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Hydro-mechanical interaction effects and channelling in threedimensional fracture networks undergoing growth and nucleation

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j.urnal of Rock Mechanics and Geotechnical Engineering 2020年第4期12卷 707-719页

作者： Adriana Paluszny robin NThomas Maria CSaceanu Robert WZimmerman Department of Earth Science and Engineering Imperial College LondonLondonSW72AZUK

The flow properties of geomechanically generated discrete fracture networks are examined in the context of *** networks are generated by growing fractures in tension,modelling the low permeability rock as a linear elastic *** are modelled as discrete surfaces which grow quasi-statically within a three-dimensional(3D)*** may have their locations specified as a simulation input,or be generated as a function of damage,quantified using the local variation in equivalent *** properties of the grown networks are shown to be a product of in situ stress,relative orientation of initial flaws,and competitive process of fracture interaction and *** grow preferentially in the direction perpendicular to the direction of maximum tension and may deviate from this path due to mechanical fracture *** is significantly channelled through a subset of the fractures in the full domain,consistent with observations of other real and simulated *** the fracture networks grow,small changes in the geometry of the fractures lead to large changes in the locations and scale of primary flow *** flow variability and formation of channels are examined for two growing networks,one with a fixed amount of fractures,and another with nucleating *** interaction between fractures is shown to modify the local stress field,and in turn the aperture of the *** for single-phase flow are the results of hydro-mechanical effects in fracture networks during *** are the results of changes to the topology of the network as well as the result of mechanical self-organisation which occurs during interaction leading to growth and intersection.

关键词： Fracture growth Fracture mechanics Stress intensity factor(SIF) Quasi-static growth Finite elements

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Binding of HIV-1 virions to α_4β_7 expressing cells and impact of antagonizing α_4β_7 on HIV-1 infection of primary CD4^+ T cells

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Virologica Sinica 2014年第6期29卷 381-392页

作者： Chang Li Wei j.n Tao Du Biao Wu Yalan Liu robin j.Shattock Qinxue Hu State Key Laboratory of Virology Wuhan Institute of VirologyChinese Academy of Sciences University of Chinese Academy of Sciences Department of General Surgery Wuhan No.1 Hospital Section of Infectious Diseases Faculty of MedicineImperial College LondonSt.Mary's CampusLondon W21PGUK Institute for Infection and Immunity St George’s University of LondonLondon SW170REUK

HIV-1 envelope glycoprotein is reported to interact with α4β7, an integrin mediating the homing of lymphocytes to gut-associated lymphoid tissue, but the significance of α4β7 in HIV-1 infection remains controversial. Here, using HIV-1 strain Ba L, the gp120 of which was previously shown to be capable of interacting with α4β7, we demonstrated that α4β7 can mediate the binding of whole HIV-1 virions to α4β7-expressing transfectants. We further constructed a cell line stably expressing α4β7 and confirmed the α4β7-mediated HIV-1 binding. In primary lymphocytes with activated α4β7 expression, we also observed significant virus binding which can be inhibited by an anti-α4β7 antibody. Moreover, we investigated the impact of antagonizing α4β7 on HIV-1 infection of primary CD4+ T cells. In α4β7-activated CD4+ T cells, both anti-α4β7 antibodies and introduction of shorthairpin RNAs specifically targeting α4β7 resulted in a decreased HIV-1 infection. Our findings indicate that α4β7 may serve as an attachment factor at least for some HIV-1 strains. The established approach provides a promising means for the investigation of other viral strains to understand the potential roles of α4β7 in HIV-1 infection.

关键词： HIV-1 integrin α4β7 binding infection RNA interference primary CD4+ T cells

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The flattening of spacetime hierarchy of the N,N-dimethyltryptamine brain state is characterized by harmonic decomposition of spacetime(HADES) framework

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National Science Review 2024年第5期11卷 46-55页

作者： j.kub Vohryzek j.ana Cabral Christopher Timmermann Selen Atasoy Leor Roseman David j.Nutt robin L.Carhart-Harris Gustavo Deco Morten L.Kringelbach Centre for Eudaimonia and Human Flourishing Linacre CollegeDepartment of Psychiatry University of Oxford Department of Psychiatry University of Oxford Center for Music in the Brain Aarhus University Center for Brain and Cognition Computational Neuroscience GroupDepartment of Information and Communication TechnologiesUniversitat Pompeu Fabra Life and Health Sciences Research Institute School of MedicineUniversity of Minho ICVS/3B's-PT Government Associate Laboratory Centre for Psychedelic Research Department of Brain Sciences Imperial College London Departments of Neurology and Psychiatry University of California San Francisco Institució Catalana de la Recerca i Estudis Avan?ats (ICREA) Department of Neuropsychology Max Planck Institute for Human Cognitive and Brain Sciences School of Psychological Sciences Monash University

The human brain is a complex system, whose activity exhibits flexible and continuous reorganization across space and time. The decomposition of whole-brain recordings into harmonic modes has revealed a repertoire of gradient-like activity patterns associated with distinct brain functions. However, the way these activity patterns are expressed over time with their changes in various brain states remains unclear. Here, we investigate healthy participants taking the serotonergic psychedelic N,N-dimethyltryptamine(DMT) with the Harmonic Decomposition of Spacetime(HADES) framework that can characterize how different harmonic modes defined in space are expressed over time. HADES demonstrates significant decreases in contributions across most low-frequency harmonic modes in the DMT-induced brain state. When normalizing the contributions by condition(DMT and non-DMT), we detect a decrease specifically in the second functional harmonic, which represents the uni-to transmodal functional hierarchy of the brain,supporting the leading hypothesis that functional hierarchy is changed in psychedelics. Moreover, HADES'dynamic spacetime measures of fractional occupancy, life time and latent space provide a precise description of the significant changes of the spacetime hierarchical organization of brain activity in the psychedelic state.

关键词： spatio-temporal brain dynamics DMT harmonic modes

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New approach for particle size and shape analysis of iron-based oxygen carriers at multiple oxidation states

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Particuology 2024年第7期90卷 493-503页

作者： Victor Purnomo Marcelo Dal Belo Takehara robin Faust Lidiya Abdisa Ej.eta Henrik Leion Division of Energy and Materials Department of Chemistry and Chemical EngineeringChalmers University of TechnologyGöteborg 41258Sweden Division of Energy Science Department of Engineering Sciences and MathematicsLuleåUniversity of TechnologyLuleå97187Sweden

One of the crucial issues in the chemical looping technology lies in its bed material:the oxygen *** size analysis of an oxygen carrier is important since in a fluidized bed the material can only work well within a specific size *** the favorable size ranges for oxygen carrier materials have already been reported,none of the published studies has analyzed the particle size and shape of oxygen carriers in ***,the effect of oxygen carriers'oxidation degree on such properties has not been considered *** study aimed to report the particle size and shape analysis of five iron-based oxygen carriers,one natural ore,one synthetic material,and three residue products,at different oxidation degrees using dynamic image analysis(DIA).The oxygen carriers were prepared at different mass conversion degrees in a fluidized bed batch *** size distribution,sphericity,and aspect ratio of the oxygen carrier particles were examined experimentally using a Camsizer *** results show that the DIA method was successfully able to analyze the particle size and shape of our oxygen carriers with satisfying accuracy for *** oxidation state of the investigated materials seems to only affect the particle size and shape of oxygen carriers to a minor ***,exposures to redox cycles in a fluidized bed reactor may alter the particle size and shape of most oxygen carriers.

关键词： Oxygen carrier Size and shape analysis Dynamic image analysis Oxidation state Fluidized bed Chemical looping

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制造业信息系统多源异构知识集成

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计算机集成制造系统 2004年第7期10卷 732-736,750页

作者：徐琪 robin Qiu 宁夏大学数学计算机学院宁夏银川750021 宾夕法尼亚州立大学信息科学系美国宾夕法尼亚州莫尔文19355

为了实现制造业信息系统中各类多源异构的数据、信息和知识层的集成,提出一个全新的可计算框架体系。通过定义一个应用领域的本体论,明确地定义其领域标准词汇和关系。同时,也形式化地定义一个对本体论具体状态进行详细说明的知识库,由... 详细信息

为了实现制造业信息系统中各类多源异构的数据、信息和知识层的集成,提出一个全新的可计算框架体系。通过定义一个应用领域的本体论,明确地定义其领域标准词汇和关系。同时,也形式化地定义一个对本体论具体状态进行详细说明的知识库,由此建立一个异构源的信息转化为通用的知识表示模型,解决知识集成过程中结构和语义两方面的异构问题。之后,应用资源描述框架模式(RDFS)作为信息和知识的核心转换技术,进行异构知识的转换和映射,实现异构知识集成。

关键词：知识集成异构信息融合资源描述框架集成信息时代制造企业

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Interplays of liver fibrosis-associated microRNAs:Molecular mechanisms and implications in diagnosis and therapy

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Genes & Diseases 2023年第4期10卷 1457-1469页

作者： Hong Li Tingli Liu Yongchun Yang William C.Cho robin j.Flynn Maj.d Fasihi Harandi Houhui Song Xuenong Luo Yadong Zheng State Key Laboratory of Veterinary Etiological Biology Key Laboratory of Veterinary Parasitology of Gansu ProvinceLanzhou Veterinary Research InstituteChinese Academy of Agricultural SciencesLanzhouGansu 730046China Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhej.ang Province Zhejiang Provincial Engineering Laboratory for Animal Health Inspection&Internet TechnologyZhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health ManagementChina-Australia Joint Laboratory for Animal Health Big Data AnalyticsCollege of Animal Science and Technology&College of Veterinary Medicine of Zhejiang A&F UniversityHangzhouZhejiang 311300China Department of Clinical Oncology Queen Elizabeth HospitalHong Kong SAR 999077China Department of Infection Biology Institute of Infection and Global HealthUniversity of LiverpoolLiverpool L35RFUK Graduate Studies Office Department of ResearchInnovation and Graduate StudiesWaterford Institute of TechnologyX91 K0EKIreland Research Center for Hydatid Disease in Iran Kerman University of Medical SciencesKerman ***Iran

microRNAs(miRNAs)are a class of non-coding functional small RNA composed of 21e23 nucleotides,having multiple associations with liver ***-associated miRNAs are roughly classified into pro-fibrosis or anti-fibrosis *** former is capable of activating hepatic stellate cells(HSCs)by modulating pro-fibrotic signaling pathways,mainly including TGF-b/SMAD,WNT/b-catenin,and Hedgehog;the latter is responsible for maintenance of the quiescent phenotype of normal HSCs,phenotypic reversion of activated HSCs(aHSCs),inhibition of HSCs proliferation and suppression of the extracellular matrix-associated gene ***,several miRNAs are involved in regulation of liver fibrosis via alternative mechanisms,such as interacting between hepatocytes and other liver cells via exosomes and increasing autophagy of ***,understanding the role of these miRNAs may provide new avenues for the development of novel interventions against hepatic fibrosis.

关键词： Diagnosis Hepatic stellate cell Liver fibrosis miRNA Therapy

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Handheld bedside ultrasound in the diagnosis of myocarditis

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World j.urnal of Emergency Medicine 2024年第1期15卷 73-74页

作者： Frank Wheeler robin Lahr j.mes Espinosa Alan Lucerna Henry Schuitema Department of Emergency Medicine Rowan University School of Osteopathic MedicineStratford 08084USA Emergency Medicine Residency Program Jeff erson HealthStratford 08084USA Department of Emergency Medicine and Associate Chief Medical Offi cer Stratford 08084USA

Myocarditis is a disease process that every emergency physician fears *** severity can be mild to life-threatening,and many cases are likely undetected because they are subclinical with nonspecifi c signs.[1]Subtle cardiac signs may be overshadowed by systemic symptoms of the underlying infectious ***,myalgias,lethargy,symptoms commonly associated with viral syndrome,can mask the life-threatening myocarditis that may be *** fact,in the United States Myocarditis Treatment Trial,almost 90%of patients reported symptoms consistent with a viral prodrome.[2]Ammirati et al[3]reported that 27%of patients with myocarditis had either reduced left ventricular ej.ction fraction,ventricular arrhythmias,or low cardiac ***,we present a case report,in which handheld point-of-care ultrasound was utilized at the bedside to aid in the critical diagnosis of *** the additional information provided through this imaging modality,this patient was able to be transferred to the appropriate tertiary care facility in an expeditious manner and receive possible defi nitive treatment.

关键词： diagnosis myocarditis Fever

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土地集约利用与城镇化协调发展评价及障碍因子诊断

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农业机械学报 2020年第6期51卷 138-151页

作者：雷勋平 QIU robin 刘晨铜陵学院工商管理学院铜陵244000 宾夕法尼亚州立大学信息科学系马尔委PA19355

为了探究土地集约利用与城镇化的耦合协调关系,促进两者协调发展,以安徽省为例,首先,运用熵权TOPSIS模型,分别评价安徽省2000—2017年土地集约利用与城镇化绩效水平,研判两者的绩效水平及其子系统变化趋势;然后,运用耦合度和协调度模型... 详细信息

为了探究土地集约利用与城镇化的耦合协调关系,促进两者协调发展,以安徽省为例,首先,运用熵权TOPSIS模型,分别评价安徽省2000—2017年土地集约利用与城镇化绩效水平,研判两者的绩效水平及其子系统变化趋势;然后,运用耦合度和协调度模型,基于耦合作用系数的取值变化,探讨不同情形下安徽省土地集约利用与城镇化协调发展关系及变化趋势;最后,运用障碍度模型,诊断影响安徽省土地集约利用与城镇化协调发展的障碍因子。结果表明:2000—2017年,安徽省土地集约利用与城镇化水平均呈逐年上升态势,稳中趋好。2000—2017年安徽省土地集约利用绩效水平从0.0536增至0.9587,年均增长18.49%;安徽省城镇化水平从0.2715增至0.8180,年均增长6.70%。从土地集约利用各子系统来看,经济绩效子系统对土地集约利用的贡献最大,生态绩效子系统对土地集约利用的贡献最小,权重分别为0.3526和0.1308;从城镇化各子系统来看,经济城镇化子系统对城镇化水平影响最大,生态城镇化子系统对城镇化水平影响最小,权重分别为0.4160和0.1377。在不同耦合作用系数取值情形下,安徽省土地集约利用与城镇化协调发展关系变化趋势除2005年和2012年略有不同外,其余16年两者协调发展变化趋势和协调类型完全相同,说明耦合作用系数对两者协调发展关系的影响十分有限。2000—2017年安徽省土地集约利用与城镇化的协调发展度呈逐年增长态势。从各子系统障碍度来看,土地集约利用经济子系统对安徽省土地集约利用与城镇化协调发展的影响最大,年均障碍度为16.48%;生态城镇化子系统对两者协调发展的影响最小,年均障碍度为6.60%。从各指标障碍度来看,2011年及以前,影响两者协调发展的障碍因子主要包括人民生活水平、地均财政收入和人均GDP;2012年及以后,影响两者协调发展的障碍因子主要包括城乡人均可支配收入差距和城镇人口密度。从各年份前5位障碍因子变化来看,各指标对土地集约利用与城镇化协调发展的影响可以分为2个阶段:第1阶段(2000—2013年)以土地集约利用的影响为主,第2阶段(2014—2017年)以城镇化的影响为主。本研究为研判土地集约利用与城镇化协调发展水平及诊断障碍因子提供了新的思路和方法,可为促进安徽省及同类省域土地集约利用与城镇化协调发展提供借鉴。

关键词：安徽省土地集约利用城镇化熵权TOPSIS模型协调发展障碍因子诊断

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Piperazine:Its role in the discovery of pesticides

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Chinese Chemical Letters 2023年第8期34卷 69-75页

作者： Wei Zhang Shengxin Guo Lij.ao Yu Ya Wang Yonggui robin Chi j.an Wu National Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationGuizhou UniversityGuiyang 550025China Division of Chemistry&Biological Chemistry School of Physical&Mathematical SciencesNanyang Technological UniversitySingapore 637371Singapore

Derivatives of piperazine,which is one of the most important heterocycles,are often used as linkers to connect active substructures that show promising bioactivities,especially in the field of *** 2000 to 2022,many piperazine-containing compounds were found to exhibit excellent activities against fungi,bacteria,insects,plant viruses,and weeds and have also been used as plant growth ***,the development of novel pesticides to prevent the invasion of crop pathogens and ensure the quality and yields of crops is still *** herein investigated and summarized the role that piperazine plays in the discovery of pesticides to provide a comprehensive summary of the broad activities of piperazine derivatives in agricultural applications and offer a potential reference for novel pesticide design using piperazine-containing ***,structure–activity relationships(SARs)analyses of bioactive piperazine-containing compounds are also discussed for a deeper understanding.

关键词： Piperazine Innovation of pesticides Activity Research review Structure-activity relationship

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基于熵权TOPSIS模型的区域土地利用绩效评价及障碍因子诊断

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农业工程学报 2016年第13期32卷 243-253页

作者：雷勋平 robin Qiu 刘勇南京航空航天大学经济与管理学院南京210016 铜陵学院工商管理学院铜陵244000 宾夕法尼亚州立大学信息科学系宾夕法尼亚州马尔委19355

定量评估土地利用绩效并诊断其障碍因子,是提高区域土地利用绩效水平的有效途径。该文综合考虑土地利用经济绩效、社会绩效、生态绩效和管理绩效4个子系统,建立区域土地利用绩效评价指标体系,结合熵权TOPSIS模型和障碍度模型,对安徽省近... 详细信息

定量评估土地利用绩效并诊断其障碍因子,是提高区域土地利用绩效水平的有效途径。该文综合考虑土地利用经济绩效、社会绩效、生态绩效和管理绩效4个子系统,建立区域土地利用绩效评价指标体系,结合熵权TOPSIS模型和障碍度模型,对安徽省近15 a(2000—2014年)的土地利用情况进行绩效评价和障碍因子诊断,并基于评价结果,运用GM(1,1)模型对安徽省未来5 a(2015—2019年)土地利用子系统绩效变化态势进行预测和分析。结果表明:安徽省土地利用综合绩效经历了较差—中级—良好—优质的发展过程,结合土地利用绩效的年均增长速度,可以分为绩效较差但高速增长(2000—2004年)、绩效中级但较快增长(2005—2009年)、绩效良好但低速增长(2010—2011年)和绩效优质且快速增长(2008—2014年)4个发展阶段。4个子系统绩效水平基本逐年提升,但变化趋势存在差异,经济绩效和管理绩效呈线性增长态势,社会绩效和生态绩效呈波动起伏变化的上升趋势;未来5 a,经济绩效子系统年均增长速度最快,社会绩效和管理绩效子系统次之,生态绩效子系统增速最慢。经济绩效子系统障碍度最大,其后依次是社会、生态和管理绩效子系统;2000—2008年,建成区工业增加值等3个指标一直稳居前3位,人民生活水平和地均就业人数轮流出现在第4或第5位;2009—2012年,前3位障碍因子发生较大变化,地均财政收入和人民生活水平成为阻碍土地利用绩效的主要因子;2013—2014年,前5位障碍因子变化较大,社会绩效成为制约土地利用绩效的主要子系统,改善人民生活水平、加强公共基础设施建设,探索节约化、集约化、高效化的土地利用方式和模式是提升安徽省土地利用绩效的重要出路;根据GM(1,1)模型预测结果,社会绩效、生态绩效和管理绩效在未来具有广阔的提升空间,安徽省在提高土地利用经济绩效的同时,应关注经济—社会—生态环境友好和谐发展,更加注重土地利用社会绩效、管理绩效特别是生态绩效的提升。该文的研究思路与方法可以为促进区域土地利用绩效提升提供现实依据。

关键词：土地利用熵模型绩效评价障碍度

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