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Evaluation of biodegradable electric conductive tube-guides and mesenchymal stem cells

World Journal of stem Cells 2015年第6期7卷 956-975页

作者： Jorge Ribeiro Tiago Pereira Ana Rita Caseiro Paulo Armada-da-silva Isabel Pires Justina Prada Irina Amorim sandra Amado Miguel Franca Carolina Goncalves Maria Ascensao Lopes Jose Domingos santos Dina Morais silva stefano Geuna Ana Lúcia Luís Ana Colette Maurício Departmento de Clínicas Veterinárias and+UPVet Instituto de Ciencias Biomedicas de Abel Salazar(ICBAS)and Centro de Estudos de Ciencia Animal(CECA)Instituto de CienciasTecnologias e Agroambiente da Universidade do Porto(ICETA)Rua de Jorge Viterbo Ferreira4050-313 PortoPortugal Centro Interdisciplinar de Estudo de Performance Humana(CIPER) Faculdade de Motricidade Humana(FMH)Universidade de Lisboa(UL)Estrada da Costa1499-002 Cruz QuebradaDafundoPortugal CECAV and Departamento de Ciencias Veterinárias Universidade de Trás-os-Montes e Alto Douro(UTAD)5001-801 Vila RealPortugal Departmento de Patologia e de Imunologia Molecular Instituto de Ciencias Biomedicas de Abel SalazarRua de Jorge Viterbo Ferreira4050-313 PortoPortugal Instituto Português de Patologia e Imunologia Molecular da Universidade do Porto(IPATIMUP) Rua Dr.Roberto Frias s/n4200-465 PortoPortugal UIs-IPL:Unidade de Investigacao em saúde da Escola superior de saúde de Leiria Instituto Politécnico de Leiria2411-901 LeiriaPortugal CEMUC Departamento de Engenharia Metalúrgica e MateriaisFaculdade de Engenharia da Universidade do Porto(FEUP)Rua Dr.Roberto Frias4200-465 PortoPortugal Biosckin Molecular and Cell Therapies S.A.Tec MaiaRua Engenheiro Frederico Ulrich 26504470-605 MaiaPortugal Neuroscience Institute of the Cavalieri Ottolenghi Foundation and Department of Clinical and Biological sciences University of Turin

AIM: To study the therapeutic effect of three tubeguides with electrical conductivity associated to mesenchymal stem cells(MsCs) on neuro-muscular regeneration after ***: Rats with 10-mm gap nerve injury were tested using polyvinyl alcohol(PVA), PVA-carbon nanotubes(CNTs) and MsCs, and PVA-polypyrrole(PPy). The regenerated nerves and tibialis anterior muscles were processed for stereological studies after 20 wk. The functional recovery was assessed serially for gait biomechanical analysis, by extensor postural thrust, sciatic functional index and static sciatic functionalindex(ssI), and by withdrawal reflex latency(WRL). In vitro studies included cytocompatibility, flow cytometry, reverse transcriptase polymerase chain reaction and karyotype analysis of the MsCs. Histopathology of lung, liver, kidneys, and regional lymph nodes ensured the biomaterials biocompatibility. REsULTs: ssI remained negative throughout and independently from treatment. Differences between treted groups in the severity of changes in WRL existed, showing a faster regeneration for PVA-CNTs-MsCs(P ss acute ankle joint angles were seen for PVA-CNTs-MsCs group(P = 0.051) suggesting improved ankle muscles function during the push off phase of the gait cycle. In PVA-PPy and PVA-CNTs groups, there was a 25% and 42% increase of average fiber area and a 13% and 21% increase of the "minimal Feret's diameter" respectively. stereological analysis disclosed a significantly(P sed myelin thickness(M), ratio myelin thickness/axon diameter(M/d) and ratio axon diameter/fiber diameter(d/D; g-ratio) in PVA-CNT-MsCs group(P sION: Results revealed that treatment with MsCs and PVA-CNTs tube-guides induced better nerve fiber regeneration. Functional and kinematics analysis revealed positive synergistic effects brought by MsCs and PVA-CNTs. The PVA-CNTs and PVA-PPy are promising scaffolds with electric conductive properties, bio- and cytocompatible th

关键词： Nerve regeneration Neurotmesis Tubeguides Mesenchymal stem cells Carbon nanotubes Functional assessment Gait biomechanical analysis Histomorfometry Polyvinyl alcohol

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Punica granatum Leaf Lipophilic Fraction Favours Mortality by Attenuating Inflammation in Mice with Polymicrobial sepsis

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Journal of Pharmacy and Pharmacology 2019年第7期7卷 355-367页

作者： Nagila Caroline Fialho sousa Isabella Fernandes da silva Figueiredo Mizael Calacio de Araujo Elaine Pereira de Andrade Thais costa Alves Bruna Letícia Rosa da silva Domingos Magno santos Pereira saulo JoseFigueiredo Mendes Joao Francisco silva Rodrigues Jaqueline Pessoa Pontes simone Aparecida Teixeira AndreAlvares Marques Vale Marcus Vinicius Dias-souza Lidio Goncalves Lima-Neto Vera Lucia dos santos Ana Paula Azevedo-santos Marcelo Nicolas Muscara Valerio Monteiro-Neto Andrea de souza Monteiro Luis Claudio Nascimento da silva Elizabeth soares Fernandes Programa de Pos-graduacao Universidade CEUMARua JosueMontellon°1RenascencaSao LuisMA 65075-120Brazil Departamento de Farmacologia Universidade de Sao PauloAv.Prof.Lineu Prestesn°1524Sala 326ButantanSao PauloSP 05508-900Brazil Programa de Pos-graduacao em Ciências em saude Universidade Federal do MaranhaoAvenida dos Portuguesesn°1966BacangaSao LuisMA 65080-805Brazil Departamento de Microbiologia Universidade Federal de Minas GeraisAv.Antonio Carlosn°6627PampulhaBelo HorizonteMG 31270-901Brazil Departamento de Patologia Universidade Federal do MaranhaoAvenida dos Portuguesesn°1966BacangaSao LuísMA 65080-805Brazil

Punica granatum *** known antimicrobial and anti-inflammatory *** of different parts of this plant have been commonly used in the folk medicine to prevent and treat infections;and studies have supported the use of *** extracts for this ***,little is known of the effects of ***-derived fractions in severe infectious diseases such as ***,we investigated the actions of the hexane fraction(HF),rich in lipophilic compounds,obtained from the leaves of this plant,in a murine model of polymicrobial *** pre-treatment with HF increased mortality in septic *** same animals presented with lower levels of interleukin-6,nitric oxide and hydrogen peroxide in their peritoneal lavage samples than vehicle *** also increased polymorphonuclear cell accumulation in to the peritoneum of mice with ***-derived nitric oxide upon lipopolysaccharide stimuli was markedly reduced by incubation with ***,triterpenes,phytosterols,vitamin E and ascorbyl palmitate were detected in the *** results indicate that *** leaf lipophilic fractions may worsen sepsis *** effect may be associated with its bioactive compounds which act synergistically or not,increasing sepsis mortality in vivo.

关键词： P.granatum infection inflammation

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Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO

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Chinese Physics C 2021年第2期45卷 93-110页

作者： Angel Abusleme Thomas Adam shakeel Ahmad sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld sylvie Blin David Blum simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen shaomin Chen shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux selma Conforti Di Lorenzo Daniele Corti salvatore costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole shuxian Du stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yan Yerevan Physics Institute YerevanArmenia UniversitéLibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro RioBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico santa Maria ValparaisoChile Beijing Institute of spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina school of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of sciences BeijingChina Jilin University ChangchunChina College of Electronic science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina sun Yat-sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of south China HengyangChina Wuyi University JiangmenChina shandong University JinanChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of science and Technology ShanghaiChina school of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi’an Jiaotong University Xi’anChina Xiamen University XiamenChina school of Physics and Microelectronics Zhengzhou UniversityZhengzhouChina Institute of Physics National Chiao-Tung University Hsinchu National United University Miao-Li Department of Physics National T

The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main *** of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator *** this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/*** ten years of data acquisition,approximately 60,000 signal and 30,000 background events are *** large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation *** m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith ***,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment.

关键词： neutrino oscillation solar neutrino JUNO

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侧前路减压、脊柱重建治疗胸腰段椎体爆裂骨折

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实用骨科杂志 2004年第2期10卷 103-105页

作者：王文跃陈顺方周海平冯健朱海涛胡祖愉王俭胡江海盐县人民医院骨科浙江海盐314300

目的　探讨胸腰段椎体爆裂骨折侧前路减压与重建的临床效果。方法　对 19例胸腰段椎体爆裂骨折侧前路减压及髂骨、肋骨、钛网植骨加 Z- plate、Kaneda内固定系统重建脊柱稳定的临床资料进行总结。结果　经平均 13个月随访 ,术后脊柱序... 详细信息

目的　探讨胸腰段椎体爆裂骨折侧前路减压与重建的临床效果。方法　对 19例胸腰段椎体爆裂骨折侧前路减压及髂骨、肋骨、钛网植骨加 Z- plate、Kaneda内固定系统重建脊柱稳定的临床资料进行总结。结果　经平均 13个月随访 ,术后脊柱序列及生理曲度恢复正常 ,椎管无占位 ,植骨融合良好 ,无继发性后凸畸形发生 ,无钢板、螺丝钉断裂及松动等并发症。结论　侧前路手术可一期实现椎管前方减压 ,且直接、彻底 ,使神经获得最大限度的功能恢复 ,Z-plate、Kaneda内固定直接作用于骨折部位可以对椎体间支撑和对植骨加压 ,促进植骨融合。

关键词：侧前路减压脊柱重建治疗胸腰段椎体爆裂骨折内固定手术方法

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