检索结果-南通市图书馆

Positive Solutions for Systems of Coupled Fractional Boundary Value Problems

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Applied Sciences 2015年第10期5卷 600-608页

作者： Johnny Henderson rodica luca Alexandru Tudorache Department of Mathematics Baylor University Waco Texas USA Department of Mathematics Gh. Asachi Technical University Iasi Romania Faculty of Computer Engineering and Automatic Control Gh. Asachi Technical University Iasi Romania

We investigate the existence and nonexistence of positive solutions for a system of nonlinear Riemann-Liouville fractional differential equations with coupled integral boundary conditions which contain some positive c... 详细信息

关键词： Riemann-Liouville Fractional Differential Equations Coupled Integral Boundary Conditions Positive Solutions

From mice to humans:a need for comparable results in mammalian neuroplasticity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 464-466页

作者： Marco Ghibaudi Enrica Boda luca Bonfanti Neuroscience Institute Cavalieri Ottolenghi OrbassanoItaly Department of Veterinary Sciences University of TurinTurinItaly Department of Neuroscience Rita Levi-Montalcini University of TurinTurinItaly

Brain plasticity-A universal tool with many variations:The study of brain plasticity has been gaining interest since almost a century and has now reached a huge amount of information(>80,000 results in PubMed).Overall,different types of plasticity,including stem cell-driven genesis of new neurons(adult neurogenesis),cells in arrested maturation(dormant neurons),neuro-glial and synaptic plasticity,can coexist and contribute to grant plastic changes in the brain,from a cellular to system level(Benedetti and Couillard-Despres,2022;Bonfanti et al.,2023).

关键词： plasticity al. arrest

Role of copper chelating agents: between old applications and new perspectives in neuroscience

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 751-762页

作者： Rosalba Leuci Leonardo Brunetti Vincenzo Tufarelli Marco Cerini Marco Paparella Nikola Puvača luca Piemontese Department of Pharmacy-Pharmaceutical Science University of Bari Aldo MoroBariItaly Department of Precision and Regenerative Medicine and Jonian Area(DiMePRe-J) Section of Veterinary Science and Animal ProductionUniversity of Bari Aldo MoroBariItaly Department of Engineering Management in Biotechnology Faculty of Economics and Engineering Management in Novi SadUniversity Business Academy in Novi SadNovi SadSerbia

The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays an important role in the central nervous system, where it is associated with glutamatergic signaling, and it is widely involved in inflammatory processes. Thus, diseases involving copper(Ⅱ) dyshomeostasis often have neurological symptoms, as exemplified by Alzheimer's and other diseases(such as Parkinson's and Wilson's diseases). Moreover, imbalanced copper ion concentrations have also been associated with diabetes and certain types of cancer, including glioma. In this paper, we propose a comprehensive overview of recent results that show the importance of these metal ions in several pathologies, mainly Alzheimer's disease, through the lens of the development and use of copper chelators as research compounds and potential therapeutics if included in multi-target hybrid drugs. Seeing how copper homeostasis is important for the well-being of animals as well as humans, we shortly describe the state of the art regarding the effects of copper and its chelators in agriculture, livestock rearing, and aquaculture, as ingredients for the formulation of feed supplements as well as to prevent the effects of pollution on animal productions.

关键词： agriculture Alzheimer's disease chelators copper feed supplements multi-target

Genetic signatures of ERCC1 and ERCC2 expression,along with SNPs variants,unveil favorable prognosis in SCLC patients undergoing platinum-based chemotherapy

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Oncology Research 2025年第1期33卷 45-55页

作者： ENRICO CALIMAN SARA FANCELLI FEDERICO SCOLARI ADRIANO PASQUI CLARA MANNESCHI DANIELE LAVACCHI FRANCESCA MAZZONI FRANCESCA GENSINI VALERIA PASINI CAMILLA EVA COMIN luca VOLTOLINI SERENA PILLOZZI LORENZO ANTONUZZO Clinical Oncology Unit Careggi University HospitalFlorence50134Italy Department of Experimental and Clinical Medicine University of FlorenceFlorence50134Italy Department of Health Sciences University of FlorenceFlorence50134Italy Medical Oncology Unit Careggi University HospitalFlorence50134Italy Department of Experimental and Clinical Biomedical Sciences“Mario Serio” University of FlorenceFlorence50134Italy Section of Anatomic Pathology Department of Health SciencesUniversity of FlorenceFlorence50139Italy Section of Surgery Histopathology and Molecular PathologyUniversity of FlorenceFlorence50139Italy Thoracic Surgery Unit Careggi University HospitalFlorence50134Italy

Background:Platinum chemotherapy(CT)remains the backbone of systemic therapy for patients with smallcell lung cancer(SCLC).The nucleotide excision repair(NER)pathway plays a central role in the repair of the DNA damage exerted by platinum *** in this repair mechanism may affect patients’*** and Methods:We conducted a retrospective analysis of data from 38 patients with extensive disease(ED)-SCLC who underwent platinum-CT at the Clinical Oncology Unit,Careggi University Hospital,Florence(Italy),from 2015 to *** expression analysis and single nucleotide polymorphism(SNP)characterization of three NER pathway genes—namely ERCC1,ERCC2,and ERCC5—were performed on patient tumor ***:Overall,elevated expression of ERCC genes was observed in SCLC patients compared to healthy *** with low ERCC1 and ERCC5 expression levels exhibited a better median progression-free survival(mPFS=7.1 vs.4.9 months,p=0.39 for ERCC1 and mPFS=6.9 vs.4.8 months,p=0.093 for ERCC5)and overall survival(mOS=8.7 vs.6.0 months,p=0.4 for ERCC1 and mOS=7.2 vs.6.2 months,p=0.13 for ERCC5).Genotyping analysis of five SNPs of ERCC genes showed a longer survival in patients harboring the wild-type genotype or the heterozygous variant of the ERCC1 rs11615 SNP(p=0.24 for PFS and p=0.14 for OS)and of the rs13181 and rs1799793 ERCC2 SNPs(p=0.43 and p=0.26 for PFS and p=0.21 and p=0.16 for OS,respectively)compared to patients with homozygous mutant ***:The comprehensive analysis of ERCC gene expression and SNP variants appears to identify patients who derive greater survival benefits from platinum-CT.

关键词： Small cell lung cancer(SCLC) Nucleotide excision repair(NER)pathway ERCC genes Single nucleotide polymorphisms(SNPs) Platinumchemotherapy(CT)

Nerve pulse propagation in biological membranes： Solitons and other invariant solutions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Biomathematics 2016年第5期9卷 185-197页

作者： rodica Cimpoiasu Research Center Frontier in Biology and Astrobiology University of Craiova 13 A. L Cuza Street Craiova Dolj Romania

We investigate a generalized form of the Boussinesq equation, relevant for nerve pulse propagation in biological membranes. The generalized conditional symmetry （GCS） method is applied in order to obtain the conditions that enable the equation to admit a special class of second-order GCSs. For the case of quadratic nonlinearities, we outline a new class of invariant solutions.

关键词： Generalized Boussinesq equation generalized conditional symmetries invari- ant solutions Riccati equation solitary solutions.

Factors that Influence Product Development and their Integration Level in Project Management Approaches

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Systems Science and Systems Engineering 2023年第4期32卷 462-482页

作者： luca Leib Faculty of Business and Economics Mendel University in BrnoBrnoCzech Republic

Project management literature provides various approaches to organize project ***,several factors influence product development about its efficiency and *** paper analyses the factors that affect product development and evaluates their integration level in project management concerning modern requirements imposed in a volatile,uncertain,complex,and ambiguous(VUCA)*** concludes by identifying undervalued influencing factors worth investigating in future research.

关键词： Communication decision making product development project management team organization VUCA

DLC coatings for hydraulic applications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国有色金属学会会刊：英文版 2009年第4期19卷 810-813页

作者： luca NOBILI luca MAGAGNIN Dip. Chimica Materiali e Ingegneria Chimica ＂G. Natta＂ Politecnico di Milano Via Mancinelli 7-20131 Milano Italy

与水或低粘性的液体润滑油的代替在许多工业领域里是高度合乎需要的，由于环境、节俭的优点。水的低润滑可能为水力的部件的合适的操作是不够的，并且像钻石的碳(DLC ) 涂层作为稳固的润滑剂电影很吸引人。一个遥远血浆的 PACVD 过程被... 详细信息

与水或低粘性的液体润滑油的代替在许多工业领域里是高度合乎需要的，由于环境、节俭的优点。水的低润滑可能为水力的部件的合适的操作是不够的，并且像钻石的碳(DLC ) 涂层作为稳固的润滑剂电影很吸引人。一个遥远血浆的 PACVD 过程被利用扔 hydrogenated DLC 涂层(交流: H ) 在不同底层上。Microindentation 大小证明涂层坚硬在 35 GPa 附近。Tribological 行为被测试与氧化铝在水和水里执行了的 block-on-ring 评估。wear 率在由激光 profilemeter 测量 wear 体积以后被计算。wear 轨道的词法、组合的分析表明那涂层失败可以由磨料发生穿或分层，取决于底层性质。难、光滑的底层给最好的结果，驱散的氧化铝粒子增加 wear 率。

关键词：类金刚石涂层液压元件氧化铝颗粒应用等离子体辅助类金刚石碳固体润滑膜 CVD工艺

Endoscopic appearance of esophageal hematomas

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2000年第2期6卷 307-309页

作者： rodica Ouatu-Lascar Gayatri Bharadhwaj George Triadafilopoulos Gastroenterology Section Palo Alto Veterans Affairs Health Care SystemPalo AltoCalifornia and Division of GastroenterologyDepartment of MedicineStanford UniversityStanfordCaliforniaUSA

INTRODUCTIONEsophageal hematomas develop from the dissectionof the mucosa from the muscular layers of theesophageal wall and represent an uncommoncondition affecting all *** the mostcommon cause of esophageal hematomas isiatrogenic mechanical injury-induced by prolongednasogastric intubation,difficult or forcefulendoscopic intubation,or the result of

关键词： esophagus hematoma/etiology endoscopy gastrointestinal hemorrhage/diagnosis hematoma/classification wounds injuries

Utilization of irradiance ratios for calculating the effect of reflections from obstructions in building energy simulation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Building Simulation 2021年第4期14卷 945-967页

作者： Gian luca Brunetti Politecnico di Milano Department of Architecture and Urban Studies(DAStU)via Bonardi 320133MilanoItaly

The ability to take into account reflections from obstructions is of fundamental importance in building energy simulation (BES), because reflections can have a substantial influence on solar gains. In BES tools, this ability is often implemented duplicating functionalities that have already been solved efficiently in lighting simulation tools. This happens because importing those functionalities from a lighting simulation tool (source) into a BES tool (target) is usually a complex operation producing non-portable results. This article demonstrates that this ability can be imported modularly and portably without intervening in the internals of the two tools. This can be obtained by: (1) creating, in the source tool, pairs of models which are analogue-on the one hand-to the original model in the target tool, and-on the other hand-to the model in the target tool hypothetically enriched with some predictive ability only available in the source tool;(2) measuring, at each time step, the ratio between the performances predicted by the source tool as regards the two analogue models;(3) re-scaling, at each time-step, the performance predicted by the target tool on the basis of that ratio. When appropriate analogue models are utilized, this strategy enables distinct simulation tools to work like an integrated computing unit.

关键词： irradiance ratios shading factors analogue models solar reflections insolation factors