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AMACR is associated with advanced pathologic risk factors in sporadic colorectal adenomas

World Journal of Gastroenterology 2010年第20期16卷 2476-2483页

作者： Sotiris Lakis Theodora Papamitsou Constantina Panagiotopoulou rodoula kotakidou Vassiliki Kotoula Laboratory of Pathology "Georgios Gennimatas" General HospitalThessaloniki 54635Greece Laboratory of Histology Embryology and AnthropologySchool of MedicineAristotle University of ThessalonikiThessaloniki 54006Greece Department of Pathology School of Medi-cineAristotle University of ThessalonikiUniversity CampusThessaloniki 54006Greece

AIM: To analyze α-methylacyl CoA racemase (AMACR) expression in relation to various dysplasia phenotypes and clinicopathological parameters of sporadic colorectal ***: Fifty-f ive cases of sporadic colorectal adenomas were categorized according to the Vienna classif ication for Gastrointestinal *** corresponded to a total of 98 different intra-lesion microscopic f ields that were further independently assigned a histological grade based on the old nomenclature (mild,moderate,severe dyplasia and carcinoma in situ).AMACR expression was evaluated by immunohistochemistry and statistical analysis was performed to investigate possible associations with various clinicopathologic parameters of adenomas ***,age,localization,grade of dysplasia,size and conf ***: Patient age ranged from 41 to 84 years (mean 65 ± 13.2 years);37 patients were males and 18 were *** ranged in size between 0.5 and 30 cm (mean 2 ± 1.3 cm),including 18 tubular,16 villous,20 mixed or tubulovillous,and 1 giant sessile villous *** expression was observed in 3 out of 16 (18.8%) of low-grade vs 23 out of 35 (62.8%) of high-grade lesions (P = 0.002).Most adenomas exhibiting high grade dysplasia with in situ carcinoma-like areas stained positive for AMACR (15/17 or 88.2%) as compared to adenomas with high grade dysplasia which contained severe dysplasia-like foci (6/15 or 40%),(P = 0.005).In AMACR positive adenomas featuring severe dysplasia-like or in situ carcinoma-like areas,AMACR staining was not necessarily observed in the in situ *** in intra-lesion of mild,moderate or severe dysplasia-like foci was more often encountered in adenomas harboring in situ,intramucosal or inf iltrative carcinoma [21/33 (63.6%) vs 9/40 (22.5%),P 1 cm stained more frequently for AMACR than smal

关键词： α-methylacyl CoA racemase Adenoma Colorectal Dysplasia Carcinoma in situ Immunohistochemistry

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