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The effect of introduction of misoprostol for induction of labour on pregnancy in gravidas with pre-eclampsia

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Open Journal of Obstetrics and Gynecology 2011年第2期1卷 64-69页

作者： Horace fletcher Marvin Reid Nadine Johnson 不详

Misoprostol has revolutionized labour induction since the early 1990’s, because it is inexpensive and very effective. Eclampsia is common unless the pregnancy can be terminated by induction or by caesarean section. This study was done to determine the impact of Misoprostol used for induction of labour, on the outcome in patients with pre-eclampsia (PE) at the University of the West Indies Kingston Jamaica. This was a retrospective analysis of pre-eclamptic women who were managed before and after the introduction of misoprostol into routine usage for induction of labour. We compared 793 women (controls) in the pre misoprostol era (1986-1991) with 709 in the misoprostol era (1993-1998). Outcome variables were the frequency of mild and severe PE, eclampsia, misoprostol and syntocinon inductions, foetal complications and use of caesarean section (CS). Analysis of frequency of eclampsia, neonatal admissions and CS, during the misoprostol years, was also done to eliminate other confounding variables because of the influence of each era. Logistic regression was used to determine the impact of all variables. In comparison to controls, patients induced in the misoprostol years had a greater incidence of severe PE (p < 0.05), neonatal admissions (p = 0.007), foetal distress (p < 0.05);a higher CS rate (p < 0.05);but fewer oxytocin inductions (p < 0.05). However, sub group analysis of the misoprostol years alone, showed a reduction in the incidence of CS, eclampsia, and neonatal admissions in women who were induced with misoprostol (p < 0.05). Logistic regression revealed a lower odds of CS delivery (OR 0.867, 95% confidence interval .02, .37) using misoprostol. These findings suggest that in patients with PE, induction of labor with Misoprostol had a beneficial effect on pregnancy outcome with a decreased incidence of CS, eclampsia and neonatal admissions, but it has not had a significant impact on the main problems in these patients between the two eras as other factors may

关键词： Misoprostol Eclampsia Labour Induction

Trithorax Group Proteins Act Together with a Polycomb Group Protein to Maintain Chromatin Integrity for Epigenetic Silencing during Seed Germination in Arabidopsis

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Molecular Plant 2018年第5期11卷 659-677页

作者： Fan Xu Tony Kuo Yenny Rosli Mao-Sen Liu Limin Wu Long-Fang Oliver Chen Jennifer C. fletcher Zinmay Renee Sung Li Pu Biotechnology Research Institute Chinese Academy of Agricultural Sciences Beijing 100081 China Department of Plant and Microbial Biology University of California Berkeley CA 94720 USA Institute of Plant and Microbial Biology Academia Sinica Taipei 11529 Taiwan China College of Life and Environmental Sciences Hangzhou Normal University Hangzhou 310036 China

Polycomb group （PcG） and trithorax group （trxG） proteins have been shown to act antagonistically to epigenetically regulate gene expression in eukaryotes. The trxG proteins counteract PcG-mediated floral repression in Arabidopsis, but their roles in other developmental processes are poorly understood. We investigated the interactions between the trxG genes, ARABIDOPSIS HOMOLOG OF TRITHORAX1 （ATX1） and ULTRAPETALA1 （ULT1）, and the PcG gene EMBRYONIC FLOWER 1 （EMF1） during early development. Unexpectedly, we found that mutations in the trxG genes failed to rescue the early-flowering phenotype of emfl mutants. Instead, emfl atxl ultl seedlings showed a novel swollen root phenotype and massive deregulation of gene expression. Greater ectopic expression of seed master regulatory genes in emfl atxl ultl triple than in emfl single mutants indicates that PcG and trxG factors together repress seed gene expression after germination. Furthermore, we found that the widespread gene derepression is asso- ciated with reduced levels of H3K27me3, an epigenetic repressive mark of gene expression, and with globally altered chromatin organization. EMF1, ATXl, and ULT1 are able to bind the chromatin of seed genes and ULT1 can physically interact with ATX1 and EMF1, suggesting that the trxG and EMF1 proteins directly associate at target gene loci for EMFl-mediated gene silencing. Thus, while ATXl, ULT1, and EMF1 interact antagonistically to regulate flowering, they work together to maintain chromatin integrity and prevent precocious seed gene expression after germination.

关键词： trxG PcG histone modification chromatin integrity seed gene repression

Conservative treatment of unruptured Ectopic pregnancy in Jamaica

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Open Journal of Obstetrics and Gynecology 2011年第1期1卷 6-11页

作者： Horace fletcher Keisha Buchanan Lennox Jacob Department of Obstetrics and Gynaecology University of the West Indies

Medical treatment with methotrexate is now successfully replacing conservative surgical treatment in selected patients. We reviewed patients treated with methotrexate, compared to salpingectomy and salpingostomy between 1990 to 1995 and 2000 to 2003. For 1990-1995 there were 21 conservative surgical treatments (5.3% ectopic pregnancies). The ratio of ectopic to normal deliveries was 1:24. Medical treatment was done for 19 pregnancies (3.4% of ectopic pregnancies) for 2000 to 2003. During the period there was an ectopic rate of 1:16.8 births. Patients treated medically were similar to those treated surgically except that none reportedly having rebound tenderness and only 1/18 having an ultrasound scan showing a foetal heart and none with a gestational sac >4cm. In the medically treated group the success rate was 68% while in the surgically treated groups success was 100%. There was no significant difference in the parameters in the conservative surgical and medically treated

关键词： Conservative treatment ectopic pregnancy methotrexate linear salpingostomy

Epstein-Barr virus infection mechanisms

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Chinese Journal of Cancer 2014年第11期33卷 545-548页

作者： Liudmila S.Chesnokova Lindsey M.Hutt-fletcher Department of Microbiology and Immunology Center for Molecular Tumor Virology and Feist-Weiller Cancer CenterLouisiana State University Health Sciences CenterShreveportLA 71130USA

Epstein-Barr virus(EBV) infection occurs by distinct mechanisms across different cell types. EBV infection of B cells in vitro minimally requires 5 viral glycoproteins and 2 cellular proteins. By contrast, infection of epithelial cells requires a minimum of 3 viral glycoproteins, which are capable of interacting with one or more of 3 different cellular proteins. The full complement of proteins involved in entry into all cell types capable of being infected in vivo is unknown. This review discusses the events that occur when the virus is delivered into the cytoplasm of a cell, the players known to be involved in these events, and the ways in which these players are thought to function.

关键词：病毒感染机制蛋白质相互作用病毒糖蛋白细胞类型细胞蛋白上皮细胞 EBV

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设计/建筑方式及其合同条件

建筑经济 2000年第12期21卷 21-23页

作者：阎长俊 Matthew fletcher 沈阳建工学院 Faculty

加工中国科学家写的英语生物医学研究论文的经验

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编辑学报 1995年第4期 239-241页

作者：钱寿初 ,Cathy fletcher Scientific Officer Infection & Immunity. The Wellcome Trust Infection and Immunity section 183 Euston Road London

为了认识中国生物医学科学家写英语研究论文所碰到的主要问题,找到解决这些问题的途径,由英语为母语的科学家加工190篇论文,并分析写作中的错误。作者均讲国语(汉语普通话)和英语。加工过的稿件退给作者,并同他们用英语讨论。许多论文... 详细信息

为了认识中国生物医学科学家写英语研究论文所碰到的主要问题,找到解决这些问题的途径,由英语为母语的科学家加工190篇论文,并分析写作中的错误。作者均讲国语(汉语普通话)和英语。加工过的稿件退给作者,并同他们用英语讨论。许多论文写得不够清楚。写作问题有两类:文章组织结构和英语语法。突出的是论文摘要结构不当,结果部分写作混乱。几乎每篇文章有语法错误,包括定冠词与不定冠词误用、动词时态错误、名词单复数不分。同作者讨论修改内容,许多作者知道动词时态、冠词误用,但不明白与数一致相关的模糊和准确问题。中国科学家写英语论文存在结构问题,英语语言学方面特殊障碍。解决办法是编辑同作者一起讨论加工过的稿子。

关键词：英语动词时态不定冠词语法错误生物医学研究中华人民共和国

A TDG/CBP/RARα Ternary Complex Mediates the Retinoic Acid-dependent Expression of DNA Methylation-sensitive Genes

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Genomics, Proteomics & Bioinformatics 2014年第1期12卷 8-18页

作者： Hélène Léger Caroline Smet-Nocca Amel Attmane-Elakeb Sara Morley-fletcher Arndt G.Benecke Sebastian Eilebrecht Vaccine Research Institute INSERM U955Institut Mondor de Recherche Biomédicale Institut des Hautes tudes Scientifiques Unité de Glycobiologie Structurale et Fonctionnelle–CNRS UMR 8576 Group of NMR and Structural BiologyUniversité Lille 1 Unité de Glycobiologie Structurale et Fonctionnelle–CNRS UMR 8576 Neuroplasticity TeamUniversité Lille 1 CNRS UMR 7224 Université Pierre et Marie Curie

The thymine DNA glycosylase （TDG） is a multifunctional enzyme,which is essential for embryonic *** mediates the base excision repair （BER） of G：T and G：U DNA mismatches arising from the deamination of 5-methyl cytosine （5-MeC） and cytosine,*** studies have pointed at a role of TDG during the active demethylation of 5-MeC within CpG *** interacts with the histone acetylase CREB-binding protein （CBP） to activate CBP-dependent *** addition,TDG also interacts with the retinoic acid receptor α （RARα）,resulting in the activation of RARα target *** we provide evidence for the existence of a functional ternary complex containing TDG,CBP and activated RARα.Using global transcriptome profiling,we uncover a coupling of de novo methylation-sensitive and RA-dependent transcription,which coincides with a significant subset of CBP target *** introduction of a point mutation in TDG,which neither affects overall protein structure nor BER activity,leads to a significant loss in ternary complex stability,resulting in the deregulation of RA targets involved in cellular networks associated with DNA replication,recombination and *** thus demonstrate for the first time a direct coupling of TDG＇s epigenomic and transcription regulatory function through ternary complexes with CBP and RARα.

关键词： CREB-binding protein Thymine DNA glycosylase Retinoic acid receptor α Transcription regulation Cytosine DNA methylation Epigenomics

Fraud Detection and Prevention:A Review of the Latest Developments in ***

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Journal of Modern Accounting and Auditing 2021年第1期17卷 1-13页

作者： Neil fletcher Ifedapo Francis Awolowo Nigel Garrow Finance Accounting and Business System Sheffield Hallam UniversitySheffieldUnited Kingdom

Proposed reforms to *** are reviewed from a fraud detection and prevention perspective.A holistic four-actor model that encompasses:the directors,auditor,shareholders,and the regulator,is used to frame the *** is drawn to the mediating role of the Audit and Assurance *** paper argues that the proposed reforms have some potential to reduce the audit expectations ***,the problem of agency costs and the advisory nature of shareholder voting on the Audit and Assurance Policy significantly limit the possible effectiveness of the reforms from a fraud detection and prevention *** for future research are made.

关键词： fraud audit expectations gap agency costs corporate governance advisory voting

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多形核中性粒细胞的获得性异常

国外医学（输血及血液学分册） 1991年第3期14卷 162-164页

作者： fletcher J 金任天

现今对中性多形核粒细胞(PMN)功能的了解多来自对健康人的体外实验,体内的情况常限于推论,疾病时PMN功能的改变可能仍属于生理性范畴,但本文作为“异常”而加以描述。在体外,PMN可被受调理素作用的颗粒或可溶性物质,如来自细胞壁的FMLP... 详细信息

现今对中性多形核粒细胞(PMN)功能的了解多来自对健康人的体外实验,体内的情况常限于推论,疾病时PMN功能的改变可能仍属于生理性范畴,但本文作为“异常”而加以描述。在体外,PMN可被受调理素作用的颗粒或可溶性物质,如来自细胞壁的FMLP(甲酰-甲硫氨酰-亮氨酰-苯丙氨酸)和C5 des arg(去精氨酸C5)

关键词： PMN 多形核粒细胞获得性异常