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Evolution of the 3.65-2.58 Ga Mairi Gneiss Complex,Brazil:Implications for growth of the continental crust in the São Francisco Craton

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Geoscience Frontiers 2022年第5期13卷 110-128页

作者： Igor de Camargo Moreira Elson Paiva Oliveira Daniel Francisco martins de Sousa Institute of Geosciences University of Campinas(UNICAMP)CampinasSPBrazil

The composition and formation of the Earth’s primitive continental crust and mantle differentiation are key issues to understand and reconstruct the geodynamic terrestrial evolution,especially during the ***,the scarcity of exposure to these rocks,the complexity of lithological relationships,and the high degree of superimposed deformation,especially with long-lived magmatism,make it difficult to study ancient *** this complexity,exposures of the Archean Mairi Gneiss Complex basement unit in the São Francisco Craton offer important information about the evolution of South America’s primitive ***,here we present field relationships,LA-ICP-SFMS zircon U-Pb ages,and LA-ICP-MCMS Lu-Hf isotope data for the recently identified Eoarchean to Neoarchean gneisses of the Mairi *** Complex is composed of massive and banded gneisses with mafic members ranging from dioritic to tonalitic,and felsic members ranging from TTG(Tonalite-Trondhjemite-Granodiorite)to granitic *** new data point to several magmatic episodes in the formation of the Mairi Gneiss Complex:Eoarchean(ca.3.65–3.60 Ga),early Paleoarchean(ca.3.55–3.52 Ga),middle-late Paleoarchean(ca.3.49–3.33 Ga)and Neoarchean(ca.2.74–2.58 Ga),with no records of Mesoarchean ***-Hf data unveiled a progressive evolution of mantle differentiation and crustal recycling over *** the Eoarchean,rocks are probably formed by the interaction between the pre-existing crust and juvenile contribution from chondritic to weakly depleted mantle sources,whereas mantle depletion played a role in the Paleoarchean,followed by greater differentiation of the crust with thickening and recycling in the middle–late Paleoarchean.A different stage of crustal growth and recycling dominated the Neoarchean,probably owing to the thickening of the continental crust by collision,continental arc growth,and mantle differentiation.

关键词： São Francisco Craton Mairi Gneiss Complex Primitive continental crust Zircon U-Pb dating Lu-Hf isotope geochemistry

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Flood Event Forecasting: A Complementary System-Theoretic Modelling

Flood Event Forecasting: A Complementary System-Theoretic Mo...

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作者： OTACHE, YUSUF martins 河海大学

学位级别：硕士

功能改进，模型率定，模型预报的验证以及其结果分析是应用概念水文模型所需要的几个主要部分。考虑到物理模型应用上的复杂，概念模型所代表的主要过程便是对客观现实的高度简化，但因此也带来了大量显著的不确定因素。鉴于此种情况本... 详细信息

功能改进，模型率定，模型预报的验证以及其结果分析是应用概念水文模型所需要的几个主要部分。考虑到物理模型应用上的复杂，概念模型所代表的主要过程便是对客观现实的高度简化，但因此也带来了大量显著的不确定因素。鉴于此种情况本文将人工神经网络算法同新安江模型相耦合以提高模型预报的精度。计算中使用了近期观测资料以及模型中径流／流量预报产生的误差／残差。本耦合模型的工作原理为：通过人工神经网络来预报模型的误差来提高用新观测资料得到的流量预报精度。从本文研究结果来看，结合人工神经网络算法的新安江模型的预报结果同只单独使用新安江模型时相比，在精度上有相当大的提高。对模型预报残差进一步分析可知，残差的时间序列并不服从正态分布，而是呈现出了逆高斯分布。同样，在误差/残差结构中存在着非常明显的固定模式。

关键词：耦合耦合模型残差持久正态分布逆高斯分布

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Structural Optimization of Metal and Polymer Ore Conveyor Belt Rollers

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Computer Modeling in Engineering & Sciences 2022年第12期133卷 601-618页

作者： Joao Pedro Ceniz Rodrigo de Sá martins Marco Antonio Luersen Tiago Cousseau Department of Mechanical Engineering Federal University of Technology-Parana(UTFPR)Curitiba81280-340Brazil

Ore conveyor belt rollers operate in harsh environments,making them prone to premature *** service lives are highly dependent on the stress field and bearing misalignment angle,for which limit values are defined in a *** this work,an optimization methodology using metamodels based on radial basis functions is implemented to reduce themass of twomodels of *** a structural point of view,one of the rollers ismade completely of metal,while the other also has some components made of polymeric *** objective of this study is to develop and apply a parametric structural optimization methodology to minimize the mass of the two models of *** represent the mechanical behavior of the rollers,simulations were performed using the finite element *** the numerical optimization process,the variable parameters were the dimensions of the shaft and external *** geometric configuration that corresponded at the same time to the lowest mass and acceptable ranges for the stress and bearingmisalignment angle was *** the proposed methodology,a 32.3% reduction in mass was obtained for a metal roller design and an 18.9% reduction for a polymer *** both cases,the constraints were not *** the all-metal roller,the safety factors for the maximum stress and bearingmisalignment angle were 1.44 and 1.75,respectively,while for the polymer roller the corresponding figures were 1.50 and *** work describes a low-computational-cost optimization methodology for roller designs that have been little studied in the ***,the methodology could be adapted for use with other types of rollers and rollers made of different materials.

关键词： Conveyor belt rollers structural optimization surrogate models radial basis functions

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Do vegetative and reproductive phenophases of deciduous tropical species respond similarly to rainfall pulses?

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Journal of Forestry Research 2013年第4期24卷 643-651页

作者： A.P.Silveira F.S.Araújo F.R.martins Itapipoca Faculty of Education Av.Monsenhor Tabosa s/ no.Ceará State University -- UECE Graduate Course of Ecology and Natural Resources Department of BiologyBuilding 906Federal University of Ceará-UFC Department of Plant Biology Institute of BiologyP.O.Box 610University of Campinas – UNICAMP

Deciduous trees with high-density wood that occur in dry seasonal tropical regions respond to rainfall seasonality with synchrony in phenophases. However, they may exhibit interannual differences in synchrony and intensity of phenophases, as strategy for large variations in duration and intensity of rainfall pulses. Nevertheless, it remains unknown how phenophases of deciduous trees of the Brazilian semi-arid region respond to rainfall variations. The phenology of Cordia oncocalyx was monitored in deciduous thorny woodland （Caatinga）, from April 2009 to March 2011, and was correlated with rainfall, soil humidity, temperature, and photoperiod. The rainy years 2009 and 2011 exhibited higher duration of rainfall pulses and lower frequency of interpulses, but in 2010 pulse duration and total rainfall were lower. Circular statistics showed leaf flush followed by flowering and fruiting in the rainy season, and leaf fall and seed dispersal in the dry season.

关键词： asynchrony circular analysis deciduous phenology riskspreading seasonality.

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NK cell dysfunction in severe COVID-19:TGF-β-induced downregulation of integrin beta-2 restricts NK cell cytotoxicity

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Signal Transduction and Targeted Therapy 2022年第2期7卷 346-348页

作者： Joana Barros-martins Reinhold Förster Berislav Bošnjak Institute of Immunology Hannover Medical School30625 HannoverGermany Cluster of Excellence RESIST(EXC 2155) Hannover Medical School30625 HannoverGermany German Centre for Infection Research(DZIF) Partner site HannoverHannoverGermany

In a recent study published in Nature,Witkowski et *** that in patients with severe forms of coronavirus disease 2019(COVID-19)deranged tumor growth factor-beta(TGF-β)secretion counteracts interferon-alpha(IFN-α)-induced activation of NK cells by decreasing expression of transcription factor ***,NK cells fail to upregulate the adhesion molecule integrin beta-2(-ß2),which impedes their attachment to and killing of SARS-CoV-2 infected cells.

关键词： interferon cytotoxicity

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Machine perfusion of the liver:Putting the puzzle pieces together

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World Journal of Gastroenterology 2021年第34期27卷 5727-5736页

作者： Yuri L Boteon Paulo N martins Paolo Muiesan Andrea Schlegel Liver Unit Hospital Israelita Albert EinsteinSão Paulo 05652-900Brazil Instituto Israelita de Ensino e Pesquisa Albert Einstein Faculdade Israelita de Ciências da Saúde Albert EinsteinSão Paulo 05652-900Brazil Department of Surgery Transplant DivisionUniversity of Massachusetts Medical SchoolWorcesterMA 01655United States Hepatobiliary Unit Careggi University HospitalUniversity of FlorenceFlorence 50134Italy Department of Visceral Surgery and Transplantation University Hospital ZurichSwiss HPB and Transplant CenterZurich 8091Switzerland

The realm of extended criteria liver transplantation created the'adjacent possible'for dynamic organ *** perfusion of the liver greatly expanded donor organ preservation possibilities,reaching before unattainable goals,including the mitigation of ischemia-reperfusion injury,viability assessment,and organ reconditioning prior to ***,current scientific evidence lacks uniformity between studies,perfusion protocols,and acceptance *** of collaborative research networks for sharing knowledge should,therefore,enable the development of high-level evidence and guidelines for machine perfusion utilization,including donor acceptance ***,this approach shall guarantee conditions for further progress to occur.

关键词： Machine perfusion of the liver Liver transplantation Organ donation Extended criteria donors Liver preservation Clinical trials

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Production of Pequi Powder by Drying Pulp

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Agricultural Sciences 2018年第8期9卷 1047-1057页

作者： Aluizio Paulo Rodrigues Silva Welisson martins Rocha David Maikel Fernandes José roberto Delalibera Finzer Faculty of Chemical Engineering-UNIUBE Uberaba MG Brazil

The pequi tree is a native plant of the Brazilian cerrado, and the scientific name is Caryocar brasiliense, whose fruits are called pequi, appreciated for its pleasant peculiarities of color, aroma and flavor. The objective of this work is to transform pequi pulp into powder, aiming at maintaining the flavor. By using the convection drying technique, the product is converted from the fluid state to the solid state in the form of a powder. Experiments were performed with drying at the following temperatures: 40°C, 50°C, 60°C, 90°C and 105°C. Interpretations were made of the experimental drying and milling results. It was verified that for all the experimental temperatures, there was no loss of the sensory characteristics of pequi. The drying of the pequi pulp in a greenhouse at 105°C consisted of a good result of preservation of the characteristics of the fruit: color, aroma and flavor. Using the Trojan Powder Coating scale, it is found that pequi powder, dried at 105°C, differs little in terms of the color of the fruit in nature.

关键词： Pequi Drying Brazilian Cerrado

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Effects of natural mineral-rich water consumption on the expression of sirtuin 1 and angiogenic factors in the erectile tissue of rats with fructose-induced metabolic syndrome

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Asian Journal of Andrology 2014年第4期16卷 631-638页

作者： Cidalia D Pereira Milton Severo Luisa Rafael Maria Joao martins Delminda Neves Department of Biochemistry Faculty of Medicine University of Porto Department of Clinical Epidemiology Predictive Medicine and Public Health Faculty of Medicine University of Porto Department of Clinical Pathology Sao Joao Hospital Centre EPE Department of Experimental Biology Faculty of Medicine and Institute for Molecular and Cell Biology (IBMC) University of Porto Portugal.

Consuming a high-fructose diet induces metabolic syndrome （MS）-Iike features, including endothelial dysfunction. Erectile dysfunction is an early manifestation of endothelial dysfunction and systemic vascular disease. Because mineral deficiency intensifies the deleterious effects of fructose consumption and mineral ingestion is protective against MS, we aimed to characterize the effects of 8weeks of natural mineral-rich water consumption on the structural organization and expression of vascular growth factors and receptors on the corpus cavernosum （CC） in 10% fructose-fed Sprague-Dawley rats （FRUCT）. Differences were not observed in the organization of the CC either on the expression of vascular endothelial growth factor （VEGF） or the components of the angiopoietins/Tie2 system. However, opposing expression patterns were observed for VEGF receptors （an increase and a decrease for VEGFR1 and VEGFR2, respectively） in FRUCT animals, with these patterns being strengthened by mineral-rich water ingestion. Mineral-rich water ingestion （FRUCTMIN） increased the proportion of smooth muscle cells compared with FRUCT rats and induced an upregulatory tendency of sirtuin I expression compared with the control and FRUCT groups. Western blot results were consistent with the dual immunofluorescence evaluation. Plasma oxidized low-density lipoprotein and plasma testosterone levels were similar among the experimental groups, although a tendency for an increase in the former was observed in the FRUCTMIN group. The mineral-rich water-treated rats presented changes similar to those observed in rats treated with MS-protective polyphenol-rich beverages or subjected to energy restriction, which led us to hypothesize that the effects of mineral-rich water consumption may be more vast than those directly observed in this study.

关键词： angiopoietins erectile tissue hypersaline sodium-rich naturally sparkling mineral water receptors sirtuin 1 vascularendothelial growth factor

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Characterization of a Putative Filovirus Vaccine:Virus-Like Particles

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Virologica Sinica 2013年第2期28卷 65-70页

作者： Karen A O martins Travis K Warren Sina Bavari US Army Medical Research Institute of Infectious Diseases

Filoviruses are hemorrhagic fever viruses endemic to parts of Africa and the Philippines. Infection carries with it a mortality rate of up to 90% and currently there are no effective vaccines or therapeutics available to combat infection. However, the filovirus virus-like particles (VLP), which are currently under development, have been shown to be a promising vaccine candidate. They provide protection from infection in the mouse, guinea pig, and nonhuman primate models of infection, eliciting high anti-glycoprotein antibody titers and T cell responses to viral proteins. In this review, we will highlight the development of the filovirus VLP and describe the current understanding of VLP immunogenicity and correlates of protection.

关键词： Filovirus Ebola Marburg Vaccine Virus-like particle Correlates of Protection

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HPV18 Utilizes Two Alternative Branch Sites for E6*I Splicing to Produce E7 Protein

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Virologica Sinica 2019年第2期34卷 211-221页

作者： Ayslan Castro Brant Vladimir Majerciak Miguel Angelo martins Moreira Zhi-Ming Zheng Tumor Virus RNA Biology Section RNA Biology Laboratory Center for Cancer Research National Cancer Institute NIH Frederick MD 21702 USA Genetics Post-Graduation Program Rio de Janeiro Federal University Rio de Janeiro Brazil Genetics Program Nacional Cancer Institute INCA Rio de Janeiro 20231-050 Brazil

Human papillomavirus 18(HPV18) E6 and E7 oncogenes are transcribed as a single bicistronic E6 E7 pre-mRNA. The E6 ORF region in the bicistronic E6 E7 pre-mRNA contains an intron. Splicing of this intron disrupts the E6 ORF integrity and produces a spliced E6*I RNA for efficient E7 translation. Here we report that the E6 intron has two overlapped branch point sequences(BPS) upstream of its 30 splice site, with an identical heptamer AACUAAC, for E6*I splicing. One heptamer has a branch site adenosine(underlined) at nt 384 and the other at nt 388. E6*I splicing efficiency correlates to the expression level of E6 and E7 proteins and depends on the selection of which branch site. In general, E6*I splicing prefers the 30 ss-proximal branch site at nt 388 over the distal branch site at nt 384. Inactivation of the nt 388 branch site was found to activate a cryptic acceptor site at nt 636 for aberrant RNA splicing. Together, these data suggest that HPV18 modulates its production ratio of E6 and E7 proteins by alternative selection of the two mapped branch sites for the E6*I splicing, which could be beneficial in its productive or oncogenic infection according to the host cell environment.

关键词： Human papillomavirus 18 (HPV18) HPV splicing Branch point E6,E7,E6 intron HPV oncogenes

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