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Role of quorum sensing in bacterial infections

World Journal of Clinical Cases 2015年第7期3卷 575-598页

作者： Israel Castillo-Juárez Toshinari Maeda Edna Ayerim Mandujano-Tinoco María Tomás Berenice Pérez-Eretza Silvia Julieta garcía-contreras Thomas K Wood rodolfo garcía-contreras Colegio de Postgraduados Campus Montecillo Department of Biological Functions and Engineering Kyushu Institute of Technology Epigenetics of Cancer Laboratory Division of Basic ResearchNational Institute of Genomic Medicine Department of Microbiology Instituto de Investigación Biomédica de A Coruña(INIBIC)Complexo Hospitalario Universitario de A Coruña(CHUAC)SergasUniversidade da Coruña(UDC)15006 A CoruñaSpain Departamento de Microbiología y Parasitología Facultad de MedicinaUniversidad Nacional Autónoma de México Centro Médico Coyoacán Department of Chemical Engineering Pennsylvania State UniversityUniversity Park Department of Biochemistry and Molecular Biology Pennsylvania State UniversityUniversity Park

Quorum sensing(QS) is cell communication that is widely used by bacterial pathogens to coordinate the expression of several collective traits, including the production of multiple virulence factors, biofilm formation, and swarming motility once a population threshold is reached. Several lines of evidence indicate that QS enhances virulence of bacterial pathogens in animal models as well as in human infections; however, its relative importance for bacterial pathogenesis is still incomplete. In this review, we discuss the present evidence from in vitro and in vivo experiments in animal models, as well as from clinical studies, that link QS systems with human infections. We focus on two major QS bacterial models, the opportunistic Gram negative bacteria Pseudomonas aeruginosa and the Gram positive Staphylococcus aureus, which are also two of the main agents responsible of nosocomial and wound infections. In addition, QS communication systems in other bacterial, eukaryotic pathogens, and even immune and cancer cells are also reviewed, and finally, the new approaches proposed to combat bacterial infections by the attenuation of their QS communication systems and virulence are also discussed.

关键词： Quorum sensing Virulence Infections Pseudomonas aeruginosa Staphylococcus aureus Animal models

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Beyond neurodegeneration:engineering amyloids for biocatalysis

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Neural Regeneration Research 2025年第10期20卷 2915-2916页

作者： Andrea Bartolomé-Nafría Javier garcía-Pardo Salvador Ventura Institut de Biotecnologia i de Biomedicina(IBB)and Departament de Bioquímica i Biologia Molecular Universitat Autònoma de BarcelonaBellaterraBarcelonaSpain Hospital Universitari Parc Taulí Institut d’Investigaciói InnovacióParc Taulí(I3PT-CERCA)Universitat Autònoma de BarcelonaSabadellSpain

Amyloid fibrils are highly organized protein or peptide aggregates,often characterized by a distinctive supramolecular cross-β-sheet *** formation and accumulation of these structures have been traditionally associated with neural or systemic human diseases,such as Alzheimer’s disease,Parkinson’s disease,type-2 diabetes,or amyotrophic lateral sclerosis(Wei et al.,2017;Wittung-Stafshede,2023).

关键词： structure amyloid

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The emerging role of mesenchymal stem cell-derived extracellular vesicles to ameliorate hippocampal NLRP3 inflammation induced by binge-like ethanol treatment in adolescence

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Neural Regeneration Research 2025年第4期20卷 1153-1163页

作者： Susana Mellado María JoséMorillo-Bargues Carla Perpiñá-Clérigues Francisco garcía-garcía Victoria Moreno-Manzano Consuelo Guerri María Pascual Department of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain Bioinformatics and Biostatistics Unit Príncipe Felipe Research CenterValenciaSpain Neuronal and Tissue Regeneration Laboratory Príncipe Felipe Research CenterValenciaSpain

Our previous studies have reported that activation of the NLRP3(NOD-,LRR-and pyrin domain-containing protein 3)-inflammasome complex in ethanol-treated astrocytes and chronic alcohol-fed mice could be associated with neuroinflammation and brain *** stem cell-derived extracellular vesicles(MSC-EVs)have been shown to restore the neuroinflammatory response,along with myelin and synaptic structural alterations in the prefrontal cortex,and alleviate cognitive and memory dysfunctions induced by binge-like ethanol treatment in adolescent *** the therapeutic role of the molecules contained in mesenchymal stem cell-derived extracellular vesicles,the present study analyzed whether the administration of mesenchymal stem cell-derived extracellular vesicles isolated from adipose tissue,which inhibited the activation of the NLRP3 inflammasome,was capable of reducing hippocampal neuroinflammation in adolescent mice treated with binge *** demonstrated that the administration of mesenchymal stem cell-derived extracellular vesicles ameliorated the activation of the hippocampal NLRP3 inflammasome complex and other NLRs inflammasomes(e.g.,pyrin domain-containing 1,caspase recruitment domain-containing 4,and absent in melanoma 2,as well as the alterations in inflammatory genes(interleukin-1β,interleukin-18,inducible nitric oxide synthase,nuclear factor-kappa B,monocyte chemoattractant protein-1,and C–X3–C motif chemokine ligand 1)and miRNAs(miR-21a-5p,miR-146a-5p,and miR-141-5p)induced by binge-like ethanol treatment in adolescent *** analysis further revealed the involvement of miR-21a-5p and miR-146a-5p with inflammatory target genes and NOD-like receptor signaling *** together,these findings provide novel evidence of the therapeutic potential of MSC-derived EVs to ameliorate the hippocampal neuroinflammatory response associated with NLRP3 inflammasome activation induced by binge drinking in adolescence.

关键词： adolescence binge-like ethanol treatment extracellular vesicles hippocampus mesenchymal stem cells neuroinflammation NOD-,LRR-and pyrin domain-containing protein 3(NLRP3)

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Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system

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Neural Regeneration Research 2025年第11期20卷 3209-3210页

作者： Marta garcía-Juan Mario Villa Irene Benito-Cuesta Lara Ordónez-Gutiérrez Francisco Wandosell Centro de Biología Molecular“Severo Ochoa”(CSIC-UAM) Nicolas Cabrera 1Universidad Autónoma de MadridMadridSpain Fisiología Animal Departamento de BiologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain Department of Clinical Neuroscience CMM Karolinska Universitetssjukhuset SolnaStockholmSweden Departamento de Bioquímica y Biología Molecular Universidad Complutense de MadridMadridSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) MadridSpain

Autophagy is a cellular degradation and recycling system,indispensable for cellular and organ development,homeostasis,and *** cellular process is evolutionarily highly conserved to quality control of many proteins and dysfunctional organelles,which finally recycle components as amino *** process is effective during normal physiology as part of anabolism and plays an additional important role during starvation(Dikic and Elazar,2018).Different types of autophagy have been chara cterized based on their dynamic,mechanism of action,target substrates,and protein *** of them are macroautophagy(hereafter called"autophagy"),microa utophagy,and chape rone-media ted autophagy(Fleming et al.,2022).

关键词： homeostasis system hereafter

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Tumor-induced neurogenesis and immune evasion as targets of innovative anti-cancer therapies

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1584-1606页

作者： rodolfo Daniel Cervantes-Villagrana Damaris Albores-garcía Alberto Rafael Cervantes-Villagrana Sara Judit garcía-Acevez Department of Pharmacology Center for Research and Advanced Studies of the National Polytechnic Institute(CINVESTAV-IPN)07360 Mexico CityMexico Department of Environmental Health Sciences Florida International University(FIU)MiamiFlorida 33199USA Laboratorio de investigación en Terapéutica Experimental Unidad Académica de Ciencias QuímicasÁrea de Ciencias de la SaludUniversidad Autónoma de Zacatecas(UAZ)ZacatecasMéxico Dirección de Proyectos e Investigación Grupo Diagnóstico Médico Proa06400 CDMX CuauhtémocMéxico

Normal cells are hijacked by cancer cells forming together heterogeneous tumor masses immersed in aberrant communication circuits that facilitate tumor growth and *** the well characterized angiogenic effect of some tumor-derived factors;others,such as BDNF,recruit peripheral nerves and *** neurogenic switch,activated by tumor-derived neurotrophins and extracellular vesicles,attracts adjacent peripheral fibers(autonomic/sensorial)and neural progenitor ***,tumor-associated nerve fibers can guide cancer cell ***,IL-1β,CCL2,PGE2,among other chemotactic factors,attract natural immunosuppressive cells,including T regulatory(Tregs),myeloid-derived suppressor cells(MDSCs),and M2 macrophages,to the tumor *** leukocytes further exacerbate the aberrant communication circuit releasing factors with neurogenic ***,cancer cells directly evade immune surveillance and the antitumoral actions of natural killer cells by activating immunosuppressive mechanisms elicited by heterophilic complexes,joining cancer and immune cells,formed by PD-L1/PD1 and CD80/CTLA-4 plasma membrane ***,nervous and immune cells,together with fibroblasts,endothelial,and bone-marrow-derived cells,promote tumor growth and enhance the metastatic properties of cancer *** by the demonstrated,but restricted,power of anti-angiogenic and immune cell-based therapies,preclinical studies are focusing on strategies aimed to inhibit tumor-induced *** we discuss the potential of anti-neurogenesis and,considering the interplay between nervous and immune systems,we also focus on anti-immunosuppression-based *** molecules,antibodies and immune cells are being considered as therapeutic agents,aimed to prevent cancer cell communication with neurons and leukocytes,targeting chemotactic and neurotransmitter signaling pathways linked to perineural invasion and metastasis.

关键词： PD1 therapies invasion

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Dendritic spine degeneration:a primary mechanism in the aging process

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Neural Regeneration Research 2025年第6期20卷 1696-1698页

作者： Gonzalo Flores Leonardo Aguilar-Hernández Fernado garcía-Dolores Humberto Nicolini Andrea Judith Vázquez-Hernández Hiram Tendilla-Beltrán Instituto de Fisiología Benemérita Universidad Autónoma de Puebla(BUAP)PueblaMexico Instituto de Ciencias Forenses(INCIFO) Tribunal Superior de Justicia de la Ciudad de México(TSJCDMX).Mexico CityMexico Instituto Nacional de Medicina Genómica(INMEGEN) Mexico CityMexico

Recent reports suggest that aging is not solely a physiological process in living beings;instead, it should be considered a pathological process or disease(Amorim et al., 2022). Consequently, this process involves a wide range of factors, spanning from genetic to environmental factors, and even includes the gut microbiome(GM)(Mayer et al., 2022). All these processes coincide at some point in the inflammatory process, oxidative stress, and apoptosis, at different degrees in various organs and systems that constitute a living organism(Mayer et al., 2022;AguilarHernández et al., 2023).

关键词： aging process stress

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Green ionic metal-organic frameworks as nanocatalysts for CO_(2)fixation

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Nano Research 2025年第1期18卷 260-269页

作者： Nuria Martín Miguel Maireles-Porcar Julián Sánchez Velandia Belén Altava Francisco G.Cirujano Eduardo garcía-Verdugo Departamento de Química Inorgánica y Orgánica Universidad Jaume IAv.Sos Baynats/nCastellóde la PlanaCastellón 12071Spain

Co,Ni,and Zn iso-reticular coordination polymers of 2,5-dihydroxyterphthalic acid(H_(2)dot)can be rapidly obtained under room temperature and aqueous conditions using either sodium or ammonium hydroxide as the bases to deprotonate the *** use of metal bromides and tetrabutylammonium hydroxide(TBAOH)as the base allows the green synthesis of ionic metal-organic frameworks(MOFs),characterized by X-ray diffraction(XRD),Fourier transform infrared(FTIR),scanning electron microscopy(SEM),thermo gravimetric analysis(TGA),H-nuclear magnetic resonance(NMR),elemental analysis,and X-ray photoelectron spectroscopy(XPS),and employed in the pressure,solvent,and additive-free CO_(2)fixation to epoxides by its cycloaddition to epichlorohydrin,exhibiting a cooperative behavior between the MOF and the ionic liquid formed within the framework,achieving TONs of the confined tetrabutylammonium bromide(TBABr)up to 700.

关键词： metal-organic frameworks(MOFs) ionic liquids heterogeneous catalysis CO_(2)conversion

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Geological setting, mining and reduction of mercury vapor contamination in the gold-silver district of Vetas-Calofornia （Santander, Colombia）

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Episodes 2005年第4期28卷 252-256页

作者： Erwin Wolff Carreno Juan Manuel Pinzon Angel rodolfo contreras Moreno Christoph Bernardy Corporacion Autonoma Regional Para la Defensa de la Mescta de Bucaramanga Carrera 23 N°37-63 Bucaramanga Colombia Formely with Corporacidn Autonoma Regional Para la Defensa de la Mescta de Bucaramanga Carrera 23 N°37-63 Bucaramanga Colombia. Formerly with Federal Institute for Geosciences and Natural Resources Stilleweg 2 30655 Hannover Germany

Bucaramanga, with a population of about one million, is the capital of the Department of Santander （Colombia）, and has the Rio Surata as its main source of drinking water. In the upper reaches of the river, small-scale gold mining has been going onfor many centuries （Vetas-California mining district）. Geologically, the Vetas-California mining district is part of the Santander Massif which is composed of pre-Devonian metamorphic rocks and Mesozoic igneous rocks. The mineralisation is restricted to structurally controlled veins and is often associated with hydrothermal alteration. There is also disseminated mineralisation, but presently only the vein-type is mined. The processing residues are discharged into the nearby watercourses, contaminating the waters of the Surata river basin. As part of a joint Colombian-German technical cooperation project, with the purpose of controlling the negative environmental effects of gold mining pollution, an integrated distillation system for the recovery of mercuury. has been designed and tested.

关键词：地质条件矿床哥伦比亚蒸发作用金银

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Perspective:Chemical Information Encoded in Electron Density

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物理化学学报 2018年第6期34卷 567-580页

作者： contreras-garcíA Julia YANG Weitao UPMC Univ Paris 06 CNRSUMR 7616Laboratoire de Chimie Théorique Department of Chemistry Duke University

In this perspective,we review the chemical information encoded in electron density and other ingredients used in semilocal *** information is usually looked at from the functional point of view:the exchange density or the enhancement factor are discussed in terms of the reduced density ***,what parts of a molecule do these 3D functions represent? We look atthese quantities in real space,aiming to understand the electronic structure information they encode and provide an insight from the quantum chemical topology(QCT).Generalized gradient approximations(GGAs) provide information about the presence of chemical interactions,whereas meta-GGAs can differentiate between the different bonding *** merging these two techniques,we show new insight into the failures of semilocal functionals owing to three main errors:fractional charges,fractional spins,and non-covalent *** build on simple *** also analyze the delocalization error in hydrogen chains,showing the ability of QCT to reveal the delocalization error introduced by semilocal ***,we show how the analysis of localization can help understand the fractional spin error in alkali atoms,and how it can be used to correct ***,we show that the poor description of GGAs of isodesmic reactions in alkanes is due to 1,3-interactions.

关键词： DFT Semi-local functional Electron density Quantum chemical topology

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Nonlinear criterion for strength mobilization in brittle failure of rock and its extension to the tunnel scale

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International Journal of Mining Science and Technology 2022年第4期32卷 685-705页

作者： rodolfo Cabezas Javier Vallejos Faculty of Engineering and Technology Universidad San SebastianSantiagoChile Advanced Mining Technology Center Universidad de ChileSantiagoChile Department of Mining Engineering Universidad de ChileSantiagoChile

As underground excavations are getting deeper and field stresses increase, the behavior of intact rock blocks plays an increasingly important role in understanding and estimating the overall rock mass strength. To model the brittle behavior of intact rock blocks, the stress–strain curve is usually idealized considering a linear strength mobilization approach(cohesion-weakening-friction-strengthening, CWFS),however, it is well recognized that rock presents a nonlinear behavior in terms of the confining *** study extends the strength mobilization in brittle failure of rock using nonlinear criteria. To determine the model parameters, a standard statistical method that uses the complete laboratory stress–strain curves of the intact rock is employed. Several hypotheses of linear and nonlinear models are statistically compared for different types of rock and confining stress levels. Results demonstrate that the best approach to model the brittle failure of rock is to consider a nonlinear strength envelope, such as the Hoek-Brown criterion assuming a residual uniaxial compressive strength different from zero and a mi parameter that increases, both with simultaneous mobilization. This model helps to recreate highconfining conditions and a more realistic transition between peak and post-peak strength. The obtained parameters are discussed and compared with literature values to verify the validity and to develop guidelines for the estimation of parameters, providing an objective mobilization criterion. Finally, the nonlinear model was applied to a finite element code and extended to a tunnel scale in the brittle rock under high-stress conditions. A reasonable fit between the simulations and the in-situ overbreak measurements was found.

关键词： Nonlinear strength Strength mobilization Brittle failure Intact rock Scaling

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