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Can blood amyloid levels be used as a biomarker for Alzheimer's disease?

Brain Science Advances 2021年第1期7卷 17-25页

作者： Yuan-Han Yang rocksy fv situmeang Paulus Anam Ong Department of Neurology Kaohsiung Medical University HospitalKaohsiung Medical UniversityKaohsiungTaiwanChina Department of Neurology Kaohsiung Municipal Ta-Tung HospitalKaohsiung Medical University HospitalKaohsiungTaiwanChina Neuroscience Research Center Kaohsiung Medical UniversityKaohsiungTaiwanChina Siloam Hospitals Lippo Village Pelita Harapan UniversityBantenIndonesia Department of Neurology Hasan Sadikin HospitalBandungIndonesia

Alzheimer’s disease(AD)increasingly affects society due to aging *** at pre-clinical stages,earlier and accurate diagnoses are essential for optimal AD management and improved clinical *** such as beta-amyloid(Aβ)or tau protein in cerebrospinal fluid(CSF)have been used as reliable markers to distinguish AD from non-AD,and predicting clinical outcomes,to attain these ***,given CSF access methods’invasiveness,these biomarkers are not used extensively in clinical *** Aβhas been proposed as an alternative biomarker since it is less invasive than CSF;however,sampling heterogeneity has limited its clinical *** this review,we investigated blood Aβas a biomarker in AD and explored how Aβcan be facilitated as a viable biomarker for successful AD management.

关键词： Alzheimer’s disease amyloid precursor protein Aβ1-40 Aβ1-42 apolipoprotein E cerebrospinal fluid plasma

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Application of virtual reality for dementia management

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Brain Science Advances 2022年第3期8卷 210-220页

作者： Yuan-Han Yang rocksy fv situmeang Paulus Anam Ong Rajka M Liscic Department of Neurology Kaohsiung Medical University HospitalKaohsiung Medical UniversityKaohsiungTaiwanChina Department of Neurology Kaohsiung Municipal Ta-Tung HospitalKaohsiung Medical University HospitalKaohsiungTaiwanChina Neuroscience Research Center Kaohsiung Medical UniversityKaohsiungTaiwanChina Siloam Hospitals Lippo Village Pelita Harapan UniversityBantenIndonesia Department of Neurology Hasan Sadikin HospitalBandungIndonesia Neuro-Spinal Hospital Dubai Science ParkDubaiUAE

Age is recognized as the major factors of dementia,especially in for Alzheimer’s disease(AD).Given to the aged population,the increased number of demented population has been receiving a great impact in our ***,so far,no cured medicines have been demonstrated to provide effective treatment in *** combination of pharmacological and non-pharmacological interventions has been proposed to manage dementia with potential benefits especially in decreasing caregiver’s burden and behavior,as well as psychological problems of demented ***,giving to the glorious development in digital technologies,the virtual reality,one of the non-pharmacological interventions has been used extensively in dementia managements for its strengths which can be adapted in accordance with the heterogeneous needs from demented patients and their ***,various study designs and other reasons made these results difficult to be *** this review our goal is to provide a better understanding for these points.

关键词： dementia virtual reality Alzheimer's disease cognition behavior and psychological problem

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