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Seroprevalence of HDV among non-hospitalized HBs Ag positive patients from KPK-region of Pakistan

Asian Pacific Journal of Tropical Biomedicine 2016年第7期6卷 609-613页

作者： Ismail Jalil Muhammad Arshad Zara Rafaque Fazle Raziq robina wazir Sajid Malik Javid Iqbal Dasti Department of Microbiology Qauid-i-Azam University Islamabad Department of Pathology Hayatabad Medical Complex Peshawar Department of Pathology Khyber Teaching Hospital Peshawar Department of Animal Sciences Qauid-i-Azam University Islamabad

Objective: To study the seroprevalence of hepatitis B virus(HBV) and hepatitis delta virus(HDV) infections in patients visiting outpatient department of a major tertiary care hospital in Khyber Pakhtunkhwa region of ***: Blood samples were collected from non-hospitalized patients. Serological analysis was done by ELISA and viral DNA was amplified by PCR. The amplified DNA was analyzed by agarose gel ***: Altogether, 946 blood samples were screened, overall percentage of HBs Agpositive patients remained 22.41%(prevalence: 224.10/1 000; CI: 0.197 5 ± 0.250 7) with the highest incidence rates among relatively younger age groups(20–29 years). The prevalence of HBV–HDV co-infection was found to be 46.75/1 000; CI: 0.031 8 ± 0.061 *** HBs Ag-positive patients, anti-HBc-total was detected in 86.79% while 25.00% were positive for anti-HBc-immunoglobulin M. Similarly, among these patients, HBV DNA was detected in 64.13% and 10.85% were co-infected with HDV. Different symptoms were associated with the prevailing infection, including malaise(62%), anorexia(66%) and fatigue(73%). The most commonly associated symptom was abdominal discomfort. Among these patients, certain risk factors, including surgery, visit to dentist and intravenus infusions were frequently associated with the infection(x^2= 95.23; df = 11; P < 0.000 1).Conclusions: Overall, this study confirmed higher prevalence of active HBV/HDV infection, among young patients from Khyber Pakhtunkhwa region having no prior history of viral hepatitis.

关键词： HBV HCV HDV Risk factors Co-infection

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