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Prevalence of Isolated “Pre-Malignant” Lesions on Prostate Biopsy in a Racially Diverse Community Screened Cohort

Open j.urnal of Urology 2015年第12期5卷 213-219页

作者： Michael A. Liss Donna Ankerst David Zapata j.vier Hernandez robin j. Leach Ian M. Thompson Department of Urology University of Texas Health Science Center San Antonio San Antonio USA Department of Epidemiology and Biostatistics University of Texas Health Science Center San Antonio San Antonio USA Department of Cellular and Structural Biology University of Texas Health Science Center San Antonio San Antonio USA Cancer Therapy and Research Center University of Texas Health Science Center San Antonio San Antonio USA

Obj.ctive: We investigated rates of prostate cancer (PCa), high-grade prostatic intraepithelial neoplaisa (HGPIN) and atypical small acinar proliferation (ASAP) in a multiethnic cohort. Methods: We evaluated prostate biopsy outcomes in men enrolled in the San Antonio Center of Biomarkers of Risk for prostate cancer (SABOR) prospective, observational study. PCa-free men underwent annual PSA testing over nearly 14 years with biopsies based on community standards. We investigated biopsy outcomes with a special interest in rates of cancer, HGPIN, and ASAP. Results: We identified 975 prostate biopsies in 801 subj.cts from 3/1/2001 to 1/9/2014. PCa, HGPIN, or ASAP was encountered in 28.8% (281/975), 10.1% (98/975), and 5.2% (51/975) of prostate biopsy specimens, respectively. The most significant risk factor for a PCa diagnosis was African American race (OR 5.0, 95% CI: 2.2 - 11.4, p < 0.001). HGPIN and ASAP occurred more commonly in association with PCa (both p < 0.001). We identified 57% (24/42) of men diagnosed with a “pre-malignant” lesion on prostate biopsy and had a subsequent biopsy. Of those only 8% (2/24) were diagnosed with prostate cancer (both Gleason 3 + 3) within 1 year of the initial biopsy. Conclusion: We note a 5-fold increased risk of PCa for African American men. The incidence of HGPIN and ASAP are consistent with previously reported incidence. If diagnosed in isolation, repeat biopsy within one year could be delayed or eliminated as it may not change prostate cancer outcomes.

关键词： Active Surveillance Ethnicity Prostate Biopsy Prostate Cancer Race

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Models and estimators linking individual-based and sample-based rarefaction, extrapolation and comparison of assemblages

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j.urnal of Plant Ecology 2012年第1期5卷 3-21页

作者： Robert K.Colwell Anne Chao Nicholas j.Gotelli Shang-Yi Lin Chang Xuan Mao robin L.Chazdon j.hn T.Longino Department of Ecology and Evolutionary Biology University of ConnecticutStorrsCT 06269USA Institute of Statistics National Tsing Hua UniversityHsin-Chu 30043Taiwan Department of Biology University of VermontBurlingtonVT 05405USA School of Statistics and Management Shanghai University of Finance and EconomicsShanghai 200433China Department of Biology University of UtahSalt Lake CityUT 84112USA

Aims In ecology and conservation biology,the number of species counted in a biodiversity study is a key metric but is usually a biased underestimate of total species richness because many rare species are not ***,comparing species richness among sites or samples is a statistical challenge because the observed number of species is sensitive to the number of individuals counted or the area *** individual-based data,we treat a single,empirical sample of species abundances from an investigator-defined species assemblage or community as a reference point for two estimation obj.ctives under two sampling models:estimating the expected number of species(and its unconditional variance)in a random sample of(i)a smaller number of individuals(multinomial model)or a smaller area sampled(Poisson model)and(ii)a larger number of individuals or a larger area *** sample-based incidence(presence–absence)data,under a Bernoulli product model,we treat a single set of species incidence frequencies as the reference point to estimate richness for smaller and larger numbers of sampling *** The first obj.ctive is a problem in interpolation that we address with classical rarefaction(multinomial model)and Coleman rarefaction(Poisson model)for individual-based data and with sample-based rarefaction(Bernoulli product model)for incidence *** second is a problem in extrapolation that we address with sampling-theoretic predictors for the number of species in a larger sample(multinomial model),a larger area(Poisson model)or a larger number of sampling units(Bernoulli product model),based on an estimate of asymptotic species *** published methods exist for many of these obj.ctives,we bring them together here with some new estimators under a unified statistical and notational *** novel integration of mathematically distinct approaches allowed us to link interpolated(rarefaction)curves and extrapolated curves to plot a unified

关键词： Bernoulli product model Coleman curve multinomial model Poisson model random placement species–area relation

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Unraveling and optimizing the metal-metal oxide synergistic effect in a highly active Co_(x)(CoO)_(1–x) catalyst for CO_(2) hydrogenation

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j.urnal of Energy Chemistry 2021年第2期30卷 241-250,I0009页

作者： Kun Zhao Marco Calizzi Emanuele Moioli Mo Li Alexandre Borsay Loris Lombardo robin Mutschler Wen Luo Andreas Zuttel Laboratory of Materials for Renewable Energy Institute of Chemical Sciences and Engineeringtcole Polytechnique Federale de Lausanne(EPFL)1951 SionSwitzerland Swiss Federal Laboratories for Materials Science and Technology(EMPA) 8600 DiibendorfSwitzerland

The relation between catalytic reactivities and metal/metal oxide ratios, as well as the functions of the metal and the metal oxides were investigated in the CO_2 hydrogenation reaction over highly active Co_x(CoO)_(1–x)catalysts in operando. The catalytic reactivity of the samples in the CO_2 methanation improves with the increased Co O concentration. Strikingly, the sample with the highest concentration of CoO, i.e., Co_(0.2)(CoO)_(0.8), shows activity at temperatures lower than 200 °C where the other samples with less CoO are inactive. The origins of this improvement are the increased amount and moderate binding of adsorbed CO_2 on CoO sites. The derivative adsorption species are found to be intermediates of the CH4 formation. The metallic Co functions as the electronically catalytic site which provides electrons for the hydrogenation steps. As a result, an abundant amount of CoO combined with Co is the optimal composition of the catalyst for achieving the highest reactivity for CO_2 hydrogenation.

关键词： Cobalt and cobalt oxide Reactivity CO_(2)hydrogenation Active site Adsorption Activation energy

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Electrophoretically deposited binder-free 3-D carbon/sulfur nanocomposite cathode for high-performance Li–S batteries

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j.urnal of Energy Chemistry 2020年第9期29卷 92-101,I0003页

作者： Sasan Ghashghaie Samson Ho-Sum Cheng j.e Fang Hafiz Khurram Shahzad robin Lok-Wang Ma Chi-Yuen Chung Department of Materials Science and Engineering City University of Hong KongHong KongChina Department of Mechanical and Aerospace Engineering The Hong Kong University of Science and TechnologyHong KongChina

In the present study,the electrophoretic deposition method was successfully applied as a binder-free and scalable approach to deposit carbonaceous nanomaterials on carbon fiber paper(CFP)for cathode applications in Li-S *** microstructural studies of the EPD-CNT film using scanning electron microscopy(SEM)revealed the formation of a crack-free and porous layer of CNTs being uniformly distributed on the CFP *** EPD:CFP/CNT/S cathode delivered a capacity around 2.2 times higher than that obtained in the absence of the EPD-CNT film(CFP/S cell)after 50 cycles and a capacity of935 mAh g^-1 after 100 cycles at 0.1 *** EPD method was then employed to fabricate layer-by-layer structures where the EPD-CNT film was decorated with carbon black *** initial capacity as well as the reversible capacity after 100 cycles was further increased by the EPD:CFP/CNT/KB/S layer-by-layer structure to 1473 and 1033 mAh g^-1,respectively,indicating effective suppression of the shuttle *** addition,the rate performance of CFP/S was improved by depositing the EPD-CNT and EPD-CNT/carbon black architectures on CFP surface,and even further enhanced through the co-deposition of CNT and Pt nanoparticles by EPD,delivering a specific capacity of around 730 mAh g^-1 at 1 ***,the cathodes fabricated by EPD were observed to outperform those made by the conventional casting method in terms of cycling performance,internal resistance,and *** difference was ascribed to the non-uniform microstructure of the Cast-CNT film,which resulted in poor interfacial connection between the CNT agglomerates,hindering uniform sulfide/sulfur deposition during *** obtained results suggested that the binder-free C/S nanocomposite cathode made by EPD is key to further enhance the specific capacity and energy density of Li-S batteries.

关键词： Electrophoretic deposition Lithium-sulfur batteries Carbon nanotubes C/S nanocomposite

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Delayed diagnosis of isolated alar ligament rupture:A case report

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World j.urnal of Radiology 2015年第10期7卷 357-360页

作者： robin A Kaufmann Ingo Marzi Thomas j.Vogl Department of Diagnostic and Interventional Radiology University Hospital FrankfurtGoethe University Department of Trauma Hand and Reconstructive SurgeryUniversity Hospital FrankfurtGoethe University

Ligament disruptions at the craniovertebral j.nction are typically associated with atlantoaxial rotatory dislocation during upper cervical spine inj.ries and require external orthoses or surgical stabilization. Only in few patients isolated ruptures of the alar ligament have been reported. Here we present a further case, in which the diagnosis was initially obscured by a misleading clinical symptomatology but finally established six month following the trauma, demonstrating the value of contrast-enhanced high resolution 3 Tesla magnetic resonance imaging in identifying this particular lesion.

关键词： Alar ligament rupture Cervical spine inj.ry Contra

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An Uncertainty-aware Workflow for Keyhole Surgery Planning using Hierarchical Image Semantics

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Visual Informatics 2018年第1期2卷 26-36页

作者： Christina Gillmann robin G.C.Maack Tobias Post Thomas Wischgoll Hans Hagen University of Kaiserslautern Erwin-Schroedinger-Strasse 167663 Kaiserslautern Wright State University 3640 Colonel Glenn HwyDaytonOH

Keyhole surgeries become mcreasingly important in clinical daily routine as they help minimizing the damage of a patient's healthy *** planning of keyhole surgeries is based on medical imaging and an important factor that influences the surgeries**** to the image reconstruction process,medical image data contains uncertainty that exacerbates the planning of a keyhole *** this paper we present a visual workflow that helps clinicians to examine and compare different surgery paths as well as visualizing the patientsj.affected *** analysis is based on the concept of hierarchical image semantics,that segment the underlying image data with respect to the input images'uncertainty and the users understanding of tissue *** can define arbitrary surgery paths that they need to investigate *** defined paths can be queried by a rating function to identify paths that fulfill user-defined *** workflow allows a visual inspection of the affected tissues and its ***,the workflow includes a linked view system indicating the three-dimensional location of selected surgery paths as well as how these paths affect the patients *** show the effectiveness of the presented approach,we applied it to the planning of a keyhole surgery of a brain tumor removal and a kneecap surgery.

关键词： Wsual Analytics Workflow Uncertainty sualization Keyhole Surgery Planning

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Rapid generation of recombinant Pseudomonas putida secondary metabolite producers using yTREX

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Synthetic and Systems Biotechnology 2017年第4期2卷 310-319页

作者： Andreas Domrose robin Weihmann Stephan Thies Karl-Erich j.eger Thomas Drepper Anita Loeschcke Institute of Molecular Enzyme Technology Heinrich Heine University DüsseldorfForschungszentrum JülichJülichGermany Bioeconomy Science Center(BioSC) Forschungszentrum JülichJülichGermany Institute of Bio-and Geosciences(IBG-1) Forschungszentrum JülichJülichGermany

Microbial secondary metabolites represent a rich source of valuable compounds with a variety of applications in medicine or *** exploitation of this wealth of chemicals requires the functional expression of the respective biosynthetic genes in amenable heterologous *** have previously established the TREX system which facilitates the transfer,integration and expression of biosynthetic gene clusters in various bacterial ***,we describe the yTREX system,a new tool adapted for one-step yeast recombinational cloning of gene *** show that with yTREX,Pseudomonas putida secondary metabolite production strains can rapidly be constructed by random targeting of chromosomal promoters by Tn5 *** of this approach was corroborated by prodigiosin production after yTREX cloning,transfer and expression of the respective biosynthesis genes from Serratia ***,the applicability of the system for effective pathway rerouting by gene cluster adaptation was demonstrated using the violacein biosynthesis gene cluster from Chromobacterium violaceum,producing pathway metabolites violacein,deoxyviolacein,prodeoxyviolacein,and *** producing both prodigiosin and violaceins could be readily identified among clones obtained after random chromosomal integration by their strong ***,the addition of a promoter-less reporter gene enabled facile detection also of phenazine-producing clones after transfer of the respective phenazine-1-carboxylic acid biosynthesis genes from Pseudomonas *** compounds accumulated to substantial titers in the mg *** thus corroborate here the suitability of *** for the biosynthesis of diverse natural products,and demonstrate that the yTREX system effectively enables the rapid generation of secondary metabolite producing bacteria by activation of heterologous gene clusters,applicable for natural compound discovery and combinatorial biosy

关键词： Synthetic biology Yeast recombinational cloning Tn5 transposition Heterologous gene cluster expression Secondary metabolite production Pseudomonas putida

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Outflow from under the Pine Island Bay Ice Shelf: finescale structure and its temporal variability

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Advances in Polar Science 2016年第4期27卷 245-263页

作者： robin Robertson School of Physical Environmental and Mathematical Sciences University of New South Wales Department of Marine Science Nanjing University of Information Science and Technology

The water column structure of the ice shelf cavity outflow from under Pine Island Glacier and its temporal variability were investigated using a hourly time series of yo-yo CTD and LADCP data collected over -24 h at the southern end of the ice shelf front. The primary water types present over the continental shelf off Pine Island Bay were Circumpolar Deep Water （CDW）, modified Circumpolar Deep Water （mCDW）, Shelf Water （SW）, and Ice Shelf Water （ISW）. As CDW transited the shelf, it transitioned into cooler, mCDW. In the upper 200 m, ISW dominated within 100 km of the ice shelf and SW further offshore. Within Pine Island Bay, the water column was partitioned into two primary layers based on their behavior： an upper outflowing layer from 100 m to 450 m composed of ISW with a significant meltwater component, 1%-2%, over an inflowing layer from -550 m to the sea bed composed of mCDW. Due to the small cavity extent, the outflowing water was warmer than the seawater freezing point. The upper ISW layer was further split into upper ISW layer #1 （100-300 m） and upper ISW layer #2 （320450 m） with the transition coinciding with the ice shelf draft. Small step-like features with heights from 1-50 m existed within both the ISW layers and were more prominent in upper ISW layer #1. A baroclinic signal at the semidiurnal frequency existed within both primary layers with the strongest signal, - 10 cm·s^-1, propagating vertically in the upper ISW layer.

关键词： Pine Island Bay double-diffusion Amundsen Sea internal tides

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用于软件维护的集成生存期模型

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计算机科学 1989年第5期16卷 14-22,7页

作者： Stephen S. Yau robin A. Nicholl j.ffrey j.-P. Tsai Sying-Syang Liu 仲源

本文提出一个用于软件维护环境的集成生存期模型,它有助于维护人员修改现有的软件系统,为工具自动化提供了基础。该模型用来表示软件系统开发和维护信息,主要表示软件生存期不同阶段间的关系。因为它只表示软件系统某些“基本的”语义性... 详细信息

本文提出一个用于软件维护环境的集成生存期模型,它有助于维护人员修改现有的软件系统,为工具自动化提供了基础。该模型用来表示软件系统开发和维护信息,主要表示软件生存期不同阶段间的关系。因为它只表示软件系统某些“基本的”语义性质:控制流、数据流和数据结构,所以与特定的规格说明、设计和程序语言无关。从软件生存期的一个阶段导出另一个阶段的软件开发过程是用图重写规则表示的,从而说明如何实现软件系统的各个成分。这种方法可以分析软件系绕在整个生存期中的基本性质。文中举例说明了该模型的使用。

关键词：软件维护集成生存期软件工程

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用于软件维护的集成生存期模型(续)

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计算机科学 1989年第6期16卷 53-58页

作者： Stephen S.Yau robin A.Nicholl j.ffrey j.-P. Tsai Sying-Syang Liu 仲源

七、集成生存期模型的构造在这一节,我们讨论如何从软件开发项目不同阶段的描述构造集成生存期模型的备个部分。首先,我们描述构造某一具体阶段模型的方法,再描述构造阶段间模型的方法。在维护开始之前,最好由软件系统的开发者来构造这... 详细信息

七、集成生存期模型的构造在这一节,我们讨论如何从软件开发项目不同阶段的描述构造集成生存期模型的备个部分。首先,我们描述构造某一具体阶段模型的方法,再描述构造阶段间模型的方法。在维护开始之前,最好由软件系统的开发者来构造这个模型。

关键词：软件工程软件维护集成生存期

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