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Atypical group 1 neuraminidase pH1N1-N1 bound to a group 1 inhibitor

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Protein & Cell 2015年第10期6卷 771-773页

作者： Ying Wu Christopher j. Vavricka Yan Wu Qina Li Santosh Rudrawar robin j.thomson Mark yon Itzstein George F. Gao jianxun Qi CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences Beijing 100101 China Institute for Glycomics Griffith University Gold Coast Campus Nathan QLD 4222 Australia

Influenza virus is a member of the Orthomyxoviridae family and is the causative agent of seasonal and pandemic flu.

关键词： Influenza Influenza Virus Oseltamivir Plaque Reduction Assay I149V Mutant

High-speed silicon photonic electro-optic Kerr modulation

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Photonics Research 2024年第1期12卷 51-60页

作者： jONATHAN PELTIER WEIWEI ZHANG LEOPOLD VIROT CHRISTIAN LAFFORGUE LUCAS DENIEL DELPHINE MARRIS-MORINI GUY AUBIN FARAH AMAR DENH TRAN XINGZHAO YAN CALLUM G.LITTLEjOHNS CARLOS ALONSO-RAMOS KE LI DAVID j.thomson GRAHAM REED LAURENT VIVIEN University Paris-Saclay CNRSCentre for Nanoscience and Nanotechnology(C2N)Palaiseau 91120France University Grenoble Alpes CEALETIGrenoble 38000France Optoelectronics Research Centre Zepler Institute for Photonics and NanoelectronicsFaculty of Engineering and Physical SciencesUniversity of SouthamptonSouthampton SO171BJUK

Silicon-based electro-optic modulators contribute to easing the integration of high-speed and low-power consumption circuits for classical optical communications and data *** the plasma dispersion modulation,an alternative solution in silicon is to exploit the DC Kerr effect,which generates an equivalent linear electro-optical effect enabled by applying a large DC electric *** some theoretical and experimental studies have shown its existence in silicon,limited contributions relative to plasma dispersion have been achieved in high-speed modulation so *** paper presents high-speed optical modulation based on the DC Kerr effect in silicon PIN *** contributions of both plasma dispersion and Kerr effects have been analyzed in different waveguide configurations,and we demonstrated that the Kerr induced modulation is dominant when a high external DC electric field is applied in PIN ***-speed optical modulation response is analyzed,and eye diagrams up to 80 Gbit/s in NRZ format are obtained under a *** of 30 *** work paves the way to exploit the Kerr effect to generate high-speed Pockels-like optical modulation.

关键词： waveguide dispersion effect

Treatment and prevention of epilepsy in onchocerciasis-endemic areas is urgently needed

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Infectious Diseases of Poverty 2024年第1期13卷 85-89页

作者： Robert Colebunders joseph Nelson Siewe Fodjo Olivia Kamoen Luis-jorge Amaral Amber Hadermann Chiara Trevisan Mark j.Taylor julia Gauglitz Achim Hoerauf Yasuaki Sato Katja Polman Maria-Gloria Basanez Dan Bhwana thomson Lakwo Gasim Abd-Elfarag Sebastien D.Pion Global Health Institute University of AntwerpAntwerpBelgium Department of Neurology Heilig Hart ZiekenhuisLierBelgium Department of Public Health Institute of Tropical MedicineAntwerpBelgium Liverpool School of Tropical Medicine LiverpoolUK Department of Computer Science University of AntwerpAntwerpBelgium Institute of Medical Microbiology Immunology and ParasitologyUniversity Hospital BonnBonnGermany German Center for Infection Research(DZIF) Partner Site Bonn-CologneBonnGermany School of Global Humanities and Social Sciences Nagasaki UniversityNagasakiJapan MRC Centre for Global Infectious Disease Analysis and London Centre for Neglected TropicalDisease Research Department of Infectious Disease EpidemiologySchool of Public HealthImperial College LondonLondonUK National Institute for Medical Research TangaTanzania Vector Control Division Ministry of HealthKampalaUganda School of Public Health University of JubaJubaSouth Sudan Access for Humanity JubaSouth Sudan French National Research Institute for Sustainable Development MontpellierFrance

Background There is increasing epidemiological evidence supporting the association between onchocerciasis and seizures, reinforcing the concept of onchocerciasis-associated epilepsy (OAE). The aim of this paper is to provide an update on the new knowledge about OAE and to propose recommendations to the World Health Organization how to address this public health *** text During the 2nd International Workshop on OAE held on 19-21 September, 2023, in Antwerp, Belgium, participants recognised OAE as a substantial yet neglected public health problem, particularly in areas of sub-Saharan Africa where onchocerciasis remains hyperendemic. Evidence from prospective population-based studies suggest that strengthening onchocerciasis elimination efforts leads to a significant reduction of OAE incidence. There is a need to validate an OAE case definition to estimate the burden of disease and identify onchocerciasis-endemic areas requiring intensification of onchocerciasis elimination programmes and integration of epilepsy care. It is expected that raising awareness about OAE will boost the population uptake of ivermectin. The implementation of a community-based epilepsy treatment programme offering free anti-seizure medications (ASMs) has shown high effectiveness in reducing the frequency of seizures and improving the overall quality of life of people with *** To reduce OAE burden, enhanced collaboration between onchocerciasis and mental health programmes at community, national, and international levels is required. Urgent efforts are needed to ensure the uninterrupted provision of free ASMs in onchocerciasis-endemic areas. Furthermore, OAE should be included in the quantification of the onchocerciasis disease burden.

关键词： Onchocerciasis Morbidity Burden of disease Prevention Ivermectin Epilepsy Nodding syndrome Treatment Children Policy

ITPK1 is an InsP/ADP phosphotransferase that controls phosphate signaling in Arabidopsis

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Molecular Plant 2024年第7期17卷 1151-1157页

作者： Esther Riemer Danye Qiu Debabrata Laha Robert K.Harmel Philipp Gaugler Verena Gaugler Michael Frei Mohammad-Reza Hajirezaei Nargis Parvin Laha Lukas Krusenbaum robin Schneider Adolfo Saiardi Dorothea Fiedler Henning j.jessen Gabriel Schaaf Ricardo F.H.Giehi 不详

(Molecular Plant 14,1864-1880;November 12021)We identified a mistake made when calculating the absolute concentrations of inositol(pyro)phosphates derived from CE-ESl-MS measurements reported in the originally published version of our *** to a calculation error when determining concentrations per fresh biomass,the absolute values shown in the manuscript are approximately 30-fold lower than they should *** mistake affects Figures 2D,3C,4C,and 7D and Figures S4,S11B,S13,and *** all conclusions made in the article referred to relative differences between genotypes and treatments,they remained unaffected by these mistakes.

关键词： ipt Arabidopsis absolute

Portable device to assess dynamic accuracy of global positioning system(GPS)receivers used in agricultural aircraft

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International journal of Agricultural and Biological Engineering 2014年第2期7卷 68-74页

作者： Steven j.thomson Yanbo Huang Lowrey A.Smith United States Department of Agriculture(USDA) Agricultural Research Service(ARS)Crop Production Systems Research UnitStonevilleMS 38776USA

A device was designed to test the dynamic accuracy of Global Positioning System(GPS)receivers used in agricultural aircraft and other aerial *** system works by directing a sun-reflected light beam from the ground to the aircraft using mirrors.A photo detector points downward from the aircraft to detect the light beam,and photo detection circuitry triggers an event in the guidance system data file at the aircraft’s location corresponding to the precisely georeferenced position on the *** details are presented on the mirror-based light reflection system and photo-electronic circuitry designed to trigger an event in the guidance system’s log *** example application evaluated the horizontal accuracy of a stand-alone GPS receiver by matching dynamic data with data from the aircraft’s guidance *** indicated a 2.16 s lead in position registered by the stand-alone receiver over that registered by the aircraft’s guidance system GPS receiver,which had been previously evaluated to be within 0.13 s of Real-Time Kinematic(RTK)-referenced time and position.

关键词： GPS receiver accuracy agricultural aircraft aerial application remote sensing georeferencing UAV

Characterization of spray deposition and drift from a low drift nozzle for aerial application at different application altitudes

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International journal of Agricultural and Biological Engineering 2011年第4期4卷 28-33页

作者： Yanbo Huang Steven j.thomson US Department of Agriculture Agricultural Research ServiceCrop Production Systems Research UnitStonevilleMS 38776USA

A complex interaction of controllable and uncontrollable factors is involved in aerial application of crop production and protection *** it is difficult to completely characterize spray deposition and drift,these important factors can be estimated with appropriate sampling protocol and *** height is an important variable influencing off-target spray drift,but this variable has not been easily measured or logged.A custom-configured aircraft-mounted laser with logging capabilities makes this *** study was designed to investigate droplet size and deposition characteristics of a low drift CP flat-fan nozzle at application altitudes 3.7 m,4.9 m,and 6.1 *** the study,CP flat-fan nozzles were set to a downward angle of 30 degrees applying a mixture of water,Syl-Tac®adjuvant,and Rubidium Chloride(RbCl)tracer at a 28.5 L/ha application *** droplets were collected using water sensitive paper(WSP)cards placed in the spray *** sheets were also placed in the swath and downwind for drift *** analysis indicated that median droplet diameter as determined by WSP in the spray swath was not significantly influenced by spray application ***,statistical analysis also indicated that concentration of RbCl tracer from Mylar samplers in the spray swath was not significantly influenced by application *** height had a significant effect on spray deposition from drift samplers,along with wind direction and relative *** results for drift samplers may have been influenced by shifts in wind direction that altered the relationship between orientation of samplers and wind.

关键词： deposition spray nozzle aerial application droplet spectra spray drift

Estimation of cotton yield with varied irrigation and nitrogen treatments using aerial multispectral imagery

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International journal of Agricultural and Biological Engineering 2013年第2期6卷 37-41页

作者： Yanbo Huang Ruixiu Sui Steven j.thomson Daniel K.Fisher Crop Production Systems Research Unit Agricultural Research ServiceUnited States Department of AgricultureStonevilleMS 38776USA

Cotton yield varies spatially within a *** variability can be caused by various production inputs such as soil properties,water management,and fertilizer *** multispectral imaging is capable of providing data and information to study effects of the inputs on yield qualitatively and quantitatively in a timely and cost-effective fashion.A 10-ha cotton field with irrigation and non-irrigation 2×2 blocks was used in this *** nitrogen application treatments were randomized with two replications within each *** plant canopy was closed,airborne multispectral images of the field were acquired using a 3-CCD MS4100 *** images were processed to generate various vegetation *** vegetation indices were evaluated for the best performance to characterize *** effect of irrigation on vegetation indices was *** for yield estimation were developed and verified by comparing the estimated and actual *** indicated that ratio of vegetation index(RVI)had a close relationship with yield(R^(2)=0.47).Better yield estimation could be obtained using a model with RVI and soil electrical conductivity(EC)measurements of the field as explanatory variables(R^(2)=0.53).This research demonstrates the capability of aerial multispectral remote sensing in estimating cotton yield variation and considering soil properties and nitrogen.

关键词： remote sensing multispectral imagery cotton yield nitrogen irrigation soil properties

Development and evaluation of low-altitude remote sensing systems for crop production management

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International journal of Agricultural and Biological Engineering 2016年第4期9卷 1-11页

作者： Yanbo Huang Steven j.thomson Howard j.Brand Krishna N.Reddy United States Department of Agriculture Agricultural Research ServiceCrop Production Systems Research UnitStoneville 38776USA United States Department of Agriculture National Institute of Food and AgricultureDivision of Agricultural SystemsWashington DC 20024USA Virginia Tech Department of Mechanical EngineeringBlacksburg 24061USA

Precision agriculture accounts for within-field variability for targeted treatment rather than uniform treatment of an entire *** is built on agricultural mechanization and state-of-the-art technologies of geographical information systems(GIS),global positioning systems(GPS)and remote sensing,and is used to monitor soil,crop growth,weed infestation,insects,diseases,and water status in farm fields to provide data and information to guide agricultural management *** agriculture began with mapping of crop fields at different scales to support agricultural planning and decision *** the development of variable-rate technology,precision agriculture focuses more on tactical actions in controlling variable-rate seeding,fertilizer and pesticide application,and irrigation in real-time or within the crop season instead of mapping a field in one crop season to make decisions for the next crop *** the development of aerial variable-rate systems,low-altitude airborne systems can provide high-resolution data for prescription variable-rate *** systems for multispectral imaging using a number of imaging sensors(cameras)were *** aerial vehicles(UAVs)provide a unique platform for remote sensing of crop fields at slow speeds and low-altitudes,and they are efficient and more flexible than manned agricultural airplanes,which often cannot provide images at both low altitude and low speed for capture of high-quality *** are also more universal in their applicability than agricultural aircraft since the latter are used only in specific *** study presents the low-altitude remote sensing systems developed for detection of crop stress caused by multiple ***,as a special platform,were discussed for crop sensing based on the researchers'studies.

关键词： low-altitude remote sensing agricultural airplane unmanned aerial vehicle(UAV) crop production management precision agriculture

Ground-based hyperspectral remote sensing for weed management in crop production

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International journal of Agricultural and Biological Engineering 2016年第2期9卷 98-109页

作者： Yanbo Huang Matthew A.Lee Steven j.thomson Krishna N.Reddy United States Department of Agriculture Agricultural Research ServiceCrop Production Systems Research UnitPO Box 350Stoneville MS 38776USA Department of Electrical and Computer Engineering Mississippi State UniversityMississippi State MS 39762USA United States Department of Agriculture National Institute of Food and AgricultureWashington DC 20024USA

Agricultural remote sensing has been developed and applied in monitoring soil,crop growth,weed infestation,insects,diseases and water status in farm fields to provide data and information to guide agricultural management *** agriculture has been implemented through prescription mapping of crop fields at different scales with the data remotely sensed from space-borne,airborne and ground-based ***-based remote sensing techniques offer portability,flexibility and controllability in applications for precision *** weed management,crop injury from off-target herbicide spray drift and herbicide resistance in weeds are two important *** precision weed management,ground-based hyperspectral remote sensing techniques were developed for detection of crop injury from dicamba and differentiation between glyphosate resistant and sensitive *** research presents the techniques for ground-based hyperspectral remote sensing for these two *** illustrate the advantages of ground-based hyperspectral remote sensing for precision weed management.

关键词： ground-based remote sensing hyperspectral crop injury herbicide resistance precision agriculture