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建筑实践 2009年第5期 65-68页

作者：独眼 Arthur casas Studio

现在的时尚设计似乎一直在唱着反调,反对那些曾经的即成规范,也反对所谓的优雅;转而琢磨着"低俗"中的美好或者根本就否定美,只是捕捉感觉、寻找刺激。最后,反对派成了一种派系,反技法成了技法,于是反设计也成了设计。曾经的时装设计,极度

关键词：商业建筑时装服装建筑设计

Electrospun PllA Membranes for Caffeine Delivery: Diffusional Approach

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Journal of Biomedical Science and Engineering 2017年第12期10卷 563-574页

作者： Ana Paula S. Immich José Antonio Tornero Francesc Cano casas Manuel J. lis Arias Institut d’Investigació Tèxtil i Cooperació Industrial de Terrassa Universitat Politècnica de Catalunya Terrassa Spain Chemical Engineering Department Universitat Politècnica de Catalunya Terrassa Spain

One of the great advantages of electrospun fibers is the large tridimensional area produced, capable of storing any type of material. The aim of our investigation is to study the electrospinning technique to produce polymer membranes for drug delivery applications, given their large surface area and ability to transport a bioactive compound. A mathematical modeling of the delivery system kinetics was also studied to find the mechanism that controls the releasing process. Results showed that electrospinning could provide regular and smooth membranes suitable for drug delivery processes. The mathematical modeling also proved that thicker PllA membranes exhibited a Fickian diffusion behavior during the drug transport, presenting better control in drug delivery processes.

关键词： Diffusion Polymer Nano Escale Kinetics

Cued aversive classical conditioning in humans: The role of trait-anxiety

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Open Journal of Psychiatry 2013年第2期3卷 230-237页

作者： óscar Andión Xavier Caseras Miquel àngel Fullana Alberto Fernandez-Teruel Marc Ferrer Miquel casas rafael Torrubia Departament de Psiquiatria i Medicina legal Institut de Neurociencies Universitat Autonoma de Barcelona Bellaterra Spain Department of Psychological Medicine Cardiff University Cardiff United Kingdom Servei de Psiquiatria Hospital Vall d’Hebron Barcelona Spain

No study so far has specifically addressed the influence of individual differences in trait-anxiety on aversive classical conditioning as indexed by the startle reflex response. We compared the startle reflex responses between participants classified as high (n = 25) and low (n = 26) in trait-anxiety while undergoing a single-cue aversive classical conditioning procedure. High trait-anxiety group showed a greater startle response to the CS relative to the ITI at the post-acquisition compared with the pre-acquisition phase. low trait-anxiety group did not show such a clear pattern of conditioning, and results from this group seem to be concealed by differences in the startle responses to the CS and the ITI during the pre-acquisition phase. However, a post-hoc analysis in which such differences at pre-conditioning were removed showed no conditioning effects in low trait-anxiety participants. Taking together, these results suggest differences between high and low trait-anxiety groups in the acquisition of the CS-US association. However, further research should clarify the unexpected pattern of responses shown by low trait-anxiety group.

关键词： Classical Conditioning Startle Reflex Trait-Anxiety Cued Conditioning Fear-Potentiated Startle

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光学模式识别技术

红外 1992年第9期13卷 34-38页

作者： casas,D 顾聚兴

Pathological response to neoadjuvant therapy with chemotherapy vs chemoradiotherapy in stage III NSClC-contribution of IASlC recommendations

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World Journal of Clinical Oncology 2021年第11期12卷 1047-1063页

作者： Diego Muñoz-Guglielmetti David Sanchez-lorente Roxana Reyes Daniel Martinez Carmen lucena Marc Boada Pilar Paredes Marta Parera-Roig Ivan Vollmer Joel Mases roberto Martin-Deleon Sergi Castillo Mariana Benegas Silvia Muñoz Maria Mayoral Carla Cases Meritxell Mollà Francesc casas radiation Oncology Department Hospital Clínic de BarcelonaBarcelona 08036CataluñaSpain Thoracic Surgery Department Thoracic UnitHospital Clínic de BarcelonaBarcelona 08036CataluñaSpain Medical Oncology Department Thoracic UnitHospital Clínic de BarcelonaBarcelona 08036CataluñaSpain Pathology Department Thoracic UnitHospital Clínic de BarcelonaBarcelona 08036CataluñaSpain Pneumology Department Thoracic UnitHospital Clínic de BarcelonaBarcelona 08036CataluñaSpain Nuclear Medicine Department Faculty of Medicine of University of BarcelonaInstitut d'Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)Barcelona 08036CataluñaSpain Medical Oncology Department Hospital Comarcal de VicVic 08500CataluñaSpain radiology Department Thoracic UnitHospital Clínic de BarcelonaBarcelona 08036CataluñaSpain Pneumology Department Hospital Universitario Reina SofiaCórdoba 14004AndalucíaSpain Medical Oncology Department Hospital de MolletMollet 08100CataluñaSpain Medical Oncology Department Hospital General de GranollersGranollers 08402CataluñaSpain Nuclear Medicine Department Thoracic UnitHospital Clínic de BarcelonaBarcelona 08036CataluñaSpain radiation Oncology Department Thoracic UnitHospital Clínic de BarcelonaBarcelona 08036CataluñaSpain

BACKGROUND Neoadjuvant treatment(NT)with chemotherapy(Ch)is a standard option for resectable stage III(N2)*** studies have suggested benefits with the addition of radiotherapy(RT)to NT *** International Association for the Study of lung Cancer(IASlC)published recommendations for the pathological response(PHR)of NSClC resection specimens after *** To contribute to the IASlC recommendations showing our results of PHR to NT Ch vs NT chemoradiotherapy(ChRT).METHODS We analyzed 67 consecutive patients with resectable stage III NSClC with positive mediastinal nodes treated with surgery after NT Ch or NT ChRT between 2013 and *** NT,all patients were evaluated for radiological response(RR)according to Response Evaluation Criteria in Solid Tumours criteria and evaluated for surgery by a specialized group of thoracic *** histological samples were examined by the same two *** was evaluated by the percentage of viable cells in the tumor and the resected lymph *** Forty patients underwent NT ChRT and 27 NT ***-six(83.6%)patients underwent surgery(35 ChRT and 21 Ch).The median time from ChRT to surgery was 6 wk(3-19)and 8 wk(3-21)for Ch *** observed significant differences in RR,with disease progression in 2.5%and 14.8%of patients with ChRT and Ch,respectively,and partial response in 62.5%ChRT vs 29.6%Ch(P=0.025).In PHR we observed≤10%viable cells in the tumor in 19(54.4%)and 2 cases(9.5%),and in the resected lymph nodes(RlN)30(85.7%)and 7(33.3%)in ChRT and Ch,respectively(P=0.001).Downstaging was greater in the ChRT compared to the Ch group(80%vs 33.3%;P=0.002).In the univariate analysis,NT ChRT had a significant impact on partial RR[odds ratio(OR)12.5;95%confidence interval(CI):1.21-128.61;P=0.034],a decreased risk of persistence of cancer cells in the tumor and RlN and an 87.5%increased probability for achieving downstaging(OR 8;95%CI:2.34-27.32;P=0.001).CONClUSION We found significant benefits in RR and PHR

关键词： Non-small cell lung cancer Chemotherapy Chemoradiotherapy Neoadjuvant treatment Resectable stage III Pathological response

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la Vinya别墅

现代装饰 2019年第2期 178-179页

作者： Roger casas Michelle Chaplow 李薇 Studio RHE

la Vinya四居室别墅位于西班牙东北部比利牛斯山脉脚下的加泰罗尼亚地区,由RHE工作室设计完成。设计团队利用山地基地的独特特征,包括天然的森林、起伏的地形和历史悠久的石墙作为别墅的特色,并与该地区的建筑传统建立起直接联系。设计... 详细信息

la Vinya四居室别墅位于西班牙东北部比利牛斯山脉脚下的加泰罗尼亚地区,由RHE工作室设计完成。设计团队利用山地基地的独特特征,包括天然的森林、起伏的地形和历史悠久的石墙作为别墅的特色,并与该地区的建筑传统建立起直接联系。设计团队在园林景观中描绘了一条简单的弧线。这条由加泰罗尼亚当地石材构成的线条如同景观中的雕塑,为这座当代住宅设计创造了强大的视觉和结构锚点。断开的石墙为漂浮的金属屋顶提供支撑,也将完美的景观载入画框,使景观与建筑融合.

关键词：设计别墅石墙景观团队

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Evaluation of ^(177)lu-Dotatate treatment in patients with metastatic neuroendocrine tumors and prognostic factors

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World Journal of Gastroenterology 2020年第13期26卷 1513-1524页

作者： Estephany Abou Jokh casas Virginia Pubul Núnez Urbano Anido-Herranz María del Carmen Mallón Araujo Maria del Carmen Pombo Pasín Miguel Garrido Pumar José Manuel Cabezas Agrícola José Manuel Cameselle-Teijeiro Ashraf Hilal álvaro Ruibal Morell Department of Nuclear Medicine Santiago de Compostela′s University HospitalSantiago de Compostela 15706A CorunaSpain Department of Oncology Santiago de Compostela′s University HospitalSantiago de Compostela 15706A CorunaSpain Department of Endocrinology Santiago de Compostela′s University HospitalSantiago de Compostela15706A CorunaSpain Department of Pathology Santiago de Compostela′s University HospitalSantiago de Compostela 15706A CorunaSpain Department of Statistics University of Santiago de CompostelaSantiago de Compostela 15706A CorunaSpain

BACKGROUND^177lu peptide receptor radionuclide therapy(PRRT)is a recently approved therapy in Spain that has been demonstrated to be a well-tolerated therapy for positive somatostatin receptor advanced gastroenteropancreatic neuroendocrine *** To determine the impact of PRRT on quality of life,radiologic and metabolic response,overall survival,prognostic factors and *** Thirty-six patients treated with^177lu-PRRT from 2016 to 2019 were *** most frequent location of the primary tumor was the gastrointestinal tract(52.8%),pancreas(27.8%),and nongastropancreatic neuroendocrine tumor(11.1%).The liver was the most common site of metastasis(91.7%),followed by distant nodes(50.0%),bone(27.8%),peritoneum(25.0%)and lung(11.1%).Toxicity was evaluated after the administration of each *** efficacywas evaluated by two parameters:stable disease and disease progression in response evaluation criteria in solid tumors 1.1 criterion and prognostic factors were *** From 36 patients,55.6%were men,with a median age of 61.1±11.8 *** previous treatments,55.6%of patients underwent surgery of the primary tumor,100%of patients were treated with long-acting somatostatin analogues,66.7%of patients were treated with everolimus,27.8%of patients were treated with tyrosine kinase inhibitor,and 27.8%of patients were treated with *** patient received radioembolization,three patients received chemoembolization,six patients received *** toxicity was registered in 14 patients(G1-G2:55.5%and G3:3.1%).Other events presented were intestinal suboclusion in 4 cases,cholestasis in 2 cases and carcinoid crisis in 1 *** median follow-up time was 3 ***,24 patients completed *** are alive with stable disease,two have disease progression,eight have died,and nine are still receiving *** median overall survival was 12.5 mo(95%confidence interval range:9.8–15.2),being inversely p

关键词： Peptide receptor radionuclide therapy Gastropancreatic neuroendocrine tumors radiological response Metabolic response

同型半胱氨酸与卒中:来自孟德尔随机法则的证据

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世界核心医学期刊文摘（神经病学分册） 2005年第6期1卷 7-8页

作者： casas J.P. Bautista l.E. Smeeth l. P. Sharma 黄卫东 Hammersmith Hospitals Acute S. Imperial College London London United Kingdom Dr.

Background Individuals homozygous for the T allele of the MTHFR C677T polymorphism have higher plasma homocysteine concentrations (the phenotype) than those with the CC genotype, which, if pathogenetic, should put them at increased risk of stroke. Since this polymorphism is distributed randomly during gamete formation, its association with stroke should not be biased or confounded. We investigated consistency between the expected odds ratio for stroke among TT homozygotes, extrapolated from genotype - phenotype and phenotype- disease studies, and the observed odds ratio from a meta- analysis of genotype- disease association studies. Methods We searched MEDlINE and EMBASE up to June, 2003, for all relevant studies on the association between homocysteine concentration and the MTHFR polymorphism, and until December, 2003, for those on the association between the polymorphism and the risk of stroke. Pooled odds ratios and 95% CI were calculated by random- effects and fixed- effects models. Consistency between expected and observed odds ratios was assessed by interaction test. Findings 111 studies met the selection criteria. Among 15 635 people without cardiovascular disease, the weighted mean difference in homocysteine concentration between TT and CC homozygotes was 1.93 μ mol/l (95% CI 1.38 to 2.47). The expected odds ratio for stroke corresponding to this difference based on previous observational studies was 1.20 (1.10 to 1.31). In our genetic meta- analysis (n=13 928) the odds ratio for stroke was 1.26 (1.14 to 1.40) for TT versus CC homozygotes, similar to the expected odds ratio (p=0.29). Consistency between the odds ratios was preserved in analyses by age- group, ethnic background, and geographical location. Interpretation The observed increase in risk of stroke among individuals homozygous for the MTHFR T allele is close to that predicted from the differencesin homocysteine concentration conferred by this variant. This concordance is consistent with a causal rel

关键词：孟德尔随机法基因多态性等位基因纯合子比值比荟萃分析心血管疾病发病风险随机模型加权平均

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西班牙比利牛斯山脉东部巴尔德里韦斯前卡拉道克统岩石中层控砷-金的矿化作用

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国外火山地质 1988年第2期 81-89页

作者： C.Avora J.M.casas 胡青

与火山岩伴生的前卡拉道克统的下部具有浸染状和透镜状的含金和 Bi—Ag—Cu—Pb—Zn—W矿物的砷黄铁矿和黄铁矿。这些金属矿物与相同矿物成分的脉和次生团块伴生。浸染状矿化产出在几厘米厚含透镜体的砂屑泥质岩的韵律层和白云岩中。产... 详细信息

与火山岩伴生的前卡拉道克统的下部具有浸染状和透镜状的含金和 Bi—Ag—Cu—Pb—Zn—W矿物的砷黄铁矿和黄铁矿。这些金属矿物与相同矿物成分的脉和次生团块伴生。浸染状矿化产出在几厘米厚含透镜体的砂屑泥质岩的韵律层和白云岩中。产在韵律层和白云岩中的次生矿体是由后成变形相引起先前的浸染状和透镜状矿化重新富集而形成的。

关键词：白云岩韵律层碳酸盐岩地层铁矿物黄铁矿矿脉群卡拉无机化矿化矿物成份矿物成分喷出岩火成岩火山岩岩石浸染状石英脉碳酸盐层砷黄铁矿硫化矿物毒砂法国中央地块韦斯矿化作用巴尔南欧西班牙