检索结果-南通市图书馆

Different Approaches on the Investigation of Ground Water

Journal of Earth Science and Engineering 2018年第1期8卷 39-49页

作者： Cassio Stein Moura roberto heemann Moises Razeira Daniela Govoni Sotelo Gabriela Borges Soares Giovanna Ramos Garcez Jfilio Cesar Gall Pires Vanessa da Conceicao Osorio Heldiane Souza dos Santos Institute of Petroleum and Natural Resources Pontifical University of Rio Grande do Sul Porto Alegre 90619-900 Brazil Federal University of the Pampa Cacapava do Sul 96570-000 Av. lpiranga 6681 Predio 96 J Porto Alegre RS Brazil

In this paper we discuss ways to obtain information about the quality of ground water and their availability. We classify the different approaches in two categories: geophysical methods, e. g., electroresistivity sounding, seismic survey, gravimetry, MT (magnetotelluric) method, and geochemical methods. The former ones are able to provide information on the geological structure, meaning depth, range, amount of water and possible connections among different exploration areas or regions at risk due to contamination. On the other hand, the last ones provide information about the quality of water and the possible of use for agriculture, industry or human consumption. As a case study we aim at the Guarani Aquifer, more specifically at its recharge zone on the southern rim.

关键词： Drought ground water geophysics geochemistry

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

MEK1 and MEK2 differentially regulate human insulin- and insulin glargine-induced human bladder cancer T24 cell proliferation

引用

Chinese Medical Journal 2012年第23期125卷 4197-4201页

作者： LIU Shan-ying LIANG Ying LIN Tian-xin SU Fang LIANG Wei-wen Uwe heemann LI Yan Key Laboratory of Malignant Tumor Gene Regulation and Target Therapy of Guangdong Higher Education Institutes Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdong 510120China Department of Endocrinology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdong 510120China Department of Nephrology Technical University Munich81675 MunichGermany

Background Increased risk of bladder cancer has been reported in diabetic patients. This study was to investigate the roles of mitogen-activated protein kinase kinase （MEK） 1 and 2 in the regulation of human insulin- and insulin glargine-induced proliferation of human bladder cancer T24 cells. Methods In the absence or presence of a selective inhibitor for MEK1 （PD98059） or a specific siRNA for MEK2 （siMEK2）, with or without addition of insulin or glargine, T24 cell proliferation was evaluated by cell counting kit （CCK）-8 assay. Protein expression of MEK2, phosphorylation of ERK1/2 and Akt was analyzed by Western blotting. Results T24 cell proliferation was promoted by PD98059 at 5-20 IJmol/L, inhibited by siMEK2 at 25-100 nmol/L. PD98059 and siMEK2 remarkably reduced phosphorylated ERKI/2. Insulin- and glargine-induced T24 cell proliferation was enhanced by PD98059, suppressed while not blocked by siMEK2. Insulin- and glargine-induced ERKI/2 activation was blocked by PD98059 or siMEK2 treatment, whereas activation of Akt was not affected. Conclusion MEK1 inhibits while MEK2 contributes to normal and human insulin- and insulin glargine-induced human bladder cancer T24 cell proliferation.

关键词： insulin glargine proliferation bladder cancer MEK

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Lipopolysaccharide-enhanced early proliferation of insulin secreting NIT-1 cell is associated with nuclear factor-kappaB- mediated inhibition of caspase 3 cleavage

引用

Chinese Medical Journal 2011年第22期124卷 3652-3656页

作者： LIU Shan-ying LIANG Qi-jun LIN Tian-xin FAN Xin-lan LIANG Ying Uwe heemann LI Yan Sun Yat-sen Memorial Hospital Sun Yat-sen University Guangzhou Guangdong 510120 China

Background Increased levels of plasma lipopolysaccharide （LPS） have been found in obesity and diabetes patients. This study was to investigate the effect of LPS on pancreatic beta-cell viability and the involvement of caspase 3 in NIT-1 cell line. Methods Mouse insulinoma NIT-1 cells were treated with LPS for the indicated time and dose. Cell viability was measured by cell counting kit-8 reagent. Toll-like receptor 4 （TLR4）, caspase 3 and cleaved caspase 3 were detected by Western blotting. Insulin was determined by radioimmunoassay （RIA）. Results LPS promoted NIT-1 cell proliferation at 1 μg/ml, peaked at 72 hours of incubation. A reduction in cleavage of caspase 3 was observed upon LPS treatment. Bay11-7082, a specific inhibitor of nuclear factor （NF）-κB, blunted LPS-induced inhibition of caspase 3 cleavage. Reduction in chronic insulin secretion was observed after treatment with LPS at 1 μg/ml for 48 and 72 hours, not for 24 hours. TLR4 protein was upregulated when NIT-1 cells were treated with LPS at 1 μg/ml for 24 hours. Conclusions LPS promotes early NIT-1 cell proliferation in association with NF-KB-mediated inhibition of caspase 3 cleavage. LPS exerts a time-dependent inhibitory effect on chronic insulin secretion from NIT-1 cells.

关键词： lipopolysaccharide NIT-1 cell toll-like receptor 4 nuclear factor-κB caspase 3

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Influence of Progesterone on Chronic Renal Allograft Dysfunction in Rat Model

引用

器官移植内科学杂志 2009年第3期4卷 134-138页

作者： Hequn Zou Shanying Liu Yousheng Yao Erwei Song Jens Lutz Uwe heemann Institute of Nephrology and Rheumatology The Third Affiliated Hospital of China Southern MedicalUniversity Guangzhou 510630 China Department of Nephrology University Hospital Essen Germany

Background It is indicated in our recent investigation that oestrogens ameliorate the progression of chronic renal allograft dysfunction. In our present study, we investigated the influence of progesterone on chronic renal allograft dysfunction. Methods The kidneys of female Fisher (F344) rats were orthotopically transplanted into ovariectomized female Lewis recipients. The recipients were divided into two groups and treated with progesterone or vehicle. Animals were harvested 24 weeks after trans- plantation for histological, immunohistological studies and molecular analysis. Results The administration of progesterone resulted in increased urinary protein excretion, profound glomerulosclerosis and mononuclear cell infiltration. Renal allograft damage paralleled intragraft mRNA expression of transforming growth factor-β1 in the two groups. Conclusions It is suggested by our results that progesterone worsened long-term renal allograft outcome.

关键词：细移植转化生长孕酮黄体酮

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Efficacy of estradiol on preventing chronic kidney allograft rejection

引用

Chinese Medical Journal 1999年第9期 18-18页

作者： Heque Zou and Uwe heemann

hronic rejection is the main factor to result in the loss of renal allograft In order to look for a potential therapy chronic rejection, we investigated the efficacy of estradiol on preventing renal chronic rejection The kidneys of female F344 rats were orthotopically transplanted into ovatiectomized female Lewis rats and treated for 16 weeks with either estradiol or vehicle Compared with controls treated with vehicle, estradiol treatment reduced urinary protein excretion, glomerular sclerosis, interstitial infiltration and fibrosis, vascular lesions, in parallel to a reduced ICAM 1 and TGF β mRNA expression Our results suggested that estrodiol could significantly decrease the progression of chronic rejection, at least in female recipients, and the reduced adhesion molecule and TGF β gene expression may be involved in the mechanism for estradiol to prevent chronic rejection

关键词： Efficacy of estradiol on preventing chronic kidney allograft rejection

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

MEK1 and MEK2 differentially regulate human insulin- and insulin glargine-induced human bladder cancer T24 cell proliferation

MEK1 and MEK2 differentially regulate human insulin- and ins...

引用

中华医学会糖尿病学分会第十六次全国学术会议

作者： LIU Shan-ying LIANG Ying LIN Tian-xin SU Fang LIANG Wei-wen Uwe heemann LI Yan Zhongshan University at SunYixian Memorial Hospital

Objective To investigate the roles of MEKl and MEK2 in the regulation of human insulin- and insulin glargine-induced proliferation of human bladder cancer T24 cells. Methods In the absence or presence of a selective inhibitor for MEKl(PD98059) or a specific siRNA for MEK2(siMEK2),with or without addition of insulin or glargine,T24 cell proliferation was evaluated by CCK-8 *** expression of MEK2,phosphorylation of ERK1/2 and Akt was analyzed by Western blot.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

粘附分子与移植

引用

国外医学情报 1994年第23期15卷 7-12页

作者： U W heemann S G Tullius H Azuma J K Weglinski N L Tilney 王敏

Metchnikoff等早在20世纪开始就提出细胞可以独立地活动和移动这一概念,并且第一次叙述单细胞微生物对损伤或对异物的反应。从进化角度系统地看。

关键词：血管细胞粘附分子血管内皮细胞淋巴细胞白细胞同种移植物同种异体结合素互相作用选择素细胞表面

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：