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Engineering（科研） 2023年第4期15卷 234-241页

作者： Andrianarivony Nomenjanahary Tiona baholy robijaona Rahelivololoniaina Génie des Procédéset des Systèmes Industriels Agricoles et Alimentaires Université d’Antananarivo Antananarivo Mada-gascar Ecole Supérieur Polytechnique Vontovorona (E.S.P.A.) Antananarivo Madagascar Ecole Supérieur des Sciences Agronomiques (E.S.S.A.) Antananarivo Madagascar

The two waves period of the COVID-19 pandemic saw the use of hydro- alcoholic gel and the consumption of capsules containing improved traditional remedies. At one point, there was a stock-out and a price increase forthese products. Furthermore, in the food industry, the catering industry adopts gelatin in its current practice. Pig gelatin dominates the international market. And for some religious practices, pork is forbidden and yet these people consume them without taking notice. The production of gelatin from broiler feet seems economically viable because broiler feet are considered slaughterhouse waste that is sold at very low prices. The poultry industry has seen an increase in broiler farming over the last twenty years. However, the latter has all the characteristics required for the production of gelatin. It will therefore comply with the standards of use described in the international codex oenological for gelatins. Physical and chemical analyses such as, ash content, moisture content, and pH measurements were done for the extracted gelatins. Sensible elements are checked with ED XRF spectroscopy. All the results were good and showed without any doubt that broiler gelatin is edible.

关键词： Gelatin Gel Amino-Acids Reticulation Collagen Broiler-Feet

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Isolation and structural elucidation of cytotoxic compounds from the root bark of Diospyros quercina (Baill.) endemic to Madagascar

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Asian Pacific Journal of Tropical Biomedicine 2014年第3期4卷 169-175页

作者： Fatiany Pierre Ruphin robijaona baholy Randrianarivo Emmanuel Raharisololalao Amelie Marie-Therese Martin Ngbolua Koto-te-Nyiwa Department of Organic Chemistry Faculty of SciencesP.O.Box 187University of Toliara601 ToliaraMadagascar Malagasy Institute of Applied Research Avarabohitra Itaosy lot AVB 77.P.OBOX 3833.102 AntananarivoMadagascar Antananarivo Poly-technique High School University of Antananarivo101 AntananarivoMadagascar Department of Organic Chemistry Faculty of SciencesP.O.Box 906 University of Antananarivo101 AntananarivoMadagascar Institute of Natural Products Chemistry National Centrefor Scientific Research CNRS 91198Gif Sur Yvette-ParisFrance Department of Biology Faculty of ScienceUniversity of KinshasaP.OBOX 190 Kinshasa XI.Democratic Republic of the Congo

Objective:To isolate and characterize the cytotoxic compounds from Diospyros quercina(Baill.)***&Lowry(Ebenaceae).Methods:An ethno-botanical survey was conducted in the south of Madagascar from July to August ***-guided fractionation assay was carried out on the root bark of Diospyros quercina,using cytotoxicity bioassay on murine P388 leukemia cell lines as *** structures of the cytotoxic compounds were elucidated by 1D and 2D NMR spectroscopy and mass ***:Biological experiments resulted in the isolation of three bioactive pure compounds(named TR-21,TR-22,and TR-23)which exhibited very good in vitro cytotoxic activities with the IC_(50)values of(0.017 5±0.0060)μg/mL,(0.089±0.005)μg/mL and(1.027±0.070)μg/mL ***,they support the claims of traditional healers and suggest the possible correlation between the chemical composition of this plant and its wide use in Malagasy folk medicine to treat ***:The ability of isolated compounds in this study to inhibit cell growth may represent a rational explanation for the use of Diospyros quercina root bark in treating cancer by Malagasy traditional *** studies are,therefore,necessary to evaluate the in vivo antineoplastic activity of these cytotoxic compounds as effective anticancer drugs.

关键词： Diospyros quercinia Cytotoxic activities Isodiospyrin 6’-Ethoxy-1’ 3’-dihydroxy-4 6-dimethyl-1,2’-binaphthyl-2,5’3,8’tetraones (E)-5,6-Dimethyl-2-(2-methyl-3-(prop-1-enyl) phenyl)-2H-Chromene Madagascar

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Antiplasmodial,cytotoxic activities and characterization of a new naturally occurring quinone methide pentacyclic triterpenoid derivative isolated from Salacia leptoclada Tul.(Celastraceae)originated from Madagascar

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Asian Pacific Journal of Tropical Biomedicine 2013年第10期3卷 780-784页

作者： Fatiany Pierre Ruphin robijaona baholy Randrianarivo Emmanuel Raharisololalao Amelie Marie-Therese Martin Ngbolua Koto-te-Nyiwa Department of Organic Chemistry Faculty of SciencesP.O.Box 187.University of Toliara601 Toliara Madagascar Malagasy Institute of Applied Research Avarabohitra Itaosy lot AVB 77.P.O.BOX 3833102 Antananarivo Madagascar Department of Organic Chemistry Faculty of SciencesP.O.Box 906 University of Antananarivo101 AntananarivoMadagascar Institute of Natural Products Chemistry National Centre for Scientific Research CNRS 91198Gif Sur Yvette-ParisFrance Department of Biology Faculty of ScienceUniversity of KinshasaP.O.BOX 190 Kinshasa XIDemocratic.Republic of the Congo

Objective:To validate scientifically the traditional use of Salacia leptoclada Tul.(Celastraceae)(***)and to isolate and elucidate the structure of the biologically active ***:Bioassay-guided fractionation of the acetonic extract of the stem barks of *** was carried out by a combination of chromatography technique and biological experiments in viro using Plasmodium falciparum and P388 leukemia cell lines as *** structure of the biologically active pure compound was elucidated by 1D and 2D NMR spectroscopy and mass ***:Biological screening of *** extracts resulted in the isolation of a pentacyclic triterpenic quinone *** pure compound exhibited both in vitro a cytotoxic effect on murine P388 leukemia cells with IC_(50)value of(0.041±0.020)μg/mL and an antiplasmodial activity against the chloroquine-resistant strain FC29 of Plasmodium falciparum with an IC_(50)value of(0.052±0.030)μg/*** this interesting anti-malarial property of the lead compound,the therapeutic index was weak(0.788).In the best of our knowledge,the quinone methide pentacyclic triterpenoid derivative compound is reported for the first time in ***:The results suggest that furthers studies involving antineoplastic activity is needed for the development of this lead compound as anticancer drug.

关键词： Salacia leptoclada Quinone methide Malaria Therapeutic index Cancer Madagascar

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