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Interleukin-1:an important target for perinatal neuroprotection?

Neural Regeneration Research 2023年第1期18卷 47-50页

作者： Sharmony B.Kelly Elys Green rod w.hunt Claudia A.Nold-Petry Alistair J.Gunn Marcel F.Nold Robert Galinsky The Ritchie Centre Hudson Institute of Medical ResearchMelbourneVictoriaAustralia Department of Obstetrics and Gynaecology Monash UniversityVictoriaAustralia Department of Pediatrics Monash UniversityVictoriaAustralia Monash Newborn Monash Children’s HospitalMelbourneAustralia Department of Physiology The University of AucklandAucklandNew Zealand

Perinatal inflammation is a significant risk factor for lifelong neurodevelopmental impairments such as cerebral *** clinical and preclinical evidence links the severity and pattern of perinatal inflammation to impaired maturation of white and grey matters and reduced brain *** pathways are involved in the pathogenesis of perinatal ***,studies of human and experimental perinatal encephalopathy have demonstrated a strong causative link between perinatal encephalopathy and excessive production of the pro-inflammatory effector cytokine *** this review,we summarize clinical and preclinical evidence that underpins interleukin-1 as a critical factor in initiating and perpatuating systemic and central nervous system inflammation and subsequent perinatal brain *** also highlight the important role of endogenous interleukin-1 receptor antagonist in mitigating interleukin-1-driven neuroinflammation and tissue damage,and summarize outcomes from clinical and mechanistic animal studies that establish the commercially available interleukin-1 receptor antagonist,anakinra,as a safe and effective therapeutic *** reflect on the evidence supporting clinical translation of interleukin-1 receptor antagonist for infants at the greatest risk of perinatal inflammation and impaired neurodevelopment,and suggest a path to advance interleukin-1 receptor antagonist along the translational path for perinatal neuroprotection.

关键词： brain inflammation interleukin-1 receptor antagonist interleukin-1 interleukin-1β neonatal encephalopathy neuroprotection preterm brain injury

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Neonatal neuroimaging after repair of congenital diaphragmatic hernia and long-term neurodevelopmental outcome

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world Journal of Pediatric Surgery 2019年第3期2卷 2-8页

作者： Julia Kate Gunn-Charlton Alice C Burnett Stephanie Malarbi Margaret M Moran Esther A Hutchinson Susan Greaves rod w.hunt Newborn Intensive Care The Royal Children’s HospitalMelbourneVictoriaAustralia Neonatal Research Group Murdoch Children’s Research InstituteMelbourneVictoriaAustralia Department of Paediatrics The University of MelbourneMelbourneVictoriaAustralia Victorian Infant Brain Studies(VIBeS)Group Murdoch Children's Research InstituteMelbourneVictoriaAustralia Department of Occupational Therapy The Royal Children’s HospitalMelbourneVictoriaAustralia

Objective Previous outcome reports of congenital diaphragmatic hernia(CDH)have described neuroimaging anomalies and neurodevelopmental ***,the link between imaging and outcome has not been *** aimed to determine whether routine postoperative neonatal neuroimaging in infants with CDH detects later neurodevelopmental *** In a prospective cohort study within a clinical service in The Royal Children’s Hospital Newborn Intensive *** ultrasound was performed in 81 children and MRI in 57 children who subsequently underwent neurodevelopmental follow-up after surgery for *** scans were analyzed using a scoring system designed to identify injury,maturation and volume *** assessment occurred at 2 years(48)and neurocognitive assessment at 5 years(26)and/or 8 years(27).Brain imaging scores corrected for gestational age at scan time were correlated with outcome measures,adjusting for known clinical *** Clinically significant findings were identified on MRI of 16(28%)*** scores were in the normal range for all domains assessed at each *** impairment was seen in 23%at 2 years and verbal intellectual impairment in 25%at 8 *** cognitive scores were lower in 2-year-old children with white matter injury on MRI(p=0.03).Mean motor scores were lower in 2-year-old children with brain immaturity(p=0.01).Associations between MRI and 5-year and 8-year assessments were no longer significant when adjusting for known clinical *** Neuroimaging abnormalities were associated with worse neurodevelopment at 2 years,but not with later neurocognitive outcomes,after accounting for clinical risk factors.

关键词： hernia routine maturity

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下面两张图中有10处不同，请你找找看吧!

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运动休闲 2015年第7期 155-155页

作者： rod hunt

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运动休闲 2014年第6期 155-155页

作者： rod hunt

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模拟定向凝固生长速率对杆形Mn-Bi合金共晶间距的影响

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铸造 2003年第6期52卷 395-399页

作者：王君卿 Mustafa Kaya Reginald w.Smith 沈阳铸造研究所辽宁沈阳110022 皇后大学

为了深入了解定向凝固过程生长速率对杆形Mn Bi合金共晶间距的影响,开展了试验和数值模拟研究工作,以期初步明确在地球上试验得到的杆形共晶间距和在外层空间(航天飞机上)同样试验条件下得到的杆形共晶间距发生变化这样一个事实的机理... 详细信息

为了深入了解定向凝固过程生长速率对杆形Mn Bi合金共晶间距的影响,开展了试验和数值模拟研究工作,以期初步明确在地球上试验得到的杆形共晶间距和在外层空间(航天飞机上)同样试验条件下得到的杆形共晶间距发生变化这样一个事实的机理。在杆形MnBi共晶相和Bi基体生长前沿,用传质方程计算了Mn在合金液中的浓度场,得到了液、固两相间台式界面前沿Mn的等浓度曲线,进而依据Jackson hunt研究的理论模型计算出杆形共晶间距。试验和数值模拟的结果显示,规则生长时,随着Peclet数Λ的不断增加,杆形共晶间距逐渐减少,试验与模拟的结果吻合良好。Λ数还可在将来被用来模拟计算该合金凝固时非规则生长时的情况。

关键词： Mn—Bi合金杆形共晶间距定向凝固数值模拟磁性材料生长速率

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世界核心医学期刊文摘（眼科学分册） 2005年第6期1卷 29-30页

作者： Michaelides M. Holder G.E. hunt D.M. A.T. Moore 王海燕 Institute of Ophthalmology University College London 11- 43 Bath Street London EC1V 9EL United Kingdom

Aim: To characterise the phenotype of an autosomal dominant cone-rod dystrophy (CORD7) associated with the Arg844His mutation in RIM1. Methods: Eight members of a four generation, non-consanguineous British family were examined clinically and underwent electrophysiological testing, automated dark adapted perimetry, dark adaptometry, colour vision assessment, colour fundus photography, fundus fluorescein angiography (FFA), and fundus autofluorescence (AF) imaging. Results: The majority of affected individuals described a progressive deterioration of central vision, night vision, and peripheral visual field usually between the third and fourth decades. The visual acuity ranged from 6/6 to3/60. Colour vision testing showed mild to moderate dyschromatopsia in the majority of individuals. Fundus changes comprised a range of macular appearances varying from mild retinal pigment epithelial (RPE) disturbance to extensive atrophy and pigmentation. In some individuals retinal vessels were attenuated and in two subjects peripheral areas of retinal atrophy were present. An absent or severely reduced PERG was detected in all subjects, indicative of marked macular dysfunction. Full field ERG showed abnormal rod and cone responses. AF imaging revealed decreased macular AF centrally surrounded by a ring of increased AF in the majority of individuals. “ Bull’ s eye” lesions were present in two individuals, comprising of a ring of decreased perifoveal AF bordered peripherally and centrally by increased AF. Photopic sensitivity testing demonstrated elevated central visual field thresholds with additional superior greater than inferior peripheral field loss. There were rod and cone sensitivity reductions in the central and peripheral visual fields, with the inferior retina being more affected than the superior. Conclusions: The detailed phenotype is described of the autosomal dominant cone-red dystrophy, CORD7, which is associated with a point mutation in RIM1, a gene encoding a photor

关键词：视杆细胞 CORD7 RIM1 基因突变表现型视锥视网膜色素上皮中心视力视野缩小视野损害

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伴近视和红色盲的X连锁视锥细胞功能障碍综合征

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世界核心医学期刊文摘(眼科学分册) 2006年第2期 61-61页

作者： Michaelides M Johnson S Bradshaw K. D.M. hunt 白芳 Institute of Oph thalmology University College London 11- 43 Bath Street London EC1V 9EL Un ited Kingdom Dr.

Purpose: To perform a detailed clinical, psychophysical, and molecular assessment of members of 4 families with an unusual X-linked cone dysfunction syndrome associated with myopia. Participants: Affected and unaffected members of 4 British nonconsanguineous families. Methods: Subjects underwent both detailed clinical examination and psychophysical testing. After informed consent was obtained, blood samples were taken for DNA extraction, and molecular genetic analysis was performed. The strategy for molecular analysis was to amplify the coding regions of the long and middle wavelength-sensitive cone opsin genes and the upstream locus control region by polymerase chain reaction and to examine these fragments for mutations by sequencing of DNA. Results: The phenotype was almost identical in all 4 families, consisting of moderate to high myopia, astigmatism, moderately reduced acuity, and normal fundi. Electroretinography showed abnormal cone but normal rod responses. Psychophysical testing showed a selective impairment of long cones in combination with well-preserved middle cone and short cone function. There was no evidence to suggest that the phenotype was progressive. Molecular analysis of the X-linked opsin gene array in the 4 families indicated that affected males have inherited the same X-chromosome from their mother. In 2 families, a long/middle hybrid gene was detected. In a third family, the commonly described deleterious Cys203Arg amino acid substitution was identified in both the long and middle opsin genes. In the fourth family, the only abnormality was absence of a middle opsin exon 2; the cause of the protanopia in this family is uncertain. Conclusions: The Xlinked cone dysfunction syndrome associated with myopia and dichromacy described here has many similarities to Bornholm eye disease, a condition previously mapped to Xq28. Except for the Cys203Arg substitution in one family, no alterations in the opsin gene array were identified that could underlie t

关键词：视锥细胞红色盲近视屈光不正功能障碍综合征综合病症

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