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Combined approach of poroelastic and earthquake nucleation applied to the reservoir-induced seismic activity in the Val d’Agri area,Italy

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Journal of Rock Mechanics and Geotechnical Engineering 2020年第4期12卷 802-810页

作者： Antonio P.Rinaldi Luigi improta Sebastian Hainzl Flaminia Catalli Luca Urpi Stefan Wiemer Swiss Seismological Service ETHZurichSwitzerland Istituto Nazionale di Geofisica e Vulcanologia INGVRomeItaly Deutsches GeoForshung e Zentrum GFZPotsdamGermany RatePAY GmbH BerlinGermany

In this work,an approach is developed to study the seismicity associated with the impoundment and level changes of a water reservoir(reservoir induced seismicity e RIS).The proposed methodology features a combination of a semi-analytical poroelastic model with an earthquake nucleation approach based on rate-and-state frictional *** combined approach was applied to the case of the Pertusillo Lake,located in the Val d’Agri area(Italy),whose large seasonal water level changes are believed to induce protracted micro-seismicity(local magnitude ML<3).Results show that the lake impoundment in 1962 could have produced up to 0.5 bar(1 bar=100 kPa)changes in Coulomb failure stress(DCFS),while the seasonal water level variation is responsible for variation up to 0.05 *** results of the seismicity rates in 20012014 show that the observed earthquakes are well correlated with the modeled ***,the reason that the seismicity is only observed at southwest of the Pertusillo Lake is provided,which is likely attributed to different rock lithologies and depletion caused by significant hydrocarbon exploitation in the northeastern sector of the lake.

关键词： Reservoir induced seismicity(RIS) Poroelasticity Rate-and-state frictional law Pertusillo lake

Clinical landscape and treatment of acute non-variceal upper gastrointestinal bleeding:Insights from a high-volume center in Shaanxi,China

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World Journal of Clinical Cases 2024年第35期12卷 6855-6858页

作者： Luca improta Department of General Surgery Fondazione Policlinico Universitario Campus Bio-MedicoRome 00128Italy

In this editorial we comment on the article by Wang et al,recently published on World Journal of Clinical *** non-variceal upper gastrointestinal bleeding(ANVUGIB)represents a common and potentially serious gastroenterological *** et al conducted a detailed study on the management of AN-VUGIB in a high-volume center in the Shaanxi region,*** data from over 530 patients provided a comprehensive overview of clinical,epidemio-logical,and treatment *** highlighted a younger patient population compared to European studies,with a higher prevalence of gastric and duodenal ulcers as the leading cause of *** treatment is cur-rently the preferred therapeutic option,offering a variety of effective *** study emphasizes the importance of implementing current guidelines in ANVUGIB management and highlights the crucial role of endoscopy in its management.

关键词： Upper gastrointestinal bleeding Gastroenterological emergencies Endoscopic treatment Epidemiological characteristics Clinical characteristics

Dysregulated microRNAs in type 2 diabetes and breast cancer:Potential associated molecular mechanisms

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World Journal of Diabetes 2024年第6期15卷 1187-1198页

作者： Alex Cleber improta-Caria Filipe Ferrari João Lucas Penteado Gomes Paloma Brasilio Villalta Úrsula Paula RenóSoci Ricardo Stein Edilamar M Oliveira Laboratory of Biochemistry and Molecular Biology of the Exercise Physical Education and Sport SchoolUniversity of São PauloSão Paulo 05508-030Brazil Graduate Program in Cardiology and Cardiovascular Sciences Federal University of Rio Grande do SulHospital de Clínicas de Porto AlegrePorto Alegre 90035003Brazil Laboratory of Metabolic Disorders(Labdime) School of Applied SciencesUniversity of Campinas-UNICAMPCampinas 13484-350Brazil Departments of Internal Medicine Molecular Pharmacology and PhysiologyCenter for Regenerative MedicineUSF Health Heart InstituteMorsani College of MedicineUniversity of South FloridaTampaFL 33602United States

Type 2 diabetes(T2D)is a multifaceted and heterogeneous syndrome associated with complications such as hypertension,coronary artery disease,and notably,breast cancer(BC).The connection between T2D and BC is established through processes that involve insulin resistance,inflammation and other *** this comprehension the specific cellular and molecular mechanisms linking T2D to BC,especially through microRNAs(miRNAs),remain *** are regulators of gene expression at the post-transcriptional level and have the function of regulating target genes by modulating various signaling pathways and biological ***,the signaling pathways and biological processes regulated by miRNAs that are associated with T2D and BC have not yet been *** review aims to identify dysregulated miRNAs in both T2D and BC,exploring potential signaling pathways and biological processes that collectively contribute to the development of BC.

关键词： Type 2 diabetes Breast cancer MicroRNAs Molecular mechanisms

Preliminary focus on the mechanical and antibacterial activity of a PMMA-based bone cement loaded with gold nanoparticles

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Bioactive Materials 2017年第3期2卷 156-161页

作者： T.Russo A.Gloria R.De Santis U.D'Amora G.Balato A.Vollaro O.Oliviero G.improta M.Triassi L.Ambrosio Institute of Polymers Composites and BiomaterialsNational Research CouncilNaplesItaly Department of Public Health School of MedicineUniversity of Naples“Federico II”NaplesItaly Department of Molecular Medicine and Medical Biotechnology School of MedicineUniversity of Naples“Federico II”NaplesItaly

In total knee arthroplasty(TKA)and total hip replacement(THR)the restoration of the normal joint function represents a fundamental feature.A prosthetic joint must be able to provide motions and to transmit functional *** reported in the literature,the stress distribution may be altered in bones after the implantation of a total joint *** scientific works have also correlated uncemented TKA to a progressive decrease of bone density below the tibial ***-loaded bone cements are commonly employed in conjunction with systemic antibiotics to treat ***,nanoparticles with antimicrobial activity have been widely ***,the current research was focused on a preliminary analysis of the mechanical and antibacterial activity of a PMMA-based bone cement loaded with gold *** obtained results demonstrated that nanocomposite cements with a specific concentration of gold nanoparticles improved the punching performance and antibacterial ***,critical aspects were found in the optimization of the nanocomposite bone cement.

关键词： Nanocomposite Bone cement Gold nanoparticles Antibacterial activity Mechanical properties