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Giant and thrombosed left ventricular aneurysm

World Journal of Cardiology 2015年第7期7卷 431-433页

作者： Jose Alberto de Agustin Jose Juan Gomez de Diego Pedro Marcos-Alberca Jose Luis rodrigo Carlos Almeria Patricia Mahia Maria Luaces Miguel Angel Garcia-Fernandez Carlos Macaya Leopoldo perez de Isla Instituto Cardiovascular Hospital Universitario San Carlos

Left ventricular aneurysms are a frequent complication of acute extensive myocardial infarction and are most commonly located at the ventricular apex. A timely diagnosis is vital due to the serious complications that can occur,including heart failure,thromboembolism,or tachyarrhythmias. We report the case of a 78-yearold male with history of previous anterior myocardial infarction and currently under evaluation by chronic heart failure. Transthoracic echocardiogram revealed a huge thrombosed and calcified anteroapical left ventricular aneurysm. Coronary angiography demonstrated that the left anterior descending artery was chronically occluded,and revealed a big and spherical mass with calcified borders in the left hemithorax. Left ventriculogram confirmed that this spherical mass was a giant calcified left ventricular aneurysm,causing very severe left ventricular systolic dysfunction. The patient underwent cardioverter-defibrillator implantation for primary prevention.

关键词： Myocardial infarction Echocardiography Coronary artery disease Left ventricular aneurysm Coronary angiography

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Time to Progression of AFP(TPA)as a Predictor of Survival in Hepatocellular Carcinoma Treated with Sorafenib(SOR)

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Journal of Cancer Therapy 2014年第14期5卷 1332-1343页

作者： Maria Varela Olegario Castano-Fernandez Marcelo Garrido Lorena Blanco-García Pablo Martínez-Camblor Alicia Mesa-alvarez Carmen Navascues Valle Cadahía-rodrigo Rafael Menendez de Llano Ramon perez-alvarez Maria Luisa Gonzalez-Dieguez Manuel Rodríguez Liver Unit Department of Gastroenterology and HepatologyAsturias Central University HospitalOviedoSpain Hemato-Oncology Department Pontifical Catholic University of ChileSantiagoChile Research Support Unit Biosanitary Research Unit(OIB/Ficyt)OviedoSpain Autonoma University of Chile SantiagoChile Department of Radiology Hospital Universitario Central de AsturiasOviedoSpain

Background: The standard therapy in advanced hepatocellular carcinoma (HCC) is sorafenib (SOR), which has the inconvenience of toxicity and discontinuation. Patient selection and the use of early markers are critical for optimizing the potential benefit of SOR. Alpha-fetoprotein (AFP) has an established role in HCC prognosis. The objective was to evaluate whether AFP variation during SOR treatment reflects the lack of progression to SOR and can be used as a prognostic factor. Methods: AFP levels were prospectively analyzed in 114 patients to determine whether the time to progression of AFP (TPA) at 3 months had a prognostic value for survival. Results: Between July 2007 and October 2012, 114 patients were included (mean age 64 years, 97 male, 96 with cirrhosis). Etiology was alcohol 47 (41%) and hepatitis C virus (HCV) 31 (27%). According to the Barcelona Clinic Liver Cancer (BCLC) staging system: A (one case), B (24 cases) and C (89 cases). The Child-Pugh was Class A in 89 cases. The general condition of the patient according to ECOG-PS was 0 in 73 cases. The median duration of treatment was 5 months (3.47 - 6.53, 95% CI). The median overall survival (OS) was 9.23 months. The standard dose was maintained in 26 patients (22.8%). Sixty-seven percent of patients experienced at least one adverse event grade 3-4. The time to progression of AFP lower or higher than 3 months was an independent prognostic factor of OS (univariate and multivariate analysis): 8.10 vs. 18.85 months, P 3 months had longer OS, and TPA was an independent prognostic factor.

关键词： Hepatocellular Carcinoma Targeted Therapy AFP Sorafenib Prognostic Value Overall Survival

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EL CAMARIN迷你公寓

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现代装饰 2019年第2期 28-35页

作者： Luciano Intile Enrico Cavaglià Fermínlndavere Esteban Basili Guillermo Mirochnic rodrigo perez de Pedro Cecile Elbel Sabine Uldry TommasoPolli Fernando Schapochnik 彭佳 IR arquitectura

这间公寓由阿根廷IR arquitectura建筑设计事务所所设计,是上世纪50年代Chacarita社区房产的一部分。它位于建筑二层的一个角落,可以俯瞰下面的街道。设计师利用空间的特点,打造了一间明亮而又灵活的迷你公寓。

关键词：世纪空间建筑设计利用角落设计师设计事务所公寓

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Hypoglycemic Therapy in Chronic Hepatic Disease Literature Review

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Open Journal of Endocrine and Metabolic Diseases 2020年第10期10卷 137-146页

作者： Pedro Luis Imbeth-Acosta Nehomar Pájaro-Galvis Víctor Leal-Martinez Jorge Rico-Fontalvo rodrigo Daza-Arnedo Orlando Castañeda-López María Cardona-Blanco Karen Mercado-Anillo José Lucas-Daza Christian perez-Calvo Jhonatan Hernández-Meza Álvaro Barraza-Pombo Marianela Florez-Ortega Jorge Hoyos-Fortich Isabella Uparella-Gulfo Blas de Lezo Clinic Cartagena Bolívar Colombia Faculty of Health Sciences University of Sinú Cartagena Bolívar Colombia New Bocagrande Hospital Cartagena Bolívar Colombia Colombian Association of Nephrology Medellín Colombia Colombian Association of Nephrology Cartagena Colombia Endocrinos SAS Cartagena Colombia Renal Unit B. Braun Medellín Antioquia Colombia University of Cartagena Cartagena Bolívar Colombia Colombian Association of Nephrology Ibagué Colombia Caribbean University Hospital Cartagena Colombia University of Sinu Cartagena Colombia Epidemiologist Blas de Lezo Clinic Cartagena Colombia Naval Hospital Cartagena Colombia Rafael Nuñ ez University Cartagena Colombia

Chronic liver disease (CLD) refers to a structural and functional change of the liver, which modifies the pharmacokinetics of multiple drugs, including hypoglycemic agents. This alteration depends on the severity degree of the liver disease, clinical characteristics of the patient, and comorbidities presence such as kidney disease and drug biochemistry. Insulin is considered a safe therapeutic strategy in patients with CLD, however, for many oral hypoglycemic agents, its use and dose adjustment will depend on the Child-Pugh score, based on the risk of hypoglycemia in this type of patient.

关键词： Cirrhosis Hypoglycemic Agents Pharmacokinetics (MeSH)

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