检索结果-南通市图书馆

Pediatric Investigation 2021年第2期5卷 136-139页

作者： Heidi C Smith-Vaughan Allen C Cheng Sepehr N.Tabrizi Danielle F Wurzel Jemima Beissbarth Amanda J leach Peter S Morris Michael J Binks Paul J Torzillo Anne B Chang robyn l marsh Menzies School of Health Research Charles Darwin UniversityDarwinAustralia School of Medicine Griffith UniversityGold CoastAustralia Monash University MelbourneAustralia Murdoch Children's Research Institute The Royal Children’s HospitalMelbourneAustralia Department of Obstetrics and Gynaecology University of MelbourneParkvilleVictoriaAustralia Royal Darwin Hospital DarwinAustralia Royal Prince Alfred Hospital SydneyAustralia Dept of Respiratory and Sleep Medicine I Queensland Children’s HospitalBrisbaneAustralia

Maternal urogenital human papillomavirus(HPV)infection may place neonates at risk of HPV acquisition and subsequently lower respiratory infections as HPV can influence development of *** respiratory HPV prevalence is not known in remote-dwelling Aboriginal infants,who are at high risk of respiratory infection and where the population prevalence of urogenital HPV in women is *** data are necessary to inform HPV vaccination regimens.A retrospective analysis using PCR specific for HPV was performed on 64 stored nasopharyngeal swabs from remote-dwelling Aboriginal infantslised *** DNA was not detected in any *** the negative result,we cannot exclude a role for HPV in respiratory infections affecting infants in this population;however,our data do not support HPV as an important contributor to acute respiratory infection in remote-dwelling Aboriginal children.

关键词： Human papillomavirus Nasopharyngeal swabs Infants

Can non-typeable Haemophilus influenzae carriage surveillance data infer antimicrobial resistance associated with otitis media?

在线全文

学校读者我要写书评

暂无评论

Pediatric Investigation 2023年第1期7卷 13-22页

作者： Sophia Bowman-Derrick Tegan M.Harris Jemima Beissbarth Mariana Kleinecke Katrina lawrence Teresa M.Wozniak Amy Bleakley Angela Rumaseb Michael J.Binks robyn l.marsh Peter S.Morris Amanda J.leach Heidi Smith-Vaughan Menzies School of Health Research Charles Darwin UniversityDarwinAustralia Australian e-Health Research Centre CSIRO BrisbaneAustralia Royal Darwin Hospital DarwinAustralia

Importance:In remote communities of the Northern Territory,Australia,children experience high rates of otitis media(OM),commonly caused by non-typeable Haemophilus influenzae(NTHi).Few data exist on antibiotic susceptibility of NTHi from ***:To determine whether population-level nasopharyngeal NTHi antibiotic susceptibility data could inform antibiotic treatment for ***:NTHi isolates(n=92)collected from ear discharge between 2003 and 2013 were selected to time-and age-match NTHi isolates from the nasopharyngeal carriage(n=95).Antimicrobial susceptibility were *** trees and a genome-wide association study(GWAS)were performed to determine the similarity of nasopharyngeal and ear isolates at a population ***:Among 174 NTHi isolates available for antimicrobial susceptibility testing,10.3%(18/174)were resistant to ampicillin and 9.2%(16/174)were resistant to *** numbers of isolates(≤3)were resistant to tetracycline,chloramphenicol,or amoxicillin-clavulanic *** was no statistical difference in the proportion of ampicillin-resistant(P=0.11)or trimethoprim-sulfamethoxazole-resistant isolates(P=0.70)between ear discharge and nasopharynx-derived NTHi *** multi-drug resistant NTHi isolates were *** trees showed no clustering of 187 Haemophilus influenzae isolates based on anatomical niche(nasopharynx or ear discharge),and no genetic variations that distinguished NTHi derived from ear discharge and nasopharyngeal carriage were evident in the ***:In this population-level study,nasopharyngeal and ear discharge isolates did not represent distinct microbial *** results support tracking of population-level nasopharyngeal NTHi antibiotic resistance patterns to inform clinical management of OM in this population.

关键词： Haemophilus influenzae Otitis media Antimicrobial resistance

Derived, still living cockroach genus Cariblattoides （Blattida： Blattellidae） from the Eocene sediments of Green River in Colorado, USA

在线全文

学校读者我要写书评

暂无评论

Insect Science 2012年第2期19卷 143-152页

作者： Peter Vrsansky l＇ubomir Vidlicka Fedor Ciampor Jr Finnegan marsh Geological Institute SlovakAcademy of Sciences BraUslava Slovakia Paleontological Institute Russian Academy of Sciences Moscow Russia Institute of Zoology Slovak Academy of Sciences Department of Biology Faculty of Education Comenius University Bratislava Slovakia Department of Paleobiology National Museum of Natural History Smithsonian Institution Washington DC USA

Cariblattoides labandeirai sp.n. from the Eocene sediments of Green River in Colorado, USA bear only two plesiomorphies, but also several significant autapomorphies within the advanced and highly derived living cockroach genus. Thus, Cariblattoides with extant occurrence in the Caribbean and South America was historically common in the Nearctic, and represents important evidence for the occurrence of derived living genera of cockroaches -50 Ma ago. Generally, the vast majority of living genera were absent during the Palaeocene, thus the diversification of most living cockroach lineages near the Palaeocene/Eocene boundary must have been extremely rapid. Females of living C. suave, the type species, have identical （sophisticated） coloration ofpronotum, but the most related living taxa are C. piraiensis and *** from Brazil （supported by phylogenetical analysis）.

关键词： Blattida -- Blattaria = Blattodea Cariblattoides Eocene fossil insects,Green River Tertiary cockroaches

The Changing Cold Regions Network:Observation,diagnosis and prediction of environmental change in the Saskatchewan and Mackenzie River Basins,Canada

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Earth Sciences 2015年第1期58卷 46-60页

作者： Chris M DEBEER Howard S WHEATER William l QUINTON Sean K CAREY Ronald E STEWART Murray D MACKAY Philip marsh Global Institute for Water Security University of SaskatchewanNational Hydrology Research Centre Cold Regions Research Centre Wilfrid Laurier University School of Geography and Earth Sciences Mc Master University Department of Environment and Geography University of Manitoba Science and Technology Branch Environment Canada

Climate change is causing rapid and severe changes to many Earth systems and processes,with widespread cryospheric,ecological,and hydrological impacts globally,and especially in high northern *** is of major societal concern and there is an urgent need for improved understanding and predictive tools for environmental *** Changing Cold Regions Network(CCRN)is a Canadian research consortium with a focus to integrate existing and new experimental data with modelling and remote sensing products to understand,diagnose,and predict changing land,water,and climate,and their interactions and feedbacks over the geographic domain of the Mackenzie and Saskatchewan River Basins in *** network operates a set of 14 unique and focused Water,Ecosystem,Cryosphere and Climate(WECC)observatories within this region,which provide opportunities to observe and understand processes and their interaction,as well as develop and test numerical simulation models,and provide validation data for remote sensing *** paper describes this network and its observational,experimental,and modelling *** overview of many of the recent Earth system changes observed across the study region is provided,and some local insights from WECC observatories that may partly explain regional patterns and trends are *** of the model products being developed are discussed,and linkages with the local to international user community are reviewed—In particular,the use of WECC data towards model and remote sensing product calibration and validation is *** future activities and prospects for the network are also presented at the end of the paper.

关键词： climate change cryosphere hydrology atmospheric science ecology modelling Canada

Folate binding protein—Outlook for drug delivery applications

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical letters 2015年第4期26卷 426-430页

作者： Rachel l.Merzel Jun-Jie Chen E.Neil G.marsh Mark M.Banaszak Holl Department of Chemistry University of Michigan

Serum proteins represent an important class of drug and imaging agent delivery vectors. In this mini- review, key advantages of using serum proteins are discussed, followed by the particular advantages and challenges associated with employing soluble folate binding protein. In particular, approaches employing drugs that target folate metabolism are reviewed. Additionally, the slow-onset, tight- binding interaction of folate with folate binding protein and the relationship to a natural oligomerization mechanism is discussed. These unique aspects of folate binding protein suggest interesting applications for the protein as a vector for further drug and imaging agent development.

关键词： Folate binding proteinSerum proteinDrug deliveryFolate conjugateFolic acid

Cadmium nanoclusters in a protein matrix： Synthesis, characterization, and application in targeted drug delivery and cellular imaging

在线全文

学校读者我要写书评

暂无评论

Nano Research 2016年第11期9卷 3229-3246页

作者： Morteza Sarparast Abolhassan Noori Hoda Ilkhani S. Zahra Bathaie Maher F. EI-Kady lisa J. Wang Huong Pham Kristofer l. marsh Richard B. Kaner Mir F. Mousavi Department of Chemistry Tarbiat Modares University Tehran 14115-175 Iran Department of Clinical Biochemistry Faculty of Medical Sciences Tarbiat Modares University Tehran 14115-111 Iran Department of Chemistry and Biochemistry University of California Los Angeles Los Angeles CA 90095 USA Department of Chemistry Faculty of Science Cairo University Giza 12613 Egypt California NanoSystems Institute University of California Los Angeles Los Angeles CA 90095 USA

Biotemplated metal nanoclusters have garnered much attention owing to their wide range of potential applications in biosensing, bioimaging, catalysis, and nanomedicine. Here, we report the synthesis of stable, biocompatible, watersoluble, and highly fluorescent bovine serum albumin-templated cadmium nanoclusters （CdNcs） through a facile one-pot green method. We covalently conjugated hyaluronic acid （HA） to the CdNcs to form a pH-responsive, tumor- targeting theranostic nanocarrier with a sustained release profile for doxorubicin （DOX）, a model anticancer drug. The nanocarrier showed a DOX encapsulation efficiency of about 75.6%. DOX release profiles revealed that 74% of DOX was released at pH 5.3, while less than 26% of DOX was released at pH 7.4 within the same 24-h period. The nanocarrier selectively recognized MCF-7 breast cancer cells expressing CD44, a cell surface receptor for HA, whereas no such recognition was observed with HA receptor-negative HEK293 cells. Biocompatibility of the nanocarrier was evaluated through cytotoxicity assays with HEK293 and MCF-7 ceils. The nanocarrier exhibited very low to no cytotoxicity, whereas the DOX-loaded nanocarrier showed considerable cellular uptake and enhanced MCF-7 breast cancer cell-killing ability. We also confirmed the feasibility of using the highly fluorescent nanoconjugate for bioimaging of MCF-7 and Hela cells. The superior targeted drug delivery efficacy, cellular imaging capability, and low cytotoxicity position this nanoconjugate as an exciting new nanoplatform with promising biomedical applications.

关键词： Cd nanoclusters hyaluronic acid targeted drug delivery fluorescence bioimaging nanocarrier

The Effects of Antibiotics, Metals, and Biotic Interactions on the Assembly of Taxonomically Diverse Single and Mixed Species Biofilms

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Microbiology 2020年第12期10卷 623-646页

作者： Roshan Angoshtari Kim T. Scribner Terence l. marsh Department of Microbiology and Molecular Genetics Michigan State University East Lansing MI USA Department of Fisheries and Wildlife Michigan State University East Lansing MI USA

To better understand the assembly of the sturgeon egg microbiome, we purified six bacterial isolates from eggs and characterized their ability to form biofilms under the stress of tobramycin, with and without exogenous protein. In experiments with single species biofilms, tobramycin reduced the metabolic activity of all isolates and increased biofilm biomass of three. The addition of exogenous protein to the assay countered the inhibition of biofilm and metabolic activity by tobramycin of Pseudomonas sp., Brevundimonas sp., Flavobacterium columnare and mixed biofilms of Pseudomonas-F. columnare and Brevundimonas-Hydrogenophaga. Two of the isolates (Pseudomonas spp.) that produced antimicrobial activity, were effective at reducing biofilm formation by Brevundimonas, but enhanced biofilm formation in other isolates. Increasing concentrations of Mg2+ had no effect on biofilm formation but Ca2+ enhanced biofilm formation of Pseudomonas aeruginosa PA01 (positive control) and Brevundimonas. Biofilm assembly by these two bacteria was inhibited by low concentrations of Ni2+. Mixed biofilms of Brevundimonas and Hydrogenophage consistently produced more robust biofilm than the strains in isolation, suggesting synergism. Established Brevundimonas biofilm appeared adept at recruiting pelagic Acidovorax and Hydrogenophaga into biofilm, suggesting that it plays an important role in the selection of species into the microbiome.

关键词： Biofilm Assembly Antimicrobial Resistance Tobramycin Metabolic Activity Metal Resistance

Microbial communities biostimulated by ethanol during uranium （VI） bioremediation in contaminated sediment as shown by stable isotope probing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Environmental Science & Engineering 2015年第3期9卷 453-464页

作者： Mary Beth lEIGH Wei-Min WU Erick CARDENAS Ondrej UHlIK Sue CARROll Terry GENTRY Terence l. marsh Jizhong ZHOU Philip JARDINE Craig S. CRIDDlE James M. TIEDJE Center for Microbial Ecology Michigan State University East Lansing MI 48824 USA Institute of Arctic Biology University of Alaska Fairbanks Fairbanks AK 99775 USA Department of Civil and Environmental Engineering Center for Sustainable Development & Global Competitiveness Codiga Resource Recovery Center Stanford University Stanford CA 94305-4020 USA Department of Biochemistry and Microbiology Institute of Chemical Technology Prague Technicka 3 166 28 Prague Czech Republic Environmental Sciences Division Oak Ridge National Laboratory Oak Ridge TN 37831 USA Department of Botany and Microbiology University of Oklahoma Norman OK 73019 USA Department of Crop and Soil Sciences Texas A&M University College Station TX 77843 USA

Stable isotope probing （SIP） was used to identify microbes stimulated by ethanol addition in microcosms containing two sediments collected from the bioremediation test zone at the US Department of Energy Oak Ridge site, TN, USA. One sample was highly bioreduced with ethanol while another was less reduced. Microcosms with the respective sediments were amended with ^13C labeled ethanol and incubated for 7 days for SIP. Ethanol was rapidly converted to acetate within 24h accompanied with the reduction of nitrate and sulfate. The accumulation of acetate persisted beyond the 7 d period. Aqueous U did not decline in the microcosm with the reduced sediment due to desorption of U but continuously declined in the less reduced sample. Microbial growth and concomitant 13C-DNA production was detected when ethanol was exhausted and abundant acetate had accumulated in both microcosms. This coincided with U（VI） reduction in the less reduced sample. I3C originating from ethanol was ultimately utilized for growth, either directly or indirectly, by the dominant microbial community members within 7 days of incubation. The microbial community was comprised predominantly of known denitrifiers, sulfate-reducing bacteria and iron （Ⅲ） reducing bacteria including Desulfovibrio, Sphingomonas, Ferribacterium, Rhodanobacter, Geothrix, Thiobacillus and others, including the known U（VI）-redueing bacteria Acidovorax, Anaeromyxobacter, Desulfovibrio, Geobac- ter and Desulfosporosinus. The findings suggest that ethanol biostimulates the U（VI）-reducing microbial com- munity by first serving as an electron donor for nitrate, sulfate, iron （IH） and U（VI） reduction, and acetate which then functions as electron donor for U（VI） reduction and carbon source for microbial growth.

关键词： Stable isotope probing (S/P) ethanol acetate uranium reduction sediment bioremediation

Phylogenetic Analysis of Anaerobic Co-Digestion of Animal Manure and Corn Stover Reveals linkages between Bacterial Communities and Digestion Performance

在线全文

学校读者我要写书评

暂无评论

Advances in Microbiology 2016年第12期6卷 879-897页

作者： Fan Yang Rui Chen Zhengbo Yue Wei liao Terence l. marsh Department of Agricultural and Biosystems Engineering Iowa State University Ames IA USA Department of Biosystems and Agricultural Engineering Michigan State University East Lansing MI USA School of Resources and Environmental Engineering Hefei University of Technology Hefei China Department of Microbiology and Molecular Genetics Michigan State University East Lansing MI USA

Over 3 million tons of manures are produced annually in the United States and pose environmental and health risks if not remediated. Anaerobic digestion is an effective method in treating organic wastes to reduce environmental impacts and produce methane as an alternative energy. Previous studies suggested that optimization of feed composition, hydraulic retention time, and other operational conditions can greatly improve total solids removal and increase methane productivity. These environmental factors improve functionality by altering the microbial community structure but explicit details of how the bacterial community shifts are poorly understood. Our investigations were conducted to investigate the relationship between environmental factors, microbial community structure and bioreactor efficiency by using metagenomic analysis of the microbial communities. Our results indicated that the bioreactor with the greatest methane production, digestion efficiency and reduced levels of E. coli/Shigella had a distinctive community structure at the genus level with unique and abundant uncultivated strains of Bacteroidetes. Moreover the same bioreactor was enriched in Aminomonas paucivorans and Clostridia populations that can utilize secondary metabolites produced during cellulose/hemicellulose degradation to generate hydrogen and acetate. Hence specific digestion conditions that enrich for these populations may provide a route to the optimization of co-digestion systems and control the variability in reactor performance.

关键词： Anaerobic Co-Digestion Bacteroidetes Cellulose Degrading Bacterial Community

Hepatic intra-arterial infusion of yttrium-90 microspheres in the treatment of recurrent hepatocellular carcinoma after liver transplantation: A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第35期12卷 5729-5732页

作者： louis Rivera Huan Giap William Miller Jonathan Fisher Donald J Hillebrand Christopher marsh Randolph l Schaffer Naval Medical Center San Diego San Diego CA 92134 United States Department of Radiation Oncology Scripps Clinic/ Green Hospital La Jolla CA 92037 United States Department of Hematology/Oncology Scripps Clinic/Green Hospital La Jolla CA 92037 United States Scripps Center for Organ and Cell Transplantation Scripps Clinic/Green Hospital La Jolla CA 92037 United States

Hepatocellular carcinoma （HCC） recurs with a reported frequency of 12%-18% after liver transplantation. Recurrence is associated with a mortality rate exceeding 75%. Approximately one-third of recurrences develop in the transplanted liver and are therefore amenable to local therapy. A variety of treatment modalities have been reported including resection, transarterial chemoembolization （TACE）, radiofrequency ablation （RFA）, ethanol ablation, cryoablation, and external beam irradiation. Goals of treatment are tumor control and the minimization of toxic effect to functional parenchyma. Efficacy of treatment is mitigated by the need for ongoing immunosuppression. Yttrium-90 microspheres have been used as a treatment modality both for primary HCC and for pre-transplant management of HCC with promising results. Twenty-two months after liver transplantation for hepatitis C cirrhosis complicated by HCC, a 42-year old man developed recurrence of HCC in his transplant allograft. Treatment of multiple right lobe lesions with anatomic resection and adjuvant chemotherapy was unsuccessful. Multifocal recurrence in the remaining liver allograft was treated with hepatic intra-arterial infusion of yttrium-90 microspheres （SIR-Spheres, Sirtex Medical Inc., lake Forest, Il, USA）. Efficacy was demonstrated by tumor necrosis on imaging and a decrease in alpha-fetoprotein （AFP） level. There were no adverse consequences of initial treatment.

关键词： Recurrent hepatocellular carcinoma Yttrium-90 microspheres liver transplantation