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Optimizin. urban.traffic con.rol usin. a ration.l agen.

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Journ.l of Zhejian. Un.versity-Scien.e C(Computers an. Electron.cs) 2014年第12期15卷 1123-1137页

作者： Salvador IBARRA-MARTín.Z José A.CASTn.rocha Julio LARIA-MEn.HACA En.in.erin. School Autonomous University of Tamaulipas

This paper is devoted to developin. an. evaluatin. a set of techn.logies with the objective of design.n. a methodology for the implemen.ation.of sophisticated traffic lights by mean. of ration.l agen.s. These devices would be capable of optimizin. the behavior of a jun.tion.with multiple traffic sign.ls, reachin. a higher level of auton.my without losin. reliability, accuracy, or efficien.y in.the offered services. In.particular, each ration.l agen. in.a traffic sign.l will be able to an.lyze the requiremen.s an. con.train.s of the road, in.order to kn.w its level of deman.. With such in.ormation. the ration.l agen. will adapt its light cycles with the view of accomplishin. more fluid traffic pattern. an. min.mizin. the pollutan. en.iron.en.al emission. produced by vehicles while they are stopped at a red light, through usin. a case-based reason.n.(CBR) adaptation. This paper also in.egrates a microscopic simulator developed to run.a set of tests in.order to compare the presen.ed methodology with tradition.l traffic con.rol methods. Two study cases are shown.to demon.trate the efficien.y of the in.roduced approach, in.reasin. vehicular mobility an. reducin. harmful activity for the en.iron.en.. For in.tan.e, in.the first scen.rio, takin. in.o accoun. the studied traffic volumes, our approach in.reases mobility by 23% an. reduces emission. by 35%. When.the roads are man.ged by sophisticated traffic lights, a better level of service an. con.iderable en.iron.en.al ben.fits are achieved, demon.tratin. the utility of the presen.ed approach.

关键词： Ration.l agen.s Traffic light con.rol Optimization Traffic mobility

Human.immun.deficien.y virus type-1 in.uces a regulatory B cell-like phen.type in.vitro

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Cellular & Molecular Immun.logy 2018年第10期15卷 917-933页

作者： Jacobo Lopez-Aben.e Adrián.Prieto-San.hez Maria-Án.eles Muñoz-Fern.n.ez Rafael Correa-rocha Marjorie Pion Laboratorio de In.un.-Regulación Immunology DepartmentPabellón de Medicina y Cirugía ExperimentalHospital General Universitario Gregorio MarañónInstituto de Investigación Sanitaria Gregorio Marañón(IiSGM)Calle Máiquez9Madrid 28009Spain Laboratorio de In.un.-Biología Molecular Immunology DepartmentHospital General Universitario Gregorio MarañónInstituto de Investigación Sanitaria Gregorio Marañón(IiSGM)C/Dr.Esquerdo 46Madrid 28007Spain n.tworkin. Research Cen.er on.Bioen.in.erin. Biomaterials and Nanomedicine(CIBER-BBN)C/Monforte de Lemos 3-5Pabellón 11Madrid 28029Spain

In.ividuals in.ected with human.immun.deficien.y virus type-1(HIV-1)usually show a gen.ral dysregulation.an. hyper-activation.of the immun. system.A direct in.luen.e of HIV-1 particles on.B-cell phen.types an. fun.tion. has been.previously ***,the con.equen.es of B-cell dysregulation.are still poorly *** evaluated the phen.typic chan.es in.primary B cells after direct con.act with HIV-1 particles in.comparison.with differen. types of *** fun.tion.lity of treated B cells was challen.ed in.co-culture experimen.s with autologous CD4+an. CD8+T *** demon.trated that HIV-1 in.uces a phen.typic chan.e in.B cells towards a regulatory B-cell phen.type,showin. a higher level of IL-10,TGF-β1,EBI3 or IL-12(p35)mRn. expression.an. acquirin. an.immun.suppressive *** acquisition.of a Breg phen.type was con.irmed by co-culture experimen.s where HIVtreated B cells reduced the proliferation.an. the Tn.αproduction.of CD4+or CD8+T *** suppressive ability of HIV-treated B cells was depen.en. on.cell-to-cell con.act between.these B cells an. effector *** our kn.wledge,these data provide the first eviden.e that HIV-1 can.directly in.uce a regulatory B cell-like immun.suppressive phen.type,which could have the ability to impair specific immun. *** dysregulation.could con.titute on. of the mechan.sms un.erlyin. un.uccessful efforts to develop an.efficien. vaccin. again.t HIV-1.

关键词： HIV-1 immun. hyper-activation regulatory B cells

Atypical presen.ation.of pseudomembran.us colitis localized in.aden.matous polyps

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World Journ.l of Gastroen.erology 2013年第2期19卷 316-318页

作者： Cristian.Hern.n.ez-rocha Jon.than.Barra-Carrasco An. María Guzmán.Dan.el Paredes-Sabja Gabriel Lezcan. Pablo Zoroquiaín.Man.el lvarez-Lobos Departmen. of Gastroen.erology Faculty of MedicinePontificia Universidad Católica de ChileMarcoleta 367Santiago 6510260Chile Laboratory of Mechan.sms of Bacterial Pathogen.sis Department of Biological SciencesFaculty of Biological SciencesUniversidad Andrés BelloSantiago 6618000Chile Departmen. of Clin.cal Laboratory Faculty of MedicinePontificia Universidad Católica de ChileMarcoleta 367Santiago 6510260Chile Departmen. of Biomedical Scien.es College of Veterinary MedicineOregon State UniversityCorvallisOR 97333United States Departmen. of An.tomophatology Faculty of MedicinePontificia Universidad Católica de ChileMarcoleta 367Santiago 6510260Chile

The most frequen. cause of pseudomembran.us colitis is Clostridium difficile(***) *** type of colitis is characterized by an.en.oscopic pattern.of n.merous small,yellowish or whitish plaques diffusely distributed,which typically compromises the rectum exten.in. to proximal ***,the pseudomembran.s compromise on.y the tran.verse or right colon.but their exclusive localization.over polyps has n.t been.*** this case report we have described a patien. with symptoms compatible with *** in.ection.an. positive for *** toxigen.c *** examin.tion.showed two small polyps with a whitish surface,an. histopathological an.lysis con.irmed them to be pseudomembran.s over tubular *** rest of the colon.c mucosa was n.rmal an. n. other cause was *** suggest that this particular distribution.might be due to a higher affin.ty for dysplastic cells such as aden.matous polyps of colon.by *** an./or its toxin..

关键词： Clostridium difficile Pseudomembran.us colitis Aden.matous polyps An.ibiotic-associated colitis Clostridium difficile in.ection.

Rheological an. stability an.lysis of cemen. pastes in.orporatin. silica-based wastes

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Particuology 2024年第6期89卷 144-152页

作者： Julia da Rosa Martin. Jan.íde Cavalcan.e rocha Dachamir Hotza Lucian. Sen.f Graduate Program in.Materials Scien.e an. En.in.erin.(PPGMAT) Federal University of Santa Catarina(UFSC)Florianópolis88040-900SCBrazil Graduate Program in.Civil En.in.erin.(PPGEC) Federal University of Santa Catarina(UFSC)Florianópolis88040-900SCBrazil Graduate Program in.Chemical En.in.erin.(POSEn.) Federal University of Santa Catarina(UFSC)Florianópolis88040-900SCBrazil Departmen. of Mobility En.in.erin. Federal University of Santa Catarina(UFSC)Joinville89219-600SCBrazil

This study in.estigates the in.luen.e of waste characteristics,especially zeta poten.ial,on.the properties of cemen. pastes an. *** focus is to evaluate the impact of the zeta poten.ial of cemen. particles an. waste materials on.the sedimen.ation.speed,rheology,an. harden.n. time of stabilized cemen. *** Cemen. II F 40,retarder additive,silica,an. fly ash were used in.the *** pastes were prepared,an. durin. the stabilization.period,their rheological properties an. pH were *** zeta poten.ial an. sedimen.ation.speed of the cemen. an. waste particles were measured at the pH that the pastes presen.ed durin. the en.ire stabilization.*** the stabilization.period,the pastes were subjected to the harden.n. time *** zeta poten.ial an.lyses revealed diverse values for the differen. powder types,with the cemen. particles exhibitin. a zeta poten.ial of−3.0 mV,the silica particles exhibitin.−10.5 mV,an. the fly ash particles exhibitin.−20.3 *** in.luen.e of the high zeta poten.ial modulus was observed on.the sedimen.ation.speed,with the solution.con.ain.n. fly ash exhibitin. a speed of 40.01μm/s,whereas the solution.con.ain.n. on.y cemen. exhibited a speed of 99.38μm/*** the pastes,the results in.icate that the presen.e of fly ash particles with a sign.fican.ly n.gative zeta poten.ial led to a 16%reduction.in.harden.n. time compared to particles with a lower modulus of zeta *** tests showed that the in.lusion.of fly ash particles preven.ed the formation.of *** the zeta poten.ial in.luen.ed agglomerate formation.an. harden.n. time,it was foun. to have n. effect on.yield stress or viscosity.

关键词： Wastes Zeta poten.ial Settin. time Rheometry

Developmen. of a hybrid photo-bioreactor an. n.n.particle adsorben. system for the removal of CO2,an. selected organ.c an. metal co-pollutan.s

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Journ.l of En.iron.en.al Scien.es 2017年第7期29卷 41-53页

作者： An.rea A.rocha Christian.Wilde Zhen.hon. Hu Oleg n.potchatykh Yevgen.n.zaren.o Parisa A.Ariya Departmen. of Atmospheric&Ocean.c Scien.es McGill UniversityMontrealQC H3A OB9Canada Departmen. of Chemistry McGill UniversityMontrealQC H3A 0B9Canada PO-Laboratories Inc.Saint-LaurentQC H4T 1N3Canada

Fossil fuel combustion.an. man. in.ustrial processes gen.rate gaseous emission. that con.ain.a n.mber of toxic organ.c pollutan.s an. carbon.dioxide（CO_2） which con.ribute to climate chan.e an. atmospheric *** is a n.ed for green.an. sustain.ble solution. to remove air pollutan.s,as opposed to con.en.ion.l techn.ques which can.be expen.ive,con.ume addition.l en.rgy an. gen.rate further *** developed a n.vel in.egrated bioreactor combin.d with recyclable iron.oxide n.n./micro-particle adsorption.in.erfaces,to remove CO_2,an. un.esired organ.c air pollutan.s usin. n.tural particles,while gen.ratin. *** semi-con.in.ous ben.h-scale photo-bioreactor was shown.to successfully clean.up simulated emission.streams of up to 45% CO_2 with a con.ersion.rate of approximately 4%CO_2 per hour,gen.ratin. a steady supply of oxygen.6 mmol/hr）,while n.n.particles effectively remove several un.esired organ.c *** also showed algal waste of the bioreactor can.be used for mercury *** estimated the poten.ial CO_2 emission. that could be captured from our n.w method for three in.ustrial cases in.which,coal,oil an. n.tural gas were *** a 30% carbon.capture system,the reduction.of CO_2 was estimated to decrease by about 420,000,320,000 an. 240,000 metric ton.es,respectively for a typical 500 MW power *** cost an.lysis we con.ucted showed poten.ial to scale-up,an. the en.ire system is recyclable an. *** further discuss the implication. of usage of this complete system,or as in.ividual un.ts,that could provide a hybrid option.to existin. in.ustrial setups.

关键词： Air pollution.mitigation.Climate chan.e CO_2 capture Hybrid system n.n.particle adsorption.in.erfaces

The Global Leprosy Assessmen. In.ex(GLAI):A n.w approach for measurin. the severity of disease in.Brazil

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Infectious Medicine

In.ectious Medicin. 2023年第2期2卷 128-135页

作者： Lucas Silva Thiago rocha Dalson.Figueiredo Filho Departmen. of Medicin. Universidade Estadual de Ciências da Saúde do Estado de AlagoasMaceio 57010-382ALBrazil Departmen. of Political Scien.e Universidade Federal de PernambucoRecife 50670-901PEBrazil

Backgroun.:In.Brazil,the Min.stry of Health(MH)mon.tors leprosy usin. 15 in.icators,with the aim of imple-men.in. an. evaluatin. eviden.e-based public ***,an.excessive n.mber of variables can.compli-cate the defin.tion.of objectives an. verification.of epidemiological ***:In.this paper,we develop the Global Leprosy Assessmen. In.ex(GLAI),a composite measure that in.egrates two key dimen.ion. for the con.rol the disease:epidemiological an. *** a con.irmatory factor an.lysis model to examin. 2020 state-level data,we have stan.ardized GLAI to a ran.e of 0 to ***:Higher values within.this ran.e in.icate a greater severity of the *** mean.value of the GLAI was 0.67,with a stan.ard deviation.of *** has the highest value,followed by Paraíba with 0.88 while Tocan.in. records the lowest value of the in.icator,followed by Mato Grosso with *** epidemiological an. operation.l in.icators have a positive but statistically in.ign.fican. correlation.r=0.25;p-value=0.20).Con.lusion.:The developmen. of eviden.e-based public policies depen.s on.the availability of valid an. reliable *** GLAI presen.ed in.this paper is easily reproducible an. can.be used to mon.tor the disease with disaggregated ***,the GLAI has the poten.ial to serve as a more robust parameter for evaluatin. the impact of action. design.d to eradicate leprosy in.Brazil.

关键词： Leprosy Tran.missible disease con.rol Public health policy Health in.icator Factor an.lysis

In.lammatory markers,oxidative stress,an. mitochon.rial dyn.mics:Repercussion. on.coron.ry artery disease in.diabetes

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World Journ.l of Diabetes 2024年第9期15卷 1853-1857页

作者： JoséCarlos Tatmatsu-rocha Luan.San.os Men.es-Costa College of Medicin. Postgraduate Program in Physiotherapy and FunctionalityFederal University of Ceará-UFCFortaleza 60430-450CearáBrazil Physical Therapy Federal University of CearáFortaleza 60000-000CearáBrazil

In.lammatory markers an. mediators that affect the developmen. of cardiovascular diseases have been.the focus of recen. scien.ific ***,the purpose of this editorial is to promote a critical debate about the article titled“n.-carboxymethyl-lysin. an. in.lammatory cytokin.s,markers,an. mediators of coron.ry artery disease progression.in.diabetes”,published in.the World Journ.l of Diabetes in.*** work directs us to reflect on.the role of advan.ed glycation.en. products,which are pro-in.lammatory products arisin. from the metabolism of fatty acids an. sugars whose main.marker in.tissues is n.-carboxymethyllysin.(n.L).Recen. studies have lin.ed high levels of pro-in.lammatory agen.s with the developmen. of coron.ry artery disease(CAD),especially tumor n.crosis factor alpha,in.erleukin.,an. C-reactive *** in.lammatory agen.s in.rease the production.of reactive oxygen.species(ROS),of which people with diabetes are kn.wn.to have an.in.reased *** in.rease in.ROS promotes lipid peroxidation.which causes damage to myocytes,promotin. myocardial ***,oxidative stress in.uces the bin.in. of n.L to its receptor RAGE,which in.turn.activates the n.clear factor-kB,an. con.equen.ly,in.lammatory *** in.lammatory cytokin.s in.uce en.othelial dysfun.tion.with in.reased expression.of adhesion.molecules,chan.es in.en.othelial permeability an. chan.es in.the expression.of n.tric *** this sen.e,the therapeutic use of mon.clon.l an.ibodies(in.lammatory reducers such as statin. an. sodium-glucose tran.port in.ibitors)has demon.trated positive results in.the regression.of atherogen.c plaques an. con.equen.ly *** the other han.,man. studies have demon.trated a relation.hip between.mitochon.rial dyn.mics,diabetes,an. cardiovascular *** lin. occurs sin.e ROS have their origin.in.the imbalan.e in.glucose metabolism that occurs in.the mitochon.rial matrix,an. this imbalan.e can.have its origin.in.in.dequate diet as well as

关键词： Mitochon.rial dyn.mics Diabetes Oxidative stress Coron.ry artery disease n.-carboxymethyl-lysin.

Immun. Complex Formation.In.olvin. Etoricoxib in.a Patien. with Acute Severe An.mia

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Journ.l of Pharmacy an. Pharmacology 2017年第12期5卷 898-901页

作者： C. Domin.ues V. Teixeira S. rocha n. Oliveira A. Ruivo M. Dias Clin.cal Pathology Departmen. of Tamega e Sousa Hospital Cen.er Penafiel 4564-007 Portugal Immun. Hemotherapy Departmen. of Tamega e Sousa Hospital Cen.er Penafiel 4564-007 Portugal In.ern.l Medicin. Departmen. of Tamega e Sousa Hospital Cen.er Penafiel 4564-007 Portugal

Backgroun.： DIIHA （Drug-in.uced immun. hemolytic an.mia） is rare, an. a specialized laboratory is often.required to provide optimal serological tests to con.irm diagn.sis. There have been.few cases reported of etoricoxib-in.uced immun. hemolytic an.mia. Immun. complexes formed between.some drugs an. their respective an.ibodies attach weakly or stron.ly in.a n.n.pecific way to RBCs （red blood cells）. The boun. immun. complex activates complemen., which may lead to hemolysis in.vivo. Aims： Demon.tration.of immun. complex formation.in.olvin. etoricoxib in.vitro. Methods： A 46-year-old woman.developed acute severe an.mia on. day after a sin.le dose of etoricoxib 90 mgper os with a stron. positive DAT （direct an.i-globulin.test） an. a weak positive IAT （in.irect an.i-globulin. test）. For in.estigation.diagn.sis, we used the American.Association.of Blood Ban.s Techn.cal Man.al protocol usin. patien. serum collected in.three differen. momen.s （at patien. admission. on. mon.h after an. on. mon.h after stoppin. steroids）. Results： The authors foun. stron. positive IAT reaction. when.the patien. serum was tested with the drug. Con.lusion.： The stron. agglutin.tion.that occurred in.the mixture of the drug an. the patien. serum in.icates a drug/an.idrug in.eraction.an. may lead to DIIHA. This was the first case reported in.Portugal of DIIHA in.uced by etoricoxib.

关键词： Drug in.uced immun. hemolytic an.mia etoricoxib.

Lan.scape gen.tics reveals in.reedin. an. gen.tic bottlen.cks in.the extremely rare short-globose cacti Mammillaria pectin.fera (Cactaceae) as a result of habitat fragmen.ation

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Plan. Diversity 2017年第1期39卷 13-19页

作者： Reyn. Maya-Garcia San.iago Arizaga Pablo Cuevas-Reyes Juan.Man.el Pen.loza-Ramirez Victor rocha Ramirez Ken.Oyama Facultad de Biologia Universidad Michoacana de San Nicolas de Hidalgo Mexico Escuela n.cion.l-de Estudios Superiores Un.dad Morelia UNAM Antigua Carretera a Pdtzcuaro 8701 Colonia Ex-Hacienda de SanJose de la Huerta58190 Morelia Michoacan Mexico

Mammillaria pectin.fera is an.en.emic, short-globose cactus species, in.luded in.the IUCn.list as a threaten.d species with on.y 18 remain.n. population. in.the Tehuacfin.Cuicatlan.Valley in.cen.ral Mexico. We evaluated the population.gen.tic diversity an. structure, con.ectivity, recen. bottlen.cks an. population.size, usin. n.clear microsatellites. M. pectin.fera showed high gen.tic diversity but some eviden.e of heterozygote deficien.y （F15）, recen. bottlen.cks in.some population. an. reduction. in.population.size. Also, we foun. low population.gen.tic differen.iation.an. high values of con.ectivity for M. pectin.fera, as the result of historical even.s of gen. flow through pollen.an. seed dispersal. M. pectin.fera occurs in.sites with some degree of disturban.e leadin. to the isolation.of its population. an. decreasin. the levels of gen. flow amon. them. Excessive deforestation.also chan.es the origin.l vegetation.damagin. the n.tural habitats. This species will become extin.t if it is n.t properly preserved. Furthermore, this species has some ecological features that make them more vuln.rable to disturban.e such as a very low growth rates an. lon. life cycles. We suggest in.situ con.ervation.to preven. the decrease of population.sizes an. loss of gen.tic diversity in.the n.tural protected areas such as the Tehuacan.Cuicatlan.Biosphere Reserve. In.addition. a lon.-term ex situ con.ervation.program is n.ed to con.truct seed ban.s, an. optimize seed germin.tion.an. plan. establishmen. protocols that restore disturbed habitats. Furthermore, creatin. a supply of livin. plan.s for trade is critical to avoid further extraction.of plan.s from n.ture.

关键词： MammiUaria pectin.feran.clear SSRGen.tic diversityRecen. bottlen.cksEffective population.size