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Syndecans in Alzheimer's disease:pathogenetic mechanisms and potential therapeutic targets

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Neural Regeneration Research 2025年第9期20卷 2594-2595页

作者： Carmela Rita Balistreri roberto Monastero Cellular Molecular and Clinical Pathological LaboratoryDepartment of BiomedicineNeuroscience and Advanced Diagnostics(Bi.N.D.)University of PalermoPalermoItaly Memory and Parkinson’s disease Center Policlinico“Paolo Giaccone”PalermoDepartment of BiomedicineNeuroscience and Advanced Diagnostics(Bi.N.D.)University of PalermoVia La Loggia 1PalermoItaly

With increasing age,humans become more susceptible to the onset of neurodegenerative diseases(NDs),and among these,Alzheimer's disease(AD)is the most frequent(Nicoletti et al.,2023).NDs are primarily characterized by neuronal loss and atrophy,but also by lesions involving the cerebral and/or cardiovascular system(Balistreri,2021).Lesions such as macroinfa rcts,microinfarcts,hemorrhages,white matter lesions,atherosclerosis,and arteriolosclerosis have also been significantly described in the preclinical stages of cognitive impairment characterizing NDs(Mariani et al.,2007).

关键词： Alzheimer cardiovascular

Therapeutic targeting of cellular prion protein: toward the development of dual mechanism anti-prion compounds

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Neural Regeneration Research 2025年第4期20卷 1009-1014页

作者： Antonio Masone Chiara Zucchelli Enrico Caruso Giovanna Musco roberto Chiesa Laboratory of Prion Neurobiology Department of NeuroscienceIstituto di Ricerche Farmacologiche Mario Negri IRCCSMilanItaly Biomolecular NMR Unit Division of Genetics and Cell BiologyIRCCS Ospedale San RaffaeleMilanItaly Department of Biotechnology and Life Sciences University of InsubriaVareseItaly

PrPSc,a misfolded,aggregation-prone isoform of the cellular prion protein(PrPC),is the infectious prion agent responsible for fatal neurodegenerative diseases of humans and other *** adopt different pathogenic conformations(prion strains),which can be resistant to potential drugs,or acquire drug resistance,posing challenges for the development of effective *** PrPCis the obligate precursor of any prion strain and serves as the mediator of prion neurotoxicity,it represents an attractive therapeutic target fo r prion *** this minireview,we briefly outline the approaches to target PrPCand discuss our recent identification of Zn(Ⅱ)-Bn PyP,a PrPC-targeting porphyrin with an unprecedented bimodal mechanism of *** argue that in-depth understanding of the molecular mechanism by which Zn(Ⅱ)-Bn PyP targets PrPCmay lead toward the development of a new class of dual mechanism anti-prion compounds.

关键词： anti-prion drug anti-PrPC antibody antisense oligonucleotide neurodegeneration pharmacological chaperone porphyrin prion disease PrPC degrader PrPC shedding zinc finger repressor

Geomorphological mapping for the valorization of the alpine environment. A methodological proposal tested in the Loana Valley(Sesia Val Grande Geopark, Western Italian Alps)

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Journal of Mountain Science 2017年第6期14卷 1023-1038页

作者： Irene BOLLATI Beatrice crosa LENZ Enrico ZANOLETTI Manuela PELFINI Earth Science Department 'A. Desio' Universita degli Studi diMilano Via Mangiagalli 34 20133 - Milan Italy C-eoexplora-C-eologia & Outdoor Via Mussi 5 28831-Baveno (VB) Italy

Geomorphological mapping plays a key role in landscape representation: it is the starting point for many applications and for the realization of thematic maps, such as hazard and risk maps, geoheritage and geotourism maps. Traditional geomorphological maps are useful for scientific purposes but they need to be simplified for different aims as management and education. In tourism valorization, mapping of geomorphological resources(i.e., geosites, and geomorphosites), and of geomorphic evidences of past hazardous geomorphological events, is important for increasing knowledge about landscape evolution and active processes, potentially involving geomorphosites and hiking trails. Active geomorphosites, as those widespread in mountain regions, testify the high dynamicity of geomorphic processes and their link with climatic conditions. In the present paper, we propose a method to produce and to update cartographic supports(Geomorphological Boxes)realized starting from a traditional geomorphological survey and mapping. The Geomorphological Boxes are geomorphological representation of single, composed or complex landforms drawn on satellite images, using the official Italian geomorphological legend(ISPRA symbols). Such cartographic representation is also addressed to the analysis(identification, evaluation and selection) of Potential Geomorphosites and Geotrails. The method has been tested in the upper portion of the Loana Valley(Western Italian Alps), located within the borders of the Sesia Val Grande Geopark, recognized by UNESCO in 2013. The area has a good potential for geotourism and for educational purposes. We identified 15 Potential Geomorphosites located along 2 Geotrails; they were ranked according to specific attributes also in relation with a Reference Geomorphosite located in the Loana hydrographic basin and inserted in official national and regional databases of geosites(ISPRA; Regione Piemonte). Finally, the ranking of Potential Geomorphosites allowed to selec

关键词： Geomorphological mapping Geomorphological Boxes Mountain geomorphosites Geotrails GIS-Geographical Information Systems Loana Valley Western Italian Alps

On the role of the uncertainty principle in superconductivity and superfluidity

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Chinese Physics B 2012年第7期21卷 125-131页

作者： roberto Onofrio Dipartimento di Fisica e Astronomia"Galileo Galilei" Universitàdi PadovaVia Marzolo 8Padova 35131Italy ITAMP Harvard-Smithsonian Center for Astrophysics60 Garden StreetCambridgeMA 02138USA

We discuss the general interplay between the uncertainty principle and the onset of dissipationless transport phenomena such as superconductivity and superfluidity. We argue that these phenomena are possible because of the robustness of many-body quantum states with respect to the external environment, which is directly related to the uncertainty principle as applied to coordinates and momenta of the carriers. In the case of superconductors, this implies relationships between macroscopic quantities such as critical temperature and critical magnetic field, and microscopic quantities such as the amount of spatial squeezing of a Cooper pair and its correlation time. In the case of ultracold atomic Fermi gases, this should be paralleled by a connection between the critical temperature for the onset of superfluidity and the corresponding critical velocity. Tests of this conjecture are finally sketched with particular regard to the understanding of the behaviour of superconductors under external pressures or mesoscopic superconductors, and the possibility to mimic these effects in ultracold atomic Fermi gases using Feshbach resonances and atomic squeezed states.

关键词： superconductivity superfluidity uncertainty principle squeezed states

EQUIVALENCE OF SEMI-LAGRANGIAN AND LAGRANGE-GALERKIN SCHEMES UNDER CONSTANT ADVECTION SPEED

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Journal of Computational Mathematics 2010年第4期28卷 461-473页

作者： roberto Ferretti Dipartimento di Matematica Università di Roma Tre

We compare in this paper two major implementations of large time-step schemes for advection equations, i.e., Semi-Lagrangian and Lagrange-Galerkin techniques. We show that SL schemes are equivalent to exact LG schemes via a suitable definition of the basis functions. In this paper, this equivalence will be proved assuming some simplifying hypoteses, mainly constant advection speed, uniform space grid, symmetry and translation invariance of the cardinal basis functions for interpolation. As a byproduct of this equivalence, we obtain a simpler proof of stability for SL schemes in the constant-coefficient case.

关键词： Semi-Lagrangian schemes Lagrange-Galerkin schemes Stability.

Recovering of Damping Coefficients for a System of Coupled Wave Equations with Neumann Boundary Conditions:Uniqueness and Stability

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Chinese Annals of Mathematics,Series B 2011年第5期32卷 669-698页

作者： roberto TRIGGIANI Department of Mathematics University of Virginia Department of Mathematics and Statistics King Fahd University of Petroleum and Minerals

The authors study the inverse problem of recovering damping coefficients for two coupled hyperbolic PDEs with Neumann boundary conditions by means of an additional measurement of Dirichlet boundary traces of the two solutions on a suitable, explicit subportion F1 of the boundary F, and over a computable time interval T 〉 0. Under sharp conditions on Г0= Г／Г1, T 〉 0, the uniqueness and stability of the damping coefficients are established. The proof uses critically the Carleman estimate due to Lasiecka et al. in 2000, together with a convenient tactical route ＂post-Carleman estimates＂ suggested by Isakov in 2006.

关键词： Inverse problem Coupled wave equations Carleman estimate

Mechanochemistry of cyclobutanes

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Science China Chemistry 2024年第12期67卷 3915-3924页

作者： roberto Obregon Junpeng Wang School of Polymer Science and Polymer Engineering University of AkronAkronOH 44325USA

The field of polymer mechanochemistry has been revolutionized by implementing force-responsive functional groups—*** rational design of mechanophores enables the controlled use of force to achieve constructive molecular reactivity and material *** a variety of mechanophores have been developed,this Mini Review focuses on cyclobutane,which has brought valuable insights into molecular reactivity and dynamics as well as innovations in *** discuss its reactivity and mechanism,dynamics and stereoselectivity,as well as impacts on material properties.

关键词： mechanochemistry mechanophore cyclobutane

Is dual therapy the correct strategy in frail elderly patients with atrial fibrillation and acute coronary syndrome?

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Journal of Geriatric Cardiology 2020年第1期17卷 51-57页

作者： Alessio Menditto roberto Antonicelli Cardiology Unit Italian National Research Centre on Aging

Atrial fibrillation(AF)is a very common arrhythmia in clinical *** incidence and prevalence are age-related and are growing in the last *** is a risk factor also for coronary artery disease(CAD),and with the evolution of preventive care,the first event(acute coronary syndrome(ACS)or percutaneous coronary intervention(PCI))takes place at a later *** elderly patients with AF and CAD undergo ACS or PCI,they have indication to assume triple *** therapy(oral anticoagulation(OAC)plus dual antiplatelet therapy(DAPT))exposes patients to high bleeding *** the last 10 years,several clinical trials have tested dual therapy(OAC plus single antiplatelet therapy)in AF patients who undergo ACS or elective *** trial has tested warfarin+clopidogrel against triple *** AF-PCI trial has tested low-dose rivaroxaban+P2Y12 inhibitor or very low-dose rivaroxaban+DAPT against standard triple therapy with ***-DUAL PCI trial has tested two doses of dabigatran+P2Y12 inhibitor against standard triple therapy with *** trial has tested apixaban against warfarin both in dual therapy with P2Y12 inhibitor and in triple therapy with a P2Y12 inhibitor and ***-AF PCI,last published study,has tested edoxaban+P2Y12 inhibitor against triple *** these trials show dual therapy reduces significantly bleeding risk than triple *** this paper,we analyze these clinical trials to understand if dual therapy results can be applied to elderly patients and what is probably the better approach in elderly AF patients undergo to ACS or PCI.

关键词： Acute coronary syndrome Atrial fibrillation Dual therapy Oral anticoagulation The elderly

Shale gas reservoirs: Theoretical, practical and research issues

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Petroleum Research 2016年第1期1卷 10-26页

作者： roberto Aguilera Schulich School of Engineering University of CalgaryCalgaryCanada

Shale gas reservoirs are found all over the *** endowment worldwide is estimated at 10,000 tcf by the GFREE team in the Schulich School of Engineering at the University of *** shale gas work and production initiated successfully in the Unites States and extended to Canada will have application,with modifications,in several other countries in the ***‘modifications’qualifier is important as each shale gas reservoir should be considered as a research project by itself to avoid fiascos and major financial *** gas reservoirs are best represented by at least quadruple porosity *** of the production obtained from shale reservoirs is dominated by diffusion *** approximate boundary between viscous and diffusion-like flow is estimated with Knudsen *** flow is present,for example,when the architecture of the rock is dominated by mega pore throat,macro pore throat,meso pore throat and sometimes micro pore *** flow on the other hand is observed at the nano pore throat *** process speed concept has been used successfully in conventional reservoirs for several ***,the concept discussed in this paper for tight gas and shale gas reservoirs,with the support of core data,has been developed only recently,and permits differentiating between viscous and diffusion dominated *** is valuable,for example,in those cases where the formation to be developed is composed of alternating stacked layers of tight sands and shales,or where there are lateral variations due to facies *** approach to develop the concept of a super-giant shale gas reservoir is presented as well as a description of GFREE,a successful research program for tight *** paper closes with examples of detailed original gas-in-place(OGIP)calculations for 3 North American shale gas reservoirs including free gas in natural fractures and the porous network within the organic matter,gas in the non-organic matter,adsorbed gas,a

关键词： shale gas reservoirs process or delivery speed quadruple porosity model Knudsen number pore throat level