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The selective retinoic acid receptor-α agonist AM580 fails to control autoimmune neuroinflammation

丛书名： Advances in Intelligent and Soft Computing

2009年

作者： Emilio Corchado rodolfo Zunino Paolo Gastaldo Álvaro Herrero

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Cellular & Molecular Immunology 2019年第8期16卷 727-729页

作者： Qing Wang rodolfo Thome Abdolmohamad Rostami Cun-Gen Ma Guang-Xian Zhang Department of Neurology Thomas Jefferson University900 Walnut StreetSuite 300PhiladelphiaPA 19107USA The Key Research Laboratory for the Study of Beneficial Qi and the Blood Circulation Activation Method in Treating Multiple Sclerosis State Administration of Traditional Chinese MedicineResearch Center of NeurobiologyShanxi University of Chinese MedicineTaiyuan 030024China

Environmental cues provided by products from the diet,gut microbiota metabolism,and exposure to sunlight are sensed by specific receptors that drive a specific genomic profile in immune cells and influence the outcome of multiple sclerosis(MS),an autoimmune disease of the central nervous system(CNS),1 which affects approximately 2.3 million people worldwide.2 Among these receptors,the ligand-activated transcription factor retinoic acid receptorα(RAR-α)senses retinoic acid and other ligands to promote the transcription of genes that have retinoic acid receptor elements in their promoter region.3 Supplementation with all-trans retinoic acid(ATRA),a metabolite of vitamin A,ameliorates inflammation in MS and the corresponding animal model,experimental autoimmune encephalomyelitis(EAE),by shifting the balance between Th17/regulatory T cells(Tregs)and inducing tolerogenic dendritic cells.4,5 To overcome the weaknesses associated with ATRA agonists,e.g.,instability,poor bioavailability and nonselective binding to a broad range of retinoid receptors,a variety of synthetic agonists specifically targeting RAR have been developed.6 One of them,AM80,inhibits Th17 cells and suppress acute neuroinflammation;however,continuous AM80 treatment is ineffective,most likely because AM80 also inhibits Tregs and IL-10 production.6 AM580,a stable benzoic derivative of retinoic acid and a selective RAR-αagonist,has been recently shown to significantly reduce the production of Th1 cytokines but promote Th2 cytokines in human PBMCs7 and to inhibit microglial activation,thus acting beneficially in Alzheimer’s disease treatment.8 In addition,AM580 protects retinal cells against diabetes-induced apoptosis by inducing neurotrophic factors.9 However,whether it has a protective effect on neuroinflammation is unknown.

关键词： inflammation autoimmune metabolism

New technologies as a strategy to decrease medication errors: how do they affect adults and children differently?

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世界儿科杂志:英文版 2016年第1期12卷 28-34页

作者： Margarita Ruano Elena Villamañán Ester Pérez Alicia Herrero rodolfo Álvarez-Sala Department of Pharmacy La Paz University HospitalMadridSpain Department of Pneumology La Paz University HospitalMadridSpain

Background:Medication error can occur throughout the drug treatment process,with special relevance in children given the risk of adverse effects resulting from a medication error is more prevalent than in *** significance of medication error in children is also greater because small error that would be tolerated in adults can cause significant damage in ***,the likelihood of injury is higher than in *** sources:Based on the data published,most medication errors take place in prescribing and administration stages in both *** in account that child's risk factors are different from those of adults,with some specific causes to pediatrics,we have reviewed available data about new technologies as a strategy to reduce pediatric medication ***:Even though there is a lack of standardized definitions and terminology that makes studies difficult to compare,we checked that new technologies have proven to be effectives in reducing medication errors,mainly computerized physician order entry(CPOE)and platforms to aid ***,we also observed that the use of these informatic tools can also generate new ***:Implementation of CPOE programs for pediatrics,communication improvement between healthcare professionals taking care of admitted children and the knowledge of these programs should be the mayor priorities for the safety of hospitalized children.

关键词： electronic prescribing new technologies pediatric medication errors

Geological setting, mining and reduction of mercury vapor contamination in the gold-silver district of Vetas-Calofornia （Santander, Colombia）

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Episodes 2005年第4期28卷 252-256页

作者： Erwin Wolff Carreno Juan Manuel Pinzon Angel rodolfo Contreras Moreno Christoph Bernardy Corporacion Autonoma Regional Para la Defensa de la Mescta de Bucaramanga Carrera 23 N°37-63 Bucaramanga Colombia Formely with Corporacidn Autonoma Regional Para la Defensa de la Mescta de Bucaramanga Carrera 23 N°37-63 Bucaramanga Colombia. Formerly with Federal Institute for Geosciences and Natural Resources Stilleweg 2 30655 Hannover Germany

Bucaramanga, with a population of about one million, is the capital of the Department of Santander （Colombia）, and has the Rio Surata as its main source of drinking water. In the upper reaches of the river, small-scale gold mining has been going onfor many centuries （Vetas-California mining district）. Geologically, the Vetas-California mining district is part of the Santander Massif which is composed of pre-Devonian metamorphic rocks and Mesozoic igneous rocks. The mineralisation is restricted to structurally controlled veins and is often associated with hydrothermal alteration. There is also disseminated mineralisation, but presently only the vein-type is mined. The processing residues are discharged into the nearby watercourses, contaminating the waters of the Surata river basin. As part of a joint Colombian-German technical cooperation project, with the purpose of controlling the negative environmental effects of gold mining pollution, an integrated distillation system for the recovery of mercuury. has been designed and tested.

关键词：地质条件矿床哥伦比亚蒸发作用金银

Latin America and the West:Constructions and Deconstructions of the Concept

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Journal of Foreign Languages and Cultures 2022年第2期6卷 56-73页

作者： Ana Regina Falkembach Simão Roberto rodolfo Georg Uebel Escola Superior de Propaganda e Marketing

The construction of the concept of Latin America has been through different processes regarding its structure and acceptance,from the colonial period to the automatic realignment to the United States,with rare exceptions,and a reorganization with the emergence of multilateralism and the multipolar *** abstraction,hitherto almost an axiom in the subcontinent,that it is a western region,leads us to the elaboration of this article,which seeks to present Latin America's post-western and de-westernized character in an environment of restructuration of its political economy,its actors,scenarios and,finally,***,we present here a review of the state of the art political economy of Latin America and its perspectives in this shifting world,especially in the context of the COVID-19 pandemic.

关键词： Latin America Western Post-Western De-Westernization Political Economy

Compression Behaviors of Parallel Bamboo Strand Lumber Under Static Loading

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Journal of Renewable Materials 2019年第7期7卷 583-600页

作者： Haitao Li Zhenyu Qiu Gang Wu Dongdong Wei rodolfo Lorenzo Conggan Yuan Huizhong Zhang Rong Liu Southeast University Key laboratory of concrete and pre-stressed concrete structure of Ministry of EducationNanjing210096China College of Civil Engineering Nanjing Forestry UniversityNanjing210037China Department of Building Engineering Nanjing Forestry UniversityNanjing210037China Jiangxi Feiyu Bamboo Stock Co.LTD Fengxin330700China University College London London WC1E 6BTUK

In order to investigate the influence of length and compression directions upon behaviour of parallel bamboo strand lumber(PBSL)specimens,240 axial compression tests have been *** three similar one different typical failure modes,the mechanical performance for PBSL specimens under compression parallel to grain and perpendicular to grain are different as a *** the point of the characteristic values,the compression strength parallel to grain is 2.1 times of the compression strength perpendicular to *** elastic modulus for compression parallel to grain is 3.64 times of the compression strength perpendicular to *** the compression ratios along two compression directions are equal to each *** bigger Poisson ratios for one typical side surface is 3.93 times of that for another typical side surface for PBSL specimens under compression perpendicular to grain,and the bigger value is equal to that for PBSL specimens under compression parallel to *** can influence the mechanical properties of the PBSL *** size 50 mm×50 mm×100 mm should be good choice for the standard or code to measure the compression *** materials have better ductility under compression parallel to grain than that under compression perpendicular to ***-strain relationship models were proposed for PBSL specimens under compression parallel to grain and perpendicular to grain,*** proposed models gave a good agreement with the test results.

关键词： Parallel bamboo strand lumber compression parallel to grain perpendicular to grain stress-strain relationship model

Productivity and energy balance of forest plantation harvesting in Uganda

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Forestry Studies in China 2012年第4期14卷 276-282页

作者： Hussein BALIMUNSI Stefano GRIGOLATO rodolfo PICCHIO Kenneth NYOMBI Raffaele CAVALLI College of Agricultural and Environmental Sciences Makerere University Department of Land EnvironmentAgriculture and ForestryUniversity of Padua Department of Environmental and Forestry Technologies Engineering and SciencesTuscia University

The study evaluated the productivity and energy balance of the harvesting and the extraction of wood in plantation of exotic tree species, i.e., Pinus patula （Schiede ex Schlectendahl et Chamisso） and Cupressus lusitanica （Mill.）. The harvesting and extraction operations concerned clear-cut felling on two different types of terrain （gentle and steep terrain） and two levels of prun- ing. The results show that cutting is not affected by the terrain gradient whereas the pruning condition shows a significant effect on the delimbing operation. The productivity of cutting is evaluated at 28.1 m3.d-1 for unpruned trees and at 30.2 m3.d t for pruned trees. For the extraction phase, rolling was significantly affected by terrain conditions. On steep terrain, the gross productivity can be evaluated at 22.5 m3.d 1 for an extraction distance of 40 m, while for the same distance on gentle terrain the productivity decreases to 14.1 m3.d~. As a result, the steep terrain condition showed higher energy efficiency, suggesting that it is the more efficient system of extraction. The productivity model and the energy balance resulting from the study provide a better understanding of the variables af- fecting motor-manual cutting and rolling extraction in exotic plantations in Uganda.

关键词： exotic tree plantation energy balance harvesting productivity clear-cut felling Uganda

Recombinant canarypox virus expressing the VP2 protein of infectious bursal disease virus induces protection in vaccinated SPF chickens

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Virologica Sinica 2016年第3期31卷 266-269页

作者： Flavia Adriana Zanetti Romina Cardona Carlos rodolfo Federico Silvina Chimeno-Zoth Gabriela Calamante Consejo Nacional de Investigaciones Cientificas y Tecnologicas(CONICET) Rivadavia 1917 (C 1033AAJ) Ciudad Autonoma de Buenos Aires Argentina Instituto de Biotecnologia Centro de Investigaciones en Ciencias Veterinarias y Agronomicas Instituto Nacional de Tecnologia Agropecuaria (INTA) Buenos Aires Argentina

Dear Editor,Infectious bursal disease virus（IBDV）causes infectious bursal disease,a highly contagious immunosuppressive disease that affects young chickens and causes economic losses in the poultry industry *** replicates mainly in actively dividing B lymphocytes within the bursa of Fabricius（BF）,leading to immunosuppression in affected flocks（Mahgoub et al.,2012）.Viral protein 2（VP2）,

关键词： bursal infectious contagious Recombinant expressing immunized vaccines affects vaccination chicken

Chloroquine reduces Th17 cell differentiation by stimulating T-bet expression in T cells

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Cellular & Molecular Immunology 2021年第3期18卷 779-780页

作者： rodolfo Thome Alexandra Boehm Larissa Lumi Watanabe Ishikawa Giacomo Casella Jaqueline Munhoz Bogoljub Ciric Guang-Xian Zhang Abdolmohamad Rostami Department of Neurology Thomas Jefferson UniversityPhiladelphiaPAUSA

Chloroquine(CQ)is a weak base that was originally used to treat malaria infection.1 However,recent findings have pinpointed the modulatory effect of CQ in models of chronic inflammation and viral *** antiviral effect of CQ and its derivative hydroxychloroquine has attracted great attention due to the recent Sars-CoV-2 virus outbreak.

关键词： Th17 stimulating inflammation

Tumors due to chronic exposure to benzene and biomarkers of exposure

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Journal of Cancer Metastasis and Treatment 2022年第1期8卷 412-421页

作者： Gilda Alves rodolfo AcatauassúNunes Karina Melo Maria Helena Faria Ornellas Circulating Biomarkers Laboratory Pathology DepartmentMedical Sciences FacultyState University of Rio de Janeiro(UERJ)Rio de Janeiro 20550-170Brazil General Surgery Department State University of Rio de Janeiro(UERJ)Rio de Janeiro 20551-030Brazil Hemotherapy and Hematology Service State University of Rio de Janeiro(UERJ)Rio de Janeiro 20551-030Brazil

Due to occupational activities,many people are exposed to carcinogenic airborne pollutants,such as ***,benzene is also present in cigarette *** main cancers associated with benzene,toluene,ethylbenzene,and xylenes(BTEX)are lung cancer and malignancies of the *** initial stages,lung cancer is often asymptomatic,but progression into metastasis is a huge clinical *** performed a review on possible biomarkers for monitoring increased genome instability and downregulation of the immune system in connection with overexposure to BTEX in a subgroup of workers being exposed to BTEX at Brazilian gas *** workers are subject to routine blood exams every semester;however,early genomic assessment is not *** evaluated available tests to be applied,including measuring benzene-derived metabolites in urine,determination of oxidative and inflammatory markers in blood,immunophenotypical profiling,micronucleus test,comet(single-cell gel electrophoresis)assay,(molecular)cytogenetics,chromosomal microarray,epigenetic-changes oriented tests,determination of mitochondrial(mt)DNA copy numbers,and studies on ***,no consensus was reached about their application and which test combination might be suited best.

关键词： Benzene BTEX lung cancer blood biomarker