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Management of hepatitis C infection before and after liver transplantation

World Journal of Gastroenterology 2015年第15期21卷 4447-4456页

作者： Stefano Fagiuoli roberto ravasio Maria Grazia Lucà Anna Baldan Silvia Pecere Alessandro Vitale Luisa Pasulo Gastroenterology and Transplant Hepatology Papa Giovanni XXIII Hospital PHarm ES Milano Liver Transplantation and Hepatobiliary Surgical Unit Padua University Hospital

Chronic hepatitis C(CHC) is the most common indication for liver transplantation(LT). Aggressive treatment of hepatitis C virus(HCV) infection before cirrhosis development or decompensation may reduce LT need and risk of HCV recurrence post-LT. Factors associated with increased HCV risk or severity of recurrence include older age, immunosuppression, HCV genotype 1 and high viral load at LT. HCV recurrence post-LT leads to accelerated liver disease and cirrhosis development with reduced graft and patient survival. Currently, interferon(IFN)-based regimens can be used in dualagent regimens with ribavirin, in triple-agent antiviral strategies with direct-acting antivirals(e.g., protease inhibitors telaprevir or boceprevir), or before transplant in compensated patients to reduce HCV viral load to prevent or reduce the risk of post-LT recurrence and complications; they cannot be used in patients with decompensated cirrhosis. IFN-based regimens are used in less than half of HCV-infected patients waiting for LT due to extremely low efficacy and poor tolerability. However, antiviral therapy is indicated after LT in patients with histologically confirmed CHC despite tolerability issues. Improvements in side effect management have increased survival in patients achieving therapeutic targets. HCV treatment pre- and post-LT results in significant health care costs especially when lack of efficacy leads to disease worsening, although studies have shown sofosbuvir treatment before LT vs conventional post-LT dual antiviral is cost effective. The suboptimal efficacy and tolerability of IFN-based therapies, plus the significant economic burden, means the need for effective and well tolerated IFN-free antiHCV therapy for pre- and post-LT remains high.

关键词： Hepatitis C virus Orthotopic liver trans plantation Interferon-free treatment Decompensated cirrhosis Chronic hepatitis C

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Measurement of iron characteristics under ramp compression

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Chinese Physics B 2017年第11期26卷 360-364页

作者：魏会冈 E Brambrink N Amadou A Benuzzi-Mounaix A ravasio G Morard F Guyot T de Rességuier N Ozaki K Miyanishi 赵刚 M Koenig Key Laboratory of Optical Astronomy National Astronomical Observatories Chinese Academy of Sciences LULI-CNRS Ecole Polytechnique CEA Université Paris-Saclay Sorbonne Universités UPMC Univ Paris 06 CNRS laboratoire d'utilisation des lasers intenses (LULI) Département de Physique Université Abdou Moumouni de Niamey Institut de Minéralogie de Physique des Matériaux et de Cosmochimie (IMPMC) Sorbonne Universités-UPMC UMR CNRS 7590Muséum National d'Histoire Naturelle Institut Pprime CNRS ENSMA Univ.Poitiers Graduate School of Engineering Osaka University

Laser-driven ramp compression was used to investigate iron characteristics along the isentropic path. The iterative Lagrangian analysis method was employed to analyze the free surface velocity profiles in iron stepped target measured with two VISARs. The onset stress for the α to ε phase transformation was determined from the sudden change in the sound velocity and was found over-pressurized compared to the static and shock results. The derived stress（26 GPa） and strain rate（up to 10-8 s^-1） are consistent with our previous experimental results. The stress-density relations were compared with those from previous ramp experiments and good agreements were found, which experimentally confirms the simulations,showing that iterative Lagrangian analysis can be applied to the ramp-compression data with weak shock.

关键词： isentropic compression iron phase transformation

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铜/二氧化硅催化剂中金属纳米粒子构性关系的一些认识（英文）

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Chinese Journal of Catalysis 2019年第11期40卷 1788-1794页

作者： Nicola Scotti Elisabetta Finocchio Claudio Evangelisti Marcello Marelli Rinaldo Psaro Nicoletta ravasio Federica Zaccheria 国家研究委员会演技中心分子科学与技术研究所催化实验室意大利米兰20133 热那亚大学理工学院土木工程与环境化学系(DICCA)意大利热那亚16145

考察了化学吸附水解法制备的两种铜/二氧化硅催化剂上3-甲基环己酮加氢反应活性.发现两种催化剂在60℃和1bar H2下催化活性非常高.吸附CO红外光谱和透电镜结果表明,催化剂中存在结晶良好的铜颗粒.通过假设一个立方八面体模型,我们可以... 详细信息

考察了化学吸附水解法制备的两种铜/二氧化硅催化剂上3-甲基环己酮加氢反应活性.发现两种催化剂在60℃和1bar H2下催化活性非常高.吸附CO红外光谱和透电镜结果表明,催化剂中存在结晶良好的铜颗粒.通过假设一个立方八面体模型,我们可以证明加氢活性与金属颗粒上的高配位点有关.本文还与蒸氨法制备的样品进行了比较,发现在相同的实验条件下,蒸氨法样品在加氢反应中没有活性.

关键词：铜颗粒金属粒子形态 Lewis酸位加氢双功能催化剂

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Biophysics of articular cartilage:What we can learn from spin relaxation?

Biophysics of articular cartilage:What we can learn from spi...

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第十七届国际生物物理大会;第十二届中国生物物理大会

作者： Konstantin I.Momot R.Mark Wellard Sabrina Barheine Alf Pawlik Jean-Philippe ravasio Gary Cowin Chris Bell James M.Pope Faculty of Science and Technology Queensland University of TechnologyBrisbaneAustralia Faculte de medecine Universite Henri PoincareNancyFrance Centre for Magnetic Resonance University of QueenslandBrisbaneAustralia

Articular cartilage(AC) is a connective tissue covering the articulating surfaces of long bones.Its structural basis is a biopolymeric extracellular matrix(ECM) based on collagen and proteoglycans.

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