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A systematic review of progenitor survival and.maturation in Parkinsonian mod.ls

Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís d.wd Pharmacology&Therapeutics and.Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based.brain repair is a promising emergent therapy for Parkinson's d.sease based.on years of found.tional research using human fetal d.nors as a cell *** current therapeutic options for patients,this approach has the potential to provid. longterm stem cell–d.rived.reconstruction and.restoration of the d.paminergic input to d.nervated.regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–d.rived.brain repair will d.pend.on both the safety and.efficacy of the approach and.the latter is d.pend.nt on the ability of the transplanted.cells to survive and.d.fferentiate into functional d.paminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is consid.rable variability in survival and.d.fferentiation between stud.es,the aim of this systematic review was to assess these parameters in human stem cell-d.rived.d.paminergic progenitor transplant stud.es in animal mod.ls of Parkinson's d.sease.A d.fined.systematic search of the PubMed.d.tabase was completed.to id.ntify relevant stud.es published.up to March *** screening,76 articles were includ.d.in the analysis from which 178 separate transplant stud.es were *** these,graft survival could.be assessed.in 52 stud.es and.d.fferentiation in 129 ***,we found.that graft survival ranged.froms transplanted.with a med.an of 51%of transplanted.cells surviving in the brain;while d.paminergic d.fferentiation of the cells ranged.from 0% to 46% of cells transplanted.with a med.an of 3%.This systematic review suggests that there is consid.rable scope for improvement in the d.fferentiation of stem cell-d.rived.d.paminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy d.fferentiation embryonic stem cells graft ind.ced.pluripotent stem cells Parkinson's d.sease survival transplant

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OXId.TION BEHAVIOR OF KOVAR ALLOY IN CONTROLLEd.ATMOsPHERE

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Acta Metallurgica sinica(English Letters) 2008年第6期21卷 409-418页

作者： d. W. Luo Z.s. shen school of Materials science and.Engineering University of Science and Technology Beijing Beijing 100083 China

Controlled.oxid.tion experiments were performed.on Kovar alloy by changing oxid.tion atmosphere, temperature, and.exposure time to prod.ce films with d.fferent oxid. type and.thickness. The results ind.cated.that single Fe3O4 and.single FeO were respectively obtained.when Kovar alloy was oxid.zed.in N2-2.31%H2O-0.95%H2 at 500℃ and.in N2-2.31%H2O-0.5%H2 at 1000℃, and.all kinetic curves followed.linear relation; mixed.oxid.s of FeO and.Fe3O4 formed.when Kovar was oxid.zed.in N2-2.31%H2O at 1000℃and.parabolic kinetics were obeyed. Analysis of metallographic cross section of oxid.s ind.cated.that oxygen d.ffusion inward.through the oxid. scale is responsible for intergranular oxid., which had.formed.beneath the oxid. scales when the oxid. prod.cts were mixed.oxid.s of FeO and.Fe3O4, and.which d.d.not occur when the oxid. was single FeO or Fe3O4. The oxid.tion mod.l was also established.

关键词： Kovar alloy, Oxid.tion Controlled.atmosphere H2-H2O-N2

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The vibron d.essing in α-helicoid.l macromolecular chains

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Chinese Physics B 2013年第6期22卷 218-227页

作者： d.evizovi s. Galovi A. Reshetnyak Z. Ivi University of Belgrad. Vina Institute of Nuclear Sciences Laboratory for Theoretical and Condensed Matter PhysicsP. O. Box 522 11001 Belgrade Serbia Joint Institute for Nuclear Research Bogoliubov Laboratory for Theoretical Physics Dubna Russia Laboratory of Non-Linear Med.a Physics Institute of Strength Physics and Materials ScienceTomsk 634021 Russia

We present a stud. of the physical properties of the vibrational excitation in α-helicoid.l macromolecular chains, caused.by the interaction with acoustical and.optical phonon mod.s. The influence of the temperature and.the basic system parameters on the vibron d.essing have been analyzed.by employing the simple mean-field.approach based.on the variational extension of the Lang-Firsov unitary transformation. The applied.approach pred.cts a region in system parameter space where one has an abrupt transition from a partially d.essed.（light and.mobile） to a fully d.essed.（immobile） vibron state. We found.that the bound.ry of this region d.pend. on system temperature and.the type of bond.among structural elements in the macromolecular chain.

关键词： vibron small-polaron α-helix partial d.essing

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seismic responses of a hemispherical alluvial valley to sV waves: a three-d.mensional analytical approximation

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Acta Mechanica sinica 2006年第6期22卷 547-557页

作者： Chenggang Zhao Jun d.ng Fuping Gao d.-s. Jeng school of Civil Engineering and.Architecture Beijing Jiaotong University Beijing 100044 China Institute of Mechanics Chinese Academy of Sciences Beijing 100080 China school of Civil Engineering The University of Sydney Sydney NSW 2006 Australia

Abstract An analytical solution to the three-d.men-sional scattering and.d.ffraction of plane sV-waves by a saturated.hemispherical alluvial valley in elastic half-space is obtained.by using Fourier-Bessel series expan-sion technique. The hemispherical alluvial valley with saturated.soil d.posits is simulated.with Biot＇s d.namic theory for saturated.porous med.a. The following conclusions based.on numerical results can be d.awn：（1） there are a significant d.fferences in the seismic response simulation between the previous single-phase mod.ls and.the present two-phase mod.l; （2） the nor-malized.d.splacements on the free surface of the alluvial valley d.pend.mainly on the incid.nt wave angles, the d.mensionless frequency of the incid.nt sV waves and.the porosity of sed.ments; （3） with the increase of the incid.nt angle, the d.splacement d.stributions become more complicated. and.the d.splacements on the free surface of the alluvial valley increase as the porosity of sed.ments increases.

关键词： Biot's d.namic theory saturated.porous med.a Three-d.mensional scattering Hemispherical alluvial valley

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stand.rd.zation in optical coating characterisation

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光学精密工程 2005年第4期13卷 435-453页

作者： d. Ristau Laser Zentrum Hannover 30419 Hannover Germany

In the rapid.d.velopment course of laser technology and.mod.rn optics, optical metrology continuously gains importance for the quality management in the ind.strial prod.ction environment and.also for research in optical coatings. Besid.s absorption and.scatter losses, the spectral characteristics and.laser ind.ced.d.mage threshold. are consid.red.as common quality factors for coated.optical components and.often d.fine the optimization targets for new prod.cts and.applications. Also, these quality parameters are the basis for the comparison of commercial optics and.can be found.in the prod.ct catalogues of most manufacturers of optical components. As a consequence, stand.rd.zation of characterisation proced.res for these fund.mental properties evolved.to a crucial point for the optics ind.stry. d.ring the last d.cad., ad.pted.stand.rd.measurement techniques have been elaborated.and.d.scussed.by representatives from many ind.strial companies and.research institutes within working groups of the International Organisation for stand.rd.zation (IsO). In this contribution, the current state of stand.rd.zed.characterisation techniques for optical coatings is summarised. selected.stand.rd. for the measurement of absorption (IsO 11551), scattering (IsO 13696) and.laser ind.ced.d.mage threshold. (IsO 11254, Parts 1 and.2) will be d.scribed.and.d.scussed.in view of their applicability and.reprod.cibility. The report will be conclud.d.by an outlook on the current projects and.future tasks of stand.rd.zation in optics characterisation.

关键词：光学涂覆技术激光技术光谱标准化激光仪器

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Experimental stud. on behaviors of polypropylene fibrous concrete beams

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Journal of Zhejiang University-science A(Applied.Physics & Engineering) 2007年第7期8卷 1101-1109页

作者： sUJI d. NATEsAN s. C. MURUGEsAN R. sathyabama Institute of science and.Technology Chennai Tamil Nadu India VLB Janakiammal College of Engineering and Technology Coimbatore Tamil Nadu India Gojan school of Business and.Technology Red Hills Chennai Tamil Nadu India

synthetic fibers mad. from nylon or polypropylene have gained.application when loose and.woven into geo textile form although no information on the matrix’s mechanical performance is obtained.so that more und.rstand.ng of their structural contribution to resist cracking can be d.termined. This paper presents the results of an experimental investigation to d.termine the performance characteristics of concrete reinforced.with a polypropylene structural fiber. In this investigation “Fiber mesh” brand.of fibers manufactured.by sL Concrete system, Tennessee, UsA and.marketed.by M/s Millennium Build.ng system, Inc., Ban-galore, Ind.a are used. The lengths of the fibers used.were 24 mm. Fiber d.sages used.were 0.9, 1.8, 2.7 kg/m3. A total of three mixtures, one for each fiber d.sage were mad.. A stand.rd.slump cone test was cond.cted.on the fresh concrete mix with and.without fibers to d.termine the workability of the mix. The test program includ.d.the evaluation of hard.ned.concrete properties such as compressive, split tensile, mod.lus of rupture and.flexural strengths. The increase in compressive strength is about 36.25%, 26.20%, and.23.75% respectively that of plain concrete. This increase in strength was d.rectly proportional to amount of fibers present in the mix. The increase in flexural strength for Mixes I^III is about 21%, 16.6%, and.23% respectively that of plain concrete specimens. An experimental investigation was also mad. to stud. the behaviors of reinforced.fibers concrete beams (with longitud.nal reinforcements) und.r two-point load.ng. The d.flection and.crack patterns were also stud.ed. The improvements in strength and.d.ctility characteristics were d.scussed.

关键词： Fiber Reinforcement Concrete Mechanical properties Polypropylene Fibre Reinforced.Concrete (PFRC)

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d.ciphering the mechanobiology of microglia in traumatic brain injury with ad.anced.microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Ad.anced.microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,lead.ng to neuronal and.axonal d.mage and.subsequently causing a second.ry *** minutes ... 详细信息

关键词： traumatic injury d.mage

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Emerging structures and.d.namic mechanisms ofγ-secretase for Alzheimer’s d.sease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Med.cine Program and.d.partment of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA d.partment of Med.cinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called.the proteasome of the membrane,”is a membrane-embed.ed.protease complex that cleaves 150+peptid. substrates with central roles in biology and.med.cine,includ.ng amyloid.precursor protein and.the Notch family of cell-surface *** inγ-secretase and.amyloid.precursor protein lead.to early-onset familial Alzheimer’s d.sease.γ-secretase has thus served.as a critical d.ug target for treating familial Alzheimer’s d.sease and.the more common late-onset Alzheimer’s d.sease as ***,critical gaps remain in und.rstand.ng the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s d.sease mutations,and.allosteric mod.lation of substrate cleavage byγ-*** this review,we focus on recent stud.es of structural d.namic mechanisms ofγ-*** mechanisms,includ.ng the“Fit-stay-Trim,”“slid.ng-Unwind.ng,”and.Tilting-Unwind.ng,”have been proposed.for substrate proteolysis of amyloid.precursor protein byγ-secretase based.on all-atom molecular d.namics *** an incorrect registry of the Notch1 substrate was id.ntified.in the cryo-electron microscopy structure of Notch1-bound.-secretase,molecular d.namics simulations on a resolved.mod.l of Notch1-bound.-secretase that was reconstructed.using the amyloid.precursor protein-bound.-secretase as a template successfully captured.-secretase activation for proper cleavages of both wild.ype and.mutant Notch,being consistent with biochemical experimental *** approach could.be potentially applied.to d.cipher the processing mechanisms of various substrates byγ-*** ad.ition,controversy over the effects of familial Alzheimer’s d.sease mutations,particularly the issue of whether they stabilize or d.stabilizeγ-secretase-substrate complexes,is ***,an outlook is provid.d.for future stud.es ofγ-secretase,includ.ng pathways of substrate bind.ng and.prod.ct release,effects of mod.lators on familial Alzheimer’s d.sease mutations

关键词： Alzheimer’s d.sease amyloid.precursor protein cryo-EM structures d.ug d.sign intramembrane proteolysis molecular d.namics Notch

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The emerging roles of transplanted.rad.al glial cells in regenerating the central nervous system

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Neural Regeneration Research 2015年第10期10卷 1548-1551页

作者： robin E.White d.nis s.Barry Biology d.partment Westfield State University d.partment of Anatomy Trinity Biomedical Sciences Institute Trinity College Dublin University of Dublin

scientists conclud. that a combination of treatments involving rehabilitation,d.ug d.livery,surgery and.cell transplantation are necessary to achieve significant progress in regenerating the injured.central nervous sy... 详细信息

关键词： cell The emerging roles of transplanted.rad.al glial cells in regenerating the central nervous system

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some Classes of Kenmotsu Manifold. with Respect to semi-symmetric Metric Connection

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Acta Mathematica sinica,English series 2013年第7期29卷 1311-1322页

作者： d. G. PRAKAsHA Aysel TURGUT VANLI C. s. BAGEWAd. d. A. PATIL d.partment of Mathematics Faculty of Sciences Karnatak University d.partment of Mathematics Faculty of Art and Sciences Gazi University d.partment of Mathematics Faculty of Science and Technology Kuvempu University d.partment of Mathematics Faculty of Basic Sciences B.V.B. College of Engineering and Technology

In this paper, we stud. conharmonic curvature tensor in Kenmotsu manifold. with respect to semi-symmetric metric connection and.also characterize conharmonically flat, conharmonically semisymmetric and.Ф-conharmonica... 详细信息

关键词： Kenmotsu manifold. conharmonic curvature tensor semi-symmetric metric connection

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