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The Prognostic Value of Myocardial Deformation in Patients with Congenital Aortic Stenosis

Congenital Heart Disease 2021年第3期16卷 221-232页

作者： roderick w.j.van grootel Allard T.van den Hoven Dan Bowen Tijmen Ris jolien w.Roos-Hesselink Annemien E.van den Bosch Department of Cardiology Erasmus Medical CentreRotterdamThe Netherlands

Aims:To assess the prognostic value of left ventricular(LV)global longitudinal strain(GLS)and global longitudinal early diastolic strain rate(GLSre)with regard to cardiovascular events,as congenital aortic stenosis(AoS)is associated with significant mortality and morbidity but predictors for clinical outcome are *** analysis provides a robust and reproducible method for early detection of LV dysfunction,which might be of prognostic ***:This prospective study,included clinically stable patients with congenital AoS between 2011–*** GLS and GLSre was performed in the apical 4,3 and 2-chamber views using Tomtec *** endpoint was a composite of death,heart failure,hospitalization,arrhythmia,thrombo-embolic events and ***:In total 138 patients were included(33[26–43]years,86(62%)male),NYHA class I:134(97%).Mean LV GLS was–15.3±3.2%,GLSre 0.66±0.18 s–*** correlated with NT-proBNP,LV volumes and ejection fraction(strongest LV GLS with LV EF:r–0.539,pwith age:r–0.376,pw-up of 5.9[5.5–6.2]years,the endpoint occurred in 53(38%)patients:4 patients died,9 developed heart failure,22 arrhythmias,8 thrombo-embolic events and 35 *** LV GLS(standardized HR(sHR 0.62(95%CI 0.47–0.81)and GLSre(sHR 0.62(95%CI 0.47–0.83)were associated with the *** multivariable analysis showed that both GLS and GLSre were associated independent of left atrial volume,NT-proBNP and prior ***:Left ventricular GLS and GLSre are reduced in adult patients with congenital *** markers are associated with adverse cardiac events and have clear clinical relevance.

关键词： Speckle tracking echocardiography congenital aortic stenosis strain prognosis

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Systolic and Diastolic Strain Measurements Show Left Ventricular Dysfunction in women with Turner Syndrome

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Congenital Heart Disease 2021年第4期16卷 357-368页

作者： Allard T.van den Hoven Sultan Yilmazer Lidia R.Bons roderick w.jvan grootel L.w.Geenen An M.van Berendoncks Anthonie L.Duijnhouwer Hans-Marc j.Siebelink jolien w.Roos-Hesselink Annemien E.van den Bosch Department of Congenital Cardiology Erasmus MCRotterdamNetherlands Department of Cardiology Radboud University Medical CenterNijmegenNetherlands Department of Cardiology Leiden University Medical CenterRotterdamNetherlands

Aim:This study aimed to describe the systolic left ventricular global longitudinal strain(LvGLS)and left ventricular peak early diastolic strain rate(Sre)in adult women with Turner syndrome(TS)and to determine its relationship with exercise capacity and clinical ***:In this cross-sectional cohort study,consecutively included adult TS women underwent an electrocardiogram,transthoracic echocardiogram(TTE)and cardiopulmonary exercise test(CPET)on the same *** and Sre were measured using 2D speckle tracking analysis(STE)and compared with age-matched healthy female ***:Ninety-four adult women(age 36±13 years)with TS and 32 healthy age-matched female controls were *** with TS had a significantly impaired/reduced systolic LvGLS(–17.82±2.98%vs.–21.80±1.85%,p0.001),compared to healthy female ***,TS women had reduced diastolic function as measured by conventional echocardiographic parameters:A higher A-wave(pwer E/A-ratio(p=0.001),longer deceleration time(p=0.006),and a higher E/E’-ratio(pwomen with TS also had a significantly reduced maximal workload(p=0.033),reduced oxygen uptake(pwere significantly associated with Sre,but not with LvGLS,in the TS ***:Systolic and diastolic strain and exercise capacity were significantly reduced in TS women compared to healthy *** correlation between strain itself and exercise capacity could be demonstrated,but correlations with conventional TTE parameters and baseline characteristics were found.

关键词： Turnersyndrome speckletracking echocardiography strain exercise capacity

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Functional outcome in conservatively treated non-displaced scaphoid fractures

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Open journal of Clinical Diagnostics 2012年第4期2卷 66-69页

作者： Tessa Drijkoningen Frank j. P. Beeres roderick H. van Leerdam Daan Ootes Diana C. Grootendorst Marleen Otoide-Vree Steven j. Rhemrev Department of Trauma Surgery Medisch Centrum Haaglanden Hague Netherlands Landsteiner Instituut Medisch Centrum Haaglanden Hague Netherlands Marleen Otoide-Vree

Purpose: This study evaluated the functional outcome after conservative treatment of non-displaced scaphoid fractures using an international validated outcome scale (DASH). Methods and materials: Between 2005 and 2010, 60 patients with a non-displaced scaphoid fracture were included. when a patient visited the emergency department and was clinically suspected of a scaphoid fracture radiography was performed. If no fracture was diagnosed with this modality a CT or MRI-scan both in combination with bonescintigraphy was performed. Patients with scaphoid fractures diagnosed with CT/MRI and bonescintigraphy were treated with a six-week scaphoid forearm cast. within 1 year after cast removal patients filled in the DASH questionnaire. Results: Sixty (80%) patients returned the DASH questionnaire at 12 months after treatment. Thirty-eight (63.3%) were male and the mean age was 35 (range 11 - 83). Forty-four (73.3%) patients had a mid-waist fracture of the scaphoid, 13 (21.7%) had a fracture of the distal pole and three (0.05%) had a proximal fracture. Median DASH score at one year after the trauma was 6 (range 3 - 15) for patients with a distal pole fracture and 5 (range 0 - 21.5) for mid-waist fractures (p = 0.7, table 2). For the three patients with a proximal scaphoid fracture the DASH scores appeared higher and were 83, 82 and 30 respectively. Conclusion: Conservative treatment for six weeks with a below the elbow cast is sufficient for the majority of patients with an occult distal or mid-waist scaphoid fracture and results in a good functional outcome according to the DASH questionnaire.

关键词： DASH Scaphoid Fracture Os scaphoideum Hand Trauma Conservative Treatment

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终末期心力衰竭患者的肌成纤维细胞表型和纤维化的可逆性

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中华高血压杂志(中英文) 2019年第10期 999-999页

作者： Nagaraju CK Robinson EL Abdesselem M Trenson S Dries E Gilbert G janssens S van Cleemput j Rega F Meyns B roderick HL Driesen RB Sipido KR 林立超余惠珍朱鹏立

心肌间质纤维化通过激活成纤维细胞分化为肌成纤维细胞(myofibroblasts, MyoFb)导致舒张及收缩功能不全,为心力衰竭的重要病理基础。近期临床证据表明,在终末期心力衰竭患者中,心肌间质纤维化是不可逆转的病理过程。本文研究目的为探讨... 详细信息

心肌间质纤维化通过激活成纤维细胞分化为肌成纤维细胞(myofibroblasts, MyoFb)导致舒张及收缩功能不全,为心力衰竭的重要病理基础。近期临床证据表明,在终末期心力衰竭患者中,心肌间质纤维化是不可逆转的病理过程。本文研究目的为探讨终末期心力衰竭患者的心肌组织中MyoFb的分化程度和细胞表型逆转的潜在性。方法:两种来源获取成纤维细胞:①从因缺血性或扩张性心肌病需心脏移植患者的左心室分离;②从捐献者的心脏中分离。成纤维细胞经体

关键词：终末期心力衰竭肌成纤维细胞纤维化可逆性

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