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比较胺碘酮加β受体阻断剂、单用索他洛尔与单用β受体阻断剂预防埋藏式复律除颤器电击的随机试验:OPTIC研究

世界核心医学期刊文摘（心脏病学分册） 2006年第5期2卷 11-12页

作者： Connolly s.J Dorian P roberts r.s. 黄浙勇 Department of Medicine McMaster University 237 Barton St E Hamilton Ont. L8L 2X2 CanadaDr.

Context: Implantable cardioverter defibrillator(ICD) therapy is effective but is associated with high-voltage shocks that are painful. Objective: To determine whether amiodarone plus β -blocker or.s.talol are better than β -blocker alone for prevention of ICD shocks. Design, setting, and Patients: A randomized controlled trial with blinded adjudication of events of 412 patients from 39 outpatient ICD clinical centers located in Canada, Germany, United states, England, sweden, and Austria, conducted from January 13, 2001, to september 28, 2004. Patients were eligible if they had received an ICD within 21 days for inducible or.s.ontaneously occurring ventricular tachycardia or fibrillation. Intervention: Patients were randomized to treatment for 1 year with amiodarone plus β -blocker, sotalol alone, or β -blocker alone. Main Outcome Measure: Primary outcome was ICD shock for any reason. r.s.lts: shocks occurred in 41 patients(38.5% ) assigned to β -blocker alone, 26(24.3% ) assigned to sotalol, and 12(10.3% ) assigned to amiodarone plus β -blocker. A reduction in the r.s. of shock was observed with use of either amiodarone plus β -blocker or.s.talol vs β -blocker alone(hazard ratio[Hr], 0.44; 95% confidence interval[CI], 0.28- 0.68; Prone plus β -blocker.s.gnificantly reduced the r.s. of shock compared with β -blocker alone(Hr, 0.27; 95% CI, 0.14- 0.52; Psotalol(Hr, 0.43; 95% CI, 0.22- 0.85; P=.02). There was a trend for.s.talol to reduce shocks compared with β -blocker alone(Hr, 0.61; 95% CI, 0.37- 1.01; P=.055). The rates of study drug discontinuation at 1 year were 18.2% for amiodarone, 23.5% for.s.talol, and 5.3% for β -blocker alone. Adverse pulmonary and thyroid events and symptomatic bradycardia were more common among patients randomized to amiodarone. Conclusions: Despite use of advanced ICD technology and treatment with a β -blocker, shocks occur commonly in the first year after ICD implant. Amiodarone plus β -blocker is effective f

关键词： β受体阻断剂复律除颤器索他洛尔胺碘酮埋藏式单用电击随机试验预防门诊患者

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吲哚美辛在早产儿应用中的性别差异

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世界核心医学期刊文摘（儿科学分册） 2006年第6期2卷 31-32页

作者： Ohlsson A. roberts r.s. schmidt B. 虎小毅

To test whether indomethacin prophylaxis has sex-mediated effects on severe intraventricular hemorrhage (grade III and IV) and on long-term outcomes in extremely-low-birth-wei-ght infants. A secondary analysis was performed in the entire “Trial of Indomethacin Prophylaxis in Preter.s.study”cohort. The r.s.lts suggest a weak differential treatment effect of indomethacin by sex.

关键词：吲哚美辛早产儿极低出生体重儿预防应用脑室内出血长期预后试验研究

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消炎痛预防动脉导管未闭及其引发支气管肺发育不良的风险:早产儿消炎痛预防性试验的进一步分析

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世界核心医学期刊文摘（儿科学分册） 2006年第11期2卷 29-30页

作者： schmidt B. roberts r.s. Fanaroff A. 贺莉 The Departments of Pediatrics and Clinical Epidemiology and Biostatistics McMaster University Hamilton Ont.Canada Dr.

Objectives: To determine the r.s. of bronchopulmonary dysplasia(BPD) in subgroups of infants with and without patent ductus arteriosus (PDA) who were randomized to indomethacin prophylaxis or placebo, and to examine whether adverse drug effects on edema formation and oxygenation may explain why indomethacin prophylaxis does not reduce BPD. study design:We studied 999 extremely low birth weight infants who participated in the Trial of Indomethacin Prophylaxis in Preter.s.TIPP) and who survived to a postmenstrual age of 36 ***: The incidence of BPD in the 2 subgroups of infants with PDA was 52%(55/105) after indomethacin prophylaxis and 56%(137/246) after placebo. In contr.s., rates of BPD in the 2 subgroups without a PDA were 43%(170/391) after indomethacin prophylaxis and 30%(78/257) after placebo (P[interaction] = 0.015). Logistic regr.s.ion analysis with adjustment for prognostic base line factors showed that adverse and independent effects of indomethacin prophylaxis on the need for.s.pplemental oxygen and on weight loss by the end of the first week of life may increase the r.s. of BPD in infants without PDA. Conclusions: Harmful side effects on oxygenation and edema formation may explain why indomethacin prophylaxis does not prevent BPD even though it reduces PDA.

关键词：消炎痛预防性试验治疗者极低出生体重儿预防剂量安慰剂预防用药对数回归辅助通气试验设计

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Astrophysical s-factor and reaction rate for 15N(p,γ)16O within the modified potential cluster model

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Chinese Physics C 2024年第4期48卷 130-145页

作者： s.B.Dubovichenko A.s.Tkachenko r.Ya.Kezer.s.vili N.A.Burkova B.M.Yeleusheva Fesenkov Astrophysical Institute 050020 AlmatyKazakhstan New York City College of Technology City University of New YorkBrooklyn11201 New YorkUSA Graduate school and University Center City University of New York10016 New YorkUSA al-Farabi Kazakh National University 050040 AlmatyKazakhstan

We study radiative p^(15)N capture on the ground state of ^(16)O at stellar energies within the framework of a modified potential cluster model(MPCM)with forbidden states,including low-lying *** investigation of the ^(15)N(p,γ0)^(16)O reaction includes the consideration of ^(3)s_(1) r.s.nances due to E1 transitions and the contribution of the ^(3)P_(1) scattering wave in the p+^(15)N channel due to the ^(3)P_(1)→^(3)P_(0)M1 *** calculated the astrophysical low-energy s-factor,and the extrapolated s(0)turned out to be within 34.7−40.4 keV·*** important role of the asymptotic constant(AC)for the ^(15)N(p,γ0)16O process with interfering ^(3)s_(1)(312)and ^(3)s_(1)(962)r.s.nances is elucidated.A compar.s.n of our calculation for the s-factor with existing experimental and theoretical data is addr.s.ed,and a reasonable agreement is *** reaction rate is calculated and compared with the existing *** has negligible dependence on the variation of AC but shows a strong impact of the interference of ^(3)s_(1)(312)and ^(3)s_(1)(962)r.s.nances in reference to the CNO Gamow windows,especially at low *** estimate the contribution of cascade transitions to the reaction rate based on the exclusive experimental data from ***.C.85,065810(2012).The reaction rate enhancement due to the cascade transitions is observed from T_(9)>0.3 and reaches the maximum factor~1.3 at T_(9)=*** pr.s.nt the Gamow energy window and a compar.s.n of rates for radiative proton capture reactions ^(12)N(p,γ)^(13)O,^(13)N(p,γ)^(14)O,^(14)N(p,γ)^(15)O,and ^(15)N(p,γ)^(16)O obtained in the framework of the MPCM and provide the temperature windows,prevalence,and significance of each process.

关键词： low and astrophysical energies p^(15)N system thermonuclear reaction rate potential cluster model CNO-cycle

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FEA-based Geometrical Modification of switched reluctance Motor for radial Force reduction

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Chinese Journal of Electrical Engineering 2024年第1期10卷 124-135页

作者： rani s Jayapragash r school of Electrical Engineering Vellore Institute of TechnologyChennai 600127India

switched reluctance motors(sr.s.are becoming increasingly popular in the automotive sector owing to their robust ***,sr.s.are preferred particularly for EV applications owing to their fault tolerance,magnet-free structure,and high power/torque *** main concer.s.of srM compared to other machines include torque ripple and *** primary cause of vibration is the radial force created by the srM.A geometry-based modification of the srM to reduce the radial force without significantly changing the average torque produced is *** primary goal is to design a 4-phase,8/6 srM with a lower radial *** possible geometrical alterations are proposed:one with square windows and the other with circular holes on the rotor *** windows are sized and positioned to avoid flux *** criteria are developed for the optimal window size and *** element analysis(FEA)modelling of the srM is used to validate its *** FEA r.s.lts are compared with the performance parameters obtained using the analytical *** the multiphysics design tool ANsYs to obtain the natural frequencies and associated deformations through modal *** to the conventional geometry,the radial force is significantly reduced by providing windows.

关键词： 8/6 srM radial force modal analysis FEA analysis natural frequencies srM with windows

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Kinematic analysis of flexible bipedal robotic systems

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Applied Mathematics and Mechanics(English Edition) 2024年第5期45卷 795-818页

作者： r.FAZEL A.M.sHAFEI s.r.NEKOO Department of Mechanical Engineering Shahid Bahonar University of KermanKerman ***Iran Departamento de Ingenieria de sistemas y Automatica Escuela Técnica Superior de IngenieriaUniversidad de SevillaSeville 41092Spain

In spite of its intrinsic complexities,the passive gait of bipedal robots on a sloping ramp is a subject of inter.s. for numerous *** distinguishes the pr.s.nt r.s.arch from similar wor.s.is the consideration of flexibility in the constituent links of this type of robotic *** is not a far-fetched assumption because in the transient(impact)phase,due to the impulsive forces which are applied to the system,the likelihood of exciting the vibration modes increases ***,the human leg bones that are involved in walking are supported by viscoelastic muscles and ***,for achieving more exact r.s.lts,it is essential to model the robot links with viscoelastic *** this end,the Gibbs-Appell formulation and Newton's kinematic impact law are used to derive the most general form of the system's dynamic equations in the swing and transient phases of *** most important issue in the passive walking motion of bipedal robots is the determination of the initial robot configuration with which the system could accomplish a periodic and stable gait solely under the effect of gravitational *** extremely unstable nature of the system studied in this paper and the vibrations caused by the impulsive forces induced by the impact of robot feet with the inclined surface are some of the very serious challenges encountered for achieving the above-mentioned *** overcome such challenges,an innovative method that uses a combination of the linearized equations of motion in the swing phase and the algebraic motion equations in the transition phase is pr.s.nted in this paper to obtain an eigenvalue *** solving this problem,the suitable initial conditions that are necessary for the passive gait of this bipedal robot on a sloping surface are *** effects of the character.s.ic parameters of elastic links including the modulus of elasticity and the Kelvin-Voigt coefficient on the walking stability of this type of

关键词： bipedal robot flexible link swing phase transient phase eigenvalue problem Kelvin-Voigt coefficient

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Parametric investigation on the novel and cost-effective nano fly ash impregnated geopolymer.s.stem for.s.stainable construction

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Frontiers of structural and Civil Engineering 2024年第2期18卷 170-183页

作者： r.MOHANA s.M.Leela BHArATHI Department of Civil Engineering Mepco Schlenk Engineering CollegeSivakasi 626123India

The hazardous environmental effects of greenhouse gas emissions and climate change demand alternative sources for cementitious materials in the construction *** development of geopolymer.s.ructur.s.provides a way of producing 100%cement-free *** this r.s.arch work,a novel and simple way of deriving nano particles from waste fly ash particles is *** effect of adding the synthesized nano fly ash particles as a filler medium in geopolymer mortars was investigated by considering strength and durability *** optimization was done by using regr.s.ion analysis on the geopolymer mortar and the impact of adding nano fly ash particles was studied by varying different percentages of addition ranging from 0 to 7.5%by weight of binder *** the r.s.lts,it was observed that 1%nano fly ash acted not only as a filler but also as nano-sized precursors of the polymerization process,r.s.lting in denser geopolymer *** can explain the extraordinary gain in strength of 72.11 MPa as well as the denser core with negligible level of chloride ion penetration,making the material suitable for the development of structur.s.susceptible to marine environment.

关键词： geopolymer nano fly ash chloride ion penetration durability polymerization fillers

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An Efficient Modelling of Oversampling with Optimal Deep Learning Enabled Anomaly Detection in streaming Data

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China Communications 2024年第5期21卷 249-260页

作者： r.rajakumar.s.sathiya Devi srinivasa ramanujan Centre SASTRA Deemed UniversityKumbakonamTamil Nadu 612001India University College of Engineering BIT CampusAnna UniversityTiruchirappalli 620024India

recently,anomaly detection(AD)in streaming data gained significant attention among r.s.arch communities due to its applicability in finance,business,healthcare,education,*** recent developments of deep learning(DL)models find helpful in the detection and classification of *** article designs an oversampling with an optimal deep learning-based streaming data classification(Os-ODLsDC)*** aim of the OsODLsDC model is to recognize and classify the pr.s.nce of anomalies in the streaming *** proposed Os-ODLsDC model initially undergoes preprocessing *** streaming data is unbalanced,support vector machine(sVM)-synthetic Minority Over.s.mpling Technique(sVM-sMOTE)is applied for oversampling ***,the Os-ODLsDC model employs bidirectional long short-term memory(Bi LsTM)for AD and ***,the root means square propagation(r.s.rop)optimizer is applied for optimal hyperparameter tuning of the Bi LsTM *** ensuring the promising performance of the Os-ODLsDC model,a wide-ranging experimental analysis is performed using three benchmark datasets such as CICIDs 2018,KDD-Cup 1999,and NsL-KDD datasets.

关键词： anomaly detection deep learning hyperparameter optimization oversampling sMOTE streaming data

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A bird's-eye overview of molecular mechanisms regulating feed intake in chickens—with mammalian compar.s.ns

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Animal Nutrition 2024年第2期17卷 61-74页

作者： Anastasiia r.Volyanskaya Ilya r.Akberdin Mikhail A.Kulyashov Ivan s.Yevshin Michael N.romanov Elena I.shagimardanova Oleg A.Gusev Fedor A.Kolpakov Department of Natural sciences Novosibirsk State University Biosoft.ru Ltd. sirius University of science and Technology school of Biosciences University of Kent L.K.Er.s. Federal r.s.arch Centre for Animal Husbandry regulatory Genomics r.s.arch Center Institute of Fundamental Medicine and BiologyKazan Federal University Life Improvement By Future Technologies (LIFT) Center Intractable Disease r.s.arch Center Juntendo University

In recent decades, a lot of r.s.arch has been conducted to explore poultry feeding behavior. However, up to now, the processes behind poultry feeding behavior remain poorly understood. The review generalizes modern expertise about the hormonal regulation of feeding behavior in chickens, focusing on signaling pathways mediated by insulin, leptin, and ghrelin and regulatory pathways with a cr.s.-reference to mammals. This overview also summarizes state-of-the-art r.s.arch devoted to hypothalamic neuropeptides that control feed intake and are prime candidates for predictors of feeding *** analysis of the signaling pathways that mediate the feed intake regulation allowed us to conclude that there are major differences in the processes by which hormones influence specific neuropeptides and their contr.s.ing roles in feed intake control between two vertebrate clades.

关键词： Chicken Feed intake Hypothalamus Neuropeptide signaling pathway Hormone

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Mathematical modelling of ball and plate system with experimental and correlation function-based model validation

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Control Theory and Technology 2024年第2期22卷 326-341页

作者： T.r.Dil Kumar.s.J.Mija Department of Electrical Engineering National Institute of Technology CalicutKozhikode673601KeralaIndia

The ball and plate system is an inherently nonlinear under actuated benchmark system used for validating the performance of various control schemes. A mathematical model depicting the dynamics close to that of the system is very much required for.s.ch a test bed. In this corr.s.ondence, the complete nonlinear model, a simplified nonlinear model, and a linearized model of the ball and plate system are developed. The system compr.s.s a ball and plate mechanism and a rotary servo unit. The ball and plate mechanism is modelled using the Euler–Lagrange method, whereas the rotary servo subsystem is modelled from the first principles. The nonlinear model of the combined system is developed by including the dynamics of the servo motor with gear and rolling r.s.stance between the ball and the plate. The simplified nonlinear model of the system is obtained with suitable assumptions. The model is linearized around the operating point using the Jacobian. The validity of the developed models is investigated through correlation function analysis. The open-loop r.s.onse of the three models, viz., nonlinear, simplified nonlinear, and linearized models, is analyzed in the MATLAB/simulink platform. since the open-loop system is unstable, the experimental validation of the model is performed with a double-loop PsO (particle swarm optimization) PID control scheme.

关键词： Ball and plate system Correlation function Model validation Particle swarm optimization(PsO) PsO PID controller

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