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Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease

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World journal of Gastroenterology 2015年第35期21卷 10080-10090页

作者： john j Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR thomson M Tom Clandinin Alberta Institute for Human Nutrition University of Alberta Edmonton AB T6G 2R1 Canada Department of Laboratory Medicine and Pathology University of Alberta Edmonton AB T6G 2B7 Canada Division of General Surgery University of Alberta Edmonton AB T6G 2B7 Canada Alberta Health Services Edmonton AB T6G 2B7 Canada Alberta Health Services Calgary AB T2N 4N2 Canada Division of Gastroenterology Western University London ON N6A 5A5 Canada Department of Medicine University of Alberta Edmonton AB T6G 2B7 Canada

AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold

关键词： Ganglioside Phospholipid Fatty acid Lipid Inflamma

Infant male circumcision: An evidence-based policy statement

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Open journal of Preventive Medicine 2012年第1期2卷 79-92页

作者： Brian j. Morris Alex D. Wodak Adrian Mindel Leslie Schrieber Karen A. Duggan Anthony Dilley robin j. Willcourt Michael Lowy David A. Cooper Eugenie R. Lumbers C. Terry Russell Stephen R. Leeder School of Medical Sciences and Bosch Institute The University of Sydney Sydney Australia

Here we review the international evidence for benefits and risks of infant male circumcision (MC) and use this to develop an evidence-based policy statement for a developed nation setting, focusing on Australia. Evidence from good quality studies that include meta-analyses and randomized controlled trials showed that MC provides strong protection against: urinary tract infections and, in infancy, renal parenchymal disease;phimosis;paraphimosis;balanoposthitis;foreskin tearing;some heterosexually transmitted infections including HPV, HSV-2, trichomonas, HIV, and genital ulcer disease;thrush;inferior hygiene;penile cancer and possibly prostate cancer. In women, circumcision of the male partner protects against HPV, HSV-2, cervical cancer, bacterial vaginosis, and possibly Chlamydia. MC has no adverse effect on sexual function, sensitivity, penile sensation or satisfaction and may enhance the male sexual experience. Adverse effects are uncommon (<1%), and virtually all are minor and easily treated. For maximum benefits, safety, convenience and cost savings, MC should be performed in infancy and with local anesthesia. A risk-benefit analysis shows benefits exceed risks by a large margin. Over their lifetime up to half of uncircumcised males will suffer a medical condition as a result of retaining their foreskin. The ethics of infant MC and childhood vaccination are comparable. Our analysis finds MC is beneficial, safe and cost-effective, and should optimally be performed in infancy. In the interests of public health and individual wellbeing, adequate parental education, and steps to facilitate access and affordability should be encouraged in developed countries.

关键词： Male Circumcision Public Health Infant Infections Sexually Transmitted Infections Cervical Cancer

A Novel LNP-Based <i>Chlamydia</i>Subunit Vaccine Formulation That Induces Th1 Responses without Upregulating IL-17 Provides Equivalent Protection in Mice as Formulations That Induced IL-17 and Th1 Cytokines

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World journal of Vaccines 2020年第4期10卷 55-75页

作者： Melissa A. Boddicker robin M. Kaufhold Kara S. Cox Bob j. Lucas jinfu Xie Deborah D. Nahas Sinoeun Touch Amy S. Espeseth Kalpit A. Vora julie M. Skinner Department of Infectious Diseases/Vaccines Merck & Co. Inc. West Point PA USA

We evaluated novel Chlamydial vaccines, consisting of major outer membrane protein (MOMP) alone or in combination with polymorphic membrane proteins D (PmpD) and G (PmpG) using a C57BL/6 mouse model. Native MOMP (nMOMP) isolated from C. muridarum elementary bodies (EBs) and recombinant PmpD and PmpG proteins were adjuvanted with Monophosphoryl lipid A (MPLA), with either lipid nanoparticles (LNPs) or the cationic lipid dimethyldioctadecylammonium bromide (DDA). Antibody titers to C. muridarum nMOMP, and EBs were evaluated by ELISA, and T-cell responses were analyzed by intracellular cytokine staining (ICS). Protection from challenge was determined by qPCR. Vaccine immunized mice showed significantly higher antibody titers to nMOMP (P C. muridarum EBs (P juvant alone group. Antibody titers in vaccine groups with Monophosphoryl lipid A (MPLA) + LNP were higher as compared to the MPLA + DDA group (P C. muridarum EBs and PmpG. ICS analysis showed more robust CD4 + T-cell responses (IFN-γ/IL-2/TNF-a) in the DDA and LNP groups compared to the adjuvant alone group. The DDA + MPLA gave robust Th17 responses in comparison to MPLA and LNP group. Mice immunized with Chlamydia antigens also showed protection from C. muridarum challenge, by reduction in bacterial shedding for all groups (P juvant control. Both vaccine formulations generated robust immunological responses, and both were protective by reducing bacterial shedding after challenge. This data indicates equal protection can be achieved without the induction of Th17 responses.

关键词： LNP Chlamydia IL-17 Mouse Model Th1 Cytokines

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二氧化碳地质捕获与储存面临的水挑战

水文地质工程地质技术方法动态 2011年第1期 102-110页

作者： robin L. Newmark Samuel j. Friedmann 赵玉军（翻译）孙建平（校对） National Renewable Energy Laboratory MS 1713 1617 Cole Boulevard Golden CO 80401 USA Lawrence Livermore National Laboratory P.O. Box 808 7000 East Avenue Livermore CA 94551 USA 不详

人们建议，二氧化碳捕获与储存（CCS）足一种能够显著减少由于持续化石燃料使用所产生的温室气体排放的手段。对于地质储存晒言，从人规模点源（例如发电厂或其他工业）捕获二氧化碳，再把捕获的二氧化碳输送到注入场地，并注入到深部... 详细信息

人们建议，二氧化碳捕获与储存（CCS）足一种能够显著减少由于持续化石燃料使用所产生的温室气体排放的手段。对于地质储存晒言，从人规模点源（例如发电厂或其他工业）捕获二氧化碳，再把捕获的二氧化碳输送到注入场地，并注入到深部岩层储存。这将面临者新的用水挑战，例如在能源开发利用中的用水量以及水利用的“捕获代价”。在特定深度，咸水在地层中运移，而二氧化碳注入可导致储层压力增大，且二氧化碳泄漏对储层具有潜在影响。在潜在影响的范围内，从捕获增大需水量到泄漏或咸水运移造成地下水污染。了解这些潜在影响及其发生条件，以狄得适当监测与控制措施的设计与执行方案，这对于确保环境安全和统计口的而言足十分重要的。二氧化碳捕获与储存也可带来潜在利益，例如水处理与同时开采既可以抵消储层增大的压力，也可以供水。

关键词：二氧化碳捕获与储存地下水资源

Flow characteristics in a parallel-plate porous channel under convective boundary conditions and triple diffusion for the non-Darcy porous matrix

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Propulsion and Power Research 2021年第4期10卷 396-411页

作者： j.C.Umavathi Department of Mathematics Gulbarga UniversityGulbarga585106KarnatakaIndia

This article inspects the effect of triple diffusion in a vertical conduit encapsulated with porous matrix and subjected to third kind boundary *** kind boundary condition is a combination of Dirichlet and Neumann boundary conditions which specifies a linear combination of function and its derivative values on the *** chemical reaction along with viscous and Darcy dissipation effects are *** the Boussinesq approximation,the soultal buoyancy effects due to concentration gradients of the dispersed components are taken into *** suitable transformations,the conservation equations are reduced into dimensionless form and the dimensionless parameters evolved are thermal Grashof number (0≤Λ_(1)≤20),solutal Grashof number(for species 1 and 2,0≤Λ_(2);Λ_(3)≤20),porous (2≤σ≤8) and inertial parameters (0≤Ι≤6),Biot numbers(at the left and right walls,1≤Bi_(1);Bi_(2)≤10),Brinkman number (0≤Br≤1),Schmidt numbers (0≤Sc_(1);Sc_(2)≤6),Soret numbers (Sr_(1) =Sr_(2) =1) and temperature difference ratio (R_(T) = 1).Adopting perturbation technique,the analytical solutions which are applicable only when the Brinkman number is less than one is *** for any values of the Brinkman number,Runge-Kutta shooting method is *** impact of selected parameters on the momentum,heat and dual species concentration fields are presented in the form of *** solutions computed by numerical method are justified by comparing with the analytical *** numerical and analytical solutions are equal in the absence of Darcy and viscous dissipations and the discrepancy advances as the Brinkman number *** the solutions obtained are also justified by comparing the results with Zanchini[1]in the absence of chemical reaction for clear *** thermal field is augmented with the Brinkman number for symmetric and asymmetric Biot *** the profiles are highly distinct at the cold plate for unequal Biot numbers

关键词： Mixed convection robin boundary conditions Darcy-Forchheimer-Brinkman model Soret number Runge-Kutta shooting method

制约天然金刚石的形成深度:基于机器学习的多硅石榴子石压力计

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矿物岩石地球化学通报 2021年第4期40卷 957-957页

作者： thomson A R Kohn S C Prabhu A Walter M j 夏群科(编译) 不详

石榴子石的化学成分会随压力的变化而改变,因此石榴子石就成为制约金刚石形成深度的重要矿物。基于石榴子石,尤其是多硅石榴子石的成分和压力关系,人们发现了一系列来自岩石圈以下深度的金刚石。这些超深金刚石及其包裹体是了解深部地... 详细信息

石榴子石的化学成分会随压力的变化而改变,因此石榴子石就成为制约金刚石形成深度的重要矿物。基于石榴子石,尤其是多硅石榴子石的成分和压力关系,人们发现了一系列来自岩石圈以下深度的金刚石。这些超深金刚石及其包裹体是了解深部地幔物质组成的唯一直接样品。但是,将已知压力和成分的多硅石榴子石实验结果和前人提出的经典公式进行比较,发现经典公式得出的深度存在高达±10 GPa的误差。

关键词：石榴子石天然金刚石机器学习经典公式形成深度压力计化学成分包裹体

二次脑创伤对鼠脑EAA、TXA2及PGI2代谢的影响及意义

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二次脑创伤对鼠脑EAA、TXA2及PGI2代谢的影响及意义

Delayed diagnosis of isolated alar ligament rupture:A case report

“科技增强国力，青年开创未来——携手走向辉煌的新世纪”中国科协第三届青年学术年会

作者：费舟章翔易声禹 I.R.Piper D.thomson j.D.Miller 第四军医大学西京医院神经外科英国爱丁堡大学临床神经科学研究所

目的是探讨合并二次脑创伤如低血压或高热时鼠脑海马细胞外液兴奋性氨基酸(EAA)与皮层血栓素A(TXA)、前列环素(PGI)含量变化及意义。在大鼠加速性弥漫性脑损伤模型基础上,造成低血压及高热形成二次脑创伤,32只SD大鼠随机分为假手术对照... 详细信息

目的是探讨合并二次脑创伤如低血压或高热时鼠脑海马细胞外液兴奋性氨基酸(EAA)与皮层血栓素A(TXA)、前列环素(PGI)含量变化及意义。在大鼠加速性弥漫性脑损伤模型基础上,造成低血压及高热形成二次脑创伤,32只SD大鼠随机分为假手术对照、脑损伤、二次脑创伤及脑损伤并二次脑创伤4组。在二次创伤后1h检测EAA含量,4h断头处死大鼠检测TXA与PGI含量。结果:与假手术组对比,单纯二次脑创伤组有EAA及PGI含量增高(P<0.05);合并二次脑创伤组EAA、TXA及PGI含量均显著增高(P<0.05)。结论:单纯二次脑创伤组PGI这个脑保护剂含量增加,可能与参予脑损伤修复有关。在合并二次脑创伤组,EAA、TXA及PGI含量均增高提示其参予加重原发性脑损伤。

关键词：脑损伤兴奋性氨基酸血栓素A2 前列环素低血压高热

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World journal of Radiology 2015年第10期7卷 357-360页

作者： robin A Kaufmann Ingo Marzi Thomas j Vogl Department of Diagnostic and Interventional Radiology University Hospital FrankfurtGoethe University Department of Trauma Hand and Reconstructive SurgeryUniversity Hospital FrankfurtGoethe University

Ligament disruptions at the craniovertebral junction are typically associated with atlantoaxial rotatory dislocation during upper cervical spine injuries and require external orthoses or surgical stabilization. Only in few patients isolated ruptures of the alar ligament have been reported. Here we present a further case, in which the diagnosis was initially obscured by a misleading clinical symptomatology but finally established six month following the trauma, demonstrating the value of contrast-enhanced high resolution 3 Tesla magnetic resonance imaging in identifying this particular lesion.

关键词： Alar ligament rupture Cervical spine injury Contra

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健康领域的文化能力

中国卫生政策研究 2016年第2期9卷 71-78页

作者： Napier A D Ancarno C Butler B Calabrese j Chater A Chatterjee H Guesnet F Home R jacyna S jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen j.thomson L Tyler N Volkmann A M Walker T Watson j Williams AC Willott C Wilson j Woolf K 伦敦大学学院英国伦敦WC1E6BT 伦敦国王学院英国伦敦WC2R2LS 贝德福特大学英国贝德福特LV13JV 国际长寿中心英国伦敦SW1P3QB

1背景尽管人类对其他社会的兴趣纵贯历史的各个阶段，但是检验不同文化概念对人类健康实践的影响从20世纪才开始，当时是伴随着长期的人类学田野调查产生的，这些田野调查揭露了不同文化之间相关卫生实践的多样性、复杂性和连续性。

关键词：文化能力人类健康人类学多样性连续性复杂性调查