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Pan-retinal ganglion cell markers in mice, rats, and rhesus macaques

Zoological Research 2023年第1期44卷 226-248页

作者： Francisco M.Nadal-Nicolás Caridad Galindo-Romero Fernando lucas-Ruiz Nicholas marsh-Amstrong Wei li Manuel Vidal-Sanz Marta Agudo-Barriuso Grupo de Oftalmología Experimental Instituto Murciano de Investigación Biosanitaria Pascual Parrilla(IMIB)Murcia 30120Spain Dpto.Oftalmología Facultad de MedicinaUniversidad de MurciaMurcia 30120Spain Retinal Neurophysiology Section National Eye InstituteNational Institutes of HealthBethesdaMaryland 20892-2510USA Department of Ophthalmology and Vision Science University of CaliforniaDavisCA 95817USA

Univocal identification of retinal ganglion cells(RGCs) is an essential prerequisite for studying their degeneration and neuroprotection. Before the advent of phenotypic markers, RGCs were normally identified using retrograde tracing of retinorecipient areas. This is an invasive technique, and its use is precluded in higher mammals such as monkeys. In the past decade, several RGC markers have been described. Here, we reviewed and analyzed the specificity of nine markers used to identify all or most RGCs, i.e., pan-RGC markers, in rats, mice, and macaques. The best markers in the three species in terms of specificity, proportion of RGCs labeled, and indicators of viability were BRN3A, expressed by vision-forming RGCs, and RBPMS, expressed by vision-and non-vision-forming RGCs. NEUN, often used to identify RGCs, was expressed by non-RGCs in the ganglion cell layer, and therefore was not RGC-specific. γ-SYN, TUJ1, and NF-l labeled the RGC axons, which impaired the detection of their somas in the central retina but would be good for studying RGC morphology. In rats, TUJ1 and NF-l were also expressed by non-RGCs. BM88, ERRβ,and PGP9.5 are rarely used as markers, but they identified most RGCs in the rats and macaques and ERRβ in mice. However, PGP9.5 was also expressed by non-RGCs in rats and macaques and BM88 and ERRβ were not suitable markers of viability.

关键词： RGC Optic nerve crush BM88 BRN3A Estrogen-related receptorβ ERRβ NEUN Neurofilament-l PGP9.5 RBPMS γ-SYN βIII-tubulin TUJ1

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Embedding hollow Co3O4 nanoboxes into a three- dimensional macroporous graphene framework for high-performance energy storage devices

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Nano Research 2018年第5期11卷 2836-2846页

作者： Mengping li Maher F. EI-Kady Jee Y. Hwang Matthew D. Kowal Kristofer marsh Haosen Wang Zhijuan Zhao Richard B. Kaner Department of Chemistry and Biochemistry and California NanoSystems Institute University of California Los Angeles Los Angeles CA 90095 USA Department of Chemistry Faculty of Science Cairo University Giza 12613 Egypt Department of Materials Science and Engineering University of California Los Angeles Los Angeles CA 90095 USA

Carbon materials are widely used for supercapacitor applications thanks to their high surface area, good rate capability, and excellent cycling stability. However, the development of high energy density carbon supercapacitors still remains a challenge. In this work, hollow Co3O4 nanoboxes have been embedded into three-dimensional macroporous laser-scribed graphene （lSG） to produce composite electrodes with improved electrochemical performance. Here, Co3O4 provides high capacity through fast and reversible redox reactions, while lSG serves as a conductive network to maintain high power. The open nanobox morphology is a unique solution for extracting the maximum capacity from Co3O4, resulting in electrodes whose surfaces, both internal and external, are accessible to the electrolyte. The electrochemical performance of the composite material is promising with a volumetric capacity of 60.0 C/cm^3 and a specific capacity of 542.3 C/g, corresponding to 682.0 C/g of the constituent Co3O4. With a low equivalent series resistance of 0.9 Ω, the Co3O4/lSG electrode is able to maintain 113.1% of its original capacity after 10,000 cycles. This work provides new insights into the design of high-performance carbon/metal oxide nano- composites for next-generation energy storage devices.

关键词： supercapacitor graphene cobalt oxide laser composite hybrid capacitor

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Inheritance of marsh spot disease resistance in cranberry common bean(Phaseolus vulgaris l.)

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The Crop Journal 2022年第2期10卷 456-467页

作者： Bosen Jia Robert l.Conner Nadeem Khan Anfu Hou Xuhua Xia Frank M.You Ottawa Research and Development Centre Agriculture and Agri-Food CanadaOttawaOntario K1A 0C6Canada Department of Biology University of OttawaOttawaOntario K1N 6N5Canada Morden Research and Development Centre Agriculture and Agri-Food CanadaMordenManitoba R6M 1Y5Canada

Common bean(Phaseolus vulgaris) is an annual legume crop that is grown worldwide for its edible dry seeds and tender pods. marsh spot(MS) of the seeds is a physio-genic stress disease affecting seed quality in beans. Studies have suggested that this disease involves a nutritional disorder caused by manganese deficiency, but the inheritance of resistance to this disease has not been reported. A biparental genetic population composed of 138 recombinant inbred lines(RIls) was developed from a cross between an MS resistant cultivar ‘Cran09’ and an MS susceptible cultivar ‘Messina’. The 138 RIls and their two parents were evaluated for MS resistance during five consecutive years from 2015 to 2019 in sandy and heavy clay soils in Morden, Manitoba, Canada. The MS incidence(MSI) and the MS resistance index(MSRI) representing disease severity were shown to be both highly correlated heritable traits that had high broad-sense heritability values(H;) of 86.5% and 83.2%, respectively. No significant differences for MSI and MSRI were observed between the two soil types in all five-(MSI) or four-year(MSRI) data collection, but significant correlations among years were observed despite MS resistance was moderately affected by year. The MSIs and MSRIs displayed a right-skewed distribution, indicating a mixed genetic model involving a few major genes and polygenes. Using the joint segregation analysis method, the same four major genes with additive-epistasis effects showed the best fit for both traits, explaining 84.4% and85.3% of the phenotypic variance for MSI and MSRI, respectively. For both traits, the M1, M2, M3 and m4 acted as the favorable(resistant) alleles for the four genes where M and m represent two alleles of each gene. However, due to epistatic effects, only the individuals of the M1 M2 M3 M4 haplotype appeared to be highly resistant, whereas those of the m1 m2 m3 M4 haplotype were the most susceptible. The m4 allele significantly suppressed the additive effects of M1 M

关键词： Common bean Cranberry bean marsh spot Resistance Recombinant inbred line(RIl) Joint segregation analysis Major gene Polygene

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Morphological and Physiological Development of Organic Greenhouse Grown Ginger (Zingiber officinalis, Rosc) in a Temperate Climate as Influenced by Container and Transplant Origin

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American Journal of Plant Sciences 2022年第4期13卷 443-456页

作者： lurline marsh Gabrielle Morris Brett Smith Petrina McKenzie-Reynolds Department of Agriculture Food and Resource Sciences University of Maryland Eastern Shore Princess Anne MD USA

Ginger (Zingiber officinale Rosc) is a spice produced from underground rhizomes. This makes it necessary to consider the size of its growing area. There is limited information on the phenological development of the plant in containerized greenhouse conditions in temperate regions where natural daylength decreases as the growing season advances. This study determined the effects of container and rhizome sources on ginger shoot growth, chlorophyll concentration, leaf chlorophyll index, transpiration rate, and rhizome yield. Ginger, from non-tissue culture (O1) and tissue culture (O2) origins, were transplanted in a greenhouse in June 2019, 2020 and 2021, and monitored in five container types of different sizes. These were (C1) plastic Supertub (113.2 l), (C2) large Sterilite box (55.3 l), (C3) small Sterilite box (36.7 l), (C4) Husky heavy duty contractor plastic clean up bags (26.3 l) and (C5) Root Trapper Grounder Squat bag (27.9 l). The results did not show consistent trends for the effects of the respective size and origin combinations on most of the morphological characteristics, and all the physiological characteristics evaluated. Increasing container size increased the shoot biomass in all studies and increased fresh rhizome yield in two of three studies in the greenhouse. The effect of transplant origin was inconclusive, with a tissue culture advantage one year and no effect the other year. During the first 5 months after transplanting, the morphological development of tillers and height increased. leaf chlorophyll index, chlorophyll concentration and stomatal conductance varied across sampling months, and within container and rhizome origin at individual sampling dates. The development of the plants in a greenhouse with decreasing natural day length posed a challenge as some plants senesced within 5 months after transplanting. Further opportunities to arrest senescence and extend growth should be introduced as another approach to extend growth and increase rh

关键词： Container Transplant Origin Organic Agriculture

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Is analysis of lower esophageal sphincter vector volumes of value in diagnosing gastroesophageal reflux disease?

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World Journal of Gastroenterology 2003年第1期9卷 174-178页

作者： Robert E.marsh Christopher l.Perdue Ziad T.Awad Patrice Watson Mohamed Selima Richard E.Davis Charles J.Filipi Department of Surgery Creighton University School of MedicineOmaha Nebraska USA Department of Preventive Medicine Creighton University School of MedicineOmaha Nebraska USA

AIM:With successful surgical treatment of gastroesophageal reflux disease(GERD),there is interest in understanding the anti-reflux barrier and its mechanisms of *** date, the potential use of vector volumes to predict the DeMeester score has not been adequately explored. METHODS:627 patients in the referral database received esophageal manometry and ambulatory 24-hour pH *** data included lES resting pressure(lESP), overall lES length(Ol)and abdominal length(Al),total vector volume(TVV)and intrabdominal vector volume(IVV). RESUlTS:In cases where lESP,TVV or IVV were all below normal,there was an 81.4%probability of a positive DeMeester *** cases where all three were normal, there was an 86.9%probability that the DeMeester score would be ***-operating characteristics(ROC) for lESP,TVV and IVV were nearly identical and indicated no useful cut-off *** regression demonstrated that lESP and IVV had the strongest association with a positive DeMeester score;however,the regression formula was only 76.1%accurate. CONClUSION:While the indices based on TVV,IVV and lESP are more sensitive and specific,respectively,than any single measurement,the measurement of vector volumes does not add significantly to the diagnosis of GERD.

关键词： Adolescent Adult Aged Aged, 80 and over Child Child, Preschool Esophagogastric Junction Female Gastroesophageal Reflux Humans Hydrogen-Ion Concentration Male Manometry Middle Aged ROC Curve Regression Analysis

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汽液平衡实验装置及其微机控制

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天津大学学报 1994年第1期27卷 117-121页

作者：张于峰 marsh,KN 天津大学

阐述作者设计的定温汽液平衡实验装置的构造、性能及调试方法，并利用微机实现了实验装置的控制、参数测量和数据整理。装置的最高实验压力３０ＭＰａ，测压精度０．０５％，最高恒温３００℃，恒温精度±０．０１℃。还给出装置的控温... 详细信息

阐述作者设计的定温汽液平衡实验装置的构造、性能及调试方法，并利用微机实现了实验装置的控制、参数测量和数据整理。装置的最高实验压力３０ＭＰａ，测压精度０．０５％，最高恒温３００℃，恒温精度±０．０１℃。还给出装置的控温精度、压力和温度偏差曲线。

关键词：汽液平衡实验微机控制热物性实验

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Exogenous Protein as an Environmental Stimulus of Biofilm Formation in Select Bacterial Strains

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Advances in Microbiology 2020年第3期10卷 123-144页

作者： Donna Ye lekha Bapu Mariane Mota Cavalcante Jesse Kato Maggie lauria Sneideman Kim Scribner Thomas loch Terence l. marsh Department of Microbiology and Molecular Genetics Michigan State University East Lansing MI USA Department of Biology Universidade Federal de São Carlos Sorocaba SP Brazil Department of Biology Kalamazoo College Kalamazoo MI USA Department of Fisheries and Wildlife Michigan State University East Lansing MI USA

A screening of environmental conditions that would elicit robust biofilm in a collection of Serratia marcescens isolated from soil revealed that exogenous milk protein increased biofilm productivity up to ten-fold. A select screening of fish pathogens, freshwater and human isolates identified several other species that responded similarly to exogenous protein. The optimal protein concentration was species specific;S. marcescens at 5% milk protein, Aeromonas sp. at 2% - 3%, Flavobacterium columnare at 1% and Pseudomonas aeruginosa at 0.1% - 0.4%. Media supplemented with milk protein also increased the cell counts in biofilm as well as the protein incorporated into the biofilm matrix. These data suggest that relatively high concentrations of exogenous protein may serve as an environmental trigger for biofilm formation, particularly for pathogenic bacteria exposed to relatively high concentrations of protein in bodily fluids and mucosal surfaces.

关键词： Biofilm Environmental Stimulus Exogenous Protein Serratia marcescens Aeromonas sp. Flavobacterium columnare

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伴精神病的帕金森病患者患其他精神障碍的共病率

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世界核心医学期刊文摘（神经病学分册） 2005年第1期1卷 36-37页

作者： marsh l. Williams J.R. Rocco M. 赵正卿 Johns Hopkins Univ. Sch. ofMedicine 600 N.Wolfe Street Baltimore MD 21287 United States Dr.

Objective: To determine the prevalence and impact of comorbid psychiatric disturbances in Parkinson disease (PD) patients with psychosis. Methods: Subject data were derived from a research database of 116 PD patients participating in standardized motor, cognitive, psychiatric, and care giver assessments. Results: There were 25 patients (22% ) with psychosis manifest as hallucinations (n = 9), delusions (n = 1), or hallucinations and delusions (n = 15) and 25 patients (22% ) who had no current or past psychiatric comorbidities (PDN). In the psychotic group, 44% had psychosis only (PSY), and 56% had psychosis plus at least one other comorbid psychiatric disturbance (PSY+ ), including depressive disorders (71% ), anxiety disorders (21% ), apathetic syndromes (14% ), and delirium (14% ). There were no differences in age, sex, education, or age onset or duration of PD among the PSY, PSY+ , and PDN groups. Both psychotic groups had greater motor, functional, and frontal cognitive deficits and increased caregiver burden scores relative to PDN. PSY+ showed greater global and selective cognitive deficits compared to PDN. Psychosis was a primary predictor of caregiver burden, whereas depressive symptoms indirectly enhanced motor impairments. Conclusions: Nonpsychotic psychiatric disturbances, especially affective disturbances, are common comorbidities in PD patients with

关键词：帕金森病共病率精神病患者精神障碍郁症研究数据库运动损害护理人员认知缺陷发病年龄

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血型系统同种抗体的临床意义

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国外医学（输血及血液学分册） 2001年第4期24卷 360-363页

作者： Marion E.Reid Ragnhid Oyen W.l.marsh 牛海江孙国栋邯郸市中心血站

红细胞血型抗原决定簇位于红细胞膜表面,为糖和多肽,具有多态性和遗传性.检查和鉴定血型抗原和抗体有助于安全输血,也有助于对可能患新生儿溶血病(HDN)孕妇的治疗.

关键词：血型系统同种抗体输血 lutheran血型系统 Kell血型系统

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Influence of flooding and vegetation on carbon,nitrogen,and phosphorus dynamics in the pore water of a Spartina alterniflora salt marsh

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Journal of Environmental Sciences 2011年第2期23卷 212-221页

作者： Vanesa l.Negrin Carla V.Spetter Raúl O.Asteasuain Gerardo M.E.Perillo Jorge E.Marcovecchio Argentine Institute of Oceanography (IADO CONICETCCT-Bahía Blanca)Camino La Carrindanga km 75Building E-1 CC 804Bahía Blanca 8000Argentina Department of Chemistry Southern National Institute of Chemistry (INQUISUR)Southern National University (UNS)Av Alem 1253Bahía Blanca 8000Argentina Department of Geology Southern National University (UNS)San Juan 670Bahía Blanca 8000Argentina National Technological University Regional Faculty of Bahía Blanca (UTN-FRBB)11 de Abril 461Bahía Blanca 8000Argentina University of the Fraternity of Associations Santo Toms de Aquino (FASTA) Gascón 3145Mar del Plata 7600Argentina

Four sites were selected in a salt marsh in the Bahia Blanca Estuary （Argentina）：（1） low marsh （flooded by the tide twice daily） vegetated by S. alterniflora; （2） non-vegetated low marsh; （3） high marsh （flooded only in spring tides） vegetated by S. alterniflora; （4） non-vegetated high marsh. The pH and Eh were measured in sediments, while dissolved nutrients （ammonium, nitrate, nitrite and phosphate） and particulate organic matter （POM） were determined in pore water, pH （6.2-8.7） was only affected by vegetation in low areas. Eh （from -300 to 250 mV） was lower at low sites than at high ones; in the latter, the values were higher in the non-vegetated sediments. The POM concentration was greater in the high marsh than in the low marsh, with no effect of vegetation. Ammonium was the most abundant nitrogen nutrient species in pore water, except in the non-vegetated high marsh where nitrate concentration was higher. All nitrogen nutrients were affected by both flooding and vegetation. Phosphate was always present in pore water at all sites throughout the year and its concentration varied within narrow limits, with no effect of flooding and greater values always at non-vegetated sites. Our results showed that the variability of the pore water composition within the marsh is greater than the temporal variation, meaning that both tidal flooding and vegetation are important in the dynamics of nutrients and organic matter in the sediment pore water.

关键词： organic matter nutrients flooding Spartina alterniflora

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