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An efficient improved Gradient Boosting for strain prediction in Near-Surface Mounted fiber-reinforced polymer strengthened reinforced concrete beam

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Frontiers of Structural and Civil Engineering 2024年第8期18卷 1148-1168页

作者： Abdelwahhab KHATIR roberto CAPOZUCCA Samir KHATIR Erica MAGAGNINI Brahim BENAISSA Thanh CUONG-LE Structural Section DICEA Polytechnic University of MarcheAncona 60131Italy Centre for Engineering Application&Technology Solutions Ho Chi Minh City Open UniversityHo Chi Minh City 70000Vietnam Design Engineering Laboratory Toyota Technological InstituteNagoya 468-8511Japan

The Near-Surface Mounted(NSM)strengthening technique has emerged as a promising alternative to traditional strengthening methods in recent *** the past two decades,researchers have extensively studied its potential,advantages,and applications,as well as related parameters,aiming at optimization of construction ***,there is still a need to explore further,both from a static perspective,which involves accounting for the nonconservation of the contact section resulting from the bond-slip effect between fiber-reinforced polymer(FRP)rods and resin and is typically neglected by existing analytical models,as well as from a dynamic standpoint,which involves studying the trends of vibration frequencies to understand the effects of various forms of damage and the efficiency of *** address this gap in knowledge,this research involves static and dynamic tests on simply supported reinforced concrete(RC)beams using rods of NSM carbon fiber reinforced polymer(CFRP)and glass fiber reinforced polymer(GFRP).The main objective is to examine the effects of various strengthening *** research conducts bending tests with loading cycles until failure,and it helps to define the behavior of beam specimens under various damage degrees,including concrete *** analysis by free vibration testing enables tracking of the effectiveness of the reinforcement at various damage levels at each stage of the loading *** addition,application of Particle Swarm Optimization(PSO)and Genetic Algorithm(GA)is proposed to optimize Gradient Boosting(GB)training performance for concrete strain prediction in NSM-FRP *** GB using Particle Swarm Optimization(GBPSO)and GB using Genetic Algorithm(GBGA)systems were trained using an experimental data set,where the input data was a static applied load and the output data was the consequent *** models of GBPSO and GBGA have been shown to provide highly accurate results for predicting *** model

关键词： NSM technique fiber-reinforced polymer rods static and dynamic analysis GB PSO GA finite element analysis

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Interleukin 1βreceptor and synaptic dysfunction in recurrent brain infection with Herpes simplex virus type-1

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Neural Regeneration Research 2025年第2期20卷 416-423页

作者： roberto Piacentini Claudio Grassi Department of Neuroscience UniversitàCattolica del Sacro CuoreRomeItaly Fondazione Policlinico Universitario A.Gemelli IRCCSRomeItaly

Several experimental evidence suggests a link between brain Herpes simplex virus type-1 infection and the occurrence of Alzheimer’s ***,the molecular mechanisms underlying this association are not completely *** the molecular mediators of synaptic and cognitive dysfunction occurring after Herpes simplex virus type-1 infection and reactivation in the brain neuroinflammatory cytokines seem to occupy a central ***,we specifically reviewed literature reports dealing with the impact of neuroinflammation on synaptic dysfunction observed after recurrent Herpes simplex virus type-1 reactivation in the brain,highlighting the role of interleukins and,in particular,interleukin 1βas a possible target against Herpes simplex virus type-1-induced neuronal dysfunctions.

关键词： herpes simplex virus type 1 interleukin 1β microglia neuroinflammation synaptic dysfunction

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Effects of freeze-thaw cycles on sandstone in sunny and shady slopes

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2503-2515页

作者： Dian Xiao Xiaoyan Zhao Corrado Fidelibus roberto Tomás Qiu Lu Hongwei Liu Academy of Railway Sciences Corporation Limited BeijingChina Faculty of Geosciences and Environmental Engineering Southwest Jiaotong UniversityChengduChina Department of Civil Engineering University of AlicanteAlicanteSpain Department of Innovation Engineering University of SalentoLecceItaly Department of Earth and Environmental Sciences University of Milano BicoccaMilanItaly

A growing rock engineering activity in cold regions is facing the threat of freeze-thaw(FT)weathering,especially in high mountains where the sunny-shady slope effects strongly control the difference in weathering behavior of *** this paper,an investigation of the degradation of petrophysical characteristics of sandstone specimens subjected to FT cycle tests to simulate the sunny-shady slope effects is *** this aim,non-destructive and repeatable testing techniques including weight,ultrasonic waves,and nuclear magnetic resonance methods on standard specimens were *** the sunny slope specimens,accompanied by the enlargement of small pores,100 FT cycles caused a significant decrease in P-wave velocity with an average of 23%,but a consistent rise of 0.18%in mass loss,34%in porosity,67%in pore geometrical mean radius,and a remarkable 14.5-fold increase in ***,slight changes with some abnormal trends in physical parameters of the shady slope specimens were observed during FT cycling,which can be attributed to superficial granular disaggregation and pore throat *** shocks enhance rock weathering on sunny slopes during FT cycles,while FT weathering on shady slopes is restricted to the small pores and the superficial *** two factors are primarily responsible for the differences in FT weathering intensity between sunny and shady *** conclusions derived from the interpretation of the experimental results may provide theoretical guidance for the design of slope-failure prevention measures and the selection of transportation routes in cold mountainous regions.

关键词： Sunny-shady slope Freeze and thaw Pore structure Tight rocks Talus slope Cold regions

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Towards a new frontier in wrist rehabilitation:The traction-free posture orthosis

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Medicine in Novel Technology and Devices 2024年第3期23卷 136-138页

作者： Paolo Boccolari roberto Tedeschi Danilo Donati Azienda Ospedaliero Universitaria di Modena PoliclinicoItaly Department of Biomedical and Neuromotor Sciences Alma Mater StudiorumUniversity of BolognaBolognaItaly Physical Therapy and Rehabilitation Unit Policlinico di ModenaModenaItaly Clinical and Experimental Medicine PhD Program University of Modena and Reggio EmiliaModenaItaly

This study presents the novel Traction-Free Posture Orthosis,designed to address wrist stiffness without the use of traditional traction *** orthosis employs a velcro system to stabilize the position of the wrist in flexion or extension,thereby avoiding the compression and rotational disadvantages associated with non-perpendicular traction ***-shaped cuts in the brace allow for plastic material flexibility,ensuring movement and *** is the absence of a traction strap,which traditionally reduces the support surface and could create pressure points leading to patient discomfort or treatment *** design facilitates a wide contact surface with the hand,optimal load distribution,and the capacity to adjust dual traction straps independently,adapting to the natural wrist *** single-piece base orthosis offers a stable,cost-effective,and patientfriendly alternative to conventional ***,patients with stiffness in both flexion and extension may require two separate orthoses,potentially increasing costs and patient ***,the Traction-Free Posture Orthosis represents an innovative step in wrist rehabilitation,providing a quick-to-construct,easy-to-wear solution with the promise of enhanced patient compliance and comfort.

关键词： Wrist rehabilitation Orthotic devices Hand therapy Occupational therapy

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Syndecans in Alzheimer's disease:pathogenetic mechanisms and potential therapeutic targets

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Neural Regeneration Research 2025年第9期20卷 2594-2595页

作者： Carmela Rita Balistreri roberto Monastero Cellular Molecular and Clinical Pathological LaboratoryDepartment of BiomedicineNeuroscience and Advanced Diagnostics(Bi.N.D.)University of PalermoPalermoItaly Memory and Parkinson’s disease Center Policlinico“Paolo Giaccone”PalermoDepartment of BiomedicineNeuroscience and Advanced Diagnostics(Bi.N.D.)University of PalermoVia La Loggia 1PalermoItaly

With increasing age,humans become more susceptible to the onset of neurodegenerative diseases(NDs),and among these,Alzheimer's disease(AD)is the most frequent(Nicoletti et al.,2023).NDs are primarily characterized by neuronal loss and atrophy,but also by lesions involving the cerebral and/or cardiovascular system(Balistreri,2021).Lesions such as macroinfa rcts,microinfarcts,hemorrhages,white matter lesions,atherosclerosis,and arteriolosclerosis have also been significantly described in the preclinical stages of cognitive impairment characterizing NDs(Mariani et al.,2007).

关键词： Alzheimer cardiovascular

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Virtual Transmission Solution Based on Battery Energy Storage Systems to Boost Transmission Capacity

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 466-474页

作者： Matías Agüero Jaime Peralta Eugenio Quintana Victor Velar Anton Stepanov Hossein Ashourian Jean Mahseredjian roberto Cárdenas Coordinador Eléctrico Nacional SantiagoChile PGSTech Montreal Canada Ecole Polytechnique de Montréal Montréal Canada University of Chile Santiago Chile IEEE

The increasing penetration of variable renewable energy(VRE)generation along with the decommissioning of conventional power plants in Chile,has raised several operational challenges in the Chilean National Power Grid(NPG),including transmission congestion and VRE *** mitigate these limitations,an innovative virtual transmission solution based on battery energy storage systems(BESSs),known as grid booster(GB),has been proposed to increase the capacity of the main 500 kV corridor of the *** paper analyzes the dynamic performance of the GB using a wide-area electromagnetic transient(EMT)model of the *** GB project,composed of two 500 MVA BESS units at each extreme of the 500 kV corridor,allows increasing the transmission capacity for 15 min during N-1 contingencies,overcoming transmission limitations under normal operation conditions while maintaining system stability during *** dynamic behavior of the GB is also analyzed to control power flow as well as voltage *** results show that the GB is an effective solution to allow greater penetration of VRE generation while maintaining system stability in the NPG.

关键词： Battery energy storage system(BESS) grid booster transient stability voltage stability electromagnetic transient(EMT)

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Grouping tree species to estimate basal area increment in temperate multispecies forests in Durango,Mexico

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Forest Ecosystems 2024年第1期11卷 1-13页

作者： Jaime roberto Padilla-Martínez Carola Paul Kai Husmann Jose Javier Corral-Rivas Klaus von Gadow Department of Forest Economics and Sustainable Land-use Planning Faculty of Forest Sciences and Forest EcologyUniversity of GottingenBüsgenweg 137077GottingenGermany Facultad de Ciencias Forestales Universidad Juarez del Estado de DurangoRío Papaloapan y Boulevard Durango S/N34120DurangoMexico Faculty of Forestry and Forest Ecology Georg-August-UniversitatBüsgenweg 537077GottingenGermany Department of Forestry and Wood Science Faculty of AgriSciencesStellenbosch UniversityStellenbosch Private Bag X1Stellenbosch7602South Africa

Multispecies forests have received increased scientific attention,driven by the hypothesis that biodiversity improves ecological ***,a greater species diversity presents challenges for forest management and *** study aims to develop basal area growth models for tree species *** analysis is based on a dataset of 423 permanent plots(2,500 m^(2))located in temperate forests in Durango,***,we define tree species cohorts based on individual and neighborhood-based variables using a combination of principal component and cluster ***,we estimate the basal area increment of each cohort through the generalized additive model to describe the effect of tree size,competition,stand density and site *** principal component and cluster analyses assign a total of 37 tree species to eight cohorts that differed primarily with regard to the distribution of tree size and vertical position within the *** generalized additive models provide satisfactory estimates of tree growth for the species cohorts,explaining between 19 and 53 percent of the total variation of basal area increment,and highlight the following results:i)most cohorts show a"rise-and-fall"effect of tree size on tree growth;ii)surprisingly,the competition index"basal area of larger trees"had showed a positive effect in four of the eight cohorts;iii)stand density had a negative effect on basal area increment,though the effect was minor in medium-and high-density stands,and iv)basal area growth was positively correlated with site quality except for an oak *** developed species cohorts and growth models provide insight into their particular ecological features and growth patterns that may support the development of sustainable management strategies for temperate multispecies forests.

关键词： Temperate multispecies forests Cluster analysis Basal area increment Generalized additive models

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Highly-sensitive wafer-scale transfer-free graphene MEMS condenser microphones

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Microsystems & Nanoengineering 2024年第1期10卷 267-275页

作者： roberto Pezone Sebastian Anzinger Gabriele Baglioni Hutomo Suryo Wasisto Pasqualina M.Sarro Peter G.Steeneken Sten Vollebregt Laboratory of Electronic Components Technology and Materials(ECTM)Department of MicroelectronicsDelft University of TechnologyDelftThe Netherlands Infineon Technologies AG Am Campeon 1-15Neubiberg 85579Germany Kavli Institue of Nanoscience Department of Quantum NanoscienceDelft University of TechnologyDelftthe Netherlands Department of Precision and Microsystems Engineering(PME) Delft University of TechnologyDelftThe Netherlands

Since the performance of micro-electro-mechanical system(MEMS)-based microphones is approaching fundamental physical,design,and material limits,it has become challenging to improve *** works have demonstrated graphene’s suitability as a microphone *** potential for achieving smaller,more sensitive,and scalable onchip MEMS microphones is yet to be *** address large graphene sizes,graphene-polymer heterostructures have been proposed,but they compromise performance due to added polymer mass and *** work demonstrates the first wafer-scale integrated MEMS condenser microphones with diameters of 2R=220-320μm,thickness of 7 nm multi-layer graphene,that is suspended over a back-plate with a residual gap of 5μ*** microphones are manufactured with MEMS compatible wafer-scale technologies without any transfer steps or polymer layers that are more prone to contaminate and wrinkle the *** designs,all electrically integrated are fabricated and characterized allowing us to study the effects of the introduction of a back-plate for capacitive *** devices show high mechanical compliances C_(m)=0.081-1.07μmPa^(−1)(10-100×higher than the silicon reported in the state-of-the-art diaphragms)and pull-in voltages in the range of 2-9.5 *** addition,to validate the proof of concept,we have electrically characterized the graphene microphone when subjected to sound *** estimated sensitivity of S_(1kHz)=24.3-321 mV Pa^(−1)for a V_(bias)=1.5 V was determined,which is 1.9-25.5×higher than of state-of-the-art microphone devices while having a~9×smaller area.

关键词： transfer plate approaching

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Nutrient restriction-activated Fra-2 promotes tumor progression via IGF1R in miR-15a downmodulated pancreatic ductal adenocarcinoma

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1132-1146页

作者： Gian Luca Rampioni Vinciguerra Marina Capece Luca Reggiani Bonetti Giovanni Nigita Federica Calore Sydney Rentsch Paolo Magistri roberto Ballarin Fabrizio Di Benedetto Rosario Distefano roberto Cirombella Andrea Vecchione Barbara Belletti Gustavo Baldassarre Francesca Lovat Carlo M.Croce Department of Cancer Biology and Genetics and Comprehensive Cancer Center The Ohio State UniversityColumbus 43210 OHUSA Department of Clinical and Molecular Medicine Faculty of Medicine and PsychologySant’Andrea HospitalUniversity of Rome“Sapienza”Rome 00189Italy Department of Diagnostic Clinic and Public Health MedicineUniversity of Modena and Reggio EmiliaModena 41100Italy Hepato-pancreato-biliary Surgery and Liver Transplantation Unit University of Modena and Reggio EmiliaModena 41100Italy Division of Molecular Oncology Centro di Riferimento Oncologico di Aviano(CRO)Istituto di Ricovero e Cura a Carattere Scientifico(IRCCS)National Cancer InstituteAviano 33081Italy

Pancreatic ductal adenocarcinoma(PDAC)is a lethal disease,characterized by an intense desmoplastic reaction that compresses blood vessels and limits nutrient *** aggressiveness largely relies on its extraordinary capability to thrive and progress in a challenging tumor *** of the onco-suppressor miR-15a has been extensively documented in ***,we identified the transcription factor Fos-related antigen-2(Fra-2)as a miR-15a target mediating the adaptive mechanism of PDAC to nutrient *** report that the IGF1 signaling pathway was enhanced in nutrient deprived PDAC cells and that Fra-2 and IGF1R were significantly overexpressed in miR-15a downmodulated PDAC ***,we discovered that miR-15a repressed IGF1R expression via Fra-2 *** miR-15a-low context,IGF1R hyperactivated mTOR,modulated the autophagic flux and sustained PDAC growth in nutrient *** a genetic mouse model,Mir15aKO PDAC showed Fra-2 and Igf1r upregulation and mTOR activation in response to diet ***,nutrient restriction improved the efficacy of IGF1R inhibition in a Fra-2 dependent ***,our results point to a crucial role of Fra-2 in the cellular stress response due to nutrient restriction typical of pancreatic cancer and support IGF1R as a promising and vulnerable target in miR-15a downmodulated PDAC.

关键词： IGF1R Fra miR

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Evaluation of neutron cross sections of^(48)Ti based on the Unified-Monte-Carlo-B method

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Chinese Physics C 2024年第7期48卷 118-130页

作者：夏候琼续瑞瑞刘萍 roberto Capote 田源陶曦吴小飞张玥葛智刚舒能川冯松 China Nuclear Data Center China Institute of Atomic EnergyBeijing 102413China NAPC–Nuclear Data Section P.O.Box 100Vienna International CentreA-1400ViennaAustria School of Nuclear Science and Technology University of South ChinaHengyang 421001China

A cross section evaluation of neutron induced reactions on^(48)Ti is undertaken using the Unified Monte Carlo-B(UMC-B)*** evaluation concentrates on estimating the covariance and the use of the UMC-B allows avoiding the deficiencies of linear regression brought by the traditional least squares *** main neutron and charged particle emission reactions from n+^(48)Ti in the fast neutron energy region below 20 MeV are studied in this *** posterior probability density function(PDF)of each neutron cross section is obtained in a UMC-B Bayesian approach by convoluting the model PDFs sampled based on model parameters and the likelihood functions for the experimental *** model parameters including level density,pair corrections,optical model and Kalbach matrix element parameter are stochastically sampled with the assumption of normal distributions to estimate the model *** Cholesky factorization approach is applied to consider potential parameter ***,the posterior covariance matrices are generated using the UMC-B generated *** new evaluated results are compared with the CENDL-3.2,ENDF/B-VIII.0,JEFF-3.3,TENDL-2021 and JENDL-5 evaluations and differences are discussed.

关键词： covariance Unified Monte Carlo B(UMC-B) ^(48)Ti neutron cross sections Cholesky factor-ization approach

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