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自体骨与脱蛋白牛骨基质在严重上颌骨萎缩行同期上颌窦侧壁开窗提升术中的应用：随机对照试验

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中国口腔医学继续教育杂志 2015年第6期18卷 338-345页

作者： Mauro Merli Marco Moscatelli Giorgia Mariotti roberto rotundo Michele Nieri 刘长营李钧不详首都医科大学附属北京口腔医院北京市东城区天坛西里4号 100050

目的：在随机对照优效性试验中比较100％脱蛋白牛骨基质（deproteinised bovine bone ***）移植（试验组）和100％自体骨（autogenous ***）移植（平行对照组）的差异。材料与方法：对上颔实底剩余牙槽骨高度在1～3mm的患者进行上颌窦... 详细信息

目的：在随机对照优效性试验中比较100％脱蛋白牛骨基质（deproteinised bovine bone ***）移植（试验组）和100％自体骨（autogenous ***）移植（平行对照组）的差异。材料与方法：对上颔实底剩余牙槽骨高度在1～3mm的患者进行上颌窦提升术，随机分为两组．分别植入DBBM和AB，并且同期植入种植体。随机化是由计算机分配并用信封密封，影像学检查人员对于分组不知情。术后8个月安装愈合基台并且在术后9个月安装临时修复体。观察的结果变量有种植体失败、修复体失败、并发症、椅旁时间、术后疼痛和负重6个月后的放射线评估骨量变化。结果：共40名患者随机分为两组：DBBM组20名（32颗种植体）．AB组20名（27颗种植体）。AB组1名患者失访。DBBM组有2颗种植体失败．而AB组无种植体失败（P=0.4872）。所有计划安装的修复体都顺利实施。DBBM组有1例出现并发症．AB组有2例（P=0.6050）。DBBM组的椅旁时间更短．能缩短大约27．3min（P=0.0428）。采用视觉模拟评分法（VAS）测量术后6d的疼痛差异．发现DBBM组比AB组有0．2的差异．疼痛更轻（P=0.6838）。垂直骨量的差异为0.0mm（95％CI-1．1,1.1；P=0.9703）；边缘骨吸收的差异在AB组更明显．为0.3mm（95％Cl-03，0．9：P=0．3220）。结论：在上颌寞提升同期行种植体植入时比较DBBM和AB移植的差异．发现除了椅旁时间外其余均无差异。

关键词： Bio—Gide Bio—Oss 骨替代材料牙种植体上颌窦提升

Liver injury induced by paracetamol and challenges associated with intentional and unintentional use

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World Journal of Hepatology 2020年第4期12卷 125-136页

作者： Laura rotundo Nikolaos Pyrsopoulos Department of Medicine Rutgers New Jersey Medical SchoolNewarkNJ 07103United States Department of Gastroenterology and Hepatology Rutgers New Jersey Medical SchoolNewarkNJ 07103United States

Drug induced liver injury(DILI)is a common cause of acute liver ***,also known as acetaminophen,is a widely used anti-pyretic that has long been established to cause liver toxicity once above therapeutic *** from paracetamol overdose,whether intentional or nonintentional,is the most common cause of DILI in the United States and remains a global *** the increased prevalence of combination medications in the form of pain relievers and antihistamines,paracetamol can be difficult to identify and remains a significant cause of acute hepatotoxicity,as evidenced by its contribution to over half of all acute liver failure cases in the United *** is especially concerning given that,when co-ingested with other medications,the rise in serum paracetamol levels may be delayed past the 4-hour post-ingestion mark that is currently used to determine patients that require medical *** review serves to describe the clinical and pathophysiologic features of hepatotoxicity secondary to paracetamol and provide an update on current available knowledge and treatment options.

关键词： Paracetamol Drug-induced liver injury Hepatotoxicity Acute liver failure

Hospital teaching status on the outcomes of patients with esophageal variceal bleeding in the United States

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World Journal of Hepatology 2020年第6期12卷 288-297页

作者： Pavan Patel Laura rotundo Evan Orosz Faiz Afridi Nikolaos Pyrsopoulos Division of Gastroenterology and Hepatology Rutgers-New Jersey Medical SchoolNewarkNJ 07101-1709United States Department of Medicine Rutgers-New Jersey Medical SchoolNewarkNJ 07101-1709United States

BACKGROUND Acute variceal bleeding is a major complication of portal hypertension and is a leading cause of death in patients with *** is limited data on the outcomes of patients with esophageal variceal bleeding in teaching versus nonteaching *** esophageal variceal bleeding requires complex management,it may be hypothesized that teaching hospitals have lower *** To assess the differences in mortality,hospital length of stay(LOS)and cost of admission for patients admitted for variceal bleed in teaching versus nonteaching hospitals across the *** The National Inpatient Sample is the largest all-payer inpatient database consisting of approximately 20%of all inpatient admissions to nonfederal hospitals in the United *** collected data from the years 2008 to *** of variceal bleeding were identified using the International Classification of Diseases,Ninth Edition,Clinical Modification *** in mortality,LOS and cost were evaluated for patients with esophageal variceal bleed between teaching and nonteaching hospitals and adjusted for patient characteristics and *** Between 2008 and 2014,there were 58362 cases of esophageal variceal bleeding *** with teaching hospitals,mortality was lower in nonteaching hospitals(8.0%vs 5.3%,P<0.001).Median LOS was shorter in nonteaching hospitals as compared to teaching hospitals(4 d vs 5 d,P<0.001).A higher proportion of non-white patients were managed in teaching *** far as procedures in nonteaching vs teaching hospitals,portosystemic shunt insertion(3.1%vs 6.9%,P<0.001)and balloon tamponade(0.6%vs 1.2%)were done more often in teaching hospitals while blood transfusions(64.2%vs 59.9%,P=0.001)were given more in nonteaching *** binary logistic regression models and adjusting for baseline patient demographics and comorbid conditions the mortality,LOS and cost in teaching hospitals remained *** In patient

关键词： Variceal bleeding Teaching hospital Mortality National Inpatient Sample Length of stay Bleeding Cirrhosis

Vitamin D Is Associated with Severity and Mortality of Non-alcoholic Fatty Liver Disease: A US Population-based Study

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Journal of Clinical and Translational Hepatology 2017年第3期5卷 185-192页

作者： Hyun-Seok Kim Laura rotundo Neil Kothari Sung-Hoon Kim Nikolaos Pyrsopoulos Department of Medicine Division of Gastroenterology and Hepatology Rutgers New Jersey Medical School Newark NJ USA College of Korean Medicine Kyung-hee University Seoul South Korea Division of Gastroenterology and Hepatology Rutgers New Jersey Medical School Newark NJ USA

Background and Aims:There has been increasing evidence that vitamin D deficiency may increase the risk of metabolic *** metabolic syndrome is a major risk factor for non-alcoholic fatty liver disease (NAFLD),we aimed to investigate the association between vitamin D and the severity and mortality of ***:Data was obtained from the United States Third National Health and Nutrition Examination Survey conducted in 1988-1994,with followup mortality data through *** was defined by ultrasonographic detection of hepatic steatosis in the absence of other liver diseases and categorized as normal,mild,moderate or *** severity of hepatic fibrosis was determined by NAFLD fibrosis score (NFS).ANOVA (F-test) was used to evaluate the association between vitamin D level and degree of NAFLD,and Cox proportional hazards regression analysis was used for survival ***:Vitamin D levels for normal,mild,moderate and severe steatosis were 25.1 ± 0.29 ng/mL,24.7 ± 0.42 ng/mL,23.7 ± 0.37 ng/mL and 23.6 ± 0.60 ng/mL,respectively (trend p < 0.001).Likewise,vitamin D levels for low,intermediate and high NFS categories were 24.7 ± 0.38 ng/mL,23.4 ± 0.42 ng/mL and 21.5 ± 0.57 ng/mL,respectively (trend p < 0.001).After median-follow up over 19 years,vitamin D deficiency was significantly associated with diabetes-and Alzheimer's diseaserelated mortality (hazard ratio (HR):3.64,95%CI:1.51-8.82 and HR:4.80,95%CI:1.53-15.1,respectively),with a borderline significance in overall mortality (HR:1.16,95%CI:0.99-1.36,p =0.06).Conclusion:Vitamin D level was inversely related to the degree of liver steatosis and ***,vitamin D deficiency was associated with diabetes-and Alzheimer's disease-related mortality in NAFLD patients.

关键词： Vitamin D Non-alcoholic fatty liver disease Mortality Severity

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World Journal of Gastroenterology 2022年第12期28卷 1226-1238页

作者： Nadia Marascio Salvatore rotundo Angela Quirino Giovanni Matera Maria Carla Liberto Chiara Costa Alessandro Russo Enrico Maria Trecarichi Carlo Torti Department of Health Sciences Unit of MicrobiologyUniversity“Magna Graecia”of CatanzaroCatanzaro 88100Italy Department of Medical and Surgical Sciences Unit of Infectious and Tropical Diseases"Magna Graecia"University of CatanzaroCatanzaro 88100Italy

Hepatitis E virus(HEV)and hepatitis C virus(HCV)are both RNA viruses with a tropism for liver parenchyma but are also capable of extrahepatic *** E is usually a viral acute fecal-oral transmitted and self-limiting disease presenting with malaise,jaundice,nausea and ***,HEV causes a chronic infection in immunocompromised persons and severe fulminant hepatitis in pregnant *** HCV infection is typically asymptomatic for decades until chronic complications,such as cirrhosis and cancer,*** being two very different viruses in terms of phylogenetic and clinical presentations,HEV and HCV show many similarities regarding possible transmission through organ transplantation and blood transfusion,pathogenesis(production of antinuclear antibodies and cryoglobulins)and response to treatment with some direct-acting antiviral *** both HEV and HCV are well studied individually,there is a lack of knowledge about coinfection and its *** aim of this review is to analyze current literature by evaluating original articles and case reports and to hypothesize some interactions that can be useful for research and clinical practice.

关键词： Hepatitis C virus Hepatitis E virus Co-infection Genomic variability Extrahepatic diseases Vaccine

Increasing thirty-day readmissions of Crohn’s disease and ulcerative colitis in the United States:A national dilemma

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World Journal of Gastrointestinal Pathophysiology 2022年第3期13卷 85-95页

作者： Dushyant Singh Dahiya Abhilash Perisetti Asim Kichloo Amandeep Singh Hemant Goyal Laura rotundo Madhu Vennikandam Hafeez Shaka Gurdeep Singh Jagmeet Singh Sailaja Pisipati Mohammad Al-Haddad Madhusudhan R Sanaka Sumant Inamdar Department of Internal Medicine Central Michigan University College of MedicineSaginawMI 48601United States Division of Gastroenterology Parkview Cancer InstituteFort WayneIN 46845United States Division of Gastroenterology and Hepatology Cleveland Clinic FoundationClevelandOH 44195United States Department of Internal Medicine The Wright Center for Graduate Medical EducationScrantonPA 18505United States Department of Internal Medicine Mercer University School of MedicineMaconGA 31207United States Department of Gastroenterology and Hepatology Sparrow Hospital/Michigan State University College of Human MedicineLansingMI 48912United States Department of Internal Medicine John H.StrogerJr.Hospital of Cook CountyChicagoIL 60612United States Department of Internal Medicine Our Lady of Lourdes Memorial HospitalBinghamtonNY 13905United States Department of Internal Medicine Guthrie Robert Packer HospitalSayrePA 18840United States Division of Gastroenterology and Hepatology Mayo ClinicScottsdaleAZ 85259United States Division of Gastroenterology and Hepatology Indiana University School of MedicineIndianapolisIN 46202United States Division of Gastroenterology and Hepatology University of Arkansas for Medical SciencesLittle RockAR 72205United States

BACKGROUND The prevalence of Crohn’s disease(CD)and ulcerative colitis(UC)is on the rise *** rising prevalence is concerning as patients with CD and UC may frequently relapse leading to recurrent hospitalizations and increased healthcare *** To identify trends and adverse outcomes for 30 d readmissions for CD and *** This was a retrospective,interrupted trends study involving all adult(≥18 years)30 d readmissions of CD and UC from the National Readmission Database(NRD)between 2008 and ***<18 years,elective,and traumatic hospitalizations were excluded from this *** identified hospitalization characteristics and readmission rates for each calendar *** of inpatient mortality,mean length of hospital stay(LOS)and mean total hospital cost(THC)were calculated using a multivariate logistic trend analysis adjusting for age,gender,insurance status,comorbidity burden and hospital ***,trends between CD and UC readmissions were compared using regression of the interaction coefficient after adjusting for age and gender to determine relative trends between the two ***®Version 16 software(StataCorp,TX,United States)was used for statistical analysis and P value≤0.05 were considered statistically *** Total number of 30 d readmissions increased from 6202 in 2010 to 7672 in 2018 for CD and from 3272 in 2010 to 4234 in 2018 for *** noted increasing trends for 30-day all-cause readmission rate of CD from 14.9%in 2010 to 17.6%in 2018(P-trend<0.001),CD specific readmission rate from 7.1%in 2010 to 8.2%in 2018(P-trend<0.001),30-day all-cause readmission rate of UC from 14.1%in 2010 to 15.7%in 2018(P-trend=0.003),and UC specific readmission rate from 5.2%in 2010 to 5.6%in 2018(P-trend=0.029).There was no change in the risk adjusted trends of inpatient mortality and mean LOS for CD and UC ***,we found an increasing trend of mean THC for UC *** comparison,there w

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis Readmissions Trends