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Nanotechnology meets atopic dermatitis: Current solutions, challenges and future prospects. Insights and implications from a systematic review of the literature

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Bioactive Materials 2019年第1期4卷 380-386页

作者： Giovanni Damiani roberto eggenhöffner Paolo Daniele Maria Pigatto Nicola Luigi Bragazzi Clinical Dermatology IRCCS Istituto Ortopedico GaleazziMilanItaly Department of Biomedical Surgical and Dental SciencesUniversity of MilanMilanItaly Department of Dermatology Case Western Reserve UniversityClevelandOHUSA Young Dermatologists Italian Network Centro Studi GISEDBergamoItaly Department of Surgical Sciences and Integrated Diagnostics University of GenoaGenoaItaly Postgraduate School of Public Health Department of Health SciencesUniversity of GenoaGenoaItaly Laboratory for Industrial and Applied Mathematics(LIAM) Department of Mathematics and StatisticsYork UniversityTorontoOntarioCanada Department of Neuroscience RehabilitationOphthalmologyGenetics and Maternal/Child Sciences(DINOGMI)University of GenoaGenoaItaly

Atopic dermatitis is a chronic,relapsing,non-contiguous,exudative eczema/dermatitis,which represents a complex,multi-factorial disorder,due to an impairment of the stratum corneum *** available drugs have a low skin bioavailability and may give rise to severe adverse ***,including nanoparticles,liposomes,nano-gels,nano-mixtures,nano-emulsions and other nano-carriers,offer unprecedented solutions to these issues,enabling:i)the management of different clinical forms of atopic dermatitis,especially the recalcitrant ones,i)a better bio-availability and trans-dermal drug targeted delivery at the inflammation site,ii)dose control,iii)significant improvements both in clinical symptoms and immune responses,iv)with less adverse events being reported and a better safety ***,some nano-sized structures could amplify and even worsen symptoms in particularly susceptible ***,most studies included in the present systematic review have been conducted in-vitro or in-vivo,with few randomized controlled clinical trials(RCTs).Future investigations should adopt this design in order to enable scholars achieving robust findings and ***,given the above-mentioned shortcomings,further research in the field is urgently warranted.

关键词： Nanodermatology Nanobiotechnologies Atopic dermatitis

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