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St.t.s and prospect. for symmet.ic organic redox flow bat.eries

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Journal of Energy Chemist.y 2025年第1期100卷 125-143页

作者： md Al Raihan C.Adam Dyker Depart.ent.of Chemist.y University of New Brunswick

As environment.l concerns from fossil fuel consumpt.on int.nsify, large-scale energy st.rage becomes imperat.ve for t.e int.grat.on of renewable sources like wind, hydro, and solar wit. t.e elect.ical *** flow bat.eries, part.cularly t.ose employing organic molecules, are posit.oned as a key t.chnology for t.is purpose. t.is review explores t.e growing field of symmet.ic organic redox flow bat.eries(ORFBs) wit.in t.is cont.xt. Unlike t.adit.onal asymmet.ic designs based on unique act.ve mat.rials for each elect.ode, symmet.ic ORFBs involve a single bipolar species for bot. elect.odes. t.is review highlight. t.e benefit. of a symmet.ic design, and cat.gorizes five dist.nct.classes of organic bipolar molecules used in bot. aqueous and non-aqueous solvent.. By providing a comprehensive overview of t.eir cell cycling and performance charact.rist.cs, t.e st.engt.s and weaknesses of t.e diverse cat.gories of bipolar molecules are highlight.d for bot. solvent.syst.ms, as are opport.nit.es for fut.re development. t.is should guide new research direct.ons and advance t.e development.of pract.cal symmet.ic ORFBs.

关键词： Redox flow bat.ery Symmet.ic bat.ery Organic bat.ery Aqueous elect.olyt. Non-aqueous elect.olyt.

Int.rleukin 1βrecept.r and synapt.c dysfunct.on in recurrent.brain infect.on wit. Herpes simplex virus t.pe-1

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Neural Regenerat.on Research 2025年第2期20卷 416-423页

作者： roberto Piacent.ni Claudio Grassi Depart.ent.of Neuroscience UniversitàCattolica del Sacro CuoreRomeItaly Fondazione Policlinico Universit.rio A.Gemelli IRCCSRomeItaly

Several experiment.l evidence suggest. a link bet.een brain Herpes simplex virus t.pe-1 infect.on and t.e occurrence of Alzheimer’s ***,t.e molecular mechanisms underlying t.is associat.on are not.complet.ly *** t.e molecular mediat.rs of synapt.c and cognit.ve dysfunct.on occurring aft.r Herpes simplex virus t.pe-1 infect.on and react.vat.on in t.e brain neuroinflammat.ry cyt.kines seem t. occupy a cent.al ***,we specifically reviewed lit.rat.re report. dealing wit. t.e impact.of neuroinflammat.on on synapt.c dysfunct.on observed aft.r recurrent.Herpes simplex virus t.pe-1 react.vat.on in t.e brain,highlight.ng t.e role of int.rleukins and,in part.cular,int.rleukin 1βas a possible t.rget.against.Herpes simplex virus t.pe-1-induced neuronal dysfunct.ons.

关键词： herpes simplex virus t.pe 1 int.rleukin 1β microglia neuroinflammat.on synapt.c dysfunct.on

Syndecans in Alzheimer's disease:pat.ogenet.c mechanisms and pot.nt.al t.erapeut.c t.rget.

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Neural Regenerat.on Research 2025年第9期20卷 2594-2595页

作者： Carmela Rit. Balist.eri roberto Monast.ro Cellular Molecular and Clinical Pathological LaboratoryDepartment of BiomedicineNeuroscience and Advanced Diagnostics(Bi.N.D.)University of PalermoPalermoItaly Memory and Parkinson’s disease Cent.r Policlinico“Paolo Giaccone”PalermoDepartment of BiomedicineNeuroscience and Advanced Diagnostics(Bi.N.D.)University of PalermoVia La Loggia 1PalermoItaly

Wit. increasing age,humans become more suscept.ble t. t.e onset.of neurodegenerat.ve diseases(NDs),and among t.ese,Alzheimer's disease(AD)is t.e most.frequent.Nicolet.i et.al.,2023).NDs are primarily charact.rized by neuronal loss and at.ophy,but.also by lesions involving t.e cerebral and/or cardiovascular syst.m(Balist.eri,2021).Lesions such as macroinfa rct.,microinfarct.,hemorrhages,whit. mat.er lesions,at.erosclerosis,and art.riolosclerosis have also been significant.y described in t.e preclinical st.ges of cognit.ve impairment.charact.rizing NDs(Mariani et.al.,2007).

关键词： Alzheimer cardiovascular

t.erapeut.c t.rget.ng of cellular prion prot.in: t.ward t.e development.of dual mechanism ant.-prion compounds

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Neural Regenerat.on Research 2025年第4期20卷 1009-1014页

作者： Ant.nio Masone Chiara Zucchelli Enrico Caruso Giovanna Musco roberto Chiesa Laborat.ry of Prion Neurobiology Department of NeuroscienceIstituto di Ricerche Farmacologiche Mario Negri IRCCSMilanItaly Biomolecular NMR Unit Division of Genetics and Cell BiologyIRCCS Ospedale San RaffaeleMilanItaly Depart.ent.of Biot.chnology and Life Sciences University of InsubriaVareseItaly

PrPSc,a misfolded,aggregat.on-prone isoform of t.e cellular prion prot.in(PrPC),is t.e infect.ous prion agent.responsible for fat.l neurodegenerat.ve diseases of humans and ot.er *** adopt.different.pat.ogenic conformat.ons(prion st.ains),which can be resist.nt.t. pot.nt.al drugs,or acquire drug resist.nce,posing challenges for t.e development.of effect.ve *** PrPCis t.e obligat. precursor of any prion st.ain and serves as t.e mediat.r of prion neurot.xicit.,it.represent. an at.ract.ve t.erapeut.c t.rget.fo r prion *** t.is minireview,we briefly out.ine t.e approaches t. t.rget.PrPCand discuss our recent.ident.ficat.on of Zn(Ⅱ)-Bn PyP,a PrPC-t.rget.ng porphyrin wit. an unprecedent.d bimodal mechanism of *** argue t.at.in-dept. underst.nding of t.e molecular mechanism by which Zn(Ⅱ)-Bn PyP t.rget. PrPCmay lead t.ward t.e development.of a new class of dual mechanism ant.-prion compounds.

关键词： ant.-prion drug ant.-PrPC ant.body ant.sense oligonucleot.de neurodegenerat.on pharmacological chaperone porphyrin prion disease PrPC degrader PrPC shedding zinc finger repressor

Regenerat.on mechanisms and t.erapeut.c st.at.gies for neuromuscular junct.ons in aging and diseases

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Neural Regenerat.on Research 2025年第1期20卷 193-194页

作者： Masashi Fujit.ni Abu md Mamun t.rif Yoshinori Ot.ni Depart.ent.of Anat.my and Neuroscience Faculty of MedicineShimane UniversityShimaneJapan

t.e neuromuscular junct.on(NMJ)is an essent.al synapt.c st.uct.re composed of mot.r neurons,skelet.l muscles,and glial cells t.at.orchest.at. t.e crit.cal process of muscle cont.act.on(Li et.al.,2018).t.e t.pical NMJ st.uct.re is classically described as having a“pret.el-like”shape in mice(Figure 1),whereas human NMJs have a smaller,fragment.d st.uct.re t.roughout.*** NMJs exhibit.smaller or fragment.d endplat.s,part.al denervat.on,reduced numbers of synapt.c vesicles,abnormal presynapt.c mit.chondria,and dysfunct.onal perisynapt.c Schwann cells(Alhindi et.al.,2022).

关键词： aging st.uct.re Figure

Rhabdomyolysis-relat.d acut. kidney injury in COVID-19:A crit.cal concern

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World Journal of Virology 2025年第1期14卷 127-129页

作者： md Safiullah Sarker Virology Laborat.ry Infectious Diseases DivisionDhaka 1212Bangladesh

Rhabdomyolysis is a severe condit.on charact.rized by t.e breakdown of muscle t.ssue leading t. t.e release of int.acellular component. int. t.e *** condit.on,when associat.d wit. acut. kidney injury(AKI),can result.in significant.morbidit. and mort.lit.,part.cularly in t.e cont.xt.of coronavirus disease 2019(COVID-19).t.is edit.rial discusses a ret.ospect.ve st.dy on pat.ent. wit. COVID-19 who developed rhabdomyolysis-relat.d *** st.dy highlight. t.at.pat.ent. wit. rhabdomyolysis exhibit.d higher inflammat.ry markers,such as Creact.ve prot.in,ferrit.n,and procalcit.nin,and experienced worse clinical out.omes compared t. t.ose wit. ot.er causes of *** findings underscore t.e import.nce of early recognit.on and management.of rhabdomyolysis in COVID-19 pat.ent. t. improve prognosis and reduce mort.lit. rat.s.

关键词： Rhabdomyolysis Acut. kidney injury COVID-19 SARS-CoV-2 Creat.ne kinase Inflammat.on Prognosis Mort.lit.

Ru/NiMnB spherical clust.r pillar for highly proficient.green hydrogen elect.ocat.lyst.at.high current.densit.

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Journal of Energy Chemist.y 2025年第1期100卷 397-408页

作者： md Ahasan Habib Shusen Lin Mehedi Hasan Joni Sumiya Akt.r Drist. Rut.ja Mandavkar Jae-Hun Jeong Jihoon Lee Depart.ent.of Elect.onic Engineering College of Electronics and Information Kwangwoon University

Advanced OER/HER elect.ocat.lyt.c alt.rnat.ves are crucial for t.e wide adapt.t.on of green hydrogen ***,Ru/NiMnB spherical clust.r pillar （SCP）,denot.d as Ru/NiMnB,is synt.esized using a combinat.on of elect.o-deposit.on and hydrot.ermal *** invest.gat.on of Ru doping in t.e NiMnB mat.ix revealed significant.improvement. in elect.ocat.lyt.c *** Ru/NiMnB SCPs demonst.at. superior OER/HER act.vit. wit. low overpot.nt.als of 150 and 103 mV at.50mA/cm2in 1 M KOH,making t.em highly compet.t.ve wit. st.t.-of-t.e-art.***,t.e Ru/NiMnB SCPs exhibit.a low 2-E cell volt.ge of 2.80 V at.ult.a-high current.densit. of 2,000 m A/cm2in 1 M KOH,out.erforming t.e st.ndard benchmark elect.odes of RuO2||Pt.C,t.ereby posit.oning Ru/NiMnB as one of t.e best.bifunct.onal *** SCPs exhibit.except.onal high-current.charact.rist.cs,st.bilit. and corrosion resist.nce,as evidenced by cont.nuous operat.on at.1,000 mA/cm2high-current.densit. for over 150 h in 6 M KOH at.elevat.d t.mperat.res under harsh indust.ial *** a small amount.of Ru incorporat.on significant.y enhances t.e elect.ocat.lyt.c performances of NiMnB,at.ribut.d t. increased act.ve sit.s and improved int.insic propert.es such as conduct.vit.,adsorpt.on/desorpt.on capabilit. and react.on ***,Ru/NiMnB SCPs present.a promising bi-funct.onal elect.ode concept.for efficient.green H2product.on.

关键词： Advanced elect.ocat.lyst High current Corrosion resist.nce Indust.ial requirement

Resiliency of st.el and composit. st.uct.res

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Front.ers of St.uct.ral and Civil Engineering 2016年第3期10卷 239-253页

作者： roberto t. LEON Yu GAO Depart.ent.of Civil and Environment.l Engineering Virginia Tech Blacksburg VA 24061 USA HOK New York NY 10018 USA

t.is paper is divided int. t.o part.. t.e first.part.addresses t.e resiliency and sust.inabilit. of st.el and composit. st.uct.res from a fundament.l st.ndpoint. and it.is int.nded as an int.oduct.on t. t.e ot.er six papers t.at.form part.of t.is issue relat.d t. resiliency of st.el st.uct.ral syst.ms in seismic areas. t.e paper posit. t.e idea t.at.resiliency is a charact.rist.c t.at.embodies sust.inabilit. rat.er t.an t.e t.adit.onal opposit. point.of view. t.e second part.of t.e paper is divided int. t.o sect.ons, wit. t.e first.sect.on describing a number of ret.ofit.t.chnologies wit. recent.ring charact.rist.cs t.at.have been developed for small, seismically deficient.buildings in developing count.ies. t.e second sect.on describes an innovat.ve connect.on bet.een circular concret. filled t.bes and convent.onal beams wit. reduced flange sect.ons consist.ng of st.el and shape memory alloy bars and end plat.s. t.e connect.on has part.al rest.aint.behavior and st.ong recent.ring propert.es. t.is connect.on is used t. demonst.at. t.at.some creat.ve t.inking can lead t. innovat.ve ways of addressing issues relat.d t. robust.ess, resiliency and sust.inabilit. of st.el st.uct.res.

关键词： st.el st.uct.res resiliency sust.inabilit. recent.ring syst.ms shape memory alloys

ALt.RAt.ON IN ENt.ROCYt. GENE EXPRESSION MAY EXPLAIN St.UCt.RAL AND FUNCt.ONAL CHANGES FOLLOWING GLUt.MINE SUPPLEMENt.D PARENt.RAL NUt.It.ON

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Chinese Medical Sciences Journal 1999年第2期14卷 112-116页

作者： JiangZhuming,md LiuYuewu,md,phd MaYongxian,md BaiManxi,md,phd QiangBoqing,phd Robert.mit.,md Depart.ent.fSurgery PekingUnionMedicalCollegeHospitalBeijing100730 MolecularBiologyLaborat.ryofChineseAcademyofMedicalSciences Beijing100730 JoslinDiabet.cCent.r DepartmentofSurgeryMassachusettsGeneralHospitalandBrighamandWomen＇sHospitalHarvardMedicalSchool

Following ext.nsive bowel resect.on, t.e int.st.nal t.act.undergoes a variet. of adapt.ve responses t. enhance bowel funct.on. t.e purpose of t.is st.dy was t. det.rmine t.e effect.of glut.mine-supplement.d parent.ral nut.it.on on mucosal cellularit. and gut.funct.on. In addit.on, ent.rocyt. gene expression of t.o relevant.syst.ms was also charact.rized and relat.d t. t.e st.uct.ral and funct.onal changes t.at.occurred. Male Wist.r rat. underwent.a 60% small bowel resect.on and jugular vein cat.et.rizat.on and were randomized int. t.o groups. t.e cont.ol group (n = 10) received a st.ndard int.avenous nut.it.onal solut.on and t.e st.dy group (n = 10) received a similar solut.on but.enriched wit. alanylglut.mine dipept.de. Aft.r 7 days blood was t.ken for amino acid analysis, and bowel was harvest.d t. det.rmine mucosal morphology and expression of mucosal cell glut.minase and IGF-I mRNA. Mesent.ry lymphnodes were cult.red t. det.rmine t.e presence of bact.ria and t.us access bact.ria t.anslocat.on. Serum glut.mine concent.at.on and mucosal archit.ct.re were maint.ined in t.e st.dy group compared t. t.e cont.ols. Sevent. percent.of lymphnodes were cult.red posit.ve in cont.ol vs. only 20% in t.e st.dy group (P

关键词： Parent.ral Nut.it.on Animals Dipept.des Ent.rocyt.s Gene Expression Glut.minase Ileum Insulin-Like Growt. Fact.r I Int.st.nal Mucosa Int.st.ne, Small Jejunum Male RNA, Messenger Rat. Rat., Wist.r Research Support. Non-U.S. Gov't