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Advancing the.National Immunization Program in an e.a of achie.ing unive.sal vaccine.cove.age.in China and be.ond

贫困所致传染病(英文) 2024年第2期13卷 1-5页

作者： Che. Shu rode.ald lance e. He.g Du Anna Tang She.glan ARC Ce.tre.of e.ce.le.ce.in Population Age.ng Re.e.rch (Ce.AR) University of New South Wales Sydney Australia School of Risk and Actuarial Studie. University of New South Wales Sydney Australia De.artme.t of the.National Immunization Program Chinese Center for Disease Control and Prevention National Immunization Program China CDC Beijing China China Country Office Bill &amp Me.inda Gate. Foundation Beijing China Duke.Global He.lth Institute Duke University Durham NC USA Global He.lth Re.e.rch Ce.te. Duke Kunshan University No. Duke Avenue Kunshan Jiangsu China SingHe.lth Duke.NUS Global He.lth Institute Duke-NUS Singapore Singapore

Background Immunization is a corne.stone.of public he.lth. De.pite.gre.t succe.s, China’s National Immunization Program (NIP) face. challe.ge., such as the.inte.ration of se.e.al World He.lth Organization-re.omme.de. vaccine. and othe. syste.ic issue.. The.Innovation Laboratory for Vaccine.De.ive.y Re.e.rch (VaxLab), supporte. by the.Bill & Me.inda Gate. Foundation and e.tablishe. in 2021 at Duke.Kunshan Unive.sity, focuse. on e.hancing China’s NIP through re.e.rch and policy advocacy. This e.itorial aims to summarize.the.ke. findings of the.manuscripts publishe. in the.colle.tion contribute. by VaxLab te.m and se. the.future.re.e.rch *** findings The.colle.tion contains e.e.e. manuscripts discussing China’s immunization landscape.and strate.ie. to improve.cove.age. particularly for non-NIP vaccine. like.human papillomavirus vaccine.(HPV), pne.mococcal conjugate.vaccine.(PCV),Hae.ophilus influe.zae.type.b vaccine.(Hib), and rotavirus vaccine.. Ke. findings include. (i) The.COVID-19 vaccination campaign de.onstrate. China’s capacity for rapid, large.scale.immunization e.forts, sugge.ting pote.tial for broade. vaccine.cove.age.improve.e.ts; (ii) e.forts in combating ce.vical cance. through the.HPV vaccine.indicate.progre.s but also highlight challe.ge. like.vaccine.supply and e.uitable.acce.s; (iii) The.lag in adopting highe.-vale.t pae.iatric combination vaccine. in China ne.ds atte.tion to addre.s re.ulatory and he.lth syste. hurdle.; (iv) Disparitie. in acce.s to non-NIP vaccine. unde.score.the.ne.d for gove.nme.t initiative. to improve.vaccine.cove.age. e.pe.ially for re.ote.are.s and marginalize. populations; (v) Original studie. e.phasize.the.influe.ce.of care.ive.s’ knowle.ge. he.lth worke.s’ financial ince.tive., and conce.ns about vaccine.e.ficacy on immunization rate.; (vi) Case.studie. from the.We.fang City of China and Indone.ia to introduce.PCV offe. insights on succe.sful vaccine.introduction strate.ie. and the.impact of innovative.financing and g

关键词： National Immunization Program Ne. vaccine.introduction Unive.sal vaccine.cove.age He.lth syste. stre.gthe.ing

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De.ision-Making and Manage.e.t of Se.f-Care.in Pe.sons with Traumatic Spinal Cord Injurie.: A Pre.iminary Study

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Journal of Be.avioral and Brain Scie.ce 2024年第2期14卷 47-63页

作者： Paul e. Plonski Jasmin Vassile.a Ryan Shahidi Paul B. Pe.rin William Carte. lance L. Goe.z Ambe. Broche.ti Jame. M. Bjork Institute.for Drug and Alcohol Studie. Virginia Commonwealth University Richmond VA USA Richmond Ve.e.ans Affairs Me.ical Ce.te. Richmond VA USA De.artme.t of Psychiatry Virginia Commonwealth University Richmond VA USA De.artme.t of Psychology Virginia Commonwealth University Richmond VA USA De.artme.t of Physical Me.icine.and Re.abilitation Virginia Commonwealth University Richmond VA USA De.artme.t of Spinal Cord Injury Cleveland Veterans Affairs Medical Center Cleveland OH USA De.artme.t of Pharmacology and Toxicology Virginia Commonwealth University Richmond VA USA

Patie.ts and physicians unde.stand the.importance.of se.f-care.following spinal cord injury (SCI), ye. many individuals with SCI do not adhe.e.to re.omme.de. se.f-care.activitie. de.pite.logistical supports. Ne.robe.avioral de.e.minants of SCI se.f-care.be.avior, such as impulsivity, are.not wide.y studie., ye. unde.standing the. could inform e.forts to improve.SCI se.f-care. We.e.plore. associations be.we.n impulsivity and se.f-care.in an obse.vational study of 35 US adults age.18 - 50 who had traumatic SCI with paraple.ia at le.st six months be.ore.asse.sme.t. The.primary outcome.me.sure.was se.f-re.orte. se.f-care. In LASSO re.re.sion mode.s that include. all ne.robe.avioral me.sure. and de.ographics as pre.ictors of se.f-care. dispositional me.sure. of gre.te. impulsivity (ne.ative.urge.cy, lack of pre.e.itation, lack of pe.se.e.ance., and re.uce. mindfulne.s we.e.associate. with re.uce. se.f-care. Outcome.(magnitude. se.sitivity, a late.t de.ision-making parame.e. de.ive. from computationally mode.ing succe.sive.choice. in a gambling task, was also associate. with se.f-care.be.avior. The.e.re.ults are.pre.iminary;more.re.e.rch is ne.de. to de.onstrate.the.utility of the.e.findings in clinical se.tings. Information about associations be.we.n impulsivity and poor se.f-care.in pe.ple.with SCI could guide.the.de.e.opme.t of inte.ve.tions to improve.SCI se.f-care.and he.p patie.ts with e.e.ate. risks re.ate. to se.f-care.and se.ondary he.lth conditions.

关键词： Spinal Cord Injury Se.f-Care De.ision-Making Paraple.ia Impulsive.Be.avior He.lth Care

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Conside.ations for the.use.of porcine.organ donation mode.s in pre.linical organ donor inte.ve.tion re.e.rch

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Animal Mode.s and e.pe.ime.tal Me.icine 2024年第3期7卷 283-296页

作者： Fraze. I.He.nis Shahe.d Me.ani Nicholas W.Markin Kim F.Duncan Michae. J.Moulton lance Fristoe.William e.Thore.l Rae.he. A.She.rick Tami R.We.ls Matthe. T.Andre.s Marian Urban School of Natural Re.ource. Institute of Agriculture and Natural ResourcesUniversity of Nebraska-LincolnLincolnNebraskaUSA Division of Transplantation and Vascular Surge.y Department of SurgeryUniversity of Nebraska Medical CenterOmahaNebraskaUSA De.artme.t of Ane.the.iology University of Nebraska Medical CenterOmahaNebraskaUSA Division of Cardiothoracic Surge.y Department of SurgeryUniversity of Nebraska Medical CenterOmahaNebraskaUSA Clinical Pe.fusion Nebraska Medicine-Nebraska Medical CenterOmahaNebraskaUSA De.artme.t of Ne.rosurge.y University of Nebraska Medical CenterOmahaNebraskaUSA Nutrition and He.lth Scie.ce. College of Education and Human SciencesUniversity of Nebraska-LincolnLincolnNebraskaUSA De.artme.t of Comparative.Me.icine University of Nebraska Medical CenterOmahaNebraskaUSA

Use.of animal mode.s in pre.linical transplant re.e.rch is e.se.tial to the.optimization of human allografts for clinical *** mode.s of organ donation and pre.e.vation he.p to advance.and improve.te.hnical e.e.e.ts of solid organ re.ove.y and facilitate.re.e.rch of ische.ia-re.e.fusion injury,organ pre.e.vation strate.ie.,and future.donor-base. *** conside.ations include.cost,public opinion re.arding the.conduct of animal re.e.rch,translational value.and re.e.ance.of the.animal mode. for clinical *** pre.e.t an ove.vie. of two porcine.mode.s of organ donation:donation following brain de.th(DBD)and donation following circulatory de.th(DCD).The.cardiovascular anatomy and physiology of pigs close.y re.e.ble. those.of humans,making this spe.ie. the.most appropriate.for pre.clinical *** are.also conside.e. a pote.tial source.of organs for human he.rt and kidne. *** is impe.ative.to minimize.animal loss during proce.ure. that are.surgically *** pre.e.t our e.pe.ie.ce.with the.e.mode.s and de.cribe.in de.ail the.use.case.,proce.ural approach,challe.ge.,alte.native.,and limitations of e.ch mode..

关键词： animal mode. brain de.th circulatory de.th organ transplantation

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Acce.e.ating into Immunization Age.da 2030 with mome.tum from China’s succe.sful COVID-19 vaccination campaign during dynamic COVID Ze.o

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Infe.tious Dise.se. of Pove.ty 2023年第5期12卷 87-90页

作者： lance e.rode.ald National Immunization Program China CDCDepartment of the National Immunization ProgramChinese Center for Disease Control and Prevention155 Changbai RoadBeijing 102206People’s Republic of China

China’s immunization programs conducte. a unifie.,tightly coordinate. COVID-19 vaccination campaign during the.dynamic COVID Ze.o pe.iod that re.che. we.l ove. 90%of the.population with vaccine. having>90%e.fe.tive.e.s against se.ious-to-fatal *** campaign was e.ght time. the.size.of the.annual routine.national immunization program,administe.ing 3.4 billion dose. of vaccine. while.monitoring vaccine.cove.age.acce.tability,safe.y,and *** asse. of the.routine.immunization program had to be.stre.gthe.e. and e.pande. to attain high cove.age.and re.ch hundre.s of millions of adults who had not be.n vaccinate. since.*** stre.gthe.ing and e.pansion we.e.in dire.tions aligne. with the.World He.lth Organization’s Immunization Age.da 2030,which has a vision that"e.e.yone.e.e.ywhe.e.at e.e.y age.fully be.e.its from vaccine. for good he.lth and we.l-be.ng"and re.uire. re.ching all childre.,adole.ce.ts,and adults with life.aving *** from this campaign should not be.lost but should be.inve.te. into achie.ing what is possible.with a prope.ly re.ource. national immunization program that is now prove. to be.capable.of re.ching e.e.yone.in the.world’s large.t country throughout the.life.course.and to do so with all vaccine. re.omme.de. by the.World He.lth Organization.

关键词： Vaccine. Immunization Immunization program Immunization Age.da 2030 COVID-19 Life.course.vaccination

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Forty and Twe.ty Ye.rs Ago and Now--Virus e.imination Succe.se. and Ne. Challe.ge.

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China CDC we.kly 2020年第50期2卷 953-954页

作者： lance e.rode.ald National Immunization Program China CDC Immunization Se.vice. Division US CDC(2000-2012) WHO China Country Office.2012-2017)

Forty ye.rs ago,smallpox was de.lare. e.adicate. by the.World He.lth Organization(WHO).As ***,Dire.tor of the.Smallpox e.adication Programme.at the.WHO quote. from the.33^(rd) World He.lth Asse.bly(1980)(1),“...the.world and all its pe.ple. have.won fre.dom from smallpox...a most de.astating dise.se...since.e.rlie.t time.le.ving de.th,blindne.s,and disfigure.e.t in its wake.and which only a de.ade.ago was rampant in Africa,Asia and South Ame.ica.”

关键词： de.th Dire.tor dise.se.

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e.porting China’s Succe.se. in Vaccine.Pre.e.table.He.atitis

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China CDC we.kly 2020年第30期2卷 575-576页

作者： lance e.rode.ald National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina

Almost four de.ade. of scie.ce.innovation,and programmatic e.fort to control and pre.e.t vaccine.re.e.table.viral he.atitis have.paid off spe.tacularly we.l in *** the.pre.vaccine.e.a,ne.rly 10% of childre. we.e.infe.te. by he.atitis B virus(HBV)—e.pe.ially during childbirth—causing the. to be.life.ong carrie.s of HBV,able.to infe.t othe.s,and in gre.t dange. of live. cance. and cirrhosis as adults(1).

关键词： vaccine China. he.atitis

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The.acce.e.ation of a high-charge.e.e.tron bunch to 10 Ge. in a 10-cm nanoparticle.assiste. wake.ie.d acce.e.ator

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Matte. and Radiation at e.tre.e. 2024年第1期9卷 15-24页

作者： Constantin Aniculae.e. Thanh Ha Samue. Yoffe.lance Labun Ste.he. Milton e.ward McCary Michae. M.Spinks He.nan J.Que.e.o Ou Z.Labun Ritwik Sain Andre. Hannasch Rafal Zgadzaj Isabe.la Pagano Jose.A.Franco-Altamirano Martin L.Ringue.te.e.hart Gaul Scott V.Lue.tke.Gane.h Tiwari Be.nhard e.sfe.d e.rico Brune.ti Hartmut Ruhl Todd Ditmire.Sandra Bruce.Michae. e.Donovan Michae. C.Downe. Dino A.Jaroszynski Bjorn Manue. He.e.ich Unive.sity of Te.as at Austin AustinTexas 78712USA SUPA De.artme.t of Physics University of StrathclydeGlasgowScotland G4 ONGUnited Kingdom Tau Syste.s Inc.AustinTexas 78701USA Lawre.ce.Live.more.National Laboratory LivermoreCalifornia 94550USA Los Alamos National Laboratory Los AlamosNew Mexico 87545USA Brookhave. National Laboratory UptonNew York 11973USA Ludwig-Maximilians-Unive.sität MunichGermany

An inte.se.lase. pulse.focuse. onto a plasma can e.cite.nonline.r plasma *** appropriate.conditions,e.e.trons from the.background plasma are.trappe. in the.plasma wave.and acce.e.ate. to ultra-re.ativistic *** sche.e.is calle. a lase. wake.ie.d *** this work,we.pre.e.t re.ults from a lase. wake.ie.d acce.e.ation e.pe.ime.t using a pe.awatt-class lase. to e.cite.the.wake.ie.ds as we.l as nanoparticle. to assist the.inje.tion of e.e.trons into the.acce.e.ating phase.of the.*** find that a 10-cm-long,nanoparticle.assiste. lase. wake.ie.d acce.e.ator can ge.e.ate.340 pC,10±1.86 Ge. e.e.tron bunche. with a 3.4 Ge. rms convolve. e.e.gy spre.d and a 0.9 mrad rms *** can also produce.bunche. with lowe. e.e.gie. in the.4–6 Ge. range.

关键词： acce.e.ation nanoparticle charge

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Robust ge.ome.and RNA e.iting via CRISPR nucle.se. in PiggyBac syste.s

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Bioactive.Mate.ials 2022年第8期7卷 313-320页

作者： Yuqian Jiang Rache. Cathe.ine.Hoe.isch Yun Chang Xiaoping Bao Craig e.Came.on Xiaojun lance Lian De.artme.t of Biome.ical e.gine.ring Pennsylvania State UniversityUniversity ParkPA16802USA Huck Institute. of the.Life.Scie.ce. Pennsylvania State UniversityUniversity ParkPA16802USA De.artme.t of Biology Pennsylvania State UniversityUniversity ParkPA16802USA Davidson School of Che.ical e.gine.ring Purdue UniversityWest LafayetteIN47907USA De.artme.t of Microbiology and Immunology University of North Carolina School of MedicineChapel HillNC27599USA

CRISPR/Cas-me.iate. ge.ome.e.iting in human pluripote.t ste. ce.ls(hPSCs)offe.s unpre.e.e.te. opportunitie. for de.e.oping in vitro dise.se.mode.ing,drug scre.ning and ce.l-base. *** e.ficie.tly de.ive. the.CRISPR compone.ts,he.e.we.de.e.ope. two all-in-one.ve.tors containing Cas9/gRNA and inducible.Cas13d/gRNA casse.te. for robust ge.ome.e.iting and RNA inte.fe.e.ce.*** ve.tors utilize. the.PiggyBac transposon syste.,which allows stable.e.pre.sion of CRISPR compone.ts in *** Cas9 ve.tor PB-CRISPR e.hibite. high e.ficie.cy(up to 99%)of inducing ge.e.knockout in both prote.n-coding ge.e. and long non-coding *** othe. inducible.Cas13d ve.tor achie.e. e.tre.e.y high e.ficie.cy in RNA knockdown(98%knockdown for CD90)with optimize. gRNA *** toge.he.,our PiggyBac CRISPR ve.tors can se.ve.as powe.ful toolkits for studying ge.e.functions in hPSCs.

关键词： CRISPR-Cas9 Ge.ome.e.iting Cas13d RNA e.iting PiggyBac transposon Human pluripote.t ste. ce.ls

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scLM:Automatic De.e.tion of Conse.sus Ge.e.Cluste.s Across Multiple.Single.ce.l Datase.s

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Ge.omics, Prote.mics & Bioinformatics 2021年第2期19卷 330-341页

作者： Qianqian Song Jing Su lance D.Mille. We. Zhang Ce.te. for Cance. Ge.omics and Pre.ision Oncology Wake Forest Baptist Comprehensive Cancer CenterWake Forest Baptist Medical CenterWinston SalemNC 27157USA De.artme.t of Cance. Biology Wake Forest School of MedicineWinston SalemNC 27157USA De.artme.t of Biostatistics Indiana University School of MedicineIndianapolisIN 46202USA

In ge.e.e.pre.sion profiling studie.,including single.ce.l RNA se.ue.cing(scRNA-se.)analyse.,the.ide.tification and characte.ization of co-e.pre.se. ge.e. provide. critical information on ce.l ide.tity and *** co-e.pre.sion cluste.ing in scRNA-se. data pre.e.ts ce.tain *** show that commonly use. me.hods for single.ce.l data are.not capable.of ide.tifying co-e.pre.se. ge.e. accurate.y,and produce.re.ults that substantially limit biological e.pe.tations of co-e.pre.se. ***,we.pre.e.t single.ce.l Late.t-variable.Mode.(scLM),a ge.e.cocluste.ing algorithm tailore. to single.ce.l data that pe.forms we.l at de.e.ting ge.e.cluste.s with significant biologic ***,scLM can simultane.usly cluste. multiple.single.ce.l datase.s,i.e.,conse.sus cluste.ing,e.abling use.s to le.e.age.single.ce.l data from multiple.source. for nove. comparative.*** take. raw count data as input and pre.e.ve. biological variation without be.ng influe.ce. by batch e.fe.ts from multiple.*** from both simulation data and e.pe.ime.tal data de.onstrate.that scLM outpe.forms the.e.isting me.hods with conside.ably improve. *** illustrate.the.biological insights of scLM,we.apply it to our in-house.and public e.pe.ime.tal scRNA-se. *** ide.tifie. nove. functional ge.e.module. and re.ine. ce.l state.,which facilitate. me.hanism discove.y and unde.standing of comple. biosyste.s such as cance.s.A use.-frie.dly R package.with all the.ke. fe.ture. of the.scLM me.hod is available.at https://***/QSong-github/scLM.

关键词： Single.ce.l RNA se.ue.cing Conse.sus cluste.ing Late.t space Markov Chain Monte.Carlo Maximum like.ihood approach

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分子系统进化关系分析的一种新方法——贝叶斯法在硬蜱属中的应用

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动物学报 2003年第3期49卷 380-388页

作者：徐广方庆权 Jame. e. Ke.RANS lance A. DURDe. 南乔治亚大学生物系和美国国家蜱博物馆

距离矩阵邻接法、最大简约法和最大似然法是重建生物系统关系的 3种主要方法。普遍认为最大似然法在原理上优于前二种方法 ,但其计算复杂费时。由于现行计算机的能力尚达不到其要求而实用性差 ,特别是在处理大数据集样本 (即大于 2 5个... 详细信息

距离矩阵邻接法、最大简约法和最大似然法是重建生物系统关系的 3种主要方法。普遍认为最大似然法在原理上优于前二种方法 ,但其计算复杂费时。由于现行计算机的能力尚达不到其要求而实用性差 ,特别是在处理大数据集样本 (即大于 2 5个分类单元 )时 ,用此方法几乎不可能。新近提出的贝叶斯法 (Baye.ianme.hod)既保留了最大似然法的基本原理 ,又引进了马尔科夫链的蒙特卡洛方法 ,并使计算时间大大缩短。本文用贝叶斯法对硬蜱属 (Ixode.) 19个种的线粒体 16SrDNA片段进行了系统进化分析。从总体上看 ,分析结果与现有的基于形态学的分类体系基本吻合。但与现存的假说相反 ,莱姆病的主要宿主蓖籽硬蜱复合种组并非单系。通过比较贝叶斯法与其它三种方法的结果 ,我们认为贝叶斯法是一种系统进化分析的好方法 ,它既能根据分子进化的现有理论和各种模型用概率重建系统进化关系 ,又克服了最大似然法计算速度慢、不适用于大数据集样本的缺陷。贝叶斯法根据后验概率直观地表示系统进化关系的分析结果 ,不需要用自引导法进行检验。可以预料 ,贝叶斯法将会被广泛地应用到系统进化分析上.

关键词：分子系统进化贝叶斯法硬蜱属线粒体 16SrDNA

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