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Evaluation of an educational telephone intervention strategy to improve non-screening colonoscopy attendance:A randomized controlled trial

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World Journal of Gastroenterology 2020年第47期26卷 7568-7583页

作者： Agustin Seoane Xenia Font Juan C perez rocio perez Carlos F Enriquez Miriam Parrilla Faust Riu Josep M Dedeu Luis E Barranco Xavier Duran Ines A Ibanez Marco A Alvarez Digestive Department Endoscopy UnitHospital del MarParc de Salut MarBarcelona 08003Spain Colorectal Cancer Research Group IMIM(Hospital del Mar Medical Research Institute)Barcelona 08003Spain Department of Medicine Autonomous University of BarcelonaBarcelona 08003Spain Consulting Service on Methodology for Biomedical Research IMIM(Hospital del Mar Medical Research Institute)Barcelona 08003Spain

BACKGROUND Colonoscopy attendance is a key quality parameter in colorectal cancer population screening *** these programmes,educative interventions with bidirectional contact carried out by trained personnel have been proved to be an important tool for colonoscopy attendance improvement,and because of its huge clinical and economic impact,they have been widely ***,outside of this population programmes,educative measures to improve colonoscopy attendance have been poorly studied and no navigation interventions are usually *** To investigate the clinical and economic impacts of an educational telephone intervention on colonoscopy attendance outside colorectal cancer screening *** This randomized controlled trial included consecutive patients referred to colonoscopy from primary care centres from November 2017 to May *** intervention group(IG)received a telephone intervention,while the control group(CG)did *** assigned to the IG received an educational telephone call 7 d before the colonoscopy *** intervention was carried out by two nurses with deep endoscopic knowledge who were previously trained for a telephone educational intervention for *** impact on patient compliance with preparedness protocols related to bowel cleansing,antithrombotic management,and sedation scheduling was also evaluated.A second call was conducted to assess patient ***-to-treat(ITT)and perprotocol(PP)analyses were *** A total of 738 and 746 patients were finally included in the IG and CG *** hundred thirteen(83%)patients were contacted in the *** non-attendance rate was lower in the IG,both in the ITT analysis(IG 8.4%vs CG 14.3%,P<0.001)and in the PP analysis(4.4%vs 14.3%,P<0.001).In a multivariable analysis,belonging to the control group increased the risk of nonattendance in both,the ITT analysis(OR 1.81,95%CI:1.27 to 2.58,P=0.001)and the PP analysis(O

关键词： Colonoscopy Quality improvement No-show patients Nursing education Patient compliance Telephone intervention

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Role of neutrophil-to-lymphocyte and platelet-tolymphocyte ratios in Peyronie’s disease: a new diagnostic approach to predict the stage of the disease?

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Asian Journal of Andrology 2021年第3期23卷 325-329页

作者： Esther Garda Rojo Borja Garda Gomez rocio Santos-perez de la Blanca Celeste Manfredi Manuel Alonso Isa Jose Medina Polo Alfredo Rodriguez Antolin Javier Romero Otero Department of Urology Research Institute Hospital 12 de Octubre(Imasl2)Madrid 29041Spain Department of Urology University Hospital HM MonteprfncipeMadrid 28668Spain.

Neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)have been associated with multiple entities and several types of *** can be assumed as markers of inflammatory *** objective of this study is to evaluate the NLR and PLR in Peyronie’s disease(PD)and to establish a comparison of its values in the acute and chronic *** recruited patients with PD from March 2018 to March *** patients enrolled underwent medical and sexual history as well as a physical *** values of blood count of each patient were collected both in the acute and chronic *** test was used to compare the acute and chronic stage ***-Wallis test was carried out to evaluate the impact of treatments on the *** identify cutoff values,we used sensibility and specificity tables and receiver operating characteristic(ROC)curves.A total of 120 patients were *** mean age was 55.85(range:18-77)years and the mean penile curvature was 48.43°(range:10°-100°).In the acute stage,the mean NLR was 2.35 and the mean PLR was *** ratios,in the chronic stage,were 1.57 and 100.00,*** significant differences between acute and stable stages for both indices were found(NLR:P<0.0001;PLR:P=0.0202).The optimal cutoff for classification in acute or stable stage was 2 for NLR and 102 for *** to our results,with an ordinary blood count,we could have important indications regarding the disease stage of the patient,and consequently on the most appropriate type of therapy to choose.

关键词： diagnosis inflammation neutrophil-to-lymphocyte ratio Peyronie^disease platelet-to-lymphocyte ratio

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现在和未来如何进行虚构文学创作——华文作家与西语作家圆桌对话

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世界华文文学论坛 2024年第1期 84-100页

作者：赵彦罗茜奥·奥维耶多史志龙(翻译) 不详马德里康普顿斯大学文学系西班牙拉美文学研究协会尼加拉瓜西班牙语学院北美西班牙语学院

主持人语:在作家们几乎已穷尽了虚构文学所有创新方面的今天,我们面临了如何用新手段来写我们的新故事。除了作家们本人自觉在文本创作上面的积极探索和努力尝试外,社交媒体的多手段、即时更新和瞬息变化也给我们作家的文学创作发展提... 详细信息

主持人语:在作家们几乎已穷尽了虚构文学所有创新方面的今天,我们面临了如何用新手段来写我们的新故事。除了作家们本人自觉在文本创作上面的积极探索和努力尝试外,社交媒体的多手段、即时更新和瞬息变化也给我们作家的文学创作发展提供了一些可能是消极也可能是积极的新手段,换句话说,现在它们也成了我们文本创新的一种工具。当然,这种“新的写作工具”也带来了一定程度上的困惑,甚至有可能对文学本身会造成一种伤害。

关键词：华文作家文本创作即时更新社交媒体虚构文学文学创作文本创新写作工具

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Application of artificial intelligence in the diagnosis and treatment of hepatocellular carcinoma: A review

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World Journal of Gastroenterology 2020年第37期26卷 5617-5628页

作者： Miguel Jimenez perez rocio Gonzalez Grande UGC de Aparato Digestivo Unidad de Hepatologia-Trasplante HepaticoHospital Regional Universitario de MalagaMalaga 29010Spain

Although artificial intelligence(AI)was initially developed many years ago,it has experienced spectacular advances over the last 10 years for application in the field of medicine,and is now used for diagnostic,therapeutic and prognostic purposes in almost all *** application in the area of hepatology is especially relevant for the study of hepatocellular carcinoma(HCC),as this is a very common tumor,with particular radiological characteristics that allow its diagnosis without the need for a histological ***,the interpretation and analysis of the resulting images is not always easy,in addition to which the images vary during the course of the disease,and prognosis and treatment response can be conditioned by multiple *** vast amount of data available lend themselves to study and analysis by AI in its various branches,such as deeplearning(DL)and machine learning(ML),which play a fundamental role in decision-making as well as overcoming the constraints involved in human *** is a form of AI based on automated learning from a set of previously provided data and training in algorithms to organize and recognize *** is a more extensive form of learning that attempts to simulate the working of the human brain,using a lot more data and more complex *** review specifies the type of AI used by the various ***,welldesigned prospective studies are needed in order to avoid as far as possible any bias that may later affect the interpretability of the images and thereby limit the acceptance and application of these models in clinical *** addition,professionals now need to understand the true usefulness of these techniques,as well as their associated strengths and limitations.

关键词： Artificial intelligence Machine learning Hepatocellular carcinoma Diagnosis Treatment Prognosis

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Analysis of Solar Distillers for Obtaining Bio-fuel

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Journal of Environmental Science and Engineering(B) 2013年第12期2卷 702-708页

作者： rocio Solar-Gonzalez Alejandra Velasco-perez Institute for Energy Studies University of lstmo Santo Domingo Tehuantepec Oaxaca 70760 Mdxico Department of Chemical Engineering University Eeracruzana Orizaba Veracruz 94340 Mexico

In this paper, a theoretical-economic study was carried out based on the operation and construction of different types of equipments that use solar energy to carry out the distillation process. The conclusions drawn from the analysis aimed to determine what is necessary for the optimal design of an experimental distillation module that allows bioethanol with specific features to be obtained, for the area of Tehuantepec in Mexico. This study took the experiments carried out by various authors and extracted information relevant to the selection of the parameters and variables of the proposed distiller according to their efficiency and construction costs.

关键词： Distiller energy solar bio-fuel.

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Wilson's disease:Revisiting an old friend

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World Journal of Hepatology 2021年第6期13卷 634-649页

作者： Ana Lucena-Valera Domingo perez-Palacios rocio Muñoz-Hernandez Manuel Romero-Gómez Javier Ampuero Department of Gastroenterology Hospital Universitario Virgen del RocioSevilla 41013Spain SeLiver Group Instituto de Biomedicina de Sevilla(IBiS)Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaEspaña Department of Unit of Digestive Diseases Hospital Universitario Virgen del RocioSevilla 41014Spain

Wilson's disease(WD)is a rare condition caused by copper accumulation primarily in the liver and secondly in other organs,such as the central nervous *** is a hereditary autosomal recessive disease caused by a deficiency in the ATP7B *** protein facilitates the incorporation of copper into *** than 800 mutations associated with WD have been *** onset of the disease frequently includes manifestations related to the liver(as chronic liver disease or acute liver failure)and neurological symptoms,although it can sometimes be *** it being more frequent in young people,WD has been described in all life *** to its fatal prognosis,WD should be suspected in all patients with unexplained biochemical liver abnormalities or neurological or psychiatric *** diagnosis is established with a combination of clinical signs and tests,including the measurement of ceruloplasmin,urinary copper excretion,copper quantification in liver biopsy,or genetic *** pharmacological therapies include chelating drugs,such as D-penicillamine or trientine,and zinc salts,which are able to change the natural history of the disease,increasing the survival of these *** some cases of end-stage liver disease or acute liver failure,liver transplantation must be an option to increase *** this narrative review,we offer an overview of WD,focusing on the importance of clinical suspicion,the correct diagnosis,and treatment.

关键词： Wilson´s disease Copper ATP7B Ceruloplasmin Chelator Liver disease

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Preparation, characterization and gastrointestinal stability of silk fibroin nanoparticles loaded with red wine polyphenols

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Food Bioscience 2023年第2期52卷 1091-1101页

作者： Diego Paladines-Quezada Carolina Cueva rocio Gil-Munoz Jose Luis Cenis Begona Bartolome M.Victoria Moreno-Arribas Antonio Abel Lozano-perez Equipo de Enologia y Viticultura Estacion Enologica de JumillaInstituto Murciano de Investigacion y Desarrollo Agrario y Medioambiental(IMIDA)JumillaMurcia30520Spain Instituto de Investigacion en Ciencias de la Alimentacion(CIAL) CSIC-UAMC/Nicolas Cabrera 928049MadridSpain Departamento de Biotecnologia Genomica y Mejora VegetalInstituto Murciano de Investigacion y Desarrollo Agrario y Medioambiental(IMIDA)La AlbercaMurcia30150Spain Instituto Murciano de Investigacion Biosanitaria(IMIB) 30120El PalmarMurciaSpain

Silk fibroin nanoparticles(SFN)are interesting drug delivery systems due to their high load capacity and low *** aim of this study was to reveal how SFN load red wine polyphenols(RWP),and to assess their protective effect during the early stages of digestion by using the dynamic gastrointestinal simulator(simgi^(R))under physiological ***-SFN were prepared by incubation of SFN in red wine and recovered by *** obtained nanoparticles(particle size of 194.4±2.1 nm and a Zeta potential of􀀀22.7±0.1 mV)showed a significant polyphenol loading content(7386.59±1018.28μg/g)with a high encapsulation efficiency(66.66±2.58%).They were highly stable during their passage through the digestive tract,being the activity of RWP highly *** data paves the way for future developments of SFN as stabilizers with a wide range of applications in the field of food additives.

关键词： Silk fibroin nanoparticles Wine polyphenols Adsorption Dynamic gastrointestinal simulator(simgi^(R)) Protein digestion

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Characteristics of GaN Thin Films Using Magnetron Sputtering System

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Journal of Modern Physics 2016年第15期7卷 2028-2037页

作者： Hasina F. Huq rocio Y. Garza Roman Garcia-perez Electrical Engineering University of Texas Pan American Edinburg USA

The paper presents a polycrystalline GaN thin film with a hexagonal wurtzite structure under the optimized sputtering conditions of 40 W RF power, 5 mT working pressure, using pure nitrogen gas with a substrate temperature of 700°C. The study examines the effects of surface disorders and incorporates it in the thin films characteristics. A radio frequency (RF) Ultra High Vacuum (UHV) Magnetron Sputtering System has been used for the deposition of Gallium Nitride (GaN) on silicon, sapphire and glass substrates with different parameters. The power is varied from 40 W to 50 W, and the pressure from 4 mT to 15 mT. The effects of the RF sputtering powers and gas pressures on the structural properties are investigated experimentally. Sputtering at a lower RF power of 15 W does increase the N atomic percentage, however the deposition rate is substantially slower and the films are amorphous. GaN deposited on both silicon and sapphire wafer resulted in thin films close to stoichiometric once the N2 concentration is 60% or higher. It is also observed that the substrate cooling/heating effects improve the quality of the thin films with fewer defects present at the surface of the GaN epi-structure.

关键词： GaN UHV Magnetron Sputtering RF Power HEMT Thin Film Characterization

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Satisfaction of the Service Provider with the Organization of the Timely Cervical Cancer Detection Program

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Health 2017年第2期9卷 289-298页

作者： Gutierrez-Enriquez Sandra Olimpia Teran-Figueroa Yolanda Gaytan-Hernandez Dario Diaz-Oviedo Aracely Zuniga-Martinez Ma.de Lourdes Hernandez-Nava Nereyda Cruz Ortiz Maribel perez Rodriguez Maria del Carmen Ramirez-Ramirez rocio Faculty of Nursing and Nutrition Autonomous University of San Luis PotosiSan Luis PotosiMexico Academic Coordination Altiplano Region Autonomous University of San Luis PotosiSan Luis PotosiMexico

Cervical cancer is a priority health problem in Mexico. The objective of this work was to know the degree of satisfaction of the service provider with the organization of the program of Timely Detection of Cervical Cancer, specifically in taking of the cervical cytology. The study design was observational, transversal and prospective conducted from January to May 2015 in Jurisdiction 1 of the Health Services of San Luis Potosí, Mexico, in 20 health centers. Participants were 87 service providers whose function is to take cervical cytology (Pap smears). A 32-question questionnaire was applied, with Likert scale with 5 levels of response: 1 (dissatisfied), 2 (little satisfied), 3 (indifferent), 4 (satisfied) and 5 (very satisfied). The score range was 32 points (minimum job satisfaction) up to 160 points (Maximum job satisfaction). We analyzed 2 dimensions: 1) intrinsic factors that have to do with motivation and professional recognition, and 2) extrinsic factors related to infrastructure, materials, remuneration and labor policies. Each factor consisted of four categories. Descriptive statistics and linear correlation of Pearson were applied for the analysis of data. Participants signed an informed consent letter. Of 4 categories, in the intrinsic dimension, the one with the highest percentage of satisfaction was “delegation of activities” with 28.8%. In the extrinsic dimension, the category with the highest percentage of satisfaction was “infrastructure and materials” with 49.4%;while satisfaction increase in intrinsic dimensions also does in extrinsic dimensions, such correlations are significant (p < 0.05), except between delegation of activities and remuneration (r = 0.074 and p = 0.497). The higher hierarchical level, the men, the bachelor academic level and older people showed the highest level of satisfaction.

关键词： Job Satisfaction Cervical Cancer Health Providers

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HVEM,a cosignaling molecular switch,and its interactions with BTLA,CD160 and LIGHT

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Cellular & Molecular Immunology 2019年第7期16卷 679-682页

作者： Jose Ignacio Rodriguez-Barbosa Pascal Schneider Andreas Weigert Kyung-Mi Lee Tae-Jin Kim Jose-Antonio perez-Simon Maria-Luisa del Rio Transplantation Immunobiology Section Research Institutes of the University of LeonCampus of Vegazana s/n24071 LeonSpain Leon Regional Transplantation Coordination Center Leon University HospitalLeonSpain Acción Estratégica en Salud Consorcio CIBER-ONCSevilleSpain Department of Biochemistry University of Lausanne1066 EpalingesSwitzerland Institute of Biochemistry I Faculty of MedicineGoethe-University Frankfurt60590 FrankfurtGermany Department of Biochemistry and Molecular Biology Korea University College of MedicineSeoul 02841Republic of Korea Department of Biomedical Engineering Center for Bio-Integrated ElectronicsSimpson Querrey Institute for BioNanotechnologyNorthwestern UniversityEvanstonIL 60208USA Department of Hematology Virgen del Rocio University HospitalBiomedical Institute of SevillaSevillaSpain

Temporal and spatial expression of cosignaling receptors and their ligands regulates the early stages of T-cell activation(signal 1,T-cell receptor(TCR)signaling and signal 2,costimulation/coinhibition),clonal expansion and T-cell survival during their differentiation towards effector T *** the inflammatory stimulus is eliminated,effector T cells return to homeostasis after undergoing a contraction phase by activation-induced cell death and the intervention of ligands for coinhibitory receptors,leaving a population of long-term memory T *** expression of ligands for coinhibitory receptors on hematopoietic cells and,more importantly,on non-hematopoietic cells of peripheral tissues is a key process in tuning the functional activity of effector T cells to prevent excess tissue inflammation that may lead to immunopathology and subsequent tissue dysfunction.

关键词： stimulation homeostasis inflammation

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