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Hepatobiliary Surgery and Nutrition 2021年第4期10卷 518-521页

作者： Alessandro mantovani Giovanni Targher Section of Endocrinology Diabetes and MetabolismDepartment of MedicineUniversity and Azienda Ospedaliera Universitaria Integrata of VeronaVeronaItaly

Nonalcoholic fatty liver disease(NAFLD)is the commonest cause of chronic liver disease *** affects around 25%of the general adult population,and up to∼70-80%of patients,who are obese or have type 2 diabetes mellitus(T2DM)(1,2).Over the past decades,it has become increasingly clear that NAFLD is a“multisystem”disease,requiring a multidisciplinary and holistic approach(3).

关键词： NAFLD liver hepatitis

The dawn of a new era for nonalcoholic fatty liver disease?

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Hepatobiliary Surgery and Nutrition 2019年第6期8卷 629-631页

作者： Alessandro mantovani Chiara Zusi Section of Endocrinology Diabetes and MetabolismDepartment of MedicineUniversity and Azienda Ospedaliera Universitaria Integrata of VeronaVeronaItaly

Non-alcoholic fatty liver disease(NAFLD)has become the most frequent chronic liver disease in several developed and developing countries,affecting roughly 30%of adults in the general population,65-70%of individuals with type 2 diabetes mellitus and,virtually,all patients with obesity(1).Of note,its prevalence is believed to rise dramatically over the next decade,along with an increase of prevalence in obesity,diabetes mellitus and metabolic syndrome.

关键词： obesity prevalence liver

Obligatory parthenogenesis and TE load： Bacillus stick insects and the R2 non-LTR retrotransposon

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Insect Science 2017年第3期24卷 409-417页

作者： Livia Bonandin Claudia Scavariello Valentina Mingazzini Andrea Luchetti Barbara mantovani Dipartimento di Scienze Biologiche Geologiche e Ambientali Universit~ di Bologna Bologna Italy

Transposable elements （TEs） are selfish genetic elements whose self-replication is contrasted by the host genome. In this context, host reproductive strategies are predicted to impact on both TEs load and activity. The presence and insertion distribution of the non- LTR retrotransposon R2 was here studied in populations of the strictly bisexual Bacillus grandii maretimi and of the obligatory parthenogenetic Bacillus atticus atticus. Further- more, data were also obtained from the offspring of selected B. a. atticus females. At the population level, the gonochoric B. g. maretimi showed a significantly higher R2 load than the obligatory parthenogenetic B. a. atticus. The comparison with bisexual and unisexual Bacillus rossius populations showed that their values were higher than those recorded for B. a. atticus and similar, or even higher, than those of B. g. maretimi. Consistently, an R2 load reduction is scored in B. a. atticus offspring even if with a great variance. On the whole, data here produced indicate that in the obligatory unisexual B. a. atticus R2 is active and that mechanisms of molecular turnover are effective. Furthermore, progeny analyses show that, at variance of the facultative parthenogenetic B. rossius, the R2 activ- ity is held at a lower rate. Modeling parental-offspring inheritance, suggests that in B. a. atticus recombination plays a major role in eliminating insertions rather than selection, as previously suggested for unisexual B. rossius progeny, even if in both cases a high variance is observed. In addition to this, mechanisms of R2 silencing or chances of clonal selection cannot be ruled out.

关键词： insertion activity Muller's ratchet Phasmida recombination retrotranspo-son unisexuality

Tumor-associated myeloid cells:diversity and therapeutic targeting

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Cellular & Molecular Immunology 2021年第3期18卷 566-578页

作者： Alberto mantovani Federica Marchesi Sebastien Jaillon Cecilia Garlanda Paola Allavena Department of Immunology and Inflammation Humanitas Clinical and Research Center-IRCCSRozzanoItaly Department of Biomedical Science Humanitas UniversityRozzanoItaly The William Harvey Research Institute Queen Mary University of LondonLondonUK Department of Biotechnology and Translational Medicine University of MilanMilanItaly

Myeloid cells in tumor tissues constitute a dynamic immune population characterized by a non-uniform phenotype and diverse functional *** tumor-associated macrophages(TAMs),which are more abundantly represented,and tumor-associated neutrophils(TANs)are known to sustain tumor cell growth and invasion,support neoangiogenesis and suppress anticancer adaptive immune *** recent decades,several therapeutic approaches have been implemented in preclinical cancer models to neutralize the tumor-promoting roles of both TAMs and *** of the most successful strategies have now reached the clinic and are being investigated in clinical *** this review,we provide an overview of the recent literature on the evergrowing complexity of the biology of TAMs and TANs and the development of the most promising approaches to target these populations therapeutically in cancer patients.

关键词： tumor-associated macrophages tumor microenvironment macrophage targeting

Glucose-lowering agents and reduced risk of incident non-alcoholic fatty liver disease:new insights

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Hepatobiliary Surgery and Nutrition 2022年第1期11卷 156-160页

作者： Alessandro mantovani Rosa Lombardi Andrea Dalbeni Section of Endocrinology Diabetes and MetabolismDepartment of MedicineUniversity and Azienda Ospedaliera Universitaria Integrata of VeronaVeronaItaly Unit of Internal Medicine and Metabolic Disease Fondazione IRCCS Ca’Granda Ospedale Maggiore PoliclinicoMilanItaly Department of Pathophysiology and Transplantation Universitàdegli Studi di MilanoMilanItaly Section of General Medicine C and Liver Unit University and Azienda Ospedaliera Universitaria Integrata of VeronaVeronaItaly

Non-alcoholic fatty liver disease(NAFLD)is classically defined as the hepatic manifestation of metabolic syndrome(1).Histologically,NAFLD covers a range of conditions,spanning from simple steatosis to non-alcoholic steatohepatitis(NASH)and cirrhosis(2).At present,NAFLD is the most frequent chronic liver disease seen in clinical practice in high-income countries,as it affects nearly 30%of adults in the general population,up to 70%of patients with type 2 diabetes(T2DM)and almost all patients with obesity(2).

关键词： NAFLD liver hepatic

Geospatial web services pave new ways for server-based on-demand access and processing of Big Earth Data

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International Journal of Digital Earth 2018年第1期11卷 7-25页

作者： Julia Wagemann Oliver Clements Ramiro Marco Figuera Angelo Pio Rossi Simone mantovani Forecast Department European Centre for Medium-Range Weather ForecastsReadingUK Remote Sensing Group Plymouth Marine LaboratoryPlymouthUK Department of Physics and Earth Sciences Jacobs UniversityBremenGermany MEEO S.r.l. FerraraItaly

Big Earth Data has experienced a considerable increase in volume in recent years due to improved sensing technologies and improvement of numerical-weather prediction *** traditional geospatial data analysis workflow hinders the use of large volumes of geospatial data due to limited disc space and computing *** web service technologies bring new opportunities to access large volumes of Big Earth Data via the Internet and to process them at *** practical examples are presented from the marine,climate,planetary and earth observation science communities to show how the standard interface Web Coverage Service and its processing extension can be integrated into the traditional geospatial data *** service technologies offer a time-and cost-effective way to access multidimensional data in a user-tailored format and allow for rapid application development or time-series *** transport is minimised and enhanced processing capabilities are *** research is required to investigate web service implementations in an operational mode and large data centres have to become more progressive towards the adoption of geo-data standard *** the same time,data users have to become aware of the advantages of web services and be trained how to benefit from them most.

关键词： Geospatial web services interoperability Big Earth Data open data Open Geospatial Consortium(OGC)

Effects of total replacement of corn silage with sorghum silage on milk yield,composition, and quality

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Journal of Animal Science and Biotechnology 2017年第3期8卷 652-659页

作者： M.Cattani N.Guzzo R.mantovani L.Bailoni Department of Comparative Biomedicine and Food Science(BCA) University of PadovaViale dell'Universita 1635020 LegnaroPDItaly Department of Agronomy Food Natural resources Animals and Environment(DAFNAE) University of PadovaViale dell'Università1635020 LegnaroPDItaly

Background： In the last years, difficulties occurring in corn cultivation（i.e., groundwater shortages, mycotoxin contamination） have been forcing dairy farmers to consider alternative silages. Some experiments conducted on lactating cows have proven that the total replacement of corn silage with sorghum silage did not reduce milk ***, this kind of substitution involves supplementing sorghum-based diets with grains, to compensate for the lower starch content of sorghum silage compared to corn silage. Change of silage type and inclusion of starch sources in the diet would influence rumen fermentations, with possible effects on milk composition（i.e., fatty acid profile） and coagulation properties. A worsening of milk coagulation properties would have a negative economic impact in Italy, where most of the milk produced is processed into *** study was designed to compare milk composition and quality, with emphasis on fatty acid profile and coagulation properties, in dairy cows fed two diets based on corn or sorghum ***： The sorghum diet reduced milk yield（P = 0.043） but not 4% fat corrected milk（P = 0.85）. Feeding sorghum silage did not influence milk contents of protein（P = 0.07） and lactose（P = 0.65）, and increased fat content（P = 0.024）.No differences emerged for milk concentrations of saturated（P = 0.61） and monounsaturated fatty acids（P = 0.50）,whereas polyunsaturated fatty acids were lower（P 〈 0.001） for the sorghum diet. Concentrations of n-6（P 〈 0.001） and n-3 fatty acids（P = 0.017） were lower in milk of cows fed the sorghum diet. Milk coagulation properties did not differ between the two diets, except the ＂a30＂（the curd firmness, expressed in mm, 30 min after rennet addition）, that was lower（P = 0.042） for the sorghum ***： Feeding a forage sorghum silage, properly supplemented with corn meal, as total replacement of corn silage maintained milk composition and did not influence negatively milk coagulation properties, whic

关键词： Dairy cows Forage sorghum silage Mean particle size Milk coagulation properties Milk fatty acid profile

Prevalence and incidence of intra-and extrahepatic complications of NAFLD in patients with type 2 diabetes mellitus

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Hepatoma Research 2020年第11期6卷 39-60页

作者： Alessandro mantovani Giorgia Beatrice Roberta Stupia Andrea Dalbeni Section of Endocrinology Diabetes and MetabolismUniversity and Azienda Ospedaliera Universitaria Integrata of VeronaVerona 37126Italy Section of General Medicine Hypertension and Liver UnitUniversity and Azienda Ospedaliera Universitaria Integrata of VeronaVerona 37126Italy

Nonalcoholic fatty liver disease(NAFLD)is linked to abdominal obesity,insulin resistance and type 2 diabetes mellitus(T2DM).The association of NAFLD with T2DM is *** fact,evidence suggests that abdominal obesity,T2DM and metabolic syndrome play a part in the development and progression of ***,NAFLD is associated with an increased risk of having T2DM and metabolic *** to this background,it is unsurprising that patients with T2DM patients also have a higher prevalence of NAFLD than those with no T2DM,as well as an increased risk of developing liver-related and extrahepatic complications,mainly cardiovascular and renal *** the relationship of NAFLD with insulin resistance,obesity and T2DM,recent consensus proposes a change in nomenclature from NAFLD to metabolic associated fatty liver *** this review,we will discuss the prevalence and incidence of NAFLD(as detected by imaging techniques or liver biopsy)in patients with type T2DM with particular regard to hepatic and extrahepatic complications.

关键词： Nonalcoholic fatty liver disease NASH metabolic associated fatty liver disease diabetes type 2 diabetes

Effect of silver in thermal treatments of Fe-Mn-C degradable metals:Implications for stent processing

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Bioactive Materials 2022年第6期7卷 30-41页

作者： Sergio Loffredo Sofia Gambaro Francesco Copes Carlo Paternoster Nicolas Giguere Maurizio Vedani Diego mantovani Laboratory for Biomaterials and Bioengineering Canada Research Chair I in Biomaterials and Bioengineering for the Innovation in SurgeryDepartment of Min-Met-Materials EngineeringResearch Center of CHU de QuebecDivision of Regenerative MedicineLaval UniversityQuebec CityQC G1V 0A6Canada Department of Mechanical Engineering Politecnico di MilanoMilan20156Italy National Research Council Institute of Condensed Matter Chemistry and Technologies for Energy CNR-ICMATEGenoa16149Italy Quebec Metallurgy Center CMQ Trois-RivieresQCG9A 5E1Canada

Twinning-induced plasticity(TWIP)steels are considered excellent materials for manufacturing products requiring extremely high mechanical properties for various applications including thin medical devices,such as biodegradable intravascular *** is also proven that the addition of Ag can guarantee an appropriate degradation while implanted in human body without affecting its bioactive *** order to develop an optimized manufacturing process for thin stents,the effect of Ag on the recrystallization behavior of TWIP steels needs to be *** is of major importance since manufacturing stents involves several intermediate recrystallization annealing *** this work,the recrystallization mechanism of two Fe-Mn-C steels with and without Ag was thoroughly investigated by microstructural and mechanical *** was observed that Ag promoted a finer microstructure with a different texture evolution,while the recrystallization kinetics resulted *** presence of Ag also reduced the effectiveness of the recrystallization *** behavior was attributed to the presence of Ag-rich second phase particles,precipitation of carbides and to the preferential development of grains possessing a{111}orientation upon thermal *** prominence of{111}grains can also give rise to premature twinning,explaining the role of Ag in reducing the ductility of TWIP steels already observed in other ***,in vitro biological performances were unaffected by *** findings could allow the design of efficient treatments for supporting the transformation of Fe-Mn-C steels alloyed with Ag into commercial products.

关键词： Twinning Recrystallization Biomaterials Silver Steels

Surface processing for iron-based degradable alloys:A preliminary study on the importance of acid pickling

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Bioactive Materials 2022年第5期7卷 166-180页

作者： Leticia Marin de Andrade Carlo Paternoster Pascale Chevallier Sofia Gambaro Paolo Mengucci Diego mantovani Laboratory for Biomaterials and Bioengineering Canada Research Chair I in Biomaterials and Bioengineering for the Innovation in SurgeryDepartment of Min-Met-Materials EngineeringResearch Center of CHU de QuebecDivision of Regenerative MedicineLaval UniversityQuebec CityQCG1V 0A6Canada National Research Council Institute of Condensed Matter Chemistry and Technologies for Energy CNR-ICMATEGenoa16149Italy Polytechnic University of Marche Ancona60121Italy

The formation of a heterogeneous oxidized layer,also called scale,on metallic surfaces is widely recognized as a rapid manufacturing event for metals and their *** or total removal of the scale represents a mandatory integrated step for the industrial fabrication processes of medical *** biodegradable metals,acid pickling has already been reported as a preliminary surface preparation given further processes,such as ***,biodegradable medical prototypes presented discrepancies concerning acid pickling studies based on samples with less complex geometry(e.g.,non-uniform scale removal and rougher surface).Indeed,this translational knowledge lacks a detailed investigation on this process,deep characterization of treated surfaces properties,as well as a comprehensive discussion of the involved *** this study,the effects of different acidic media(HCl,HNO_(3),H_(3)PO_(4),CH_(3)COOH,H_(2)SO_(4) and HF),maintained at different temperatures(21 and 60℃)for various exposition time(15-240 s),on the chemical composition and surface properties of a Fe-13Mn-1.2C biodegradable alloy were *** in mass loss,morphology and wettability evidenced the combined effect of temperature and time for all *** in HCl and HF solutions favor mass loss(0.03-0.1 g/cm^(2))and effectively remove the initial scale.

关键词： Biodegradable metals Iron-based alloys Acid pickling Surface finishing Pre-treatment