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Genome-wide QTL analysis of tomato fruit cuticle deposition and composition

Horticulture Research 2021年第1期8卷 1443-1457页

作者： Rida Barraj Barraj Patricia Segado rocio moreno-gonzalez Antonio Heredia Rafael Fernandez-Munoz Eva Dominguez Instituto de Hortofruticultura Subtropical y Mediterranea La Mayora Universidad de Malaga-Consejo Superior de Investigaciones CientificasDepartamento de Mejora Genetica y BiotecnologiaEstacion Experimental La MayoraAlgarrobo-CostaE-29750 MalagaSpain Instituto de Hortofruticultura Subtropical y Mediterranea La Mayora Universidad de Malaga0Consejo Superior de Investigaciones CientificasDepartamento de Biologia Molecular y BioquimicaUniversidad de MalagaE-29071 MalagaSpain Departament de Bioquimica i Fisiologia and Institut de Recerca en Nutricioi Seguretat Alimentaria(INSA-UB) Universitat de Barcelona(UB)E-08028 BarcelonaSpain

Genetics of traits related to fruit cuticle deposition and composition was studied in two red-fruited tomato *** mapping populations derived from the cross between the cultivated tomato(Solanum lycopersicum L.)and its closest relative wild species Solanum pimpinellifolium *** employed to conduct a QTL analysis.A combination of fruit cuticle deposition,components and anatomical traits were investigated and the individual effect of each QTL evaluated.A total of 70 QTLs were identified,indicating that all the cuticle traits analyzed have a complex polygenic nature.A combination of additive and epistatic interactions was observed for all the traits,with positive contribution of both parental lines to most of *** of QTLs for various traits uncovered novel genomic regions producing extensive changes in the *** density emerges as an important trait since it can modulate cuticle thickness and invagination thus providing a strategy for sustaining mechanical strength without compromising *** genomic regions,located in chromosomes 1 and 12,are responsible for the negative interaction between cuticle waxes and phenolics identified in tomato *** candidate genes,including transcription factors and structural genes,are postulated and their expression analyzed throughout development.

关键词： cultivated traits additive

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Application of artificial intelligence in the diagnosis and treatment of hepatocellular carcinoma: A review

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World Journal of Gastroenterology 2020年第37期26卷 5617-5628页

作者： Miguel Jimenez Perez rocio gonzalez Grande UGC de Aparato Digestivo Unidad de Hepatologia-Trasplante HepaticoHospital Regional Universitario de MalagaMalaga 29010Spain

Although artificial intelligence(AI)was initially developed many years ago,it has experienced spectacular advances over the last 10 years for application in the field of medicine,and is now used for diagnostic,therapeutic and prognostic purposes in almost all *** application in the area of hepatology is especially relevant for the study of hepatocellular carcinoma(HCC),as this is a very common tumor,with particular radiological characteristics that allow its diagnosis without the need for a histological ***,the interpretation and analysis of the resulting images is not always easy,in addition to which the images vary during the course of the disease,and prognosis and treatment response can be conditioned by multiple *** vast amount of data available lend themselves to study and analysis by AI in its various branches,such as deeplearning(DL)and machine learning(ML),which play a fundamental role in decision-making as well as overcoming the constraints involved in human *** is a form of AI based on automated learning from a set of previously provided data and training in algorithms to organize and recognize *** is a more extensive form of learning that attempts to simulate the working of the human brain,using a lot more data and more complex *** review specifies the type of AI used by the various ***,welldesigned prospective studies are needed in order to avoid as far as possible any bias that may later affect the interpretability of the images and thereby limit the acceptance and application of these models in clinical *** addition,professionals now need to understand the true usefulness of these techniques,as well as their associated strengths and limitations.

关键词： Artificial intelligence Machine learning Hepatocellular carcinoma Diagnosis Treatment Prognosis

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Pain assessment and management in the newborn:A systematized review

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World Journal of Clinical Cases 2021年第21期9卷 5921-5931页

作者： Maria Teresa Garcia-Rodriguez Sergio Bujan-Bravo rocio Seijo-Bestilleiro Cristina gonzalez-Martin Research in Nursing and Health Care Institute of Biomedical Research of A Coruña(INIBIC)Complexo Hospitalario Universitario de A Coruña(CHUAC)SERGASAs Xubias 8415006 A Coruña Universidade da Coruña(UDC)A Coruña 15006Spain Health Sciences Complexo Hospitalario Universitario de A CoruñaA Coruña 15006Spain

BACKGROUND Neonatal pain has been underdiagnosed due to several false *** To determine the status of neonatal pain in newborns who are admitted to intensive care *** Different databases were *** reviews and research reports conducted in newborns that were written in English,Spanish,or Portuguese,published between 2010 and 2020,and having free access to the full text were selected.A total of 135 articles were found,and 18 articles were finally *** Newborns are exposed to numerous painful *** order to assess their pain levels,several scales have been used,although they are sometimes not correctly *** terms of pain management,the nursing team plays a very important role based mainly on both pharmacological and non-pharmacological *** Nursing staff members must be well trained in order to identify pain and to interpret the scales ***,they have an important role in performing non-pharmacological procedures for pain management.

关键词： Neonatal pain Intensive care unit Nursing Management Treatment Systematized review

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What is the most effective exercise protocol to improve cardiovascular fitness in overweight and obese subjects？

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Journal of Sport and Health Science 2017年第4期6卷 454-461页

作者： Eliane Aparecida Castro Ana Belen Peinado Pedro Jose Benito MercedeS Galindo Marcela gonzalez-Gross rocio Cupeiro Department of Health and Human Performance Faculty of Physical Activity and Sport Sciences Universidad Polit~cnica de Madrid Madrid 28040 Spain LFE Research Group Universidad PolitOcnica de Madrid Madrid 28040 Spain Faculty of Physical Activity and Sport Sciences Universidad Politecnica de Madrid Madrid 28040 Spain ImFINE Research Group Universidad PolitOcnica de Madrid Madrid 28040 Spain

Background: Increased peak oxygen consumption(VO2 peak) can reduce cardiovascular risks associated with obesity. Our aim was to analyze the effect of a weight loss program on cardiovascular fitness in overweight(W) and obese(O) ***: One hundred and sixty-seven subjects(77 males and 90 females), aged 18–50 years, performed a modified Bruce protocol before(pre)and after(post) a weight loss program of 24 weeks. This program combined physical training(strength, S; endurance, E; combined strength + endurance, SE; or physical activity recommendation, PA) 3 times per week, with a 25%–30% caloric restriction ***: VO2 peak improved in overweight and obese males(pre and post values in L/min, respectively; W = 3.2 ± 0.6 vs. 3.7 ± 0.5, p < 0.001;O = 3.6 ± 0.6 vs. 3.8 ± 0.6, p = 0.013) as well as in overweight females(2.0 ± 0.3 vs. 2.3 ± 0.4, p < 0.001). VO2 peak in the first ventilatory threshold(VT1) increased for all 4 interventions in males(p < 0.05), except for S in the obese group(1.6 ± 0.2 vs. 1.7 ± 0.3, p = 0.141). In females, it increased in E(0.9 ± 0.2 vs. 1.4 ± 0.3, p < 0.001), SE(0.9 ± 0.2 vs. 1.2 ± 0.4, p = 0.003), and PA(0.9 ± 0.1 vs. 1.2 ± 0.2, p = 0.006) in overweight groups. Time-to-exhaustion improved in all subjects except for females in PA group(15.7 ± 0.3 min vs. 15.9 ± 0.3 min, p = 0.495).Conclusion: Our results suggest that all methods, including the recommendation of physical activity, can improve cardiovascular fitness in overweight subjects and obese males.

关键词： Combined training Endurance training Obesity Oxygen consumption Physical activity Strength training Ventilatory threshold

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Effect of magnesium on the aluminothermic reduction rate of zinc oxide obtained from spent alkaline battery anodes for the preparation of Al–Zn–Mg alloys

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International Journal of Minerals,Metallurgy and Materials 2016年第4期23卷 458-465页

作者： rocio Ochoa Alfredo Flores Jesus Torres Cinvestav-Saltillo

The aluminothermic reduction of zinc oxide（ZnO） from alkaline battery anodes using molten Al may be a good option for the elaboration of secondary 7000-series alloys. This process is affected by the initial content of Mg within molten Al, which decreases the surface tension of the molten metal and conversely increases the wettability of ZnO particles. The effect of initial Mg concentration on the aluminothermic reduction rate of ZnO was analyzed at the following values： 0.90wt%, 1.20wt%, 4.00t%, 4.25wt%, and 4.40wt%. The ZnO particles were incorporated by mechanical agitation using a graphite paddle inside a bath of molten Al maintained at a constant temperature of 1123 K and at a constant agitation speed of 250 r/min, the treatment time was 240 min and the ZnO particle size was 450？500 mesh. The results show an increase in Zn concentration in the prepared alloys up to 5.43wt% for the highest initial concentration of Mg. The reaction products obtained were characterized by scanning electron microscopy and X-ray diffraction, and the efficiency of the reaction was measured on the basis of the different concentrations of Mg studied.

关键词： aluminothermic reduction alkaline batteries zinc oxide waste utilization aluminum zinc magnesium alloys

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Excitatory synapse impairment and mitochondrial dysfunction in Huntington’s disease: heat shock factor 1 (HSF1) converging mechanisms

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Neural Regeneration Research 2020年第1期15卷 69-70页

作者： Nicole Zarate rocio Gomez-Pastor Department of Neuroscience School of Medicine University of Minnesota

Heat shock factor 1(HSF1)is abnormally degraded in Huntington’s disease(HD):HD is a neurodegenerative disorder characterized by severe cognitive and motor *** is caused by a CAG repeat expansion within exon 1 of the huntingtin(HTT)gene(The Huntington’s Disease Collaborative Research Group,1993).These expansions lead to the production of an aberrant mutant huntingtin protein(mHTT)that is prone to misfolding and *** and aggregation of mHTT is present in virtually all cell types in the body but preferentially affects medium spiny neurons of the striatum,a brain region that controls movement and some forms of *** of mHTT leads to,but not only,transcriptional dysregulation,DNA damage,mitochondrial dysfunction and excitatory synaptic failure ultimately causing neuronal ***,the molecular mechanisms by which mHTT exerts these defects are still unclear.

关键词： Huntington impairment shock

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Critical care specialists,the missing link in organ procurement for transplantation

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World Journal of Critical Care Medicine 2024年第2期13卷 1-6页

作者： Francisca Del rocio gonzalez Cohens Fernando M gonzalez Web Intelligence Centre Faculty of Physics and Mathematical SciencesUniversidad de ChileSantiago 8370397Chile Department of Nephrology Faculty of MedicineUniversidad de ChileSantiago 7500922Chile

The procurement process for organ donation begins with the identification of potential organ donors in emergency or critical care units(CCU),followed by their clinical evaluation,diagnostic procedures,and therapeutic interventions,mostly conducted in *** concludes with the request for organ donation and,if accepted,the retrieval of *** most interventions occurring in detection units,there has been a neglect of the strategic role played by critical care specialists(CCS)in managing and caring for brain-dead or near-brain-death *** arise:Are they willing to undertake this responsibility?Do they fully comprehend the nature of organ procurement?Are they aware of the specific interventions required to maintain possible organ donors in optimal physiological condition?Our objective is to examine the role of CCS in organ procurement and propose ways to enhance it,ultimately aiming to increase and enhance organ donation rates.

关键词： Organ procurement Transplantation Brain death Cardiac death Organ donation

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Preparation, characterization and gastrointestinal stability of silk fibroin nanoparticles loaded with red wine polyphenols

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Food Bioscience 2023年第2期52卷 1091-1101页

作者： Diego Paladines-Quezada Carolina Cueva rocio Gil-Munoz Jose Luis Cenis Begona Bartolome M.Victoria moreno-Arribas Antonio Abel Lozano-Perez Equipo de Enologia y Viticultura Estacion Enologica de JumillaInstituto Murciano de Investigacion y Desarrollo Agrario y Medioambiental(IMIDA)JumillaMurcia30520Spain Instituto de Investigacion en Ciencias de la Alimentacion(CIAL) CSIC-UAMC/Nicolas Cabrera 928049MadridSpain Departamento de Biotecnologia Genomica y Mejora VegetalInstituto Murciano de Investigacion y Desarrollo Agrario y Medioambiental(IMIDA)La AlbercaMurcia30150Spain Instituto Murciano de Investigacion Biosanitaria(IMIB) 30120El PalmarMurciaSpain

Silk fibroin nanoparticles(SFN)are interesting drug delivery systems due to their high load capacity and low *** aim of this study was to reveal how SFN load red wine polyphenols(RWP),and to assess their protective effect during the early stages of digestion by using the dynamic gastrointestinal simulator(simgi^(R))under physiological ***-SFN were prepared by incubation of SFN in red wine and recovered by *** obtained nanoparticles(particle size of 194.4±2.1 nm and a Zeta potential of􀀀22.7±0.1 mV)showed a significant polyphenol loading content(7386.59±1018.28μg/g)with a high encapsulation efficiency(66.66±2.58%).They were highly stable during their passage through the digestive tract,being the activity of RWP highly *** data paves the way for future developments of SFN as stabilizers with a wide range of applications in the field of food additives.

关键词： Silk fibroin nanoparticles Wine polyphenols Adsorption Dynamic gastrointestinal simulator(simgi^(R)) Protein digestion

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Tentative Identification of Phytochemicals and Antioxidant Activities during Fruit-Ripening on Chamaedorea radicalis Mart.

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Phyton-International Journal of Experimental Botany 2020年第2期89卷 361-373页

作者： Gerardo Montelongo-Ruiz Yolanda del rocio moreno-Ramirez Maria Cruz Juarez-Aragon NohemiNino-Garcia Reyna Ivonne Torres-Acosta Torres-Castillo Jorge Ariel Universidad Autonoma de Tamaulipas Instituto de Ecologia AplicadaCiudad Victoria87019Mexico Universidad Autonoma de Tamaulipas Unidad Academica Multidisciplinaria ManteCiudad Mante89840Mexico

This work aims to determine the phytochemical characterization of the pericarp of Chamaedorea radicalis *** as a non-timber product with potential to obtain phytochemicals with potential applications in the *** from *** were grouped in four ripening stages named as S1,S2,S3 and S4,according to maturity;S1 the most unripe stage and S4 the completely ripe *** of total phenolic compounds,free radical scavenging activities and total flavonoid contents using spectrophotometric methods were ***,the tentative identification of phytochemicals during fruit ripening was done using *** phenolic compound(TPC)content ranged from 7.24 to 12.53 mg gallic acid equivalents per gram of fresh weight(mg GAE/g FW).Total flavonoids(TF)contents ranged from 0.163 to 0.23 mg of quercetin equivalents per g FW(mg QE/g FW).Free radical scavenging activity against DPPH and ABTS radicals varied from 40.80 to 53.68 and from 22.29 to 37.76 mmol Trolox equivalents g FW(mmol TE/g FW),*** assay in vitro by FRAP(ferric reducing antioxidant power)method showed that S3 was the highest level with antioxidant power while S4 was the lowest with Red ripeness stage showed the lowest contents for all *** spectrometry allowed detection of 26 compounds,including phenolics,alkaloids and ***,Kaempferol 3-neohesperidoside and the four saponins identified were present in all ripeness *** phytochemical identification and the spectrophotometric determinations showed that the pericarp of *** presented antioxidants and compounds related to alkaloids,phenolics and *** presence and abundance of each phytochemical regarding each ripeness stage should be considered.

关键词： Metabolite identification palm free radical scavenging phenolic compounds saponins

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Analysis of Solar Distillers for Obtaining Bio-fuel

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Journal of Environmental Science and Engineering(B) 2013年第12期2卷 702-708页

作者： rocio Solar-gonzalez Alejandra Velasco-Perez Institute for Energy Studies University of lstmo Santo Domingo Tehuantepec Oaxaca 70760 Mdxico Department of Chemical Engineering University Eeracruzana Orizaba Veracruz 94340 Mexico

In this paper, a theoretical-economic study was carried out based on the operation and construction of different types of equipments that use solar energy to carry out the distillation process. The conclusions drawn from the analysis aimed to determine what is necessary for the optimal design of an experimental distillation module that allows bioethanol with specific features to be obtained, for the area of Tehuantepec in Mexico. This study took the experiments carried out by various authors and extracted information relevant to the selection of the parameters and variables of the proposed distiller according to their efficiency and construction costs.

关键词： Distiller energy solar bio-fuel.

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