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Calabrian and Ionian： A proposal for the definition of Mediterranean stages for the Lower and Middle Pleistocene

Episodes 2006年第2期29卷 107-114页

作者： Maria Bianca Cita Luca Capraro Neri Ciaranfi Enrico Di Stefano Maria Marino Domenico Rio rodolfo Sprovieri Gian Battista Vai Universita di Milano Dipartimento di Scienze della Terra ‘Ardito Desio＇ via Mangiagalli 34. 20133 Milano Italy Universita di Padova Dipartimento di Geologia Paleontologia e Geofisica via Giottol 35137 Padova Italy Universita di Bari Dipartimento di Geologia e Geofisica via Orabona 4 70125 Bari Italy Universita di Palermo Dipartimento di Geologia e Geodesia corso Tukory 131 90134 Palermo Italy Universita di Bologna Dipartimento di Scienze della Terra e Geologico-Ambientali Piazza di Porta San Donato 140126 Bologna Italy

The need to standardise stratigraphical subdivisions of continuous marine sedimentary successions that outcrop for hundreds metres, using clearly defined points fixed in the field is strongly felt. A proposal is presented here to formalize regional stages for the Lower Pleistocene （Calabrian） and for the Middle Pleistocene （Ionian） in Italy. The sections are well exposed, carefully investigated using multiple criteria （an integrated stratigraphical approach） and located in the central part of the Mediterranean. This area is recognized worldwide as a classical region for the Neogene and the Pleistocene sequences. The terrestrial record is directly correlated with the deep-sea record, as determined from ODP Sites 653 （Tyrrhenian Sea）, 963 （Sicily Channel） and 964 （Ionian Sea）from the central Mediterranean. The present formal proposal is consistent with the INQUA and ICS decision to define and correlate the Plio/Pleistocene boundary （GSSP at Vrica） within the Olduvai Subchron, at 1.81 My, the Lower/Middle Pleistocene boundary at the Matuyama/Brunhes reversal at 0. 78 My and the Middle/ Upper Pleistocene boundary with the base of MIS 5, approximately 0. 13My. The present proposal also is consistent with the call for stage unit stratotypes that emphasize both the physical content of a stage and its boundaries （Hilgen et al., 2006）.

关键词：卡拉布里亚爱奥尼亚地中海更新世

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Effects of estrogen receptor modulators on cytoskeletal proteins in the central nervous system

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Neural Regeneration Research 2017年第8期12卷 1231-1240页

作者： Julia J.Segura-Uribe rodolfo Pinto-Almazán Angélica Coyoy-Salgado Claudia E.Fuentes-Venado Christian Guerra-Araiza Unidad de Investigacion Modica en Enfermedades Neurologicas Hospital de Especialidades Centro Medico Nacional Siglo XXI Instituto Mexicano del Seguro Social Mexico City Mexico Seccion de Estudios de Posgrado e Investigacion Escuela Superior de Medicina Instituto Politecnico Nacional Mexico City Mexico Unidad de Investigacion Hospital Regional de Alta Especialidad Ixtapaluca Ixtapaluca Mexico Institute for the Developing Mind Children's Hospital Los Angeles Los Angeles CA USA Department of pediatrics Keck School of Medicine University of Southern California Los Angeles CA USA Consejo Nacional de Ciencia y Tecnologia Mexico City Mexico Clinica de Trastornos del Sueno Universidad Autonoma Metropolitana-Iztapalapa Mexico City Mexico Servicio de Medicina Fisica y Rehabilitacion Hospital General de Zona No. 197 Texcoco Mexico Unidad de Investigacion Modica en Farmacologla Hospital de Especialidades Centro Medico Nacional Siglo XXI Instituto Mexicano del Seguro Social Mexico City Mexico

Estrogen receptor modulators are compounds of interest because of their estrogenic agonistic/antagonistic effects and tissue specificity. These compounds have many clinical applications, particularly for breast cancer treatment and osteoporosis in postmenopausal women, as well as for the treatment of climacteric symptoms. Similar to estrogens, neuroprotective effects of estrogen receptor modulators have been described in different models. However, the mechanisms of action of these compounds in the central nervous system have not been fully described. We conducted a systematic search to investigate the effects of estrogen receptor modulators in the central nervous system, focusing on the modulation of cytoskeletal proteins. We found that raloxifene, tamoxifen, and tibolone modulate some cytoskeletal proteins such as tau, microtuble-associated protein 1（MAP1）, MAP2, neurofilament 38（NF38） by different mechanisms of action and at different levels： neuronal microfilaments, intermediate filaments, and microtubule-associated proteins. Finally, we emphasize the importance of the study of these compounds in the treatment of neurodegenerative diseases since they present the benefits of estrogens without their side effects.

关键词： estrogen receptor modulators selective estrogen receptor modulators microtubules neurofilaments tibolone tamoxifen raloxifene

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Desimplification to multi-tablet antiretroviral regimens in human immunodeficiency virus-type 1 infected adults: A cohort study

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World Journal of Clinical Cases 2019年第14期7卷 1814-1824页

作者： Maria C Rossi Walter O Inojosa Giuseppe Battistella Antonella Carniato Francesca Farina Mario Giobbia rodolfo Fuser Pier G Scotton Infectious Diseases Unit Treviso HospitalTreviso 31100Italy Epidemiology and Statistic Unit Azienda ULSS 2 “Marca Trevigiana”Treviso 31100Italy

BACKGROUND Highly active antiretroviral therapy (HAART) is provided free of charge to all human immunodeficiency virus (HIV) positive residents in Italy. As fixed dose coformulations (FDCs) are often more expensive in comparison to the same drugs administered separately in a multi-tablet regimen (MTR), we considered a costeffective strategy involving patients in the switch from their FDCs to corresponding MTRs including generic antiretrovirals. AIM To verify if this would affect the virological and immunological response in comparison to maintaining the FDC regimens. METHODS From January 2012 to December 2013, we assessed the eligibility of all the HIV-1 positive adults on stable HAART being treated at our hospital-based outpatient clinic in Treviso, Italy. Participants who accepted to switch from their FDC regimen to the corresponding MTR joined the MTR group, while those who maintained a FDC regimen joined the FDC group. Clinical data, including changes in HAART regimens, respective reasons why and adverse effects, were recorded at baseline and at follow-up visits occurring at weeks 24, 48 and 96. All participants were assessed for virological and immunological responses at baseline and at weeks 24, 48 and 96. RESULTS Two hundred and forty-three eligible HIV-1 adults on HAART were enrolled: 163 (67%) accepted to switch to a MTR, joining the MTR group, while 80 (33%) maintained their FDCs, joining the FDC group. In a parallel analysis, there were no significant differences in linear trend of distribution of HIV-RNA levels between the two groups and there were no significant odds in favour of a higher level of HIV-RNA in either group at any follow-up and on the overall three strata analysis. In a before-after analysis, both FDC and MTR groups presented no significant differences in distribution of HIV-RNA levels at either weeks 48 vs 24 and weeks 96 vs 24 cross tabulations. A steady increase of mean CD4 count was observed in the MTR group only, while in the FDC grou

关键词： Fixed-dose coformulations Fixed dose coformulation regimens Multitablet regimens Human immunodeficiency virus Highly active antiretroviral therapy

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Transdiagnostic considerations of mental health for the post-COVID era:Lessons from the first surge of the pandemic

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World Journal of Clinical Cases 2023年第4期11卷 809-820页

作者： Sari Goldstein Ferber Gal Shoval rodolfo Rossi Viviana Trezza Giorgio Di Lorenzo Gil Zalsman Aron Weller J John Mann Aron Weller Department of PsychologyBar Ilan UniversityRamat Gan 5290002Israel Department of Neuroscience Princeton UniversityPrinceton NJ 08544United States Geha Mental Health Center Petah TiqvaIsrael and Sackler Faculty of MedicineTel Aviv UniversityTel Aviv 77096Israel Department of Systems Medicine University of Rome Tor VergataRome 00133Italy Department of Science Rome Tre UniversityRome 00154Italy Department of Psychiatry Rome University Tor VergataRome 00179Italy IRCCS-Fondazione Santa Lucia Rome 00179Italy Division of Molecular Imaging and Neuropathology Department of PsychiatryColumbia UniversityNY10032United States

BACKGROUND The Coronavirus disease 19(COVID-19)-related psychiatric burden partly results from prolonged social stress *** have examined the psychiatric impact of COVID-19 on Diagnostic and Statistical Manual of Mental Disorders,Fifth Edition(DSM 5)and International Classification of Diseases 11th Revision(ICD-11)categories,implicating multiple diagnoses,complicating clinical *** To verify whether COVID-19-related psychopathology spans multiple DSM-5 and ICD-11 diagnoses,but not in a random ***,empirical analysis of the multiple associated symptoms will better describe COVID-19-related *** We conducted a bi-national study during the first surge of the pandemic:an Italian sample(n=21217,studied March-April 2020);and three representative longitudinal samples from Israel(n=1276,1189,and 1432 respectively,studied May-July 2020).Data in Italy were collected by a national internet-based survey with an initially approached sample of about one million persons and in Israel by the Israeli Central Bureau of Statistics using probability-based national representative *** analysis focused on the frequency and patterns of reported multiple mental health *** Combinations with all symptoms were more prevalent than combinations with fewer symptoms,with no majorities-minorities differences in both countries,demonstrating the generalizability of the transdiagnostic pattern of mental health issues in both nations.A history of previous mental disorder(Italian study)and an increase in symptom prevalence over time(Israel study)were associated with an increased number of ***:Based on finding correlated symptom diversity spanning conventional diagnostic categories,we suggest that the pattern of mental health issues associated with the COVID-19 pandemic is *** The findings have implications for improving prevention and treatment of COVID-19 related psychopathology and

关键词： Post-COVID-19 Diagnosis Stress Mental disorders Transdiagnosis Reactive psychiatric disorders

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Immune strategies of phagoctytic cells stimulated in vitro with live and heat-inactivated Streptococcus pyogenes

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BIOCELL 2013年第3期37卷 63-69页

作者： Agustín César MÖHLINGER Virginia Paula SIFFREDI Serenela CHULIBERT Adriana PONESSA rodolfo David NOTARIO Diana Graciela DLUGOVITZKY Inmunology Section Microbiology DepartmentFaculty of Medical SciencesRosario National UniversityArgentina Microbiology Department Faculty of Medical SciencesRosario National UniversityArgentina

Streptococcus pyogenes(group A Streptococcus)is frequently involved in a wide range of human *** we evaluated polymorphonuclear neutrophils and mononuclear cells from healthy subjects for their bactericidal function after stimulation with live and inactivated Streptococcus pyogenes(Streptococcus Group A).Mononuclear cells and Neutrophils were isolated from heparinized blood samples(n=18)using a Ficoll-Hypaque gradient and cultured in RPMI 1640 for 18 hours with a suspension of either live or inactivated Streptococcus *** the respiratory burst(flow cytometry)and nitrite,TNF and IL17 production(ELISA)were measured in the cell culture *** increased respiratory burst(expressed as R index)was induced by both live and inactivated ***,increased nitrite,TNF and IL17 concentrations were found in cell culture supernatants in both *** findings may provide some explanation as to the roles played by neutrophils and mononuclear cells in Streptococcus pyogenes immunopathogenicity。

关键词： Respiratory burst nitrites TNFa IL17

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Extraction method of nanoparticles concentration distribution from magnetic particle image and its application in thermal damage of magnetic hyperthermia

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中国物理B:英文版 2023年第9期32卷 304-311页

作者：汤云东陈鸣 rodolfo C.C.Flesch 金涛 College of Physics and Information Engineering Fuzhou UniversityFuzhou 350108China Departamento de Automação e Sistemas Universidade Federal de Santa Catarina88040-900 FlorianópolisSCBrazil College of Electrical Engineering and Automation Fuzhou UniversityFuzhou 350108China

Magnetic particle imaging(MPI)technology can generate a real-time magnetic nanoparticle(MNP)distribution image for biological tissues,and its use can overcome the limitations imposed in magnetic hyperthermia treatments by the unpredictable MNP distribution after the intratumoral injection of ***,the MNP concentration distribution is generally difficult to be extracted from MPI *** study proposes an approach to extract the corresponding concentration value of each pixel from an MPI image by a least squares method(LSM),which is then translated as MNP concentration distribution by an interpolation *** resulting MPI-based concentration distribution is used to evaluate the treatment effect and the results are compared with the ones of two baseline cases under the same dose:uniform distribution and MPI-based distribution considering ***,the treatment effect for all these cases is affected by the blood perfusion rate,which is also investigated deeply in this *** results demonstrate that the proposed method can be used to effectively reconstruct the concentration distribution from MPI images,and that the weighted LSM considering a quartic polynomial for interpolation provides the best results with respect to other cases ***,the results show that the uniformity of MNP distribution has a positive correlation with both therapeutic temperature distribution and thermal damage degree for the same dose and a critical power dissipation value in the *** MNPs uniformity inside biological tissue can be improved by the diffusion behavior after the nanofluid injection,which can ultimately reflect as an improvement of treatment *** addition,the blood perfusion rate considering local temperature can have a positive effect on the treatment compared to the case which considers a constant value during magnetic hyperthermia.

关键词： magnetic hyperthermia magnetic nanoparticles distribution thermal damage blood perfusion rate

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Child abuse and psychopathy: Interplay, gender differences and biological correlates

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World Journal of Psychiatry 2021年第12期11卷 1167-1176页

作者： Ester di Giacomo Mario Santorelli rodolfo pessina Daniele Rucco Valeria Placenti Francesca Aliberti Fabrizia Colmegna Massimo Clerici School of Medicine and Surgery University of Milano BicoccaMonza 20900Italy Department of Psychiatry ASST MonzaMonza 20090Italy School of Medicine and Surgery Psychiatric Residency Training ProgramUniversity of Milano BicoccaMonza 20900Italy Department of Psychology Linguistics and Cognitive NeuroscienceUniversity of Milano BicoccaMonza 20900Italy Department of Psychiatric Residency Training Program University of GenovaGenova 16126Italy Department of Medicine and Surgery University of Milano-BicoccaMonza 20900Italy

Child abuse is an important source of mental and physical adverse consequences for victims,their family,and their *** impact of violence during childhood on the development of the victim is a very sensitive *** than internalizing symptoms,it is interesting to analyze the possibility that a victim may assume the role of *** this aim,we evaluate Literature and examine the interplay among different types of child abuse(emotional neglect,emotional abuse,physical neglect,physical abuse and sexual abuse)and the development of *** consider the role of post-traumatic stress disorder and that of personal environment as potential mediators between abuse and ***,an in-depth analysis on possible differences due to the victim's gender is ***,analysis focused on genetic variants,such as the polymorphism of 5HTT and MAO-A,or a biological alteration,like the difference in daily cortisol levels that could be related to the development of psychopathy after a trauma.

关键词： Child abuse Sexual abuse Physical abuse Psychopathy Neglect Intergenerational transmission

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Geospatial Analysis of Geotechnical Data Applied to Urban Infrastructure Planning

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Journal of Geographic Information System 2010年第1期2卷 23-31页

作者： rodolfo Moreda MENDES Reinaldo LORANDI 不详

The urbanization process inside the State of S?o Paulo (Brazil) facilitated, in approximately five decades, the migration of thousands of peasants to the urban areas of great industrial centers inducing and requesting, at the same time and very often, an amplification of the systems of local urban infrastructure not appropriate for the natural potential of the physical territory. In this content, the city of S?o José do Rio Preto (State of S?o Paulo) with little more than 350.000 inhabitants, currently faces serious problems related to the urban planning originating from the unusual occupation and without previous study of suitability. Therefore, the present paper intends to guide and indicate the areas whose potential of urban development leads to an occupation suitable for the construction of shallow foundations in residential buildings of single floor, using an interpretative chart produced by the software GIS-SPRING-4.0 developed by Instituto Nacional de pesquisas Espaciais/INpe (Brazil), and based in the methodology of geotechnical mapping developed by the department of geotechnical engineering of EESC/USP (Brazil). The chart for shallow foundation shows that a large portion of the studied area presents serious relationship problems with layers of highly collapsible soils.

关键词： GIS geotechnical mapping urban planning urban infrastructure shallow foundations

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Therapeutic termination of pregnancy and women’s mental health:Determinants and consequences

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World Journal of Psychiatry 2021年第11期11卷 937-953页

作者： Ester di Giacomo rodolfo pessina Mario Santorelli Daniele Rucco Valeria Placenti Francesca Aliberti Fabrizia Colmegna Massimo Clerici School of Medicine and Surgery University Milan BicoccaMonza 20900LombardyItaly Department of Psychiatric ASST MonzaMonza 20900LombardyItaly Psychiatric Residency Training Program University Milan BicoccaMonza 20900LombardyItaly PhD Program in Psychology Linguistics and Cognitive NeuroscienceUniversity Milan BicoccaMilano 20126LombardyItaly Psychiatric Residency Training Program University of GenovaGenova 16126LiguriaItaly

The therapeutic termination of pregnancy(TToP)is an induced abortion following a diagnosis of medical *** is applied to avoid the risk of substantial harm to the mother or in cases of fetal *** type of induced abortion is provided after the second semester of gestation if fetal illness or the pregnancy cause physical danger or pathological mental distress to the *** and economic determinants could influence the desire for children and family planning in couples,as well as the use of effective contraception and the choice to perform an induced ***,pre-existing mental health problems could affect the decision between carrying on a problematic pregnancy or having ***,the TToP is a reproductive event with an important traumatic burden,but also with an intrinsic therapeutic effect and it can produce different psychological and psychopathological effects on women and *** aim of this review is to evaluate what demographic,reproductive and psychopathological determinants are involved in the choice of undergoing a TToP in ***,we will examine both positive and negative consequences of this procedure on women’s mental health,underlying which factors are related to a worse outcome in order to provide the best clinical support to vulnerable groups.

关键词： Therapeutic abortion Women’s health Depression PostTraumatic stress disorder perinatal care Psychiatry

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Acute hepatitis C in a chronically HIV-infected patient:Evolution of different viral genomic regions

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World Journal of Gastroenterology 2003年第7期9卷 1496-1500页

作者： Diego Flichman Veronica Kott Silvia Sookoian rodolfo Campos Catedra de Virologia Facultad de Farmacia y BioquimicaUniversidad de Buenos AiresArgentina Unidad de Higado Hospital"Dr.Cosme Argerich"Argentina

AIM: To analyze the molecular evolution of different viral genomic regions of HCV in an acute HCV infected patient chronically infected with HIV through a 42-month ***: Serum samples of a chronically HIV infected patient that seroconverted to anti HCV antibodies were sequenced, from the event of superinfection through a period of 17 months and in a late sample (42nd month). Hypervariable genomic regions of HIV (V3 loop of the gp120) and HCV (HVR-1 on the E2 glycoprotein gene) were studied. In order to analyze genomic regions involved in different biological functions and with the cellular immune response, HCV core and NS5A were also chosen to be sequenced. Amplification of the different regions was done by RT-PCR and directly sequenced. Confirmation of sequences was done on reamplified material. Nucleotide sequences of the different time points were aligned with CLUSTAL W 1.5, and the corresponding amino acid ones were ***: Hypervariable genomic regions of both viruses (HVR1 and gp120 V3 loop) presented several nonsynonymous changes but, while in the gp120 V3 loop mutations were detected in the sample obtained right after HCV superinfection and maintained throughout, they occurred following a sequential and cumulative pattern in the HVR1. In the NS5A region of HCV, two amino acid changes were detected during the follow-up period, whereas the core region presented several amino acid replacements, once the HCV chronic infection had been ***: During the HIV-HCV superinfection, each genomic region analyzed shows a different evolutionary *** of the nucleotide substitutions observed are nonsynonymous and clustered in previously described epitopes,thus suggesting an immune-driven evolutionary process.

关键词： Acute Disease Adolescent Amino Acid Sequence Female Genome, Viral HIV HIV Envelope Protein gp120 HIV Infections Hepacivirus Hepatitis C Humans Molecular Sequence Data Research Support, Non-U.S. Gov't Superinfection Viral Nonstructural Proteins Viral Proteins

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