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Endoscopic papillary balloon dilation for diffi cult common bile duct stones:Our experience

World Journal of Clinical Cases 2013年第1期1卷 19-24页

作者： Maddalena Zippi Isabella De Felici roberta pica Giampiero Traversa Giuseppe Occhigrossi Unit of Gastroenterology and Digestive Endoscopy Sandro Pertini Hospital 00157 Rome Italy

AIM: To evaluate the eff icacy and safety of endoscopic balloon dilation(EBD) performed for common bile duct(CBD) ***: From a computer database, we retrospectively analyzed the data relating to EBD performed in patients at the gastrointestinal unit of the Sandro Pertini Hospital of Rome(small center with low case volume) who underwent endoscopic retrograde cholangiopancreatography(ERCP) for CBD from January 1, 2010 to February 29, 2012. All patients had a proven diagnosis of CBD stones studied with echography, RMN cholangiography and, when necessary, with computed tomography of the abdomen(for example, in cases with pace-makers). Prophylactic therapies, with gabexate mesilate 24 h before the procedure and with an antibiotic(ceftriaxone 2 g) 1 h before, were administered in all patients. The duodenum was intubated with a side-viewing endoscope under deep sedation with intravenous midazolam and propofol. The patients were placed in the supine position in almost all cases. EBDof the ampulla was performed under endoscopic and f luoroscopic guidance with a balloon through the scope(Hercules, wireguided balloon, Cook Ireland Ltd. and CRE, Microvasive, Boston Scientific Co., Natick, MA, United States). RESULTS: A total of 14 patients(9 female, 5 male; mean age of 73 years; range 57-82 years) were enrolled in the study, in whom a total of 15 EBDs were performed. All patients underwent minor endoscopic sphincterotomy(ES) prior to the EBD. The size of balloon insuff lation depended on stone size and CBD dilation and this was performed until it reached 16 mm in diameter. EBD was performed under endoscopic and f luoroscopic guidance. The balloon was gradually f illed with diluted contrast agent and was maintained inf lated in position for 45 to 60 s before def lation and removal. The need for precutting the major papilla was 21.4%. In one patient(an 81-year-old), EBD was performed in a Billroth Ⅱ. Periampullary diverticula were found only in a 74-year-old female. T

关键词： Choledocholithiasis Endoscopic balloon dilation Endoscopic retrograde cholangiopancreatography Endoscopic sphincterotomy Mechanical lithotripsy

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Paradoxical relationship between proton pump inhibitors and COVID-19: A systematic review and meta-analysis

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World Journal of Clinical Cases 2021年第12期9卷 2763-2777页

作者： Maddalena Zippi Sirio Fiorino roberta Budriesi Matteo Micucci Ivan Corazza roberta pica Dario de Biase Claudio Giuseppe Gallo Wandong Hong Unit of Gastroenterology and Digestive Endoscopy Sandro Pertini HospitalRome 00157Italy Unit of Internal Medicine Maggiore HospitalLocal Health Unit of BolognaBologna 40133Italy Food Chemistry and Nutraceuticals Laboratory Department of Pharmacy and Biotechnology(FaBiT)Alma Mater StudiorumUniversity of BolognaBologna 40133Italy Experimental Diagnostic and Speciality Medicine DepartmentUniversity of BolognaBologna 40138Italy Department of Pharmacy and Biotechnology University of BolognaBologna 40138Italy Internal Medicine Unit Budrio Hospital Azienda USLBologna 40138Italy Department of Gastroenterology and Hepatology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND The proton pump inhibitors(PPIs),used to reduce gastric acid secretion,represent one of the most widely used pharmaceutical classes in the *** consumption as a risk factor for the evolution of severe forms of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has been investigated as well as the mortality of these *** risks also appear to be linked to the duration and the *** the other hand,several studies have emerged with regard to the protective or therapeutic effects of these *** and more evidence underlines the immunomodulatory and anti-fibrotic role of *** addition,their ability to alkalize the contents of endosomes and lysosomes serves as an obstacle to the entry of the virus into the host *** To identify studies on the relationship between the intake of PPIs and coronavirus disease 2019(COVID-19)in patients affected by SARS-CoV-2 infection,with the main objective of evaluating the outcomes related to severity and *** A literature review was performed in November *** MEDLINE/PubMed,Cochrane Library,EMBASE and Google Scholar databases were searched for all relevant articles published in English on this *** search terms were identified by means of controlled vocabularies,such as the National Library of Medicine’s MESH(Medical Subject Headings)and *** MESH terms and keywords used were as follows:“COVID-19”,“proton pump inhibitors”,“PPIs”,“SARS-CoV-2”,“outcomes”,“severity”and“mortality”.The inclusion criteria regarding the studies considered in our analysis were:meta-analysis,casecontrol,hospital-based case-control,population-based case-control,retrospective studies,online survey,as well as cohort-studies,while articles not published as full reports,such as conference abstracts,case reports and editorials were *** tried to summarize and pool all the data if *** A total of 9 studies were found that described the use of PPIs,of which only 5

关键词： COVID-19 Proton pump inhibitors SARS-CoV-2,Severity Mortality

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Schwannoma of the rectum:A case report and literature review

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World Journal of Clinical Cases 2013年第1期1卷 49-51页

作者： Maddalena Zippi roberta pica Renzo Scialpi Claudio Cassieri Eleonora Veronica Avallone Giuseppe Occhigrossi Department of Gastroenterology and Digestive Endoscopy Sandro Pertini Hospital 00157 Rome Italy Department of Pathology Sandro Pertini Hospital 00157 Rome Italy

Schwannoma is a tumor originating from the Schwann cells. Gastrointestinal schwannomas are uncommon stromal tumors of the intestinal tract and, in particular, rectal schwannomas are extremely rare. In fact, it is well established that schwannomas appear more frequently in the stomach and in the small intestine, while location in the colon or in the rectum is uncommon. Reading the literature, only few cases of rectal schwannoma have been reported. Their diagnosis is confirmed by the immunohisto chemical panel(S-100 protein). When these tumors are located in the colon and in the rectum, radical excision with wide margins is mandatory, due to their tendency to recur locally or become malignant, if left untreated. In the present study, we describe a case of a rectal schwannoma occured in a 72-year-old man, presented as a small polypoid lesion, which was successfully removed in toto by hot-biopsy, during the same endoscopy, due to the dimensons. No recurrence of the lesion was observed after 6 mo of follow-up.

关键词： Rectum Schwannoma Immunohistochemistry S-100 protein Treatment

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Extraintestinal manifestations in a large series of Italian inflammatory bowel disease patients

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World Journal of Gastroenterology 2014年第46期20卷 17463-17467页

作者： Maddalena Zippi Claudia Corrado roberta pica Eleonora Veronica Avallone Claudio Cassieri Daniela De Nitto Paolo Paoluzi Piero Vernia Unit of Gastroenterology and Digestive Endoscopy Sandro Pertini Hospital00157 RomeItaly Department of Internal Medicine and Medical Specialties Gastroenterology Unit"Sapienza"University of Rome00157 RomeItaly

AIM: To investigate prevalence, type and time of onset of extraintestinal manifestations (EIMs) in a series of Italian inflammatory bowel disease (IBD) patients.

关键词： Crohn’ s disease Extraintestinal manifestations Inflammatory bowel diseases Musculoskeletal manifestations Ulcerative colitis

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Mesenteric adenitis caused by Yersinia pseudotubercolosis in a patient subsequently diagnosed with Crohn's disease of the terminal ileum

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World Journal of Gastroenterology 2006年第24期12卷 3933-3935页

作者： Maddalena Zippi Maria Chiara Colaiacomo Adriana Marcheggiano roberta pica Paolo Paoluzi Giancarlo Iaiani Renzo Caprilli Francesca Maccioni Department of Clinical Sciences GI Unit Umberto Ⅰ Viale del Policlinico 15500161RomeItaly Department of Radiological Sciences Umberto Ⅰ Viale del Policlinico 155 00161RomeItaly Department of Infectious Diseases Umberto Ⅰ Viale del Policlinico 155 00161RomeItaly

Although the association between inflammatory bowel disease and gastrointestinal infections has been suggested, the mechanisms involved in the pathogenesis of Crohn＇s disease （CD） are still undetermined. We report the case of a man, who presented with mesenteric adenitis initially due to a Yersinia pseudotubercolosis infection, who was later diagnosed with Crohn＇s disease. This case is in keeping with recent evidence in the literature which suggests that CD is a disease linked to abnormal immune responses to enteric bacteria in genetically susceptible individuals.

关键词： Yersinia pseudotubercolosis Crohn's disease Ileitis

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Infliximab for the treatment of pouchitis

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World Journal of Clinical Cases 2013年第6期1卷 191-196页

作者： Maddalena Zippi Claudio Cassieri Eleonora Veronica Avallone roberta pica Unit of Gastroenterology and Digestive Endoscopy Sandro Pertini Hospital 00157 RomeItaly Gastroenterology Unit Department of Internal Medicine and Medical Specialties " La Sapienza" University 00161 Rome Italy

Pouchitis is not a rare complication that develops after an ileal-pouch anastomosis, performed after colectomy in patients refractory to treatment or with complicated ulcerative colitis. This condition may become chronic and unresponsive to medical therapies, including corticosteroids, antibiotics and probiotics. The advent of biological therapies(tumor necrosis factor-α inhibitors) has changed the course of these complications. In particular, in these cases, infliximab(IFX) may represent a safe and effective therapy in order to avoid the subsequent operation for a permanent ileostomy. This article reviews the therapeutic effects of one of the most widely used anti-tumor necrosis factor-α molecules, IFX, for the treatment of complicated pouchitis(refractory to conventional treatment and/or fistulizing).

关键词： Ileal pouch-anal anastomosis Infliximab Pouchitis Tumor necrosis factor-α Ulcerative colitis

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Biological therapy for dermatological manifestations of inflammatory bowel disease

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World Journal of Clinical Cases 2013年第2期1卷 74-78页

作者： Maddalena Zippi roberta pica Daniela De Nitto Paolo Paoluzi Unit of Gastroenterology and Digestive Endoscopy Sandro Pertini Hospital Department of Internal Medicine and Medical Specialties La Sapienza University

Ulcerative colitis and Crohn's disease are the two forms of inflammatory bowel disease(IBD). The advent of biological drugs has significantly changed the management of these conditions. Skin manifestations are not uncommon in IBD. Among the reactive lesions(immunemediated extraintestinal manifestations), erythema nodosum(EN) and pyoderma gangrenosum(PG) are the two major cutaneous ills associated with IBD, while psoriasis is the dermatological comorbidity disease observed more often. In particular, in the last few years, anti-tumor necrosis factor(TNF)-α agents have been successfully used to treat psoriasis, especially these kinds of lesions that may occur during the treatment with biological therapies. The entity of the paradoxical manifestations has been relatively under reported as most lesions are limited and a causal relationship with the treatment is often poorly understood. The reason for this apparent side-effect of the therapy still remains unclear. Although side effects may occur, their clinical benefits are undoubted. This article reviews the therapeutic effects of the two most widely used anti-TNF-α molecules, infliximab(a fusion protein dimer of the human TNF-α receptor) and adalimumab(a fully human monoclonal antibody to TNF-α), for the treatment of the major cutaneous manifestations associated with IBD(EN, PG and psoriasis).

关键词： Biological therapies Erythema nodosum Inflammatory bowel disease Psoriasis Pyoderma gangrenosum

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A nanostructured look of collagen apatite porosity into human mineralized collagen fibril

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BIOCELL 2022年第10期46卷 2225-2229页

作者： FABIANO BINI ANDRADA pica ANDREA MARINOZZI FRANCO MARINOZZI Department of Mechanical and Aerospace Engineering Sapienza University of RomeRome00184Italy Orthopedy and Traumatology Area Campus Bio-Medico UniversityRome00128Italy

Bone tissue is a hierarchical material characterized at nanoscale by the mineralized collagen fibril,a recurring structure mainly composed of apatite minerals,collagen and *** nanostructure has a fundamental role in determining the mechanical behavior of the tissue and its mass transport *** phenomenon allows to maintain an adequate supply of metabolites in the mechanisms of bone remodeling,adaptation and *** analytical and computational models have been developed to analyze and predict bone tissue ***,the fine replication of the natural tissue still represents a *** on the structural organization at nanoscale and on the influence of apatite mineral crystals on the diffusion coefficient lead to outline the functional conditions for the development of biomimetic strategies for bone tissue *** understanding of bone nanostructure is essential to improve longevity of bioscaffolds and to decrease the risk of failure by controlling their mechanical and biological performance.

关键词： Bone nanostructure Diffusivity Biomimicking Bioscaffolds Tissue engineering

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Antitumor effects of the benzophenanthridine alkaloid sanguinarine: Evidence and perspectives

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World Journal of Gastrointestinal Oncology 2016年第1期8卷 30-39页

作者： roberta Gaziano Gabriella Moroni Cristina Buè Martino Tony Miele Paola Sinibaldi-Vallebona Francesca pica Department of Experimental Medicine and Surgery University of Rome Tor Vergata

Historically, natural products have represented a significant source of anticancer agents, with plant-derived drugs becoming increasingly explored. In particular, sanguinarine is a benzophenanthridine alkaloid obtained from the root of Sanguinaria canadensis, and from other poppy Fumaria species, with recognized anti-microbial, anti-oxidant and anti-inflammatory properties. Recently, increasing evidence that sanguinarine exibits anticancer potential through its capability of inducing apoptosis and/or antiproliferative effects on tumor cells, has been proved. Moreover, its antitumor seems to be due not only to its pro-apoptotic and inhibitory effects on tumor growth, but also to its antiangiogenic and anti-invasive properties. Although the precise mechanisms underlying the antitumor activity of this compound remain not fully understood, in this review we will focus on the most recent findings about the cellular and molecular pathways affected by sanguinarine, together with the rationale of its potential application in clinic. The complex of data currently available suggest the potential application of sanguinarine as an adjuvant in the therapy of cancer, but further pre-clinical studies are needed before such an antitumor strategy can be effectively translated in the clinical practice.

关键词： Sanguinarine Cancer Apoptosis Cell-cycle Chemotherapy

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精妙织边璀璨如梦

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芭莎珠宝 2022年第2期 86-91页

作者： Luo pica(摄影) 不详

无论是从面料的丝锻质感还是从礼服上的织锦图案,高订礼服总能给维多利娅·德卡斯特兰(Victoiit de Castellane)源源不断的灵感。这一次,她以宝石为媒介,探索高级订制领域异彩纷呈的织边元素,携81件全新Galons Dior高级珠宝系列的倾心... 详细信息

无论是从面料的丝锻质感还是从礼服上的织锦图案,高订礼服总能给维多利娅·德卡斯特兰(Victoiit de Castellane)源源不断的灵感。这一次,她以宝石为媒介,探索高级订制领域异彩纷呈的织边元素,携81件全新Galons Dior高级珠宝系列的倾心臻作向梦之设计师Christian Dior先生致以恒久敬意并为迪奥高订主题珠宝翻开崭新篇章。

关键词：迪奥礼服维多利织锦图案珠宝面料

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