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Journal of Environmental Sciences 2022年第11期34卷 1-12页

作者： Xiang-Yang Lou roberto boada Veronica Verdugo Laura Simonelli Gustavo Pérez Manuel Valiente GTS-UAB Research Group Department of ChemistryFacultat de CiènciesUniversitat Autonoma de Barcelona08193 BellaterraSpain ALBA Synchrotron Carrer de la llum 2-26Cerdanyola del Valles08290 BarcelonaSpain Centro de Excelencia en Nanotecnologia Leitat ChileSantiago 7500724Chile

In this study, a commercial cube-shaped open-celled cellulose sponge adsorbent was modified by in-situ co-precipitation of superparamagnetic iron oxide nanoparticles(SPION) and used to remove As(V) from aqueous solutions. Fe K-edge X-ray absorption spectroscopy(XAS) and TEM identified maghemite as the main iron phase of the SPION nanoparticles with an average size 13 nm. Batch adsorption experiments at 800 mg/L showed a 63% increase of adsorption capacity when loading 2.6 wt.% mass fraction of SPION in the *** determination of the adsorption thermodynamic parameters indicated that the As(V) adsorption on the composite material is a spontaneous and exothermic *** K-edge XAS results confirmed that the adsorption enhancement on the composite can be attributed to the nanoparticles loaded. In addition, adsorbed As(V) did not get reduced to more toxic As(Ⅲ) and formed a binuclear corner-sharing complex with SPION. The advantageous cube-shape of the sponge-loaded SPION composite together with its high affinity and good adsorption capacity for As(V), good regeneration capability and the enhanceddiffusion attributed to its open-celled structure make this adsorbent a good candidate for industrial applications.

关键词： Adsorption Cube composite adsorbent Arsenate removal Regeneration X-ray absorption spectroscopy

Analysis of tumor-draining vein secretome: A direct access to tumor-derived extracellular vesicles in surgical lung cancer patients

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BIOCELL 2023年第5期47卷 951-957页

作者： YANGYI HE DAVID SANCHEZ-LORENTE MELISSA ACOSTA-PLASENCIA MARC boada ANGELA GUIRAO RAMON MMARRADES LAUREANO MOLINS ALFONS NAVARRO Molecular Oncology and Embryology Laboratory Department of Surgery and Surgical SpecializationsHuman Anatomy UnitFaculty of Medicine and Health SciencesUniversitat de Barcelona(UB)Barcelona08036Spain School of Basic Medical Sciences Chengdu UniversityChengdu610106China Department of Thoracic Surgery Hospital Clínic de BarcelonaUniversitat de Barcelona(UB)Barcelona08036Spain Thoracic Oncology Unit Hospital ClinicBarcelona08036Spain Institut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS) Barcelona08036Spain Department of Pneumology Institut Clínic Respiratori(ICR)Hospital Clínic de BarcelonaUniversitat de Barcelona(UB)Barcelona08036Spain Centro de Investigación Biomédica en Red de Enfermedades Respiratorias(CIBERES) Instituto de Salud Carlos IIIMadrid28029Spain

Tumor-secreted extracellular vesicles(EVs)participate in the metastasis process through different mechanisms,including the preparation of the pre-metastatic niche to grant circulating tumor cells(CTCs)implantation and *** study of the metastasis process through the analysis of CTCs and tumor-derived EVs is difficult because of the dilution grade of these elements in peripheral *** early-stage lung cancer patients,the tumor-secreted products are even more *** attractive strategy in surgical lung cancer patients is to purify them from a pulmonary tumor-draining vein where they are *** information obtained from the analysis of EVs and CTCs purified from this source could give more accurate information about tumor biology and could be an important source of biomarkers to identify patients at high risk of relapse after curative surgery.

关键词： Lung cancer Liquid biopsy Tumor-draining vein Extracellular vesicles Exosomes

Simultaneous pars plana vitrectomy,panretinal photocoagulation,cryotherapy,and Ahmed valve implantation for neovascular glaucoma

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International Journal of Ophthalmology(English edition) 2021年第9期14卷 1396-1401页

作者： Carolina Bernal-Morales Marina Dotti-boada Alvaro Olate-Perez Manuel J.Navarro-Angulo Laura Pelegrín Marc Figueras-Roca Institut Clínic d’Oftalmologia(ICOF) Hospital ClínicBarcelona 08028Spain August Pi i Sunyer Biomedical Research Institute(IDIBAPS) Barcelona 08028Spain

AIM:To describe and evaluate the efficacy of Ahmed glaucoma valve implantation(AGV)combined with pars plana vitrectomy(PPV)in a single surgical act for the treatment of advanced neovascular glaucoma(NVG).METHODS:Retrospective observational case series included 51 eyes from 50 patients with severe NVG treated with PPV,AGV,and panretinal photocoagulation and/or cryotherapy in a single surgical act during a 13-year period(2005-2018).Preoperative,intraoperative and postoperative data at day 1 and months 1,3,6,21,and 24 were systematically *** of surgical success was stablished at IOP between 6 and 21 mm Hg with or without topical ***:Main indications for surgery were NVG secondary to proliferative diabetic retinopathy(39.2%)and central retinal vein occlusion(37.3%).Mean(±SD)preoperative IOP was 42.0±11.2 mm Hg decreasing to 15.5±7.1 mm Hg at 12 mo and 15.8±9.1 mm Hg at 24 mo of follow *** incidence of success of IOP control was 76.0%at first postoperative month,reaching 88.3%at 6 *** of successful IOP control at long term was 74.4%at 12 mo and 71.4%at 24 *** evisceration for unsuccessful NVG management was required in 1 case(2.0%).CONCLUSION:Combination of AGV implantation and PPV in a single act may be a suitable option for severe forms of NVG in a case-by-case basis for effective IOP control and a complete panretinal photocoagulation.

关键词： neovascular glaucoma Ahmed valve pars plana vitrectomy panretinal photocoagulation cryotherapy

Suitability of the South Caribbean Coast of Costa Rica for Reintroduction of the Great Green Macaw <i>Ara ambiguus</i>

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Natural Resources 2014年第11期5卷 653-665页

作者： Sara Fraixedas álvaro Fernández-Llamazares Anna Rico Albert Bach Marta Borrós Carles Barriocanal Martí boada Institut de Ciència i Tecnologia Ambientals (ICTA) Universitat Autònoma de Barcelona (UAB) Bellaterra (Cerdanyola del Vallès) Spain Institut de Ciència i Tecnologia Ambientals (ICTA) Universitat Autònoma de Barcelona (UAB) Bellaterra (Cerdanyola del Vallès) Spain La Ceiba Nature Reserve Punta Uva Puerto Viejo de Talamanca Refugio de Vida Silvestre Gandoca-Manzanillo Caribe Sur Costa Rica Institut de Ciència i Tecnologia Ambientals (ICTA) Universitat Autònoma de Barcelona (UAB) Bellaterra (Cerdanyola del Vallès) Spain La Ceiba Nature Reserve Punta Uva Puerto Viejo de Talamanca Refugio de Vida Silvestre Gandoca-Manzanillo Caribe Sur Costa Rica Metapopulation Research Group (MRG) Department of Biosciences University of Helsinki Helsinki Finland Institut de Ciència i Tecnologia Ambientals (ICTA) Universitat Autònoma de Barcelona (UAB) Bellaterra (Cerdanyola del Vallès) Spain La Ceiba Nature Reserve Punta Uva Puerto Viejo de Talamanca Refugio de Vida Silvestre Gandoca-Manzanillo Caribe Sur Costa Rica The Helsinki Lab of Ornithology (HelLO) Finnish Museum of Natural History University of Helsinki Helsinki Finland La Ceiba Nature Reserve Punta Uva Puerto Viejo de Talamanca Refugio de Vida Silvestre Gandoca-Manzanillo Caribe Sur Costa Rica

The Great Green Macaw Ara ambiguus is an endangered species whose most important food resource and nesting site in Costa Rica is the mountain almond tree Dipteryx panamensis, threatened mainly by deforestation. In this study, we analyse the suitability of reintroducing A. ambiguus in the South Caribbean Coast of Costa Rica by examining whether the ecological and socio-cultural conditions required for the reintroduction are met in the area. The methods developed in this work include biological sampling, cartographical analysis and semi-structured interviews, among others. We set La Ceiba Nature Reserve as study unit and starting point of the analysis due both to its conservation status, favouring the potential release of individuals, and its ecosystem representativeness. Our results suggest that the habitat is suitable for reintroduction, with frequent presence of D. panamensis in the region, as well as other feeding options and potential nesting sites in the study area. The cartographic study reveals that the species could rely on a forested surface of up to 7000 hectares, which would be sufficient for sustaining a viable population. As for the socio-cultural analysis, illegal logging and low protective frameworks were identified as the main potential threats for the species. Nevertheless, we perceived positive conservation attitudes among local people and a pro-active commitment of political stakeholders. We conclude that a viable South Caribbean reintroduction of A. ambiguus is possible in conjunction with a threat mitigation programme.

关键词： Psittacine Conservation Reintroduction Threatened Species Suitability Analysis

Pathological response to neoadjuvant therapy with chemotherapy vs chemoradiotherapy in stage III NSCLC-contribution of IASLC recommendations

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World Journal of Clinical Oncology 2021年第11期12卷 1047-1063页

作者： Diego Muñoz-Guglielmetti David Sanchez-Lorente Roxana Reyes Daniel Martinez Carmen Lucena Marc boada Pilar Paredes Marta Parera-Roig Ivan Vollmer Joel Mases roberto Martin-Deleon Sergi Castillo Mariana Benegas Silvia Muñoz Maria Mayoral Carla Cases Meritxell Mollà Francesc Casas Radiation Oncology Department Hospital Clínic de BarcelonaBarcelona 08036CataluñaSpain Thoracic Surgery Department Thoracic UnitHospital Clínic de BarcelonaBarcelona 08036CataluñaSpain Medical Oncology Department Thoracic UnitHospital Clínic de BarcelonaBarcelona 08036CataluñaSpain Pathology Department Thoracic UnitHospital Clínic de BarcelonaBarcelona 08036CataluñaSpain Pneumology Department Thoracic UnitHospital Clínic de BarcelonaBarcelona 08036CataluñaSpain Nuclear Medicine Department Faculty of Medicine of University of BarcelonaInstitut d'Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)Barcelona 08036CataluñaSpain Medical Oncology Department Hospital Comarcal de VicVic 08500CataluñaSpain Radiology Department Thoracic UnitHospital Clínic de BarcelonaBarcelona 08036CataluñaSpain Pneumology Department Hospital Universitario Reina SofiaCórdoba 14004AndalucíaSpain Medical Oncology Department Hospital de MolletMollet 08100CataluñaSpain Medical Oncology Department Hospital General de GranollersGranollers 08402CataluñaSpain Nuclear Medicine Department Thoracic UnitHospital Clínic de BarcelonaBarcelona 08036CataluñaSpain Radiation Oncology Department Thoracic UnitHospital Clínic de BarcelonaBarcelona 08036CataluñaSpain

BACKGROUND Neoadjuvant treatment(NT)with chemotherapy(Ch)is a standard option for resectable stage III(N2)*** studies have suggested benefits with the addition of radiotherapy(RT)to NT *** International Association for the Study of Lung Cancer(IASLC)published recommendations for the pathological response(PHR)of NSCLC resection specimens after *** To contribute to the IASLC recommendations showing our results of PHR to NT Ch vs NT chemoradiotherapy(ChRT).METHODS We analyzed 67 consecutive patients with resectable stage III NSCLC with positive mediastinal nodes treated with surgery after NT Ch or NT ChRT between 2013 and *** NT,all patients were evaluated for radiological response(RR)according to Response Evaluation Criteria in Solid Tumours criteria and evaluated for surgery by a specialized group of thoracic *** histological samples were examined by the same two *** was evaluated by the percentage of viable cells in the tumor and the resected lymph *** Forty patients underwent NT ChRT and 27 NT ***-six(83.6%)patients underwent surgery(35 ChRT and 21 Ch).The median time from ChRT to surgery was 6 wk(3-19)and 8 wk(3-21)for Ch *** observed significant differences in RR,with disease progression in 2.5%and 14.8%of patients with ChRT and Ch,respectively,and partial response in 62.5%ChRT vs 29.6%Ch(P=0.025).In PHR we observed≤10%viable cells in the tumor in 19(54.4%)and 2 cases(9.5%),and in the resected lymph nodes(RLN)30(85.7%)and 7(33.3%)in ChRT and Ch,respectively(P=0.001).Downstaging was greater in the ChRT compared to the Ch group(80%vs 33.3%;P=0.002).In the univariate analysis,NT ChRT had a significant impact on partial RR[odds ratio(OR)12.5;95%confidence interval(CI):1.21-128.61;P=0.034],a decreased risk of persistence of cancer cells in the tumor and RLN and an 87.5%increased probability for achieving downstaging(OR 8;95%CI:2.34-27.32;P=0.001).CONCLUSION We found significant benefits in RR and PHR

关键词： Non-small cell lung cancer Chemotherapy Chemoradiotherapy Neoadjuvant treatment Resectable stage III Pathological response

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更昔洛韦植入伴随囊样异常

美国医学会眼科杂志（中文版） 2005年第4期17卷 235-235,237页

作者： N. Meidn Yenerel Robert boada Jing Zhang David A. Saperstein 李扬（译）

一名47岁男性艾滋病患者既往有巨细胞病毒性视网膜炎的病史．接受联合抗逆转录病毒治疗无效后选择进行8个月的右眼植入更昔洛韦疗法（Vitrasert, Bausch ＆ Lomb, Rochester．纽约）。患者视力右眼20／30．左服20／20．双眼眼底显示不... 详细信息

一名47岁男性艾滋病患者既往有巨细胞病毒性视网膜炎的病史．接受联合抗逆转录病毒治疗无效后选择进行8个月的右眼植入更昔洛韦疗法（Vitrasert, Bausch ＆ Lomb, Rochester．纽约）。患者视力右眼20／30．左服20／20．双眼眼底显示不活动的巨细胞病毒以及右眼更昔洛韦植人物顶端囊样结构（图1A）。

关键词：更昔洛韦巨细胞病毒性视网膜炎囊样植入抗逆转录病毒治疗艾滋病患者异常右眼植人物

PKR and PP1C Polymorphisms in Alzheimer’s Disease Risk

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Neuroscience & Medicine 2011年第3期2卷 226-231页

作者： Ernest Palomer Gerard ILL-Raga Marta Tajes Eva Ramos-Fernández Mònica Bosch-Morató Biuse Guivernau Jose J.Galan Jordi Clarimon Carmen Antunez Merce boada Luis M.Real César Fandos Francisco J.Munoz Laboratory of Molecular Physiology and Channelopathies Department of Experimental and Health SciencesPompeu Fabra University(UPF)BarcelonaSpain NeoCodex SevillaSpain Alzheimer Laboratory Neurology DepartmentSanta Creu and Sant Pau HospitalBiomedical Research Center on Neurodegenerative Diseases(CIBERNED)BarcelonaSpain Fundacion Alzheimur Dementia UnitVirgen de la Arrixaca HospitalMurciaSpain Memory Clinic of ACE Foundation Catalan Institute of Applied NeurosciencesBarcelonaSpain Neurology Department Vall d’Hebron Universitary HospitalBarcelonaSpain

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by senile plaques and neurofibrillary tangles. Senile plaques are deposits of amyloid ?-peptide (A?) produced by the cleavage of a transmembrane protein termed Amyloid Precursor Protein (APP). The amyloidogenic cleavage of APP is performed by γ-secretase complex and ?-site APP cleaving enzyme 1 (BACE1), a key enzyme in AD that can be activated by different noxious stimuli. Interestingly, some viruses could activate double-stranded RNA-activated protein kinase (PKR), which phosphorylates Eukaryotic Initiation Factor 2 alpha (eIF2α). This phosphorylation stops global translation to avoid any synthesis of viral infective proteins, but paradoxically up-regulates BACE1 translation. One of the viral mechanisms to circumvent eIF2α phosphorylation is the recruitment of protein phosphatase 1 (PP1), to fully dephosphorylate eIF2α and allow viral protein synthesis. Due to the functional relationship between BACE1, PKR, PP1 and AD we have performed a large (1122 cases and 1191 control individuals) case-control genetic analysis using two biallelic polymorphisms rs2254958 and rs7480390, located within the genes coding for PKR and the catalytic unit A of PP1, respectively. Although a trend to association of the rs2254958 TT genotype with AD risk was found, our results show that neither rs7480390 nor rs2254958 are associated with AD susceptibility.

关键词： Alzheimer’s Disease BACE1 PKR PP1 eIF2α