检索结果-南通市图书馆

Role for mycobacterial infection in pathogenesis of primary biliary cirrhosis?

World Journal of Gastroenterology 2012年第35期18卷 4855-4865页

作者： daniel Smyk Eirini I Rigopoulou Yoh Zen robin daniel abeles Charalambos Billinis Albert Pares Dimitrios P Bogdanos Institute of Liver Studies and Liver Unit King's College London School of Medicine at King's College Hospital and Kings College Hospital NHS Trust Foundation TrustLondon SE5 9RSUnited Kingdom Institute of Biomedical Research and Technology(BIOMED) CERETETHLarissa 41222Greece Dimitrios P Bogdanos Department of MedicineUniversity Hospital of LarissaUniversity of Thessaly Medical SchoolBiopolisLarissa 41110Greece Faculty of Veterinary Medicine University of Thessaly Liver Unit Digestive Diseases InstituteHospital ClínicIDIBAPSCIBEREHDUniversity of BarcelonaBarcelona 08036Spain

Primary biliary cirrhosis （PBC） is a progressive cho- lestatic liver disease characterized by the immune- mediated destruction of biliary epithelial cells in small intrahepatic bile ducts. The disease is characterized by circulating antimitochondrial antibodies （AMAs） as well as disease-specific antinuclear antibodies, cholestatic liver function tests, and characteristic histological fea- tures, including granulomas. A variety of organisms are involved in granuloma formation, of which mycobacte- ria are the most commonly associated. This has led to the hypothesis that mnycobacteria may be involved in the pathogenesis of PBC, along with other infectious agents. Additionally, AMAs are found in a subgroup of patients with rnycobacterial infections, such as lep- rosy and pulmonary tuberculosis. Antibodies against species-specific mycobacterial proteins have been re- ported in patients with PBC, but it is not clear whether these antibodies are specific for the disease. In addi- tion, data in support of the involvement of the role of molecular mimicry between rnycobacterial and human mitochondrial antigens as triggers of cross-reactive im- mune responses leading to the loss of immunological tolerance, and the induction of pathological features have been published. Thus, antibodies against myco- bacterial heat shock protein appear to cross-recognize AMA-specific autoantigens, but it is not clear whether these autoantibodies are mycobacterium-species-spe- cific, and whether they are pathogenic or incidental. The view that mycobacteria are infectious triggers of PBC is intriguing, but the data provided so far are not conclusive.

关键词： Antimitochondrial antibodies Autoantibody Autoimmunity Cholestasis Heat shock Infection Liverdisease Liver failure Mycobacterium Tuberculosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Characteristics of patients with Wilson disease in the United States: An insurance claims database study

引用

World Journal of Hepatology 2024年第5期16卷 791-799页

作者： Thomas daniel-robin Pradeep Kumar Bernard Benichou Jean-Philippe Combal Vivet Therapeutics Paris 75008France Clarivate Noida 201301Uttar PradeshIndia

BACKGROUND Wilson disease(WD)is a progressive,potentially fatal degenerative disease affecting the liver and central nervous *** its low prevalence,collecting data on large cohorts of patients with WD is *** insur-ance claims databases provide powerful tools to collect retrospective data on large numbers of patients with rare *** To describe patients with WD in the United States,their treatment and clinical outcome,using a large insurance claims *** This retrospective,longitudinal study was performed in the Clarivate Real-World Data Product *** patients with≥2 claims associated with an Interna-tional Classification of Diseases 10(ICD-10)diagnostic code for WD(E83.01)between 2016 and 2021 were included and followed until death or study *** were divided into two groups by whether or not they were documented to have received a specific treatment for *** manifestations,hospital-isations,liver transplantation and death were *** Overall,5376 patients with an ICD-10 diagnostic code for WD were *** mean age at inclusion was 41.2 years and 52.0%were men.A specific WD treatment was documented for 885 patients(15.1%),although the number of patients taking zinc salts may be underestimated due to over the counter *** inclusion,the mean age of patients with a documented treatment was 36.6±17.8 years vs 42.2±19.6 years in those without a documented *** follow-up,273 patients(5.1%)*** with the American general population,the standardised mortality ratio was *** proportion of patients with a documented WD-specific treatment who died during follow-up was 4.0%and the mean age at death 52.7 *** Patients treated for WD in the United States had an excess early mortality compared with the American *** findings indicate that there is a significant unmet need for effective treatment for WD in the United States.

关键词： Wilson disease Mortality Treatment Copper chelators Zinc acetate United States

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Wind Turbine Noise Reduction through Blade Retrofitting

引用

Open Journal of Modelling and Simulation 2024年第3期12卷 75-88页

作者： Sarah Seevers robin Ward Scotty Hutto Darryl House Nick Zelenka Manuel Perea daniel Fonseca Department of Mechanical Engineering The University of Alabama Tuscaloosa USA

This paper outlines a plan for the effective reduction of the audible sound level produced by aerodynamic noise from the power-generating turbine blades. The contribution of aerodynamic noise can be divided into two categories: inflow turbulence and airfoil self-noise. The base model and retrofit blade designs were modeled in SolidWorks. Subsequently, noise prediction simulations were conducted and compared to the base blade model to determine which modification provided the greatest benefit using SolidWorks Flow Simulation. The result of this project is a series of blade retrofit recommendations that produce a more acoustically efficient design and reduce noise complaints while enabling turbines to be placed in locations that require quieter operations.

关键词： Wind Turbine Noise Blade Retrofitting Aerodynamic Noise Electricity Generation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Conservation of Traditional Agriculture as Living Knowledge Systems,Not Cultural Relics

引用

Journal of Resources and Ecology 2016年第3期7卷 231-236页

作者： NILES daniel ROTH robin 综合地球环境学研究所日本京都府603-8047 圭尔夫大学地理学院加拿大圭尔夫N1G2W1

Agricultural heritage has potential significance far beyond its common representation as the ＂traditional＂ system of ＂traditional peoples＂.The *** and Agricultural Organization＇s Globally Important Agricultural Heritage Systems（GIAHS） program is an important designation that treats heritage agro-ecosystems as living systems,rather than cultural *** order for the GIAHS designation to achieve its full potential,however,the role of human knowledge within the continuous cultural and ecological evolution of GIAHS requires much closer examination and *** paper explores the limits of contemporary nature and cultural conservation,and draws on a coevolutionary theoretical framework in order to better conceptualize the dynamism of such complex agro-ecological *** such a view,GIAHS can be seen as evolving systems of sustainable agriculture of great potentail relevance to contemporary society-environment challenges,rather than as relics of the past.

关键词： Globally Important Agricultural Heritage Systems(GIAHS) conservation cultural preservation UNESCO coevolution dynamic conservation knowledge systems

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sonicating bees demonstrate flexible pollen extraction without instrumental learning

引用

Current Zoology 2019年第4期65卷 425-436页

作者： Callin M. Switzer Avery L. Russell daniel R. Papaj Stacey A. Combes robin Hopkins Department of Organismic and Evolutionary Biology Harvard University Cambridge MA USA Arnold Arboretum Harvard University Boston MA USA Department of Ecology and Evolutionary Biology University of Arizona Tucson AZ USA Department of Neurobiology Physiology and Behavior University of California at Davis Davis CA USA Department of Biology and eScience Institute University of Washington Seattle WA USA Department of Biological Sciences University of Pittsburgh Pittsburgh PA USA

Pollen collection is necessary for bee survival and important for flowering plant reproduction, yet if and how pollen extraction motor routines are modified with experience is largely unknown. Here, we used an automated reward and monitoring system to evaluate modification in a common pollen-extraction routine, floral sonication. Through a series of laboratory experiments with the bumblebee, Bombus impatiens, we examined whether variation in sonication frequency and acceleration is due to instrumental learning based on rewards, a fixed behavioral response to rewards, and/or a mechanical constraint. We first investigated whether bees could learn to adjust their sonication frequency in response to pollen rewards given only for specified frequency ranges and found no evidenee of instrumental learning. However, we found that absenee versus receipt of a pollen reward did lead to a predictable behavioral resp on se, which depe nded on bee size. Fin ally, we found some evide nee of mechanical con straints, in that flower mass affected sonication acceleration (but not frequency) through an interaction with bee size. In generalz larger bees showed more flexibility in sonication frequency and acceleration, potentially reflecting a size-based constraint on the range over which smaller bees can modify frequency and accelerati on. Overall our results show that although bees did not display instrumental learning of sonication frequency, their sonication motor routine is nevertheless flexible.

关键词： Bombus impatiens buzz pollination foraging innate behavior learned behavior Solanum

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Switchable carbamate coagulants to improve recycling ionic liquid from biomass solutions

引用

Green Chemical Engineering 2021年第4期2卷 384-391页

作者： Julia L.Shamshina Ying Qin Ken Belmore daniel T.Daly robin D.Rogers Fiber and Biopolymer Research Institute Department of Plant and Soil ScienceTexas Tech UniversityLubbockTX79409USA Alabama Institute for Manufacturing Excellence The University of AlabamaTuscaloosaAL35487USA Department of Chemistry and Biochemistry The University of AlabamaTuscaloosaAL35487USA College of Arts&Sciences The University of AlabamaTuscaloosaAL35487USA Solutions Inc.P.O.Box 2206TuscaloosaAL35403USA

A reversible amine-carbamate approach has been developed to reduce the use of antisolvents such as water in the coagulation of biopolymers from ionic liquid(IL)solution and thus improve the economy of IL *** and chitin were recovered from 1-ethyl-3-methylimidazolium acetate([C_(2)mim][OAc])solution by introducing the miscible amines triethanolamine(TEA),ethylenediamine(EDA),or butylamine(BA)and bubbling CO_(2) at 40℃ and atmospheric pressure through the solutions to form carbamate salts in situ which resulted in biopolymer *** gave the best results because of its low boiling point and low viscosity,which benefited both biopolymer recovery and IL *** films and fibers could be formed by extrusion of an MCC/[C_(2)mim]-[OAc]solution into a coagulating bath comprised of a 1:1 M mixture of[C_(2)mim][OAc]and butylammonium butylcarbamate(BA-carbamate).The cellulose,IL,amine,and CO_(2) were easily separated,although the cellulose recovered required some water washings to remove traces of *** to 96.4%of the[C_(2)mim][OAc]could be recovered,76.2%from the coagulation bath and 20.2%from the water *** recycled IL was suitable for another cycle of cellulose dissolution and extrusion and 84.6%of the IL used for the second cycle was *** further work is needed,not the least of which will be reducing the amount of water needed for washing steps,some promising features of this process point the way for new directions for more economically viable IL recycling processes in biomass treatment with ILs.

关键词： Carbamate Ionic liquid Recovery Switchable Coagulation Biopolymers Carbamates IL recycle

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Identification of four novel DC-SIGN ligands on Mycobacterium bovis BCG

引用

Protein & Cell 2010年第9期1卷 859-870页

作者： Maria V.Carroll Robert B.Sim Fabiana Bigi Anne Jäkel robin Antrobus daniel A.Mitchell Department of Pharmacology University of OxfordMansfield RoadOxford OX13QTUK Institute of Biotechnology CICVyA-INTALos Reseros y Las Cabañas1712 CastelarArgentina Cambridge Institute of Medical Research Addenbrooke’s HospitalHills RoadCambridge CB20XYUK CSRI-UHCW Walsgrave Campus University of WarwickCoventryCV22DXUK

Dendritic-cell-specific intercellular adhesion molecule-3-grabbing non-integrin(DC-SIGN;CD209)has an important role in mediating adherence of Mycobacteria species,including *** and *** BCG to human dendritic cells and macrophages,in which these bacteria can survive ***-SIGN is a C-type lectin,and interactions with mycobacterial cells are believed to occur via mannosylated structures on the mycobacterial *** studies suggest more varied modes of binding to multiple mycobacterial *** we identify,by affinity chromatography and mass-spectrometry,four novel ligands of *** BCG that bind to *** novel ligands are chaperone protein DnaK,60 kDa chaperonin-1(Cpn60.1),glyceraldehyde-3 phosphate dehydrogenase(GAPDH)and lipoprotein *** published work strongly suggests that these are on the cell *** these ligands,lprG appears to bind DC-SIGN via typical proteinglycan interactions,but DnaK and Cpn60.1 binding do not show evidence of carbohydrate-dependent *** was also identified as a ligand for DC-SIGNR(L-SIGN;CD299)and the *** orthologue of lprG has been found previously to interact with human toll-like receptor ***,these findings offer new targets for combating mycobacterial adhesion and within-host survival,and reinforce the role of DCSIGN as an important host ligand in mycobacterial infection.

关键词： DC-SIGN Mycobacteria lectins

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Treatment effect of multilayer vermifiltration on living wastewater

Treatment effect of multilayer vermifiltration on living was...

引用

2010 First International Conference on Cellular,Molecular Biology, Biophysics and Bioengineering(CMBB 2010)

作者： Paul robin daniel Cluzeau Philippe Morand INRA Agrocampus-Ouest UMR SAS 65 Rue de Saint-Brieuc 35000 Rennes France CNRS Université Rennes 1 UMR 6553 EcoBio Station Biologique 35380 Paimpont France

Former studies and application of vermifiltration process to organic wastewater treatment has given an affirmative effect for the pollutant removal in wastewater. It could be used for the disperse wastewater treatment, especially for rural living sewage. We developed a new multilayer vermifiltration system in this study, expecting to enhance this ability for the disposal of rural living sewage. The result showed that all the COD, BOD5 and SS values in outflow after vermifiltration could meet GB18918-2002. The removal rates of COD,BOD5 and SS were above 75%, 85% and 90% respectively. The N and P could be partly removed. These preliminary results give a positive prospective for the application of multilayer vermifiltration in rural sewage treatment in the future.

关键词： vermifiltration multilayer rural sewage COD BOD5 SS TN TP

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Body Pushers: Low-Dose CT, Always the Best Choice? A Study of the Diagnostic Performance of CT Scout View

引用

Open Journal of Radiology 2017年第2期7卷 112-120页

作者： robin Fabian Gohmann Frauke Heckner Diane Uschner Christiane Katharina Kuhl Sebastian daniel Reinartz Department of Diagnostic and Interventional Radiology University Hospital RWTH Aachen University Aachen Germany University Hospital RWTH Aachen University Aachen Germany Department of Medical Statistics University Hospital RWTH Aachen University Aachen Germany

Purpose: The purpose of this study has been to evaluate the diagnostic information contained in the CT scout view in the detection of body packing. Materials and methods: Retrospect analysis of 43 CT scans between July 2011 and June 2013 in asymptomatic suspects of body packing (29 men, 14 females, mean age 38 ± 9 years). Results: A total of 11 positive cases of body packing were identified. In 10 (91%) of the cases packets were relatively large and spares in number (3 or less);in 7 (64%) a single packet has been identified. 6 (55%) of the packets were located rectally, 4 (36%) vaginally and in 1 (9%) case multiple small packets of approximately 1 cm in size were found to have been ingested orally. Maximum and minimum diameters were 5.9 ± 3 cm and 2.9 ± 1.4 cm, respectively. The mean weight of packets was 7.5 ± 4.2 g (range 2 - 54 g). In 73% (n = 8) heroin had been detected;other drugs such as cocaine (n = 1) and cannabis (n = 1) were encountered once, respectively. One packet was identified retrospectively and its content could therefore not be identified. The average effective dose was 3.8 ± 2.1 mSv for CT, of that 0.12 ± 0.01 mSv was required for the CT scout view. Conclusion: If CT scout view were treated as a diagnostic image, some CT scans may be omitted, thereby maintaining streamlined operations and achieving further dose reduction jointly in the workup of body packing.

关键词： Body Packing CT Scout View CT Dose Reduction X-Ray

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

对新型连续制粒和干燥系统的考察

引用

流程工业 2022年第11期 54-56页

作者： robin Meier M.Sc.daniel Emanuele L.B.Bohle Maschinen+Verfahren GmbH(德国)公司德国多特蒙德应用科学大学

颗粒干燥在连续生产工艺中也是非常重要的环节。这是因为在干燥过程中可以实现一些特定工艺,如改善流动性、防止离析、减少灰尘等。然而,目前市面上还没有能够满足制药质量要求的连续式干燥器。对于连续式干燥器来说,颗粒在干燥器中停... 详细信息

颗粒干燥在连续生产工艺中也是非常重要的环节。这是因为在干燥过程中可以实现一些特定工艺,如改善流动性、防止离析、减少灰尘等。然而,目前市面上还没有能够满足制药质量要求的连续式干燥器。对于连续式干燥器来说,颗粒在干燥器中停留的时间要短,停留的时间分布也要窄,如此才能确保精准地去除有缺陷的产品,而不必丢弃批次中的大部分产品。

关键词：干燥系统连续生产工艺干燥器干燥过程制药

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：