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Label-free biosensing with singular-phaseenhanced lateral position shift based on atomically thin plasmonic nanomaterials

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Light(Science & Applications) 2024年第5期13卷 810-822页

作者： Shaodi Zhu rodolphe Jaffiol Aurelian Crunteanu Cyrille Vézy Sik-To Chan Wu Yuan Ho-Pui Ho Shuwen Zeng Light Nanomaterials&Nanotechnologies(L2n)CNRS-EMR 7004University of Technology of Troyes10000 TroyesFrance. Department of Biomedical engineering The Chinese University of Hong KongShatinNew TerritoriesHong KongChina XLIM Research Institute UMR 7252 CNRS/University of Limoges123Avenue Albert ThomasLimogesFrance

Rapid plasmonic biosensing has attracted wide attention in early disease diagnosis and molecular biology ***,it was still challenging for conventional angle-interrogating plasmonic sensors to obtain higher sensitivity without secondary amplifying labels such as plasmonic *** address this issue,we developed a plasmonic biosensor based on the enhanced lateral position shift by phase *** singularity presents as a sudden phase retardation at the dark point of reflection from resonating plasmonic substrate,leading to a giant position shift on reflected ***,for the first time,the atomically thin layer of Ge2Sb2Te5(GST)on silver nanofilm was demonstrated as a novel phase-response-enhancing plasmonic *** GST layer was not only precisely engineered to singularize phase change but also served as a protective layer for active silver *** new configuration has achieved a record-breaking largest position shift of 439.3μm measured in calibration experiments with an ultra-high sensitivity of 1.72×10^(8)nm RIU−1(refractive index unit).The detection limit was determined to be 6.97×10^(−7)RIU with a 0.12μm position ***,a large figure of merit(FOM)of 4.54×10^(11)μm(RIU∙°)^(−1)was evaluated for such position shift interrogation,enabling the labelfree detection of trace amounts of *** targeted biosensing experiments,the optimized sensor has successfully detected small cytokine biomarkers(TNF-αand IL-6)with the lowest concentration of 1×10^(−16)*** two molecules are the key proinflammatory cancer markers in clinical diagnosis,which cannot be directly screened by current clinical *** further validate the selectivity of our sensing systems,we also measured the affinity of integrin binding to arginylglycylaspartic acid(RGD)peptide(a key protein interaction in cell adhesion)with different Mn2+ion concentrations,ranging from 1 nM to 1 mM.

关键词： diagnosis protective silver

Analyzing the Cytotoxic and Genetic Impact of Datura stramonium extract on MCF7 and HT29 Cancer Cells:A Metabolite and Gene expression Study

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Phyton-International Journal of experimental Botany 2025年第1期94卷 181-198页

作者： Fayez Althobaiti Hadeer Darwish Raghad Alruqayb Saqer S.Alotaibi Fahad e.Alharthi Ibrahim Jafri Sarah Awwadh Altalhi Ghadi Alsharif Hussam Awwadh e Althagafi Hesham Noureldeen Sarah Alharthi Jawaher Albaqami Najla Amin T.Al Kashgry Ahmed Noureldeen Department of Biotechnology College of ScienceTaif UniversityTaif21944Saudi Arabia Department of Biology College of ScienceTaif UniversityTaif21944Saudi Arabia Department of Clinical Laboratory Sciences College of Applied Medical SciencesKing Saud Bin Abdulaziz University for Health SciencesJeddah21423Saudi Arabia Department of Biomedical Research King Abdullah International Medical Research CenterJeddah21423Saudi Arabia Biology Department Faculty of Science and ArtsAl-Baha UniversityAl-Mikhwah65731Saudi Arebia Faculty of Medicine Mansoura UniversityMansoura35516Egypt Department of Chemistry Collage of ScienceTaif UniversityTaif21944Saudi Arabia

The interest in using the Datura stramonium plant is due to its natural products,which are used in many pharmaceutical *** objective of the current study was to assess the therapeutic and cytotoxic effects of the *** plant on two types of human cancer cell models(MCF7 and HT29)in vitro.A soxhlet apparatus was used to obtain methanolic extract from dried plant *** recovered crude,after the solvent had evaporated,was then dispersed at varied concentrations of extract 100,50,20,and 0.0µg/mL and tested to see how the cells ***,the cancer-testis antigen(CTA)gene transcription in the two cell types exposed to the plant extract was examined using a semi-quantitative real-time polymerase chain *** chromatography–mass spectrometry(GC-MS)results produced the significant main metabolites Nonanoic acid,Tropine N-Oxide,3,6-Ditigloyloxy-7-hydroxytropane,Hexadecanoic acid,2-Pentadecanone,6,10,14-trimethyl-,Carvenone,methyl ester,Phytol,Aposcopolamine,Hyoscyamine,4,8,12,16-Tetramethylheptadecan-4-olide,Scopolamine,Alpha.-Tocospiro A,1,2-Cycloheptanedione,3,3,7,7-tetramethyl-,dihydrazone,Campesterol,Stigmasterol,Gamma-Sitosterol and dl-.alpha.-*** results showed that the two types of cell lines impacted by *** extract,through untreated type 1 cells(MCF7)gave a highly significant transcription according to all applicable *** implemented analyses cleared the strong genetic impacts of Datura extract on cancer cells’***2LY and C2orf63 transcript accumulation were also significantly elevated when exposed to plant extract at a level of 50µg/mL in cell line type 2(HT29),but TGIF2LY and P53 had the lowest relative expression at a level of 100µg/mL when treated the same cell line type.

关键词： Datura stramonium secondary metabolites GC-MS analysis cytotoxicity breast and colon cancer cell lines MTT assay

Green synthesis of glycolic acid through the electrocatalytic reduction of oxalic acid over black TiO_(2): An experimental and theoretical study

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Journal of energy Chemistry 2025年第1期100卷 544-556页

作者： Hugo Olvera-Vargas Oscar Andrés Jaramillo-Quintero Luis Darío Alarcón León Orlando Castro-Ocampo Christian A.Celaya Marina e.Rincón Jesús Muñiz Instituto de energías Renovables Universidad Nacional Autónoma de México(IER-UNAM)Priv.Xochicalco s/nCol.CentroTemixcoMorelos.CP 62580Mexico Centro de Nanociencias y Nanotecnología Universidad Nacional Autónoma de México(UNAM)Km 107Carretera Tijuana-EnsenadaEnsenadaB.C.C.P.22800Mexico

Herein,we present the electrocatalytic four-electron hydrogenation of oxalic acid into glycolic acid using black TiO_(2)as an *** acid is an abundant compound found in several sources of organic *** results showed a high selectivity of black TiO_(2)toward glycolic acid,with the formation of glyoxylic acid being the rate-limiting step (glyoxylic acid is the two-electron intermediate).The highest Faradaic efficiency (Fe) of 69.6%±8.3% was achieved at 10.2 mA cm^(-2)in 4 h of electrolysis using an H-type cell operated at room temperature,with 50.2%±3.8% of oxalic acid conversion (degradation kinetic constant k=0.0042±0.0001 min-1),58.8%±7.0%of reaction yield and 1.2±0.18 g L-1of glycolic acid production.A theoretical model of black TiO_(2)coming from anatase TiO_(2)was implemented by introducing Ti3+defects,which gave black TiO_(2)the theoretical capability to easily transform oxalic acid into glycolic acid as experimentally *** reaction mechanism was supported and described in detail by density functional theory calculations,which revealed that surface Ti^(3+)states were the main catalytic *** is the first time that a detailed step-by-step mechanism at the atomic level has been proposed for this electrocatalytic reaction,which represents a valuable contribution to the understanding of this process of high energy/environmental *** is also the first time that black TiO_(2)has been used as an electrocatalyst for this sustainable process.

关键词： Chemical energy storage electrochemical hydrogenation Density functional theory Renewable energy Oxalic acid

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Four-wave mixing in a laser diode gain medium induced by the feedback from a high-Q microring resonator

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Photonics Research 2025年第1期13卷 59-68页

作者： DARIA M.SOKOL NIKITA YU DMITRIeV DMITRY A.CHeRMOSHeNTSeV SeRGeY N.KOPTYAeV ANATOLY V.MASALOV VALeRY e.LOBANOV IGOR A.BILeNKO ARTeM e.SHITIKOV Russian Quantum Center Moscow Institute of Physics and Technology (MIPT) Skolkovo Institute of Science and Technology Lebedev Physical Institute Russian Academy of Sciences Faculty of Physics M.V.Lomonosov Moscow State University

Laser diodes are widely used and play a crucial role in myriad modern applications including nonlinear optics and ***,we explore the four-wave mixing effect in a laser diode gain medium induced by the feedback from the high-Q microring *** phenomenon can be observed at a laser frequency scan close to the microresonator eigenfrequency,prior to the transition of the laser diode from a free-running to a self-injection locking *** effect opens up the possibility for generation of remarkably low-noise,stable,and adjustable microwave *** provide a detailed numerical study of this phenomenon proven with experimental results and demonstrate the generation of the signals in the GHz *** obtained results reveal the stability of such regime and disclose the parameter ranges enabling to achieve ***,our findings uncover,to our knowledge,a novel laser diode operation regime and pave the way for the creation of new types of chip-scale,low-noise microwave sources,which are highly demanded for diverse applications,including telecommunication,metrology,and sensing.

关键词： Four wave mixing

Iron-promoted zirconia-alumina supported Ni catalyst for highly efficient and cost-effective hydrogen production via dry reforming of methane

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Journal of environmental Sciences 2025年第2期148卷 274-282页

作者： Ahmed S.Al-Fatesh Naitik Patel Vijay Kumar Srivastava Ahmed I.Osman David W.Rooney Anis H.Fakeeha Ahmed e.Abasaeed Mohammed F.Alotibi Rawesh Kumar Chemical engineering Department College of EngineeringKing Saud UniversityP.O.Box 800Riyadh 11421Saudi Arabia Department of Chemistry Indus UniversityAhmedabadGujarat 382115India School of Chemistry and Chemical engineering Queen’s University BelfastBelfast BT95AGNorthern IrelandUK Institute of Refining and Petrochemicals Technologies King Abdulaziz City for Science and Technology(KACST)P.O.Box 6086Riyadh 11442Kingdom of Saudi Arabia

Developing cost-effective and high-performance catalyst systems for dry reforming of methane(DRM)is crucial for producing hydrogen(H_(2))***,we investigate using iron(Fe)as a promoter and major alumina support in Ni-based catalysts to improve their DRM *** addition of iron as a promotor was found to add reducible iron species along with reducible NiO species,enhance the basicity and induce the deposition of oxidizable *** incorporating 1 wt.%Fe into a 5Ni/10ZrAl catalyst,a higher CO_(2) interaction and formation of reducible"NiO-species having strong interaction with support"was observed,which led to an∼80%H_(2) yield in 420 min of Time on Stream(TOS).Further increasing the Fe content to 2 wt.%led to the formation of additional reducible iron oxide species and a noticeable rise in H_(2) yield up to 84%.Despite the severe weight loss on Fe-promoted catalysts,high H_(2) yield was maintained due to the proper balance between the rate of CH_(4) decomposition and the rate of carbon deposit ***,incorporating 3 wt.%Fe into the 5Ni/10ZrAl catalyst resulted in the highest CO_(2) interaction,wide presence of reducible NiO-species,minimumgraphitic deposit and an 87%H_(2) *** findings suggest that ironpromoted zirconia-alumina-supported Ni catalysts can be a cheap and excellent catalytic system for H_(2) production via DRM.

关键词： Dry reforming of methane Coke resistant Hydrogen production Cheap catalyst Fe-promoted catalyst

Selective laser melting(SLM)of CX stainless steel:Theoretical calculation,process optimization and strengthening mechanism

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Journal of Materials Science & Technology 2021年第14期73卷 151-164页

作者： Dongdong Dong Cheng Chang Hao Wang Xingchen Yan Wenyou Ma Min Liu Sihao Deng Julien Gardan rodolphe Bolot Hanlin Liao Guangdong Academy of Sciences Guangdong Institute of New MaterialsNational Engineering Laboratory for Modern Materials Surface Engineering TechnologyThe Key Lab of Guangdong for Modern Surface Engineering TechnologyGuangzhou510651China ICD-LASMIS UMR CNRS 6281University of Technology of Troyes12 rue Marie CurieCS 4206010004Troyes CedexFrance ePF Ecole d’ingenieurs2 rue Fernand SastreTroyesFrance ICB-PMDM UMR 6303 CNRSUniv.Bourgogne Franche-ComtéUBFCF-71200Le Creusot/UTBMF-71200.Le Creusot/UTBMF-90010BelfortFrance

In the present work,selective laser melting(SLM)technology was utilized for manufacturing CX stainless steel samples under a series of laser *** effect of laser linear energy density on the microstructure characteristics,phase distribution,crystallographic orientation and mechanical properties of these CX stainless steel samples were investigated theoretically and experimentally via scanning electron microscope(SeM),X-ray diffraction(XRD),electron backscatter diffraction(eBSD)and transmission electron microscope(TeM).Based on the systematic study,the SLM CX stainless steel sample with best surface roughness(Ra=4.05±1.8μm)and relative density(Rd=99.72%±0.22%)under the optimal linear density(η=245 J/m)can be *** CX stainless steel was primarily constituted by a large number of fine martensite(α’phase)structures(i.e.,cell structures,cellular dendrites and blocky grains)and a small quantity of austenite(γphase)*** pre ferred crystallographic orientation(i.e.,direction)can be determined in the XZ plane of the SLM CX ***,under the optimal linear energy density,the good combinations with the highest ultimate tensile strength(UTS=1068.0%±5.9%)and the best total elongation(Te=15.70%±0.26%)of the SLM CX sample can be *** strengthening dominates the strengthening mechanism of the SLM CX sample in as-built state.

关键词： Selective laser melting CX stainless steel Forming quality Mechanical property Strengthening Mechanism

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Therapeutic potential of exercise-hormone irisin in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1555-1564页

作者： eunhee Kim Rudolph eTanzi Se Hoon Choi Genetics and Aging Research Unit MassGeneral Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMAUSA McCance Center for Brain Health Massachusetts General HospitalBostonMAUSA

Irisin is a myokine that is generated by cleavage of the membrane protein fibronectin type Ⅲ domain-containing protein 5(FNDC5) in response to physical exercise. Studies reveal that irisin/FNDC5 has neuroprotective functions against Alzheimer's disease, the most common form of dementia in the elderly, by improving cognitive function and reducing amyloid-β and tau pathologies as well as neuroinflammation in cell culture or animal models of Alzheimer's disease. Although current and ongoing studies on irisin/FNDC5 show promising results, further mechanistic studies are required to clarify its potential as a meaningful therapeutic target for alleviating Alzheimer's disease. We recently found that irisin treatment reduces amyloid-β pathology by increasing the activity/levels of amyloid-β-degrading enzyme neprilysin secreted from astrocytes. Herein, we present an overview of irisin/FNDC5's protective roles and mechanisms against Alzheimer's disease.

关键词： Alzheimer's disease exercise fibronectin typeⅢdomain-containing protein 5(FNDC5) irisin

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Optimal Distributed Dispatch of Smart Multi-Agent energy Hubs Based on Consensus Algorithm Considering Lossy Communication Network and Uncertainty

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CSee Journal of Power and energy Systems 2025年第1期11卷 352-364页

作者： Abdelfattah A.eladl Magda I.el-Afifi Magdi M.el-Saadawi Bishoy e.Sedhom electrical engineering Department Faculty of EngineeringMansoura UniversityEl-MansouraEgypt

This paper proposes an IoT-Fog-Cloud distributed consensus algorithm for solving the energy hub(eH)dispatch problem with packet-dropping communication links and some of eH elements'*** generating and consumption unit in this algorithm is required to estimate total power generated,total load,and power *** node coordination is accomplished using a distributed *** a distributed approach wins in work sharing,enduring a single link failure,effective decision-making,quickest convergence,and autonomy for global power *** method works with all grid types in connected and islanded *** total operation cost and emissions while meeting total demand and system constraints are the most crucial contributions of this *** case studies are applied to explain performance and effectiveness of the proposed algorithm with different packet loss *** uncertainty,sensitivity of the system was *** show mismatch between generated and consumed power is improved by 100%in the electricity grid,99.94%in heating grid,and 99.91%in gas ***,total operating cost,total emissions,and emissions cost decreased by 8.6%,13.48%,and 18.73%,respectively.

关键词： Consensus algorithm CO_(2)emissions energy hubs multi-energy systems packet drops.

Survival with Trastuzumab emtansine in Residual HeR2-Positive Breast Cancer

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四川生理科学杂志 2025年第1期47卷 145-145页

作者： Charles e Geyer Jr the National Surgical Adjuvant Breast and Bowel Project AGO-B and Helios Klinikum Berlin–Buch Berlin Instituto do Câncer do estado de São Paulo São Paulo Orlando Health Cancer Institute Orlando FL the National Center for Tumor Diseases Heidelberg University Hospital and German Cancer Research Center Heidelberg Hospital Universitario La Paz–Instituto de Investigación del Hospital Universitario La Paz Madrid evangelische Kliniken Gelsenkirchen Gelsenkirchen L’Institut du Cancer de Montpellier–Val d’Aurelle Montpellier Providence Cancer Institute Portland OR the Department of Surgery Oncology and Gastroenterology University of Padua and Oncology 2 Istituto Oncologico Veneto IRCCS Padua Stanford University School of Medicine Stanford CA Arbeitsgemeinschaft Gynäkologische Onkologie–Breast and Sana Klinikum Offenbach Offenbach the National Cancer Institute Mexico City the Department of Gynecology and Obstetrics University Hospital Erlangen Comprehensive Cancer Center Erlangen–EMN Friedrich–Alexander University Erlangen–Nuremberg Erlangen Yale University School of Medicine Yale Cancer Center and Smilow Cancer Hospital New Haven CT the All-Ireland Cooperative Oncology Research Group German Breast Group Neu-Isenburg Fudan University Shanghai Cancer Center Shanghai China Institute for Oncology and Radiology of Serbia Belgrade Grupo Médico Ángeles Guatemala City Guatemala Roche Products Welwyn Garden City United Kingdom F. Hoffmann–La Roche Basel Switzerland

Background:Patients with human epidermal growth factor receptor 2(HeR2)-positive early breast cancer with residual invasive disease after neoadjuvant systemic therapy have a high risk of recurrence and *** primary analysis of KATHeRINe,a phase 3,open-label trial,showed that the risk of invasive breast cancer or death was 50%lower with adjuvant trastuzumab emtansine(T-DM1)than with trastuzumab alone.

关键词： Survival cancer breast