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Science China Chemistry 2021年第6期64卷 985-990页

作者： Jie Lv Jun Xu Xuling Pan Zhichao Jin Yonggui robin Chi State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationGuizhou UniversityGuiyang 550025China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Division of Chemistry&Biological Chemistry School of Physical&Mathematical SciencesNanyang Technological UniversitySingapore 637371Singapore

An N-heterocyclic carbene(NHC)-catalyzed enantioselective Mannich reaction of the remoteγ-carbon of cyclopropylcarbaldehydes is disclosed for the first ***-and enantiomerically enriched multicyclicδ-lactam compound is afforded as the main product from 8 possible stereo-specific isomers through dynamic kinetic asymmetric transformation(DYKAT)*** chiral functional molecules can be afforded from the lactam products through simple protocols with retentions of the optical purities.

关键词： N-heterocyclic carbene organocatalysis dynamic kinetic asymmetric transformation 1-cyclopropylcarbaldehydes asymmetric reactions

Exercise and hippocampal neurogenesis: a dogma re-examined and lessons learned

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Neural Regeneration Research 2018年第8期13卷 1354-1355页

作者： Patrick Z.Liu robin Nusslock Department of Psychology Northwestern University

Exercise is a potent force of nature with significant potential for extending longevity and boosting physical fitness. It is also be- ing increasingly used as a prophylactic and curative measure for various physical a... 详细信息

关键词： a dogma re-examined and lessons learned Exercise and hippocampal neurogenesis

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解读贝努:星际快递启封

环球科学 2024年第17期 38-43页

作者：罗宾·乔治·安德鲁斯陈子鹏(翻译) 不详

陨石是来自时间深处的信使。它们是剥离自小行星或彗星的碎片,与我们的太阳同龄,是由同一批更早的原材料形成的。但是它们携带的信息一旦与地球相遇便会分崩离析,它们会和大气层剧烈摩擦、燃烧变质,再被地球上纷乱复杂的环境所污染。

关键词：小行星陨石彗星大气层

Changing face of hepatic encephalopathy:Role of inflammation and oxidative stress

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World Journal of Gastroenterology 2010年第27期16卷 3347-3357页

作者： Amit S Seyan robin D Hughes Debbie L Shawcross Institute of Liver Studies King's College London School of Medicine at King's College HospitalKing's College Hospital

The face of hepatic encephalopathy(HE) is *** review explores how this neurocognitive disorder,which is associated with both acute and chronic liver injury,has grown to become a dynamic syndrome that spans a spectrum of neuropsychological impairment,from normal performance to *** central role of ammonia in the pathogenesis of HE remains ***,over the past 10 years,the HE community has begun to characterise the key roles of inflammation,infection,and oxidative/nitrosative stress in modulating the pathophysiological effects of ammonia on the *** review explores the current thoughts and evidence base in this area and discusses the potential role of existing and novel therapies that might abrogate the oxidative and nitrosative stresses inflicted on the brain in patients with,or at risk of developing,HE.

关键词： Hepatic encephalopathy Ammonia Inflammation Oxidative stress Astrocyte

Unexpectedly large energy variations from dopant interactions in ferroelectric HfO_(2) from high-throughput ab initio calculations

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npj Computational Materials 2018年第1期4卷 45-53页

作者： Max Falkowski Christopher Künneth robin Materlik Alfred Kersch Munich University of Applied Sciences Lothstr.3480335 MunichGermany

Insight into the origin of process-related properties like small-scale inhomogeneities is key for material ***,we analyze DFT calculations of randomly doped HfO_(2) structures with Si,La,and VO and relate them to the kind of production *** energies of the relevant ferroelectric Pbc2_(1) phase are compared with the competing crystallographic phases under the influence of the arising local inhomogeneities in a coarse-grained *** interaction among dopants adds to the statistical effect from the random positioning of the *** anneals after atomic layer or chemical solution deposition processes,which are short compared to ceramic process tempering,the large energy variations remain because the dopants do not *** the energy difference is the criterion for the phase stability,the large variation suggests the possibility of nanoregions and diffuse phase transitions because these local doping effects may move the system over the paraelectric-ferroelectric phase boundary.

关键词： ferroelectric dopant grain

The Anomalous Mei-yu Rainfall of Summer 2020 from a Circulation Clustering Perspective:Current and Possible Future Prevalence

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Advances in Atmospheric Sciences 2021年第12期38卷 2010-2022,I0002-I0008页

作者： robin T.CLARK Peili WU Lixia ZHANG Chaofan LI Met Office Hadley Centre FitzRoy RoadExeter EX13PBUK LASG Institute of Atmospheric Physics(IAP)Chinese Academy of SciencesBeijing 100029China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science&TechnologyNanjing 210044China Center for Monsoon System Research Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China

Highly unusual amounts of rainfall were seen in the 2020 summer in many parts of China,Japan,and South *** the intercontinental scale,case studies have attributed this exceptional event to a displacement of the climatological western North Pacific subtropical anticyclone,potentially associated Indian Ocean sea surface temperature patterns and a mid-latitude wave train emanating from the North *** clusters of spatial patterns of sea level pressure,we show that an unprecedented 80%of the 2020 summer days in East Asia were dominated by clusters of surface pressure greater than normal over the South China *** examining the rainfall and water vapor fluxes in other years when these clusters were also prevalent,we find that the frequency of these types of clusters was likely to have been largely responsible for the unusual rainfall of *** two ensembles of future climate projections,we show that summers like 2020 in East Asia may become more frequent and considerably wetter in a warmer world with an enhanced moisture supply.

关键词： circulation clustering mei-yu front 2020 summer rainfall climate projections

Hydro-mechanical interaction effects and channelling in threedimensional fracture networks undergoing growth and nucleation

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Journal of Rock Mechanics and Geotechnical Engineering 2020年第4期12卷 707-719页

作者： Adriana Paluszny robin NThomas Maria CSaceanu Robert WZimmerman Department of Earth Science and Engineering Imperial College LondonLondonSW72AZUK

The flow properties of geomechanically generated discrete fracture networks are examined in the context of *** networks are generated by growing fractures in tension,modelling the low permeability rock as a linear elastic *** are modelled as discrete surfaces which grow quasi-statically within a three-dimensional(3D)*** may have their locations specified as a simulation input,or be generated as a function of damage,quantified using the local variation in equivalent *** properties of the grown networks are shown to be a product of in situ stress,relative orientation of initial flaws,and competitive process of fracture interaction and *** grow preferentially in the direction perpendicular to the direction of maximum tension and may deviate from this path due to mechanical fracture *** is significantly channelled through a subset of the fractures in the full domain,consistent with observations of other real and simulated *** the fracture networks grow,small changes in the geometry of the fractures lead to large changes in the locations and scale of primary flow *** flow variability and formation of channels are examined for two growing networks,one with a fixed amount of fractures,and another with nucleating *** interaction between fractures is shown to modify the local stress field,and in turn the aperture of the *** for single-phase flow are the results of hydro-mechanical effects in fracture networks during *** are the results of changes to the topology of the network as well as the result of mechanical self-organisation which occurs during interaction leading to growth and intersection.

关键词： Fracture growth Fracture mechanics Stress intensity factor(SIF) Quasi-static growth Finite elements

Geographical inhomogeneity and temporal variability of mixing property and driving mechanism in the Arctic Ocean

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Journal of Oceanology and Limnology 2022年第3期40卷 846-869页

作者： Jia YOU Zhenhua XU robin ROBERTSON Qun LI Baoshu YIN CAS Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of SciencesQingdao 266071China Pilot National Laboratory for Marine Science and Technology(Qingdao) Qingdao 266237China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China CAS Engineering Laboratory for Marine Ranching Institute of OceanologyChinese Academy of SciencesQingdao 266071China China-Asean College of Marine Science Xiamen University MalaysiaSepang 43900Malaysia MNR Key Laboratory for Polar Science Polar Research Institute of ChinaShanghai 200120China

Upper ocean mixing plays a key role in the atmosphere-ocean heat transfer and sea ice extent and thickness via modulating the upper ocean temperatures in the Arctic *** of diffusivities in the Arctic that directly indicate the ocean mixing properties are ***,the spatiotemporal pattern and magnitude of diapycnal diffusivities and kinetic energy dissipation rates in the upper Arctic Ocean are important for atmosphere-ocean heat transfers and sea ice *** were first estimated from the Ice-Tethered Profilers dataset(2005–2019)using a strain-based fine-scale *** resultant mixing properties showed signifi cant geographical inhomogeneity and temporal *** diff usivities and dissipation rates in the Atlantic sector of the Arctic Ocean were stronger than those on the Pacific *** in the Atlantic sector increased significantly during the observation period;whereas in the Pacific sector,it weakened before 2011 and then *** impact factors include wind,sea ice,near inertial waves,and stratifi cation,while their relative contributions vary between the two sectors of the Arctic *** the Atlantic sector,turbulent mixing dominated,while in the Pacific sector,turbulent mixing was inhibited by strong stratification prior to 2011,and is able to overcome the stratifi cation gradually after *** vertical turbulent heat fl ux constantly increased in the Atlantic sector year by year,while it decreased in the Pacific sector post *** estimated heat flux variability induced by enhanced turbulent mixing is expected to continue to diminish sea ice in the near future.

关键词： mixing the Arctic Ocean near-inertial waves stratification heat flux

The positive and negative emotion functions related to loneliness:a systematic review of behavioural and neuroimaging studies

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Psychoradiology 2023年第1期3卷 118-134页

作者： Qianyi Luo robin Shao Department of Clinical Psychology The Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510370P.R.China Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China Guangzhou Medical UniversityGuangzhou 511436P.R.China Department of Affective Disorder The Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 511370P.R.China

Loneliness is associated with high prevalences of major psychiatric illnesses such as major ***,the underlying emotional mechanisms of loneliness remained *** hypothesized that loneliness originates from both decreases in positive emotional processing and increases in negative emotion *** test this,we conducted a systematic review of 29 previous studies(total participants n=19560,mean age=37.16 years,female proportion=59.7%),including 18 studies that included ques-tionnaire measures of emotions only,and 11 studies that examined the brain correlates of *** main findings were that loneliness was negatively correlated with general positive emotions and positively correlated with general negative ***-thermore,limited evidence indicates loneliness exhibited negative and positive correlations with the brain positive(*** striatum)and negative(***)emotion systems,respectively,but the sign of correlation was not entirely ***,loneli-ness was associated with the structure and function of the brain emotion regulation systems,particularly the prefrontal cortex,but the direction of this relationship remained *** concluded that the existing evidence supported a bivalence model of lone-liness,but several critical gaps existed that could be addressed by future studies that include adolescent and middle-aged samples,use both questionnaire and task measures of emotions,distinguish between general emotion and social emotion as well as between positive and negative emotion regulation,and adopt a longitudinal design that allows us to ascertain the causal relationships between loneliness and emotion *** findings provide new insights into the underlying emotion mechanisms of loneliness that can inform interventions for lonely individuals.

关键词： loneliness positive emotion negative emotion emotion regulation social emotion striatum prefrontal cortex

Ergodic switching control for diffusion-type processes

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Probability, Uncertainty and Quantitative Risk 2023年第1期8卷 53-74页

作者： Jose-Luis Menaldi Maurice robin Department of Mathematics Wayne State UniversityDetroitMI 48202USA Fondation Campus Paris-Saclay 91190 Saint-AubinFrance

We consider the control of the diserete component n_(t)of a owitching Markov proceaa x_(t)=(z_(t),n_(t))when there ia a running cost and an immediate coat c(i,j)for owitching n_(t)from i to *** satudy the minimization of the ergodic(or long-term average)total ***,this paper trento the cnce where,for n_(t)=n fixed,z_(t)ia a reflected diffusion or a reflected diffusion with jumps,nt being,for fixed z,a continuous-time Markov *** the vanishing discount appronch,we exctend existing reoulta dealing with the situation where nt evolvea only by the switching control action and the diffusion is ***,we solve the ergodic problem for a claso of diffusiono which can be degenerate and for an example with aboorbing atate.

关键词： Markov–Feller processes Information constraints Switching control Impulse control Control by interventions Ergodic control