilized Halotag fusion proteins constructed for CRC *** together,our results highlight the usefulness of the approach defined here to identify the TAAs specific to chronic diseases;they also demonstrate that the measurement of autoantibody levels in plasma against the TAAs identified here

关键词： Autoantibodies Diagnosis Colorectal cancer Exosomes Tumor microenviroment Humoral immune response Point of care Biosensors

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Metabolic complications in liver transplant recipients

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World Journal of Gastroenterology 2016年第28期22卷 6416-6423页

作者： Miguel jim.nez-Pérez Rocío González-Grande Edith Omonte Guzmán Víctor Amo Trillo Juan Miguel rodrigo López UGC de Aparato Digestivo Unidad de Hepatología-Trasplante Hepático Hospital Universitario Regional de Málaga

The metabolic syndrome(MS), which includes obesity,dyslipidaemia, hypertension and hyperglycaemia according to the most widely accepted definitions now used, is one of the most common post-transplant complications, with a prevalence of 44%-58%. The MS, together with the immunosuppression, is considered the main risk factor for the development of cardiovascular disease(CVD) in transplant recipients, which in turn accounts for 19%-42% of all deaths unrelated to the graft. The presence of MS represents a relative risk for the development of CVD and death of 1.78. On the other hand, non-alcoholic fatty liver disease(NAFLD), considered as the manifestation of the MS in the liver, is now the second leading reason for liver transplantation in the United States after hepatitis C and alcohol. NAFLD has a high rate of recurrence in the liver graft and a direct relation with the worsening of other metabolic disorders, such as insulin resistance or diabetes mellitus. Consequently, it is vitally important to identify and treat as soon as possible such modifiable factors as hypertension, overweight, hyperlipidaemia or diabetes in transplanted patients to thus minimise the impact on patient survival. Additionally, steroid-free regimens are favoured, with minimal immunosuppression to limit the possible effects on the development of the MS.

关键词： Metabolic syndrome Liver transplantation Immunosuppressions Risk factors Non-alcoholic fatty liver disease

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Chaotic digital cryptosystem using serial peripheral interface protocol and its ds PIC implementation

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Frontiers of Information Technology & Electronic Engineering 2018年第2期19卷 165-179页

作者： rodrigo Méndez-RAMíREZ Adrian ARELLANO-DELGADO César CRUZ-HERNández Fausto ABUNDIZ-PéREZ Rigoberto MARTínez-CLARK Electronics and Telecommunications Department Scientific Research and Advanced Studies Center of Ensenada CONACYT-UABC Engineering Architecture and Design Faculty Autonomous University of Baja California Engineering Architecture and Design Faculty Autonomous University of Baja California

The current massive use of digital communications demands a secure link by using an embedded system（ES） with data encryption at the protocol level. The serial peripheral interface（SPI） protocol is commonly used by manufacturers of ESs and integrated circuits for applications in areas such as wired and wireless communications. We present the design and experimental implementation of a chaotic encryption and decryption algorithm applied to the SPI communication protocol. The design of the chaotic encryption algorithm along with its counterpart in the decryption is based on the chaotic Hénon map and two methods for blur and permute（in combination with DNA sequences）. The SPI protocol is configured in 16 bits to synchronize a transmitter and a receiver considering a symmetric key. Results are experimentally proved using two low-cost dsPIC microcontrollers as ESs. The SPI digital-to-analog converter is used to process, acquire, and reconstruct confidential messages based on its properties for digital signal processing. Finally, security of the cryptogram is proved by a statistical test. The digital processing capacity of the algorithm is validated by dsPIC microcontrollers.

关键词： Chaotic systems Statistical tests Embedded systems dsPIC microcontroller Serial peripheral interface (SPI)protocol

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Glucocorticosteroid therapy in inflammatory bowel diseases: From clinical practice to molecular biology

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World Journal of Gastroenterology 2017年第36期23卷 6628-6638页

作者： Karen Dubois-Camacho Payton A Ottum Daniel Franco-Munoz Marjorie De la Fuente Alejandro Torres-Riquelme David Díaz-jim.nez Mauricio Olivares-Morales Gonzalo Astudillo rodrigo Quera Marcela A Hermoso Innate Immunity Laboratory Immunology ProgramInstitute of Biomedical SciencesFaculty of MedicineUniversidad de Chile Neuroimmunology Laboratory Immunology ProgramInstitute of Biomedical SciencesFaculty of MedicineUniversidad de Chile Division of Research Clínica Las Condes Gastroenterology Department Inflammatory Bowel Disease ProgramClínica Las Condes

Inflammatory bowel diseases(IBDs),such as ulcerative colitis and Crohn's disease,are chronic pathologies associated with a deregulated immune response in the intestinal mucosa,and they are triggered by environmental factors in genetically susceptible *** glucocorticoids(GCs)are widely used as anti-inflammatory therapy in *** the past,patients with moderate or severe states of inflammation received GCs as a first line therapy with an important effectiveness in terms of reduction of the disease activity and the induction of ***,this treatment often results in detrimental side *** downside drove the development of second generation GCs and more precise(non-systemic)drugdelivery *** clinical trials show that most of these new treatments have similar effectiveness to first generation GCs with fewer adverse *** remaining challenge in successful treatment of IBDs concerns the refractoriness and dependency that some patients encounter during GCs treatment.A deeper understanding of the molecular mechanisms underlying GC response is key to personalizing drug choice for IBDs patients to optimize their response to *** this review,we examine the clinical characteristics of treatment with GCs,followed by an in depth analysis of the proposed molecular mechanisms involved in its resistance and dependence associated with *** thorough analysis of current clinical and biomedical literature may help guide physicians in determining a course of treatment for IBDs patients and identifies important areas needing further study.

关键词： Inflammatory bowel diseases Ulcerative colitis Crohn's disease Glucocorticoid dependence Glucocorticoid resistance

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Helix-shaped tractor and repulsor beams enabling bidirectional optical transport of particles en masse

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Photonics Research 2022年第11期10卷 2560-2574页

作者： JOSÉA.rodrigo ÓSCAR MARTÍnez-MATOS TATIANA ALIEVA Universidad Complutense de Madrid Facultad de Ciencias FísicasCiudad Universitaria s/nMadrid 28040Spain

Three-dimensional programmable transport of micro/nano-particles can be straightforwardly achieved by using optical forces arising from intensity and phase gradients of a structured laser beam. Repulsor and tractor beams based on such forces and shaped in the form of a curved trajectory allow for downstream and upstream(against light propagation) transportation of particles along the beams, respectively. By using both types of beams, bidirectional transport has been demonstrated on the example of a circular helix beam just by tuning its phase gradient. Specifically, the transport of a single particle along a loop of the helix has been reported. However, the design and generation of helix-shaped beams is a complex problem that has not been completely addressed, which makes their practical application challenging. Moreover, there is no evidence of simultaneous transport of multiple particles along the helix trajectory, which is a crucial requisite in practice. Here, we address these challenges by introducing a theoretical background for designing helix beams of any axial extension, shape, and phase gradient that takes into account the experimental limitations of the optical system required for their generation. We have found that only certain phase gradients prescribed along the helix beam are possible. Based on these findings, we have experimentally demonstrated, for the first time, helix-shaped repulsor and tractor beams enabling programmable bidirectional optical transport of particles en masse. This is direct evidence of the essential functional robustness of helix beams arising from their self-reconstructing character. These achievements provide new insight into the behavior of helix-shaped beams, and the proven technique makes their implementation easier for optical transport of particles as well as for other light–matter interaction applications. ? 2022 Chinese Laser Press.

关键词： optical tuning shaped

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