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Asian Pacific Journal of Tropical Biomedicine 2011年第2期1卷 110-113页

作者： Clarissa Gutirrez Carvalho Simone Martins Castro Ana Paula Santin Carina Zaleski Felipe Gutirrez Carvalho roberto giugliani Genetics Service Hospital de Clinicas de Porto AlegrePGP in PediatricsUFRGS Pharmacy School UFRGS Medical School UFRGS

Objective:To evaluate the correlation between glucose-6-phosphate-dehydrogenase(G6PD) deficiency and neonatal ***:Prospective,observational case-control study was conducted on 490 newborns admitted to Hospital de Clinicas de Porto Alegre for phototherapy, who all experienced 35 or more weeks of gestation,from March to December *** screening of G6PD activity was performed,followed by ***:There was prevalence of 4.6% and a boy-girl ratio of 3:1 in jaundiced *** jaundiced neonate with ABO incompatibility presented G6PD deficiency,and no Mediterranean mutation was found.A higher proportion of deficiency was observed in *** was no association with UGT1A1 variants. Conclusions:G6PD deficiency is not related to severe hyperbilirubinemia and considering the high miscegenation in this area of Brazil,other gene interactions should be investigated.

关键词： Glucosephosphate dehydrogenase Jaundice Hyperbilirubinemia Neonatal Hemoglobin

凝聚专家的力量提高低收入国家的妇幼保健质量--美国出生缺陷基金会资助的全球妇幼保健协作项目

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北京大学学报（医学版） 2009年第4期41卷 392-394页

作者： Christopher P. HOWSON Nanbert ZHONG Carmencita PADILLA Khalid YUNIS roberto giugliani Global Programs March of Dimes Foundation White Plains NY 10605 USA Peking University Center of Medical Genetics Beijing China Laboratory of Developmental Genetics Molecular Neurogenetic Diagnostic Laboratory Institute for Basic Research in Developmental Disabilities Staten Island NY 10314 USA Carmencita Padilla National Newborn Screening So-ciety of the Philip-pines Inc. Manila Philippines National Institutes of Health University of the Philippines Manila Manila Philippines 1000 Khalid Yunis National Collaborative Perinatal Neonatal Network (NCPNN) American University of Beirut Beirut Lebanon Rober-to giugliani Medical Genetics Service Hospital de Clinicas de Porto Alegre 90035-903 Porto Alegre RS Brazil

This short report describes a model for international collaboration on perinatal health that is innovative,highly-productive and challenging. The model,funded by the U.S. March of Dimes Foundation and entitled the 'March of Dimes Global Network for Maternal and Infant Health(GNMIH)' ,allows developing country experts to more easily share their knowledge,experience,skills and materials in ways that can improve women's,maternal,newborn and child health in lower-income countries. This report begins with a brief description of the March of Dimes and its Global Programs which oversees the GNMIH. It then discusses the structure of the GNMIH,with an emphasis on the benefits and challenges of working within the network,and concludes with a brief description of the acti-vities of network members.

关键词：畸形卫生计划资助卫生保健质量妇女卫生保健服务儿童保健服务

Bone-marrow derived cells participate in extramedullary hematopoiesis in a model of acetaminophen-induced acute liver failure in rats

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Stem Cell Discovery 2013年第1期3卷 44-46页

作者： Maria Cristina Belardinelli Mónica López Talita Giacomet de Carvalho Fabiana Mayer Guilherme Baldo Luise Meurer roberto giugliani Ursula Matte Gene Therapy Center Research Center of Hospital de Clinicas de Porto Alegre Porto Alegre Brazil Pathology Service of Hospital de Clinicas de Porto Alegre Porto Alegre Brazil

Adult derived mononuclear bone marrow cells are a good alternative as cell therapy. These cells are capable of significantly improve survival rate of Wistar rats with acetaminophen (APAP) induced acute liver failure in ten days. However, long term of cell therapy is not deeply studied in the literature. Here, we report an extramedullary hematopoiesis process derived from transplanted mononuclear bone marrow cells in the liver of rats 10 days after APAP injection. This result indicates that liver maintains an adequate microenvironment for the occurrence of extramedullary hematopoiesis process. The consequence of this finding deserves more studies.

关键词： Extramedullary Hematopoiesis Bone Marrow Cells Acute Liver Failure Acetaminophen

A high-order target phase approach for the station-keeping of periodic orbits

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Astrodynamics 2024年第1期8卷 61-75页

作者： Xiaoyu Fu Nicola Baresi roberto Armellin Surrey Space Centre University of SurreyGuildfordGU27XHUK Te PūnahaĀtea-Auckland Space Institute University of AucklandAuckland1010New Zealand

A novel high-order target phase approach(TPhA)for the station-keeping of periodic orbits is proposed in this *** key elements of the TPhA method,the phase-angle Poincare map and high-order maneuver map,are constructed using differential algebra(DA)techniques to determine station-keeping epochs and calculate correction maneuvers.A stochastic optimization framework tailored for the TPhA-based station-keeping process is leveraged to search for fuel-optimal and error-robust TPhA ***-satellite orbits(QSOs)around Phobos are investigated to demonstrate the efficacy of TPhA in mutli-fidelity dynamical *** Carlo simulations demonstrated that the baseline QSO of JAXA’s Martian Moons eXploration(MMX)mission could be maintained with a monthly maneuver budget of approximately 1 m/s.

关键词： target phase approach(TPhA) station-keeping Poincarémap differential algebra(DA) quasi-satellite orbit(QSO)

Estimating the frequency of traffic overloading on road bridges

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第4期11卷 776-796页

作者： roberto Ventura Benedetto Barabino Giulio Maternini Department of Civil EnvironmentalArchitectural Engineering and MathematicsUniversity of BresciaBrescia 25123Italy

Load limits,which appear to be routinely exceeded by trucks,occasionally result in road bridge ***,predicting failures is crucial for safeguarding road *** studies have largely focused on forecasting bridge failure event probability using the reliability analysis method,whilst occasionally accounting for vehicular overloading *** recently,a study has investigated design traffic overloading event frequency using generalised linear regression models(GLRMs),including a power component and negative binomial regressions(NBRs).However,as far as the authors know,artificial neural network models(ANNMs)have never been applied to this *** paper is an attempt to fill in these *** a frequencybased metric of traffic overloading was adopted as a driver of failure ***,two alternative‘frequency'models were specified,calibrated,and *** former was based on a GLRM,the latter on ***,these models were compared using regression plots(RPs),measures of errors(Mo Es)and the ratio between the number of observed vs predicted design load overcoming events to evaluate their *** models analysed more than 2 million weigh-in-motion(WIM)data records from a pilot station on a bridge on a heavily used ring road in Brescia(Italy).Results showed that ANNMs outperformed *** have a higher correlation coefficient(between predicted and target frequencies),lower Mo Es,and a closer-to-unity ratio(between predicted and target frequencies).These findings may increase prediction accuracy of design traffic overloading events and give road authorities more effective traffic management to protect bridges from load hazards.

关键词： Road bridges Traffic load hazard Econometry Machine learning Weigh-in-motion Big-data analysis

Perturbed initial orbit determination

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Astrodynamics 2024年第3期8卷 401-416页

作者： Alberto Fossà Matteo Losacco roberto Armellin Institut Supérieur de l’Aéronautique et de l’Espace Toulouse31400France Te PūnahaĀtea-Space Institute The University of AucklandAuckland1010New Zealand

An algorithm for robust initial orbit determination (IOD) under perturbed orbital dynamics is presented. By leveraging map inversion techniques defined in the algebra of Taylor polynomials, this tool returns a highly accurate solution to the IOD problem and estimates a range centered on the aforementioned solution in which the true orbit should lie. To meet the specified accuracy requirements, automatic domain splitting is used to wrap the IOD routines and ensure that the local truncation error, introduced by a polynomial representation of the state estimate, remains below a predefined threshold. The algorithm is presented for three types of ground-based sensors, namely range radars, Doppler-only radars, and optical telescopes, by considering their different constraints in terms of available measurements and sensor noise. Finally, the improvement in performance with respect to a Keplerian-based IOD solution is demonstrated using large-scale numerical simulations over a subset of tracked objects in low Earth orbit.

关键词： initial orbit determination(IOD) range radar Doppler radar optical telescope differential algebra(DA)

Assessment of compressive strength of jet grouting by machine learning

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 102-111页

作者： Esteban Diaz Edgar Leonardo Salamanca-Medina roberto Tomas Departamento de Ingeniería Civil Escuela Politécnica SuperiorUniversidad de AlicanteP.O.Box 99E-03080AlicanteSpain

Jet grouting is one of the most popular soil improvement techniques,but its design usually involves great uncertainties that can lead to economic cost overruns in construction *** high dispersion in the properties of the improved material leads to designers assuming a conservative,arbitrary and unjustified strength,which is even sometimes subjected to the results of the test *** present paper presents an approach for prediction of the uniaxial compressive strength(UCS)of jet grouting columns based on the analysis of several machine learning algorithms on a database of 854 results mainly collected from different research *** selected machine learning model(extremely randomized trees)relates the soil type and various parameters of the technique to the value of the compressive *** the complex mechanism that surrounds the jet grouting process,evidenced by the high dispersion and low correlation of the variables studied,the trained model allows to optimally predict the values of compressive strength with a significant improvement with respect to the existing ***,this work proposes for the first time a reliable and easily applicable approach for estimation of the compressive strength of jet grouting columns.

关键词： Jet grouting Ground improvement Compressive strength Machine learning

A high aspect ratio surface micromachined accelerometer based on a SiC-CNT composite material

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Microsystems & Nanoengineering 2024年第2期10卷 219-230页

作者： Jiarui Mo Shreyas Shankar roberto Pezone Guoqi Zhang Sten Vollebregt Laboratory of Electronic Components Technology and Materials(ECTM)Department of MicroelectronicsDelft University of TechnologyDelftThe Netherlands

Silicon carbide(SiC)is recognized as an excellent material for microelectromechanical systems(MEMS),especially those operating in challenging environments,such as high temperature,high radiation,and corrosive ***,SiC bulk micromachining is still a challenge,which hinders the development of complex SiC *** address this problem,we present the use of a carbon nanotube(CNT)array coated with amorphous SiC(a-SiC)as an alternative composite material to enable high aspect ratio(HAR)surface *** using a prepatterned catalyst layer,a HAR CNT array can be grown as a structural template and then densified by uniformly filling the CNT bundle with LPCVD *** electrical properties of the resulting SiC-CNT composite were characterized,and the results indicated that the electrical resistivity was dominated by the *** demonstrate the use of this composite in MEMS applications,a capacitive accelerometer was designed,fabricated,and *** fabrication results showed that the composite is fully compatible with the manufacturing of surface micromachining *** Young’s modulus of the composite was extracted from the measured spring constant,and the results show a great improvement in the mechanical properties of the CNTs after coating with *** accelerometer was electrically characterized,and its functionality was confirmed using a mechanical shaker.

关键词： composite surface electrical

A comprehensive analysis of future solar energy potential variations using a CMIP6 multi-model ensemble approach in Colombia

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Clean Energy 2024年第4期8卷 79-89页

作者： Heli AArregocés roberto Rojano Daiver Pinto Pimienta Grupo de Investigación GISA Facultad de IngenieríaUniversidad de La GuajiraRiohachaColombia Grupo Procesos Fisicoquímicos Aplicados Facultad de IngenieríaUniversidad de Antioquia SIU/UdeACalle 70 No.52–21MedellínColombia Grupo Desarrollo de Estudios y Tecnologías Ambientales del Carbono(DESTACAR) Facultad de IngenieríaUniversidad de La GuajiraRiohachaColombia

Climate change is predicted to significantly impact solar energy generation,which is particularly concerning given that photovoltaic(PV)energy is critical to the global transition to clean energy in underdeveloped *** study analyses the PV potential variations in Colombia using a Coupled Model Intercomparison Project Phase 6(CMIP6)multi-model ensemble approach under two shared socio-economic pathway scenarios for the near(2025-50)and far(2051-2100)*** the near-future period,the Pacific,Andean and Orinoquía regions are expected to experience a decrease in PV potential ranging from 10%to 23%for all shared socio-economic *** will be particularly noticeable during the March/April/May and June/July/August *** the other hand,CMIP6 estimations indicate a 1-4%increase in PV potential across the Amazon region during the June/July/August and September/October/November *** the far future,it has been projected that the Pacific,Andean and Orinoquía regions may experience a significant decline in solar power generation due to increased cloud cover and reduced *** decrease in PV potential during the June/July/August season could range from 8%to 27%for all considered scenarios,with the Pacific region being the most *** Pacific region is projected to experience a decrease ranging from 10%to 35%for all *** is worth noting that there are noticeable differences in PV potential across various regions,which can result in changes in cloud cover and atmospheric ***,the study provides valuable insights into the PV potential in Colombia and highlights the importance of considering regional variations and climate change scenarios in future energy planning.

关键词： photovoltaic potential CMIP6 solar photovoltaic energy climate change Colombia

How can the holder trust the verifier?A CP-ABPRE-based solution to control the access to claims in a Self-Sovereign-Identity scenario

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Blockchain(Research and Applications) 2024年第3期5卷 22-41页

作者： Francesco Buccafurri Vincenzo De Angelis roberto Nardone University of Reggio Calabria 89124 Reggio CalabriaItaly University of Calabria 87036 Arcavacata di Rende(CS)Italy University of Naples“Parthenope” 80143 NaplesItaly

The interest in Self-Sovereign Identity(SSI)in research,industry,and governments is rapidly *** is a paradigm where users hold their identity and credentials issued by authorized *** is revolutionizing the concept of digital identity and enabling the definition of a trust framework wherein a service provider(verifier)validates the claims presented by a user(holder)for accessing ***,current SSI solutions primarily focus on the presentation and verification of claims,overlooking a dual aspect:ensuring that the verifier is authorized to access the holder’s *** this gap,this paper introduces an innovative SSI-based solution that integrates decentralized wallets with Ciphertext-Policy Attribute-Based Proxy Re-Encryption(CP-ABPRE).This combination effectively addresses the challenge of verifier *** solution,implemented on the Ethereum platform,enhances accountability by notarizing key operations through a smart *** paper also offers a prototype demonstrating the practicality of the proposed ***,it provides an extensive evaluation of the solution’s performance,emphasizing its feasibility and efficiency in real-world applications.

关键词： Blockchain IPFS Self Sovereign Identity Smart contract Access control